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Can a simple blood thinner keep pneumonia patients out of the ICU?

NCT ID NCT05848713

Disease control Sponsor: University of Manitoba Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a blood thinner (heparin) can help hospitalized adults with pneumonia avoid serious complications like needing a breathing machine or intensive care. About 4000 participants will receive either heparin or standard care. The goal is to see if heparin reduces the risk of severe illness or death.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 4,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients ≥18 years of age 2. Admitted to hospital for a suspected or confirmed diagnosis of CAP defined by: 1. Radiographic evidence of new or worsening infiltrate 2. One or more of the following signs and/or symptoms of lower respiratory tract infection i. New or increased cough or sputum production ii. Fever of \> 37.8C or temperature \< 36C iii. WBC \> 11 x 109/L or \< 4 x 109/L c. The primary diagnosis is believed to be CAP as per the attending physician 3. Requires supplemental oxygen to treat hypoxemia (or requires an increased level of supplemental oxygen if on chronic oxygen therapy) 4. Hospital admission anticipated to last ≥72 hours from randomization Exclusion Criteria: 1. Suspected or confirmed active COVID-19 infection 2. Hospital admission for \>72 hours prior to randomization 3. Patients receiving non-invasive or invasive ventilation, vasopressors, or extracorporeal life support (ECLS) within an ICU at the time of enrollment 4. Requirement for chronic mechanical ventilation via tracheostomy prior to hospitalization 5. Patients for whom the intent is to not use pharmacologic thromboprophylaxis 6. Patients with an independent indication for therapeutic-dose anticoagulation 7. Patients with a contraindication to therapeutic-dose anticoagulation, including: 1. Non-traumatic bleeding that requires medical evaluation or hospitalization within 30 days prior to CAP hospital admission 2. History of an inherited or acquired bleeding disorder 3. Cerebral aneurysm or mass lesions of the central nervous system 4. Ischemic stroke within 3 months of hospital admission 5. Gastrointestinal bleeding within 3 months of hospital admission 6. Platelet count \<50 x109/L OR INR \>2.0 OR hemoglobin \<80 g/L at the time of screening 7. Other physician-perceived contraindications to therapeutic anticoagulation 8. History of heparin induced thrombocytopenia (HIT) or other heparin allergy 9. Current or recent (within 7 days of screening) use of dual anti-platelet inhibitors (For example; Aspirin + one of the following; clopidogrel, ticagrelor, prasugrel) 10. Patients in whom imminent death is anticipated 11. Anticipated transfer to another hospital that is not a study site within 72 hours of randomization 12. Enrollment in other interventional trials related to anticoagulation or antiplatelet therapy during current hospitalization

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Conditions

The condition(s) this trial relates to.

Community-Acquired Pneumonia pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Community-acquired pneumonia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    58 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU de Quebec-University Laval

    RECRUITING

    Québec, Quebec, Canada

  • Centre Hospitalier Universitaire de Sherbrooke

    RECRUITING

    Sherbrooke, Quebec, Canada

  • Centre Hospitalier de Quebec - Hotel-Dieu de Levis

    NOT_YET_RECRUITING

    Lévis, Quebec, G6V 3Z1, Canada

  • Centre Hospitalier de l'université de Montréal (CHUM)

