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New test could speed up scrub typhus diagnosis

NCT ID NCT06675110

Diagnosis Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new molecular test (iiPCR) to diagnose scrub typhus, a bacterial infection spread by mites. Researchers compared the test's accuracy against standard methods in 345 participants in Thailand. The goal was to see if this tool could provide faster, reliable diagnosis in areas where scrub typhus is common.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to faster and more accurate diagnosis of scrub typhus, improving treatment in rural areas.
What could go wrong
This is a completed diagnostic accuracy study, not a treatment trial. The test may not be widely available or affordable in all settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

345 people

The number who actually took part.

Started

Jul 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Febrile patients suspected of having scrub typhus and presenting to Mae Chan or Mae Suai district hospitals

Ages

7 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

INCLUSION CRITERIA: * ≥ 7 years old AND * Weight\>15Kg AND * The patient and/or where relevant their parent/guardian/caretaker/LAR willing and able to give informed consent /assent for participation in the study AND * Acute (duration ≤14 days) fever (37.5°C or higher or a history of fever in the previous 24h) For study group • Eschar OR Positivity to any of the screening tests (Immunochromatographic RDT or iiPCR) For negative control • Negativity to all screening tests (ten patients per hospital) EXCLUSION CRITERIA: * Other clear focus of infection (e.g. lobar pneumonia by chest x-ray, abscess) OR * Other clear cause of fever (e.g. positive Dengue IgM or NS1 antigen, positive blood cultures, untreated HIV)

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Conditions

The condition(s) this trial relates to.

scrub typhus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Scrub typhus

Contacts and locations

Locations

  • Mae Chan District Hospital

    Mae Chan, Changwat Chiang Rai, Thailand

  • Mae Fah Luang District Hospital

    Chiang Rai, Thailand

  • Mae Suai District Hospital

    Chiang Rai, Thailand

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