Periodontitis

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This trial tests whether applying hyaluronic acid gel to exposed tooth roots during gum surgery improves healing compared with surgery alone. Researchers plan to enroll 80 adults with periodontitis who have suprabony defects, meaning bone loss that leaves pockets at least 5 mm de…

This trial tests whether a gel made from fucoidan, a compound found in seaweed, can improve healing and bone regrowth in people with gum disease. The study enrolls 5 systemically healthy adults aged 25 to 55 who have periodontitis with bone defects around teeth or implants. After…

This trial tests whether a deep dental cleaning, called non-surgical periodontal therapy, can reduce inflammation in people who have received a heart transplant. Heart transplant recipients often have low-level inflammation that may harm the new heart, and gum disease can be a hi…

This trial tests whether taking a probiotic supplement alongside standard deep cleaning of the tooth roots improves gum health in adults with advanced periodontitis. Researchers will compare two groups: one receiving deep cleaning alone and another receiving deep cleaning plus th…

This trial compares three ways to treat stage 3 periodontitis, a severe form of gum disease that damages the tissue and bone supporting teeth. Researchers will give 60 adults either standard deep cleaning alone, deep cleaning plus diode laser therapy, or deep cleaning plus guided…

This study looks at whether deep cleaning for gum disease can improve kidney health in people with uncontrolled type 2 diabetes. 46 adults with both conditions will either get gum treatment right away or after a delay. Researchers will measure kidney markers like creatinine and u…

This trial tests whether adding a special membrane made from a patient's own blood, called A-PRF+, to standard deep-cleaning of the gums can improve healing of periodontal pockets in adults with periodontitis. Each participant receives both treatments—standard cleaning plus A-PRF…

This trial tests a new, less invasive surgical approach for treating advanced periodontitis (stage III). Instead of lifting the gum, doctors access the damaged bone through a small pinhole, clean the area, and place a bone graft to encourage regeneration. The study includes adult…

This trial tests whether a mouthwash containing chlorhexidine and sodium DNA can better control bacterial biofilm in people with advanced periodontitis (stage III or IV). Participants will receive standard non-surgical gum treatment plus one of two mouthwashes or a placebo, and r…

This study tests whether a gel made from cross-linked hyaluronic acid (Hyadent BG®) can help regrow bone and gum tissue destroyed by chronic gum disease, comparing it to a standard treatment called Emdogain®. About 53 adults with moderate periodontitis will receive one of the two…

This trial tests different combinations of biomaterials used during gum surgery to treat class II furcation defects—areas where bone loss has occurred between the roots of molars. The goal is to see which combination best encourages bone regrowth and improves gum thickness. Adult…

This trial tests whether coating a dental implant with a gel made from fucoidan — a compound from brown seaweed — can improve wound healing and bone regrowth compared to standard implant placement. Twenty adults with early-stage gum disease who need a tooth replaced will receive …

This pilot study tests whether laparoscopic sleeve gastrectomy, a weight-loss surgery, can reduce markers of inflammation in saliva and improve gum health in adults with both obesity and periodontitis (gum disease). Participants are randomly assigned to either surgery or non-surg…

This trial tests whether using a perioscope — a tiny camera that lets dentists see below the gumline — makes deep cleaning more effective for people with periodontitis. About 26 adults with moderate to advanced gum disease will receive either standard deep cleaning or cleaning gu…

This study tests whether using hypochlorous acid—a mild disinfectant—during deep dental cleaning helps treat early-stage periodontitis (gum disease) better than cleaning with water alone. Researchers will measure gum healing, pocket depth, and inflammation markers in 44 adults wi…

This trial tests whether placing a synthetic bone graft material called beta-tricalcium phosphate into the gap around a dental implant helps it stay stable and promotes bone growth. The study involves 16 adults aged 20 to 50 who need an upper front tooth replaced immediately afte…

This study tests whether adding a spermidine-based gel to standard deep-cleaning (MINST) improves gum pocket reduction in adults with periodontitis. Participants receive either the gel plus cleaning or cleaning alone, and gum health is tracked for 12 months. The goal is to see if…

This study investigates whether a collagen hydrogel called H42 can help treat deep gum pockets caused by periodontitis or peri-implantitis. Researchers will measure changes in pocket depth, plaque, gum attachment, and bleeding over 90 days in adults aged 25 to 65 with 1 to 5 gum …

