New tool could spot tough pneumonia early
NCT ID NCT07425561
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study created and tested a risk score called RESPIRE to predict whether a patient's pneumonia is caused by multidrug-resistant bacteria. Researchers looked at data from 300 adults with community-acquired pneumonia in the emergency department. The goal is to help doctors quickly identify high-risk patients, but the score is not yet ready for routine use.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could give doctors a simple tool to quickly identify pneumonia patients at risk for drug-resistant infections, helping guide early treatment decisions.
- What could go wrong
- This is an observational study, not a treatment trial. The score needs further testing in other hospitals and may not work as well in different populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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300 people
The number who actually took part.
- Started
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Jan 2022
- Finished
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Feb 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
During the initial retrospective observational phase (2 years), data were collected to establish a retrospective derivation cohort composed of patients with microbiologically confirmed etiological diagnoses of pneumonia. The derivation cohort includes patients who underwent microbiological investigations aimed at identifying the etiological cause of pneumonia within the first 48 hours of presentation to Azienda Ospedaliero Universitaria Careggi. During the second prospective observational phase (2 years), data were collected to establish a prospective cohort of Emergency Department patients, in which the performance of the clinical score derived from the retrospective cohort was evaluated in a purely observational manner.
- Ages
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18 to 90 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: All patients: * aged ≥18 years * who underwent respiratory sample collection within 48 hours of hospital admission and had subsequent positive culture results oleading to a confirmed etiological diagnosis of community-acquired pneumonia (CAP) * Pneumonia was clinically defined by the presence of two or more clinical signs or symptoms (body temperature \<36.0°C or \>38.0°C; respiratory rate \>20 breaths/min; oxygen saturation on room air \<90%; arterial partial pressure of oxygen \<60 mmHg; cough; sputum production; white blood cell count \<4,000/μL or \>10,000/μL; bandemia \>10%), in addition to radiographic evidence of a new parenchymal opacity or cavitation. * Only patients with positive respiratory culture results were included in the analysis. During the prospective phase, only patients whose microbiological samples were collected in the Emergency Department were enrolled. Exclusion Criteria: * informed consent was not provided * age was \<18 years or \>90 years * pregnant * pneumonia occurred after more than 48 hours from hospital admission (hospital-acquired pneumonia).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Careggi University Hospital
Florence, Italy
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Other studies related to the condition(s) this trial covers.
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