Saline wash may offer safer way to treat lung infections

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (≥18 years old) capable of fully understanding the study; * Complicated pleural infection (macroscopically purulent fluid, positive for bacteria on Gram's staining, positive on culture for bacterial infection, loculated effusion, pH \<7.2, great abundance) leading to thoracic drainage; * Initial ultrasound evaluation to estimate pleural fluid abundance and detect fibrinous septation; * Social security affiliation * Written informed consent * Highly effective contraceptive methods for women of childbearing age include: Combined hormonal contraception (estrogen and progestogen) associated with inhibition of ovulation (oral, intravaginal, transdermal); progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable, implantable); intrauterine device; hormone- releasing intrauterine system; bilateral occlusion of the Fallopian tubes; vasectomized partner; sexual abstinence Exclusion Criteria: * Tuberculous pleural effusions; * Previous treatment with intrapleural fibrinolytic agents (urokinase, streptokinase, alteplase, or DNase) or intrapleural saline lavage; * Previous thoracic surgery for pleural infection; * Contraindications to auxiliary treatments, to fibrinolysis or surgery as well as to procedures such as drainage and lavage; * Pregnancy or lactation; * Expected survival of less than 3 months; * Thoracic drainage since more than 24h; * Patient deprived of liberty by administrative or judicial decision or placed under judicial protection (guardianship or supervision); * Inability to give informed written consent; * Participation in another clinical trial; * Patient being a relative of the investigator or any member of the team directly involved in the study, including assistant physicians, pharmacists, nurses, and coordinators