Dartmouth-hitchcock Medical Center

This study tests whether adding tetrathiomolybdate (TM) to standard capecitabine can lower the chance of breast cancer returning in patients with high-risk triple-negative breast cancer. About 204 participants who have completed initial treatment and surgery will receive either T…

This study looks at whether giving e-cigarettes to smokers with mental illness who can't or won't quit can help them switch away from regular cigarettes. Participants will either get e-cigarettes alone or with extra behavioral support through telehealth. The goal is to reduce the…

This study is testing a laser treatment (sLITT) for people with cancer that has spread to the spine. The goal is to see if the laser can control tumor growth as well as traditional open surgery, but with a less invasive approach. The study will enroll 25 adults whose tumors are i…

This study tests whether a special music app, used at home, can reduce seizure-related brain activity in adults with drug-resistant epilepsy who have a brain implant (RNS). Twenty-four participants will listen to either the study music or a placebo sound over several months. The …

This study tests whether certain drug combinations can help people with advanced ER+ breast cancer whose cancer has stopped responding to common treatments like palbociclib. About 135 participants will receive a treatment chosen based on their tumor's genetic makeup. The goal is …

This study tests a new way of giving chemotherapy to people with certain gastrointestinal cancers, like colorectal or stomach cancer. The approach adjusts the dose of one chemotherapy drug (5-FU) based on how well each person tolerates the starting dose. The goal is to see if thi…

This study tests a surgery that moves a nerve from the neck to help people with arm weakness after a stroke. It includes 95 adults whose arm function stopped improving 1-5 years after stroke. The goal is to see if the surgery can improve arm movement and control.

This study tests whether switching between two different chemotherapy combinations can help people with borderline resectable pancreatic cancer. The goal is to shrink the tumor enough for successful surgery and to improve survival without the cancer coming back. About 35 adults w…

This study tests if a form of estrogen (estradiol) can help control advanced breast cancer that is hormone-receptor-positive (ER+). It includes 36 post-menopausal women whose cancer has spread or returned and who have already tried other hormone therapies. The goal is to see if w…

This study is testing a new, non-invasive device called a tissue oxygen imager. It uses a special light and a cream (ALA) to measure oxygen levels in skin growths. Cancerous areas have low oxygen, which the imager can detect. The goal is to see if this method can accurately tell …

This study tests a special microscope called CONVIVO that lets surgeons see brain tissue up close during surgery. The goal is to help them tell the difference between normal brain and tumor tissue right away. About 30 adults with different types of brain tumors will take part. If…

This early-phase trial tests a fluorescent dye called ABY-029 to help surgeons better see high-grade gliomas (a type of brain tumor) during surgery. About 33 adults with suspected high-grade glioma will receive a small amount of the dye before surgery. The goal is to find the rig…

This study looks at two ways to manage side effects from aromatase inhibitors, a hormone therapy for early-stage breast cancer. About half of women stop taking these pills early due to side effects, raising the risk of cancer returning. Researchers will compare switching to a dif…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants will take part in virtual coaching sessions over 6 months, learning problem-solving and relaxation techniques. The …

This study tests a digital program called I-CARE for teens aged 12-17 who are in the emergency room with suicidal thoughts or self-harm and waiting for a psychiatric bed. The program teaches coping skills through a tablet or phone, guided by a non-clinical helper. Researchers wan…

This study tests whether low-dose naltrexone (LDN) can safely reduce pain from diabetic neuropathy, a common complication of diabetes. About 35 adults with painful diabetic neuropathy who have not responded to standard treatments will receive LDN and a placebo in random order. Th…

This study tests whether regular electronic surveys can help people with advanced cancer report their symptoms and needs, so their doctors can connect them to palliative care sooner. About 90 adults with incurable solid tumors will participate. The goal is to see if this simple a…

This study tests a home-based program called HOBSCOTCH-MS for people with multiple sclerosis who have memory or thinking problems. Participants meet virtually with a coach for 8 weekly sessions to learn problem-solving and relaxation techniques. The goal is to see if the program …

