Blood tests could predict infections in ICU patients

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria for patients * Patient or next of kin having been informed of the conditions of the study and having signed the informed consent form * Patient hospitalized for : * Septic shock * Severe trauma (including severe burn) * Major surgery Inclusion criteria for healthy volunteers * Normal clinical examination * Signed informed consent form * Person with social security insurance Exclusion criteria for patients * Patient with severe neutropenia (neutrophil count \<0.5 g/l) * Patients receiving immunosuppressive therapy * Patients receiving corticosteroids (IV or Per os) * Use of therapeutic antibodies * Hematological disease under treatment, or treated within 5 years before inclusion * End of chemotherapy within the 6 months prior to inclusion * Patient with innate or acquired immune deficiency (for example severe combined immunodeficiency, HIV or AIDS, any stage) * Patients for whom a care limitation was pronounced at time of enrolment * Anticipated length of stay before discharge from the ICU is estimated at less than 48 hours * Participation in an intervention study * Extra-corporeal circulation in the month preceding inclusion in case of cardiac surgery * Pregnant or breastfeeding women * Patient with no social security insurance, with restricted liberty or under legal protection Exclusion criteria for healthy volunteers * Person with an infectious syndrome during the last 90 days * Extreme physical stress within the last week * Person having received within the last 90 days, a treatment based on * Antivirals * Antibiotics * Antiparasitics * Antifungics * Person having received within the last 15 days, a treatment based on non-steroidal anti-inflammatory drugs (NSAIDs) * Person having received within the last 24 months, a treatment based on * Immunosuppressive therapy * Corticosteroids (IV or Per os) * Therapeutic antibodies * Chemotherapy * History of : * innate or acquired immune deficiency * Hematological disease * Solid tumor * Severe chronic disease * Surgery or hospitalization within the last 2 years * Pregnancy within the last year * Participation to a phase I clinical assay during the last year * Pregnant or breastfeeding women * Person with restricted liberty or under legal protection