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New combo test aims to spot ventilator pneumonia faster

NCT ID NCT06181669

Diagnosis Sponsor: Duke University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 173 adults on ventilators to see if combining advanced germ-detection tests with a patient's immune response can improve diagnosis of ventilator-associated pneumonia. Researchers compared several molecular tests and host-response markers to standard clinical methods. The goal is to pave the way for future studies that could lead to faster, more accurate treatment decisions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

173 people

The number who actually took part.

Started

Apr 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Intubated adult patients (≥18 years of age) admitted to the ICU will be assessed for eligibility around the time of intubation according to the inclusion/exclusion criteria. Screening and consent may occur at any time within 48 hours of patients being intubated. The target sample size is 250 participants in order to observe approximately 30 clinical VAP-positive cases. Vulnerable patients, including women and minorities, will be included in this study.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Are ≥18 years old 2. Are newly intubated for less than 48 hours and for reasons other than suspected bacterial pneumonia or suspected acute bacterial infection 3. Are expected to require intubation for at least 48 hours, per the discretion of the treating clinician 4. Are able to provide protocol-accepted consent (legally authorized representative \[LAR\] is acceptable) 5. Are expected to live long enough to receive a VAP diagnosis, at the discretion of the treating clinician 6. Are able to provide study-required biological samples Exclusion Criteria: 1. Have a witnessed or suspected aspiration event prompting the need for current, new intubation 2. Have known active lung cancer or metastatic disease to a lung 3. Received a lung transplant 4. Have cystic fibrosis 5. Are receiving comfort care 6. Are receiving antibiotic treatment for suspected or proven active acute bacterial infection (eg, pneumonia, tracheobronchitis, sepsis) 7. Have a current or within-the-last-30-days diagnosis of active bacterial pneumonia 8. Were previously enrolled in this trial 9. Require long-term ventilator support 10. Have a tracheostomy tube in place 11. Are currently participating in an interventional drug or device study.

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Conditions

The condition(s) this trial relates to.

bacterial pneumonia Pneumonia, Ventilator-Associated

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pneumonia - bacterial Ventilator associated pneumonia

Contacts and locations

Locations

  • Corewell (William Beaumont)

    Royal Oak, Michigan, 48073, United States

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • Washington University School of Medicine in St. Louis

    St Louis, Missouri, 63110, United States

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