This study tests whether a gel made from Centella asiatica (a herb) can improve standard treatment for gum disease. Adults with periodontitis receive either standard deep cleaning alone or cleaning plus the gel applied to the gums once a week for three months. Researchers measure…

This study tests whether non-surgical gum treatment (deep cleaning) can improve oral health and quality of life in adults with hemophilia A or B. Researchers compare changes in gum health and daily comfort (using a questionnaire) between hemophilia patients and healthy individual…

This study compares a new, less invasive gum surgery (NIPSA) alone versus the same surgery plus a bone graft and platelet-rich fibrin to repair deep bone defects caused by advanced periodontitis. The trial enrolls adults with stage III periodontitis who have at least one deep gum…

This study looks at whether adding hyaluronic acid gel or a special blood product (Alb-PRF) to standard deep-cleaning treatment helps people with advanced gum disease (periodontitis). 51 adults aged 30-60 with Stage III periodontitis will be randomly assigned to one of three grou…

This trial investigates whether taking a collagen supplement alongside standard non-surgical gum treatment (deep cleaning) can improve outcomes for people with advanced periodontitis (stage 3-4). Half of the 52 participants will receive the supplement, while the other half gets a…

This study tested whether adding ozonated olive oil gel or curcumin gel to standard deep cleaning helps treat gum disease (stage II grade B periodontitis). Forty adults completed the 3-month trial. Researchers measured gum attachment levels, plaque, and inflammation to see which …

This study compares two minimally invasive treatments for deep gum disease bone defects: a non-surgical approach (MINST) and a surgical one (MIST). Researchers want to see if the non-surgical method can achieve similar bone and gum attachment improvements as surgery, but with les…

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into…

This study tested whether adding a light-based antibacterial treatment called photodynamic therapy (PDT) to standard deep cleaning improves gum health in people with moderate gum disease. Thirty adults received standard cleaning on one side of the mouth and standard cleaning plus…

This study tests whether a gel made from spirulina (a type of algae) can improve the treatment of stage II gum disease when used alongside standard deep cleaning. Researchers will compare different ways of preparing the spirulina gel and measure gum health and inflammation levels…

This study looked at 40 adults aged 35–55 with a history of periodontitis (gum disease) who needed a dental implant. Each received one of two implant surface types: sandblasted acid-etched or plasma-sprayed. Researchers measured bone loss around the implant and gum health over on…

This study tested whether adding a light-activated therapy, called antimicrobial photodynamic therapy (aPDT), to standard deep-cleaning for gum disease could kill more bacteria and improve gum health. Fifty adults with severe periodontitis received standard cleaning alone or with…

This early-phase study tested whether an ozonated sunflower seed oil gel could improve gum disease treatment when used alongside standard deep cleaning. Sixty adults with stage II periodontitis were divided into groups receiving either cleaning alone or cleaning plus a regular or…

This study looked at whether adding ozone gas to standard deep cleaning helps treat severe gum disease (periodontitis). 39 adults received the usual cleaning plus ozone, and researchers measured bacteria levels and gum pocket depths. The goal was to see if ozone kills more bacter…

This study tested whether adding platelet-rich fibrin (a concentrate from your own blood) plus the antibiotic minocycline works better than the antibiotic Arestin alone for treating gum disease. Fifteen adults with moderate gum disease received both treatments in different parts …

This study tested whether a melatonin gel applied to the gums can improve the results of standard deep-cleaning treatment for gum disease. Thirty adults with periodontitis received either the melatonin gel or a placebo gel alongside their regular dental cleaning. Researchers meas…

This study looked at 51 adults with advanced gum disease and loose front teeth. Researchers compared minimally invasive non-surgical therapy (MINST) alone versus MINST plus splinting (joining teeth together for support). The goal was to see if adding splints improves gum health a…

This study tested whether adding photodynamic therapy (a light-based treatment) and vitamin D to standard deep cleaning helps people with moderate gum disease. Twenty-four adults with stage II grade B periodontitis took part. The goal was to see if the combination improves gum at…

This study tested whether a special oral gel called PHTALOX® could make standard deep-cleaning treatments for gum disease more effective. Forty-five adults with moderate to severe periodontitis received standard scaling and root planing, plus either the PHTALOX® gel, a chlorhexid…

This study tested whether adding ozone gas to a standard deep cleaning (scaling and root planing) helps treat stubborn gum pockets in people with advanced gum disease. Twenty-six adults with stage III or IV periodontitis and pockets 5mm or deeper took part. Researchers measured g…

