Can a week of antibiotics beat a kidney infection?
NCT ID NCT01390623
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This trial tests whether a 7-day antibiotic course—starting with an intravenous dose of ceftriaxone followed by oral cefixime—can effectively treat acute uncomplicated pyelonephritis (a kidney infection) in women aged 18 to 65. The goal is to see if this shorter regimen works as well as longer standard treatments, while potentially reducing antibiotic use and resistance. Researchers will check for microbiological cure at day 9 and monitor for recurrence within a month.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A 7-day antibiotic course: ceftriaxone given intravenously on the first day, followed by cefixime taken orally from the second to the seventh day.
- What this could lead to
- If successful, this shorter antibiotic regimen could offer a simpler, cost-effective treatment for kidney infections in women, potentially reducing the use of fluoroquinolones and slowing antibiotic resistance.
- What could go wrong
- This is a small, early-phase trial with only 39 participants, so results may not apply broadly. The shorter treatment might be less effective than standard longer courses, and there is a risk of infection recurrence or microbiological failure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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39 people
The number who actually took part.
- Start date
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Jul 2011
- Finished
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Dec 2013
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women between 18 and 65 years old * Diagnosis of Acute Uncomplicated Pyelonephritis * Patient obliged to participate in the French national health and pensions system. * Patient who have read, understood and signed the consent Exclusion Criteria: * Women who are pregnant * Men * One of these risk factor who define a complicated pyelonephritis: Medical history of uro-nephrology problem Nephropathy Obstructive Uropathy Vesicoureteral reflux Post mictinal residue \> 100mL Urinary fistula Catheter vesicle and urethral Kidney transplantation Immunodeficiency Diabetes * Recurrent pyelonephritis * Allergy of betalactam or cephalosporin * History of hypersensitivity reactions to antibiotic medications * Patient in terminal care * Trouble of cognitive function * Patient deprive of judicial or administrative freedom * Patient participating to another trial * Refusal to participate to the trial
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU de Clermont-Ferrand
Clermont-Ferrand, 63003, France