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Keyhole surgery may beat standard care for chest infections

NCT ID NCT07550530

Disease control Sponsor: Università Politecnica delle Marche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

The PROMPT study is testing whether an early keyhole procedure called medical thoracoscopy works better than current standard treatment (medicines to break up thick fluid) for people with pleural infection. About 170 patients will be randomly assigned to one of the two treatments. Researchers will see which approach results in fewer additional procedures within 30 days, as well as how quickly people recover and whether they experience any complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
medical thoracoscopy (keyhole procedure)
What this could lead to
If it works, this could point toward a better first-line treatment for pleural infection, reducing the need for repeat procedures and speeding recovery.
What could go wrong
This is a relatively small, early-stage study (170 patients) and the procedure is more invasive than standard care, so it may not prove superior or could carry higher risks like pain or complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 170 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria * Adults ≥ 18 years * Clinical and radiological diagnosis of pleural infection (purulent, culture-positive, or pH \< 7.2) * Need of pleural drainage * Able and willing to give informed consent Exclusion criteria * Chest drain in situ \>24h before randomisation * Post-traumatic pleural effusion * Known allergy to fibrinolytic agents or contraindication to thoracoscopy * Pregnancy or breastfeeding * Life expectancy \< 3 months from another illness * Previous lung surgery (pneumonectomy) in the same side of pleural infection * Previous pleurodesis in the same side of pleural infection * Any contraindication to Medical thoracoscopy

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Conditions

The condition(s) this trial relates to.

Inflammation pleural disorder pleural empyema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pleural infection Pleural infections Pleural infections and inflammations

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.