This study tested whether taking omega-3 or vitamin D supplements daily helps treat gum disease (periodontitis) better than standard deep cleaning alone. 72 adults with moderate gum disease received either omega-3, vitamin D, or no supplement alongside their dental treatment. Res…

This study compared a liquorice nanogel to a diode laser as extra treatments for advanced gum disease (stage III). 27 adults with deep gum pockets received one of the two treatments alongside standard care. The goal was to see which approach better reduced harmful bacteria and im…

This study tested whether applying a probiotic (Lactobacillus reuteri) directly into gum pockets, alongside standard deep cleaning, improves gum health in people with type 2 diabetes. Fourteen adults with moderate to severe gum disease and controlled diabetes took part. Each pers…

This study tested a collagen-based gel called H42 in 38 adults with gum disease (periodontitis). The gel was placed into deep gum pockets after standard cleaning. Researchers measured how much pocket depth decreased over 12 weeks, along with other signs of gum health and patient …

This study looked at whether adding probiotics or antibiotics to standard non-surgical gum disease treatment helps improve gum health. Sixty adults with severe periodontitis took part. The goal was to see if probiotics could be a safer alternative to antibiotics, which can cause …

This study tested whether adding ozone therapy to standard gum surgery improves outcomes for people with advanced gum disease (stage III periodontitis). Twenty-four adults received surgery on both sides of their mouth, with one side also getting ozone treatment. Researchers measu…

This study tested whether adding vitamins A and C to a platelet-rich fibrin (PRF) treatment helps repair bone defects in the gums. Twenty-eight adults with advanced gum disease received a minimally invasive surgical technique with PRF, with or without the vitamins. The goal was t…

This study tested whether adding chlorhexidine and zinc to standard deep-cleaning (scaling and root planing) improves gum health in people with early-stage periodontitis. 44 participants were split into two groups: one received the standard cleaning with the antimicrobial solutio…

This study looked at whether a special gel could help treat gum disease. Twelve adults with moderate gum disease received standard deep cleaning plus the gel. They also used the gel and a special toothpaste at home. After 8 weeks, their gum pockets and bleeding improved. The stud…

This study tested whether taking antibiotics along with standard deep-cleaning treatment (scaling and root planing) improves gum health in adults with periodontitis. 236 participants from dental practices across the U.S. were randomly assigned to receive either antibiotics (amoxi…

This study looked at whether adding platelet-rich fibrin (PRF) or injectable PRF, made from a patient's own blood, to standard deep cleaning can improve gum health in people with periodontitis. 56 participants received either standard treatment alone or with PRF/i-PRF added. Rese…

This study tested whether a gel made from rosemary extract could help treat periodontitis, a serious gum infection. 48 adults with advanced gum disease received standard deep cleaning plus either the rosemary gel or a placebo. The goal was to see if the gel improved gum pocket de…

This study looked at whether non-surgical gum disease treatment could reduce inflammation and improve blood fat levels in young adults with severe periodontitis. Fifty participants (25 with gum disease and 25 healthy) were involved. Those with gum disease received deep cleaning a…

This study tested whether a hyaluronic acid gel or a chlorhexidine mouthwash works better as a follow-up home treatment after deep cleaning for gum disease. Forty adults with periodontitis used one of the two products for 15 days after their dental cleaning. Researchers measured …

This study tested a home-use device that uses dual-light therapy and a special mouth rinse to help control chronic gum disease. Fifty-six adults with advanced periodontitis used the device regularly. The goal was to see if it reduces gum bleeding and improves plaque control, whic…

This study tested two different materials for gum grafting in 14 adults with stage 3 gum disease. One material came from the patient's own gum tissue, the other from a donor membrane. The goal was to see which helped gums heal better by measuring pocket depth and attachment level…

This study looked at whether deep cleaning of the gums (non-surgical periodontal therapy) could reduce prostate-specific antigen (PSA) levels and urinary tract infections in men with both gum disease and chronic prostatitis or recurrent UTIs. Sixty men were split into three group…

This study tested two different lasers (Nd:YAG and diode) for treating stage II gum disease. Thirty-three adults with deep gum pockets received one of the laser treatments or standard care. Researchers measured bacteria levels and gum health to see which approach worked best.