    RECRUITING

    Montreal, Quebec, Canada

  • CiTen - Centro Hospital Municipal Antonio Giglio

    RECRUITING

    Osasco, São Paulo, Brazil

  • Cooper University Health Care

    RECRUITING

    Camden, New Jersey, 08103, United States

  • Foothills Medical Centre

    RECRUITING

    Calgary, Alberta, T2N 2T9, Canada

  • Fundação Centro Médico de Campinas

    RECRUITING

    Campinas, São Paulo, 13083-190, Brazil

  • Grace General Hospital

    RECRUITING

    Winnipeg, Manitoba, Canada

  • Grand Prairie Regional Hospital

    NOT_YET_RECRUITING

    Grande Prairie, Alberta, T8V 4B1, Canada

  • HCFMUSP

    RECRUITING

    São Paulo, São Paulo, 05403-010, Brazil

  • Hamilton Health Sciences

    RECRUITING

    Hamilton, Ontario, Canada

  • Hamilton Health Sciences - Juravinski

    RECRUITING

    Hamilton, Ontario, Canada

  • Health Sciences Center Winnipeg

    RECRUITING

    Winnipeg, Manitoba, R3A 1R9, Canada

  • Health Sciences North Research Institute

    RECRUITING

    Greater Sudbury, Ontario, P3E 2H3, Canada

  • Henry Ford Health System

    COMPLETED

    Dearborn, Michigan, 48128, United States

  • Hospital Brasilia

    COMPLETED

    Brasília, Federal District, Brazil

  • Hospital Bruno Born

    RECRUITING

    Lajeado, Rio Grande do Sul, Brazil

  • Hospital Estadual Dr. Jayme Santos Neves

    RECRUITING

    Serra, Espírito Santo, 29166-828, Brazil

  • Hospital Estadual de Serrana

    NOT_YET_RECRUITING

    Ribeirão Preto, São Paulo, Brazil

  • Hospital Evangelico de Vila Velha

    RECRUITING

    Vila Velha, Espírito Santo, Brazil

  • Hospital Felicio Rocho

    RECRUITING

    Belo Horizonte, Minas Gerais, Brazil

  • Hospital Nipo-Brasileiro

    RECRUITING

    São Paulo, São Paulo, 02189-010, Brazil

  • Hospital Regional Homero Miranda Gomes

    COMPLETED

    São José, South Carolina, Brazil

  • Hospital Regional de Presidente Prudente

    RECRUITING

    Presidente Prudente, São Paulo, Brazil

  • Hospital Ruy Azeredo

    RECRUITING

    Goiânia, Goiás, Brazil

  • Hospital Santa Cruz

    RECRUITING

    Curitiba, Paraná, Brazil

  • Hospital Sao Brasilia

    NOT_YET_RECRUITING

    Brasília, Federal District, Brazil

  • Hospital Sao Jose

    RECRUITING

    Criciúma, Santa Catarina, Brazil

  • Hospital Sao Vicente de Paulo

    RECRUITING

    Passo Fundo, Rio Grande do Sul, Brazil

  • Hospital Universitario Sao Francisco na Providencia na Deus

    RECRUITING

    Bragança Paulista, São Paulo, Brazil

  • Hospital Universitario de Santa Maria

    RECRUITING

    Santa Maria, Rio Grande do Sul, Brazil

  • Hospital Universitário Cassiano Antonio Moraes

    NOT_YET_RECRUITING

    Vitória, Espírito Santo, Brazil

  • Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo

    NOT_YET_RECRUITING

    São Paulo, São Paulo, Brazil

  • Hospital de Clínicas de Porto Alegre

    RECRUITING

    Porto Alegre, Rio Grande do Sul, Brazil

  • Hospital de Messejana Dr. Carlos Alberto Studart Gomes

    RECRUITING

    Goiânia, Goiás, Brazil

  • Hospital de Reabilitacao de Anomalias Craniofaciais

    NOT_YET_RECRUITING

    Bauru, São Paulo, Brazil

  • Hospital do Rocio

    RECRUITING

    Campo Largo, Paraná, 83606-177, Brazil

  • Hôpital Montfort

    RECRUITING

    Ottawa, Ontario, Canada

  • IPECC

    RECRUITING

    Campinas, São Paulo, Brazil

  • Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)

    RECRUITING

    Québec, Quebec, Canada

  • Instituto Goiano de Oncologia e Hematologia - INGOH

    RECRUITING

    Goiânia, Goiás, Brazil

  • Instituto de Cardiologia e Transplantes do Distrito Federal

    RECRUITING

    Brasília, Federal District, Brazil

  • Jewish General Hospital

    RECRUITING

    Montreal, Quebec, Canada

  • Maine Medical Centre

    RECRUITING

    Portland, Maine, 04102, United States

  • Markham Stouffville Hospital

    RECRUITING

    Markham, Ontario, L3P 7P3, Canada

  • McGill University Health Centre

    RECRUITING

    Montreal, Quebec, H4A3J1, Canada

  • Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Memorial University

    RECRUITING

    St. John's, Newfoundland and Labrador, A1C 5S7, Canada

  • NUPEC-Orizonti

    COMPLETED

    Belo Horizonte, Minas Gerais, Brazil

  • Nanaimo Regional General Hospital

    RECRUITING

    Nanaimo, British Columbia, Canada

  • Niagara Health System - St Catharines Site

    RECRUITING

    Saint Catherines, Ontario, L2S 0A9, Canada

  • Ochsner Clinic

    RECRUITING

    Jefferson, Louisiana, 70121, United States

  • PUCPR

    COMPLETED

    Curitiba, Paraná, Brazil

  • Regina General Hospital

    RECRUITING

    Regina, Saskatchewan, S4P 0W5, Canada

  • Santa Casa de Misericordia de Itabuna

    COMPLETED

    Itabuna, Estado de Bahia, Brazil

  • Santa Casa de Misericordia de Sao Paulo

    RECRUITING

    São Paulo, São Paulo, Brazil

  • St. Boniface General Hospital

    RECRUITING

    Winnipeg, Manitoba, Canada

  • Sunnybrook Health Sciences Centre

    RECRUITING

    Toronto, Ontario, M4N 3M5, Canada

  • The Ottawa Hospital

    RECRUITING

    Ottawa, Ontario, Canada

  • UPECLIN - Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu

    RECRUITING

    Botucatu, São Paulo, Brazil

  • University Health Network

    NOT_YET_RECRUITING

    Toronto, Ontario, M5G2C4, Canada

  • University of Chicago

    NOT_YET_RECRUITING

    Chicago, Illinois, 60637, United States

  • Vancouver General Hospital

    RECRUITING

    Vancouver, British Columbia, V5Z 1M9, Canada

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Other studies related to the condition(s) this trial covers.