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Saline vs. drugs: a simpler way to treat lung infections?

NCT ID NCT05903417

Disease control Sponsor: National University of Malaysia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two treatments for pleural infection, a serious lung condition where infected fluid builds up. One group received standard fibrinolytic drugs (alteplase and DNase) to break down clots, while the other group received simple saline (salt water) irrigation to flush out the infection. The trial involved 40 adults with poor fluid drainage. The goal was to see if the simpler saline method is as safe and effective as the drug treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
alteplase and DNase (fibrinolytic drugs)
What this could lead to
If successful, this could show that simple saline irrigation is as effective as fibrinolytic drugs for treating pleural infection, offering a cheaper and safer alternative.
What could go wrong
This is a small pilot study with only 40 participants, so results may not apply to everyone. The study is also completed, so no new data is being collected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jul 2023

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1\. Adult patient with aged ≥ 18 years old 2. Patients with pleural infection (complex parapneumonic effusion or empyema) with poor pleural fluid drainage of ≤ 150 ml after 24H of insertion of chest drain 3. Clinical features consistent with pleural infection ; fulfilling ≥ 2 of the following characteristics : i) Clinical evidence of infection such as fever and or elevated C-reactive protein (CRP) or total white blood count (TWBC) ii) Complex pleural effusion proven by thoracic ultrasound is defined as presence of fibrin strands or septations within pleural cavity iii) Pleural fluid that fulfil at least one of the characteristic : * frank pus, * exudative type of pleural effusion (according to light's criteria) * gram stain or culture positive * lactate dehydrogenase (LDH) \> 900U/L * Acidic with ph \< 7.2 * glucose level \< 3.3 mmol/L Exclusion Criteria: 1. Refusal to participate 2. Known allergy to t-PA or DNase 3. Acute stroke 4. Significant bleeding diathesis/ active gastrointestinal bleed 5. Major surgery in the previous 5 days 6. Previous pneumonectomy on the infected side 7. Bronchopleural fistula 8. Pregnancy 9. Coagulapathy (INR \> 2, APTT \> 100) 10. Platelet count \< 50000 cells

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Conditions

The condition(s) this trial relates to.

empyema pleural empyema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pleural infection

Contacts and locations

Locations

  • National University of Malaysia

    Kuala Lumpur, Kuala Lumpur, 56000, Malaysia

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Other studies related to the condition(s) this trial covers.