This study looked at whether a toothpaste made from black seed (Nigella sativa) can lower signs of gum inflammation in 100 Indonesian soldiers with gingivitis. Researchers measured certain proteins in saliva that are linked to gum disease. The goal was to see if this toothpaste c…

This study tested whether adding laser therapy to standard deep cleaning improves gum health in people with severe periodontitis. Twenty adults received either antimicrobial photodynamic therapy (using a blue dye and laser) or photobiomodulation (red or infrared laser) alongside …

This study tested whether a licorice extract gel could improve the results of deep cleaning for people with stage II periodontitis (moderate gum disease). Fifty patients were split into two groups: one got standard deep cleaning alone, and the other got deep cleaning plus licoric…

This study tested whether a gel made from patients' own blood, called albumin platelet-rich fibrin (Alb-PRF), can improve gum healing after deep cleaning for advanced gum disease. Twenty-three adults with Stage 3 periodontitis received the gel in deep gum pockets on one side of t…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This study tested whether adding ozone gas to standard deep-cleaning treatment helps people with gum disease (periodontitis). 18 healthy, non-smoking adults received standard cleaning on one side of the mouth and cleaning plus ozone on the other side. Researchers measured pocket …

This study tested whether platelet-rich fibrin (PRF), made from a patient's own blood, can improve gum and bone regeneration after standard periodontal surgery. Sixty adults with chronic gum disease and bone defects were randomly assigned to surgery alone or surgery plus PRF. Res…

This study tested whether adding omega-3 fish oil and low-dose aspirin to standard deep-cleaning treatment helps smokers with severe gum disease. Forty-five smokers were split into three groups: one got omega-3 and aspirin, another got those plus the antibiotic doxycycline, and t…

This study tested a light-activated treatment called Fotosan®630 for severe gum disease (periodontitis). The goal was to see if it could reduce deep gum pockets and infection better than standard care. The trial involved 36 adults with severe chronic periodontitis and followed th…

This study tested if a special light device used at home can help manage chronic periodontitis, a serious gum infection. 202 adults with gum disease used the device regularly to see if it reduced bleeding and improved gum health. The goal was to offer an easy, non-invasive way to…

This study tested a new combination treatment for gum disease-related bone loss. Thirty adults with deep gum pockets received a graft made from zinc-substituted nano-hydroxyapatite (a bone-like material) mixed with advanced platelet-rich fibrin (a blood-derived healing scaffold).…

This study tested whether injecting a substance made from a patient's own blood, called injectable platelet-rich fibrin (i-PRF), can improve gum healing after a deep dental cleaning. Twenty adults with advanced gum disease received i-PRF on one side of their mouth and a saltwater…

This study tested whether adding a 980nm diode laser to standard deep-cleaning gum treatment improves gum health and reduces body-wide inflammation in people who recently had a heart attack. Forty participants with gum disease (some healthy, some heart attack survivors) received …

This study tested whether splitting deep cleaning into three sessions works better than doing it all at once for people with severe gum disease. 48 non-smoking adults with advanced periodontitis were randomly assigned to one of the two cleaning methods. Researchers checked gum he…

This study looked at whether treating gum disease (periodontitis) can improve blood sugar control in people with diabetes. 91 patients were randomly assigned to receive either gum treatment or no treatment (with treatment offered later). The main measure was change in hemoglobin …

This study looked at whether treating gum disease (periodontitis) can reduce the severity of rheumatoid arthritis (RA) in people who have both conditions. Researchers enrolled 22 adults with RA and gum disease, providing periodontal treatment and measuring changes in RA activity …

This study tested two mouthwashes—one with 0.12% chlorhexidine and another with a lower dose of chlorhexidine plus cetylpyridinium chloride—to see which better controls gum inflammation and bacteria in people with gum disease. 72 adults used one of the rinses for a month after a …

This study tested whether placing a thin bone layer (cortical lamina) over the extraction site helps preserve the jawbone's shape and size. Forty adults needing a tooth pulled were randomly assigned to get the lamina or standard care. After six months, bone changes were measured …

This study tested whether a hyaluronic acid gel (HyaDent BG) works as well as Emdogain, a standard treatment, for repairing bone defects caused by gum disease. Both were used with a bone graft material during surgery. Seventeen adults with advanced periodontitis took part. The go…

This study tested a gum surgery that combines a connective tissue graft with a special protein gel (enamel matrix derivative) to help regrow bone and gum tissue in people with advanced gum disease. Seventeen adults with deep gum pockets received the treatment, and researchers mea…

