Tiny study checks antibiotic levels in lung infection fluid

NCT ID NCT04350502

Knowledge-focused Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at how the antibiotics amoxicillin and clavulanic acid get into the infected fluid around the lungs in people with pleural infections. Eleven adults with complicated infections had chest tubes placed and received the antibiotics. Researchers measured antibiotic levels in the blood and pleural fluid to see if enough drug reaches the infection site.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: amoxicillin and clavulanic acid
What this could lead to: If successful, this could help doctors choose the right antibiotic doses for pleural infections, improving treatment.
What could go wrong: This is a very small, completed pharmacokinetic study with only 11 participants. It does not test whether the antibiotics actually improve outcomes, only how they distribute in the body.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

11 people

The number who actually took part.

Started

Jul 2019

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * all adult patients (≥ 18 years old) hospitalized for a complicated community acquired pleural infection at University Hospital Amiens-Picardie. * Complicated pleural infection is defined by the presence of one of the following criteria: frank pus, loculated pleural fluid, presence of organisms identified by Gram stain and/or culture from a non-purulent pleural fluid sample, pleural fluid pH \<7.2, pleural fluid glucose \<0.32g/l or large non-purulent effusion. Exclusion Criteria: * non-infectious pleural effusion * hospital-acquired pleural infection * patient treated with amoxicillin and clavulanic acid (if treatment was started more than \> 24h ago) * Minors, pregnant women, adult patients protected by law. * Pleural infection requiring instant thoracic surgery * allergy to beta-lactam * Injection of contrast agent (Iomeron or Iohexol) during the 24 hours preceding or following the first dose of amoxicillin / clavulanic acid.

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Conditions

The condition(s) this trial relates to.

Community-Acquired Pneumonia empyema pleural empyema pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amoxicillin Community-acquired pneumonia Empyema Pharmacokinetic Pleural infection

Tiny study checks antibiotic levels in lung infection fluid

What the study statuses mean