COMMUNITY ACQUIRED PNEUMONIA

This study tests whether having patients with severe pneumonia lie on their stomachs while awake and on high-flow oxygen can reduce the need for a breathing tube. The trial will include 1078 adults in intensive care. The goal is to improve outcomes and avoid invasive procedures.

This study tests whether a blood thinner called heparin can help people hospitalized with pneumonia avoid serious complications like needing a breathing machine or intensive care. About 4000 adults will be randomly assigned to receive either heparin or standard care. The goal is …

This study compares two common antibiotics, azithromycin and doxycycline, in adults hospitalized with community-acquired pneumonia who are already receiving standard treatment. The goal is to see which one helps patients leave the hospital sooner and reduces complications. About …

This study tests whether amoxicillin alone is as effective as the broader-spectrum amoxicillin/clavulanate for treating community-acquired pneumonia in adults aged 65 and older who are hospitalized but not in intensive care. The goal is to see if using a narrower antibiotic can r…

This study tests whether the antiviral drug acyclovir improves survival in ventilated intensive care patients with pneumonia who also have herpes simplex virus (HSV) in their lungs. Almost half of these patients carry HSV, which can reactivate during severe illness. The trial ran…

This study looks at whether a 'watch and wait' approach to giving antibiotics can safely reduce unnecessary antibiotic use in children with mild pneumonia. About 2,000 children will be randomly assigned to either get antibiotics right away or wait 72 hours to see if they improve …

This study tests whether giving the antibiotic clarithromycin early, based on a blood test result, can stop pneumonia from turning into sepsis. About 330 adults with community-acquired pneumonia who are at risk will take the drug or a placebo for a few days. The goal is to see if…

This study tests whether adding trimodulin to standard care helps adults with severe community-acquired pneumonia who need a breathing machine. About 590 hospitalized patients will receive either trimodulin or a placebo. The main goal is to see if more patients survive at least 2…

This study compares two types of breathing support—high-velocity nasal insufflation (HVNI) and noninvasive ventilation (NIV)—in 100 adults with pneumonia who are having trouble breathing. The main goal is to see which method better prevents the need for a breathing tube or death …

This study follows 1,000 adults who visit fever clinics with respiratory infections. Researchers collect symptoms, lab tests, and chest images to see how the illness progresses and who develops pneumonia. No treatments are tested—participants receive standard care. The goal is to…

This study looks at whether a simple frailty scale can better predict serious outcomes like death in older adults (65+) with pneumonia. Researchers will follow 150 patients in the emergency department to compare the frailty scale with standard pneumonia scores. The goal is to see…

This study aims to learn how common community-acquired pneumonia is and what factors increase the risk, especially in people with other health conditions. Researchers will collect information from 20,000 adults, both in and out of the hospital, about their diagnosis, treatments, …