This study tests whether a new type of exercise prescription, based on how you feel during activity, helps breast cancer survivors become more active. About 85 people who finished cancer treatment in the last 5 years will be assigned to either the affect-based or an effort-based …

This study looks at how a powerful cystic fibrosis treatment (CFTR modulator therapy) changes the bacteria and inflammation in the sinuses, and whether it improves smell and daily life. About 30 adults with CF will give nose samples, take smell tests, and fill out surveys. Resear…

This study tests whether adding patients' own goals and concerns to their mental health care plan helps them stay engaged in treatment. About 2,400 adults receiving collaborative care for anxiety or depression will use an enhanced questionnaire and dashboard. Researchers will com…

This study looks at how a Mediterranean diet affects the gut health of children with cystic fibrosis. Twenty kids aged 3 and older will follow this diet for 6 months. Researchers will check changes in gut bacteria and inflammation to see if this diet can improve their health.

This study tests a new imaging device that uses a dye called indocyanine green (ICG) to help surgeons see blood flow in bones during surgery for severe fractures or bone infections. About 10 adults with open fractures or fracture-related infections will be enrolled. The goal is t…

This study looks at whether a special nutrition shake given after surgery can help older adults (70+) regain their physical and mental abilities faster. Half of the 100 participants will receive the shake daily for 30 days, while the other half gets standard recovery advice. The …

This study explores whether a brain-wave test called Visual Evoked Potential can be used in a new way for people with hearing loss. Researchers will measure how the brain responds to visual images and compare those results with standard hearing tests. The goal is to find better w…

This study involves epilepsy patients who already have electrodes in their brain as part of their surgical evaluation. Researchers will record brain activity while participants perform tasks like looking at pictures, watching videos, or answering questions. The goal is to learn e…

This study looks at whether an online program and reminder messages can help more people test their homes for radon, a gas that can cause lung cancer. About 172 adults from New Hampshire and Vermont who have never tested their homes will take surveys and view either a standard in…

This study looks at how growing up with a heart condition can affect mental health, specifically post-traumatic stress disorder (PTSD). Researchers will survey 1,000 adults with congenital heart disease to find out what experiences (like painful surgeries or bullying) raise the r…

This study looks at whether hearing tests can detect early signs of memory and thinking problems in people with Mild Cognitive Impairment (MCI). Researchers will compare hearing and thinking abilities between 70 adults with MCI and healthy volunteers aged 55-80. The goal is to se…

This study is testing whether a therapy called Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), adapted for autistic youth, can work in community mental health centers. Researchers will enroll 24 autistic youth aged 6-18 and their therapists to see if the therapy is acceptab…

This study looks at whether giving older adults (65+) with diabetes or high blood pressure written notes from their doctor visits, plus audio recordings, can improve their quality of life. About 1,022 participants will be randomly assigned to receive only written notes through a …

This pilot study compares two approaches for managing thyroid nodules that look suspicious on ultrasound: immediate biopsy (usual care) or active monitoring with regular ultrasounds. The goal is to see if monitoring causes less anxiety and maintains quality of life. Twenty adults…

This study aims to improve how women in rural areas decide about getting mammograms. Researchers will test a decision aid called MyMammogram, with or without a summary sent to their doctor, compared to usual care. About 39 women aged 39-49 and their primary care providers will pa…

This study compares two methods of involving patients, clinicians, and the public in research: one where they give advice and another where they work closely with the research team. About 136 adults with experience in pediatric mental health, cancer screening, or serious illness …

This study compares two ways to check for colon cancer in adults aged 65-82 who have had polyps before. About 9,000 participants will either get a yearly stool test (FIT) or a colonoscopy. Researchers will track which group finds more advanced polyps or cancer over up to 11 years…

This study is collecting blood samples from 1,500 cancer patients who are receiving FDA-approved immunotherapy. Researchers will analyze immune-related markers in the blood to see if they can predict whether the treatment will work. The goal is to better understand why some patie…

This study looks at whether a special team of cancer experts, called a Molecular Tumor Board, can help doctors choose better treatments based on the genetic makeup of a patient's tumor. About 192 adults with cancer will have their tumor genes analyzed, and the board will suggest …