This study tested whether adding a diode laser to standard deep cleaning helps smokers with severe gum disease. 33 smokers were split into two groups: one got standard cleaning alone, the other got cleaning plus laser. After 3 months, the laser group had shallower gum pockets, le…

This study tested whether a gel made from patients' own blood (injectable platelet-rich fibrin, or i-PRF) could improve healing after standard gum surgery for periodontitis. 42 adults with deep gum pockets received surgery alone or surgery plus i-PRF and a root-cleaning gel. Rese…

This study tested whether a special oral appliance called myTAP, combined with a mouth shield and deep dental cleaning, can reduce gum disease in people who snore and breathe through their mouth. 43 adults with mild to moderate gum disease completed the 12-week trial. The device …

This study tested two antibiotic gels (metronidazole and minocycline) in 380 adults with both diabetes and gum disease. Participants received deep cleaning alone or with one or both gels. Researchers checked gum pocket depth and gum color/texture at 7 and 15 days to see which tre…

This study tested two deep-cleaning methods for gum disease (periodontitis) in 36 adults: a water-and-powder spray (Airflow®) and traditional hand scraping. Researchers measured gum bleeding, pocket depth, and signs of inflammation in mouth fluid to see which method causes less t…

This study tested a new mouth rinse made with coconut oil and xylitol to see if it could improve gum health in people with periodontitis. 120 adults used the rinse or a placebo three times a day for three weeks. Researchers measured gum appearance and bleeding before and after us…

This completed study tested a surgical technique called Entire Papilla Preservation (EPPT) alone or with added enamel matrix derivative and bone graft for repairing bone defects from gum disease. Fifty-eight adults with moderate to severe periodontitis took part. The goal was to …

This study looked at whether smokers who switch to combustion-free nicotine products (like e-cigarettes or heated tobacco) see improvements in their gum health and tooth appearance. 460 smokers with mild gum disease were randomly assigned to keep smoking, switch to these products…

This study tested a special dental floss coated with a probiotic (good bacteria) to see if it could reduce harmful mouth germs and improve gum health. Thirty-three healthy men used the probiotic floss and a placebo floss for two weeks each, with a break in between. Researchers me…

This study looked at whether certain proteins in saliva can help tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers collected saliva from 60 people and measured three specific biomarkers. The goal is …

This study tested a non-invasive optical device that uses different types of light to detect and diagnose various mouth conditions, including oral cancer, gum disease, and dry mouth. Over 1,000 participants with and without oral lesions were imaged, and the results were compared …

This study compared a mobile app (Peribrain) to traditional manual methods for classifying the stage and grade of periodontitis (gum disease) in 122 patients. A student, a clinical student, and a clinician each classified the disease using either the app or manual measurements. T…

This study looked at whether certain proteins and metals in saliva can signal the start of gum disease before teeth are damaged. Researchers measured these markers in 106 adults with healthy gums or various stages of gum disease. The goal was to find a way to predict gum disease …

This study asks whether the phase of the menstrual cycle influences pain and anxiety during a deep dental cleaning in premenopausal women with moderate gum disease. Researchers will compare pain scores and anxiety levels when treatment is done just before or just after menstruati…

This study tests whether a personalized teaching method called 'Touch-to-Teach' helps people with stage II periodontitis clean between their teeth better than standard instructions. Forty participants will be split into two groups: one gets standard care, the other gets the new m…

This study tested two ways to clean teeth and gums in 82 people with poorly controlled type 2 diabetes and severe gum disease. One method cleaned all teeth in one day (full mouth disinfection), while the other cleaned one quarter of the mouth at a time over four weeks. Researcher…

This study looked at whether a deep dental cleaning (called subgingival instrumentation) can reduce jaw symptoms like pain, stiffness, and tension in people who grind their teeth (bruxers) and also have gum disease (periodontitis). Sixty adults aged 30-40 received the cleaning, a…

This study looked at how satisfied patients were and how much pain they felt after getting All-on-Four dental implants under sedation. 30 adults were followed for three days after surgery. Researchers measured pain, swelling, and how much pain medicine they used. The goal was to …

This study tested whether a special ultrasonic handpiece that sprays hydroxyapatite (a natural enamel mineral) can reduce tooth sensitivity during dental cleanings for people with gum disease. Forty adults with moderate to severe periodontitis had half their mouth cleaned with th…

This study looked at 168 adults with a silent tooth infection (asymptomatic apical periodontitis) to see if different root canal shaping tools affect pain after the procedure. Participants received one of four shaping methods, including using a single file or combining files. The…

