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Which works better for h. pylori? triple vs quadruple therapy showdown

NCT ID NCT07312721

Disease control Sponsor: Azfar Farogh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two different 14-day drug combinations to treat Helicobacter pylori, a bacteria that causes stomach inflammation and ulcers. Over 750 adults were randomly assigned to either a triple therapy (omeprazole, amoxicillin, clarithromycin) or a quadruple therapy (omeprazole, metronidazole, tetracycline, bismuth). Six weeks after treatment, a stool test checked if the infection was gone. The goal is to find which regimen works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Omeprazole, amoxicillin, clarithromycin (triple therapy) or omeprazole, metronidazole, tetracycline, bismuth subsalicylate (quadruple therapy)
What this could lead to
If one regimen proves more effective, it could become the preferred standard treatment for H. pylori infection, reducing ulcers and gastritis.
What could go wrong
This is a completed Phase 4 trial, so results are already in. However, the study was done at a single center in Pakistan, so findings may not apply everywhere. Both regimens have side effects like nausea or diarrhea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

752 people

The number who actually took part.

Started

Jan 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-65 years. Confirmed Helicobacter pylori infection based on a positive stool antigen test. Willing and able to provide written informed consent. Exclusion Criteria: History of allergy or hypersensitivity to any of the study drugs (omeprazole, amoxicillin, clarithromycin, metronidazole, tetracycline, or bismuth compounds). Prior H. pylori eradication therapy. Pregnancy or lactation. History of gastrointestinal bleeding, peptic ulcer perforation, or prior gastric surgery. Chronic renal failure or hepatic dysfunction. Current use of proton pump inhibitors or antibiotics within the previous six weeks. Use of traditional (Hakeem) medications or herbal remedies affecting gastric function. Psychiatric illness or inability to comply with treatment and follow-up. \-

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Conditions

The condition(s) this trial relates to.

chronic gastritis Helicobacter pylori infectious disease peptic ulcer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic gastritis Helicobacter pylori infection Peptic ulcer disease

Contacts and locations

Locations

  • Shahida Islam Medical College, Lodhran

    Lodhran, Punjab Province, 59320, Pakistan

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