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Can saline alone treat lung infections? new pilot study aims to find out

NCT ID NCT07592520

Disease control Sponsor: Dartmouth-Hitchcock Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study will test whether flushing the chest tube with saline alone can treat complicated pleural infections (fluid buildup around the lungs). If saline doesn't work, patients will receive stronger clot-busting drugs (fibrinolytics) or surgery. The study will track how long the chest tube stays in and how many people need stronger treatments. It includes 30 adults with pleural infection who need a chest tube.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
saline (normal saline), with possible escalation to alteplase and dornase alfa (fibrinolytics)
What this could lead to
If successful, this could show that simple saline flushes are enough for many pleural infections, reducing the need for stronger drugs or surgery.
What could go wrong
This is a very small pilot study (30 people) and not yet recruiting. It only observes outcomes, so it cannot prove which treatment is better. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18+ * Complicated Parapneumonic Effusion or Empyema Requiring Thoracostomy * Are able to personally or have a designated medical decision maker provide consent Exclusion Criteria: * Age \< 18 years * Have received any intrapleural medications prior to enrolment via current chest tube * Have a contraindication to tPA/DNase: * Anticoagulation * Active hemorrhage * Allergy to tPA/DNase * Pregnancy * Are unable to personally or do not have a designated medical decision maker provide consent

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Conditions

The condition(s) this trial relates to.

empyema pleural empyema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Complicated parapneumonic effusion Empyema, pleural

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dartmouth-Hitchcock Medical Center

    Hanover, New Hampshire, 03756, United States

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