This study looked at how comprehensive gum treatment affects chewing ability and quality of life in people with severe gum disease (Stage III periodontitis). Twenty patients with gum disease and twenty healthy people took part. Patients received deep cleaning and, if needed, gum …

This study tested whether using an air-polishing device with erythritol powder is as effective as standard scaling and root planing for maintaining gum health after initial treatment. Twenty adults with periodontitis were randomly assigned to one of the two cleaning methods. The …

This study tested whether non-surgical gum treatment can improve smell and reduce tongue coating in adults with periodontitis. 108 non-smoking participants had their smell tested before and three days after treatment. The goal was to see if treating gum disease leads to short-ter…

This study tested whether adding a special laser treatment (photodynamic therapy) to standard gum cleaning could reduce bad breath. Forty adults with gum disease and self-reported bad breath received full-mouth scaling plus a laser-activated gel on their tongue and deep gum pocke…

This study looked at ways to reduce tooth sensitivity after deep cleaning for gum disease. 48 adults with sensitive teeth received either a desensitizing gel (Gluma), a special laser, or both. Their pain was measured over 6 months. The goal was to see if combining treatments work…

This study tested whether low level laser therapy (LLLT) can reduce pain, speed up tooth movement, and improve gum health in people getting braces. 108 Pakistani patients aged 18-30 received either standard braces or braces plus laser treatment on their front teeth every three we…

This study tested whether a special 5-day fasting-mimicking diet (plant-based soups, bars, and drinks) could reduce inflammation after deep cleaning for advanced gum disease. Twenty-eight adults with stage III-IV periodontitis were randomly assigned to either follow the diet or e…

Researchers at Gazi University are studying whether Behçet's disease, which causes mouth sores and eye inflammation, is connected to gum disease. They compare 40 people with Behçet's plus gingivitis or periodontitis against 47 people with gum disease alone. The team measures infl…

This study looks at how oral hygiene habits and gum health affect quality of life in 160 adults. Participants will have a dental exam and fill out a questionnaire about how their mouth feels day-to-day. No treatment is given—the goal is simply to understand the connection between…

This study looks at whether non-surgical gum cleaning (scaling and root planing) can change levels of certain bone-related substances in the blood of people with advanced gum disease. Sixteen adults with stage III periodontitis will receive the treatment, and their blood will be …

This study looks at how smoking affects proteins linked to blood vessel formation in gum disease. Researchers will measure levels of KLF2, FBXW7, and other markers in fluid from around the teeth and in saliva from adults who are smokers or non-smokers, with healthy gums, gingivit…

This study looks at whether smoking and advanced gum disease (Stage III periodontitis) are linked to changes in three saliva markers: TNF-α, FoxO-1, and SIRT-1, which are involved in inflammation and stress responses. Researchers will compare saliva samples from 80 adults divided…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This study looked at three substances in saliva—Adseverin, 1-alpha defensin, and sRANKL—to see if they differ between people with healthy gums, gingivitis, or periodontitis. Researchers collected saliva from 60 non-smoking, systemically healthy adults and measured these biomarker…

This study looks at how gum disease, from mild gingivitis to more severe periodontitis, changes the activity of certain genes and proteins involved in inflammation and cellular cleanup. Researchers will collect small gum tissue samples from people with healthy gums, gingivitis, o…

This observational study looks at whether two proteins found in saliva—Gasdermin E and Granzyme B—are present in different amounts in people with periodontitis (a severe form of gum disease) compared to those with healthy gums. Researchers will collect saliva samples and measure …

This study investigates whether stress inside gum cells plays a role in periodontal disease, which causes inflammation and damage to the tissues supporting the teeth. Researchers measured markers of cell stress and inflammation in fluid and tissue samples from 72 non-smoking adul…

This study investigates whether specific proteins involved in inflammation are present at different levels in people with healthy gums, gingivitis, or periodontitis. Researchers will collect saliva, gum fluid, and gum tissue samples from 75 adults and measure the levels of these …

This study looks at how smoking and gum disease (periodontitis) affect certain proteins and genetic markers in the body. Researchers will compare these markers in smokers and non-smokers with and without gum disease, before and after a standard deep-cleaning treatment. The goal i…

This study looks at whether gum disease (periodontitis) is linked to higher levels of inflammation in people who have had a heart transplant. Inflammation is known to play a role in the long-term health of a transplanted heart. The researchers measured gum health and took blood s…

