Ventilator associated pneumonia

This trial tests whether a rapid multiplex PCR test on lung fluid can help doctors choose the right antibiotic faster for patients with ventilator-associated pneumonia. The study involves 265 adults in intensive care who have been on a ventilator for at least 48 hours and are sus…

This study tests whether the antiviral drug acyclovir helps people on breathing machines who have pneumonia and also have herpes simplex virus (HSV) in their lungs. About 616 adults in intensive care will be randomly assigned to receive acyclovir or no antiviral treatment. The go…

This study investigates whether cleaning the mouths of very low birth weight premature infants with human milk several times a day can reduce harmful bacteria and lower the risk of lung complications like pneumonia and bronchopulmonary dysplasia. Researchers will follow 168 babie…

Ventilator-associated pneumonia is a bacterial lung infection that can strike patients in intensive care who need a breathing machine. Researchers are building a network of European ICUs to observe these patients and prepare the groundwork for future trials of prevention, diagnos…

This study looks at how certain white blood cells (macrophages) in the lungs respond to inflammation in people with Acute Respiratory Distress Syndrome (ARDS) who are on breathing machines. Researchers will collect lung fluid samples and blood to compare immune responses from dif…

This study is observing 1,000 critically ill ICU patients to learn how their bodies respond to life-threatening infections and injuries. Researchers will collect blood and lung fluid samples to identify biological factors that could lead to earlier diagnosis and new treatments fo…