This study examined 318 adults to see if coffee drinking habits are linked to gum health. Participants were grouped by gum condition (healthy, gingivitis, or periodontitis) and asked about their coffee intake. Researchers measured plaque, bleeding, and gum pocket depth to find an…

This study investigates whether the severity of periodontitis (a serious gum infection) differs between Egyptian men and women. Researchers will examine 380 participants aged 20 to 40, all with periodontitis, using a clinical exam and a detailed questionnaire about oral hygiene, …

This observational study investigates whether levels of certain enzymes (ACE and ACE2) in saliva and blood are linked to the severity of gum disease in adults with cardiovascular disease. Researchers will compare these enzyme levels across different stages of gum disease—from gin…

This study examined how standard non-surgical gum disease treatment changes the jaw bone structure in 69 people with gingivitis or periodontitis. Researchers used fractal analysis of dental X-rays taken before and 6 months after treatment to detect subtle bone changes. The goal i…

This study investigates how gum disease—from mild gingivitis to severe periodontitis—affects specific proteins inside gum tissue cells that help control cellular cleanup and communication. Researchers will collect small gum samples from people with healthy gums, gingivitis, or pe…

This study measures levels of a substance called adropin in the gum fluid and blood of people with periodontitis (severe gum disease) and compares them to healthy gums. Researchers want to see if adropin changes after standard non-surgical gum treatment, and how it relates to a k…

This observational study investigates how different levels of gum health influence asprosin (a hormone) and total oxidant/antioxidant levels in people with type 2 diabetes. Researchers will collect fluid from around the gums and blood samples from 67 participants to compare these…

This study aimed to create a computer model that can predict which gum disease treatment will work best for each person. Researchers looked at dental records from 86 patients, including gum measurements, X-rays, and personal details. The goal is to help dentists choose the most e…

This study explored the connection between gum disease severity and levels of certain antibodies (ACPAs) in people with rheumatoid arthritis. Researchers measured these antibodies in fluid from the gums before and after non-surgical gum treatment. The goal was to better understan…

This study looked at how vaping and traditional smoking affect gum healing after a deep dental cleaning in people with stage II gum disease. Researchers measured gum pocket depth, bleeding, and inflammation markers in 117 participants. The goal was to see if vaping is less harmfu…

This study looked at whether certain amino acids in saliva differ between people with healthy gums, gingivitis, and periodontitis. Researchers also tracked how these amino acids changed after standard non-surgical gum treatment in 32 periodontitis patients. The goal is to see if …

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This completed study looked at 160 healthy adults to see if a blood test marker called Pan-Immune-Inflammation Value (PIV) is linked to the severity of gum disease. Researchers measured gum inflammation and compared it to PIV from routine blood work. The goal was to explore if th…

This study followed 130 adults with advanced gum disease (periodontitis) to see if those who used probiotics on their own during standard non-surgical treatment had better outcomes. Researchers measured plaque, bleeding, pocket depth, and quality of life at 1 and 3 months. The go…

This study looked at how diet affects gum inflammation in healthy people. Researchers compared vegans and omnivores by temporarily stopping their oral hygiene to see how their gums reacted. The goal was to understand if a vegan diet might reduce gum inflammation compared to an om…

This study translated a questionnaire that measures how chronic gum disease affects quality of life into Hindi. Researchers tested it on 196 patients with periodontitis to ensure it is accurate and reliable. The goal is to give Hindi-speaking patients a way to report their oral h…

This study looks at proteins that help parts of cells communicate—specifically mitochondria and the endoplasmic reticulum—in people with healthy gums, gingivitis, or advanced gum disease. Researchers measure these proteins in saliva and gum fluid to see if they relate to inflamma…

This study looked at whether a natural antioxidant marker in gum tissue can help tell how severe gum disease (periodontitis) is. Researchers measured levels of thioredoxin reductase 1 and other markers in gum samples from 60 healthy people and patients with different stages of gu…

This completed study looked at how a specific inflammation trigger (NLRP3) relates to different stages of gum disease and aging-related inflammation. Researchers measured NLRP3 levels in fluid from the gums of 80 participants with various stages of periodontitis and healthy indiv…

This study looked at 88 adults with chronic kidney disease to see how their oral health changes at different stages. Researchers checked teeth, gums, saliva, and breath to find links with nutrition and inflammation. The goal is to understand if dental problems can worsen kidney d…

This study tested a new lab method (xCELLigence system) to grow oral biofilms and select the most effective antibiotic for each patient with chronic periodontitis. 64 adults with severe gum disease received standard deep cleaning plus an antibiotic chosen by the new test. The goa…

This study looked at levels of a hormone called prolactin in the gum fluid of 26 people with obesity and gum disease (stage II or III). Researchers measured prolactin before and after non-surgical gum treatment to see if it changed. The goal was to better understand the link betw…

This study measured how often adults with gum disease have atypical swallowing (abnormal tongue movements). Researchers checked 125 adults for tongue posture and other mouth signs. The goal was to see if this swallowing pattern is linked to worse gum problems.

This study examined fluid from deep gum pockets in 30 people with severe periodontitis, both smokers and non-smokers. Researchers measured 40 inflammatory markers before and after non-surgical deep cleaning. The goal was to see which markers change with treatment and whether smok…

This completed study looked at 61 adults to see if physical fitness, body composition, and diet are linked to gum disease severity. Researchers reviewed dental records and lifestyle questionnaires from a previous study. No new treatments were tested; the goal was simply to unders…

This study measured levels of a protein called IL-36α in saliva and gum fluid from 80 people with gum disease, gingivitis, or healthy gums. The goal was to see if this protein is linked to gum inflammation and damage. No treatment was given; it was purely an observational study t…

This study measured certain inflammatory markers in the saliva and blood of 126 people with type 2 diabetes, some of whom also had kidney disease (diabetic nephropathy). The goal was to see if these markers differ based on gum health. Researchers hope to better understand the lin…

This study tested a French version of the Oral Health Impact Profile (OHIP) questionnaire, which measures how oral health affects daily life. Researchers enrolled 200 French-speaking adults, including people with gum disease and healthy controls. Participants filled out the quest…

This study measured two proteins, Dkk-1 and sFRP5, in the gum fluid of 99 people with healthy gums, gingivitis, or periodontitis. Researchers collected samples before and after non-surgical periodontal treatment (deep cleaning) to see if these proteins change with treatment. The …

This study explored whether how addicted a person is to nicotine affects their awareness of having gum disease. Researchers examined 350 smokers with gingivitis or periodontitis, measuring their nicotine dependence with a standard test and asking about their gum health. The goal …

This study looked at 42 adults with advanced gum disease to see if stress hormones (cortisol and DHEAS) found in hair could measure the body's overall stress load. Researchers took hair samples and gave questionnaires at the start and 60 days after standard gum treatment. The goa…

This study looked at whether gum inflammation affects the genes that control the body's daily (circadian) clock. Researchers collected gum tissue from 60 healthy adults with similar sleep habits, comparing those with healthy gums, gingivitis, or advanced gum disease. They measure…

This completed observational study looked at 61 people with peripheral artery disease to see if their gum health was linked to levels of a substance called TMAO in their blood and saliva. Researchers compared TMAO levels among those with healthy gums, gum disease, or no teeth. Th…

This study looked back at 126 patients who had gum regeneration surgery for severe gum disease. Researchers checked dental records and did a follow-up exam to see if the surgery helped close deep gum pockets and improve gum health. The goal was to understand how well these proced…

This study looked at 101 adults with gum disease and bad breath to see if treating the gums could also improve their sense of smell. Participants received standard deep-cleaning dental treatment. Researchers measured bad breath gases and smell function before and one week after t…

This completed study measured two immune proteins, IL-8 and IL-10, in fluid from the gums and around the tooth root during root canal treatment. Researchers wanted to see how these levels change as treatment progresses in people with infected, dead tooth pulp. Twenty-two adults a…

This study tested whether special cameras (2D and 3D) can measure swelling and temperature changes after gum surgery. 60 adults with gum disease had routine surgery, and the cameras tracked healing patterns. The goal was to see if this non-invasive method could help doctors monit…

This completed study looked at 51 people having surgery to remove plaque from their neck arteries. Researchers checked the plaque for oral bacteria and measured mitochondrial DNA. The goal was to see if mouth germs might play a role in artery disease. No treatment was given—it wa…

This study examined 95 adults with diabetes and gum disease to see if blood sugar control and gum disease severity are linked to changes in gum cells. Researchers looked at cell samples under a microscope for signs of damage. The goal was to better understand how these conditions…

This study looked at the oral health of 61 obese adults, comparing those who had bariatric surgery to those who did not. Researchers measured tooth wear, cavities, and gum disease to understand how surgery might affect the mouth. The goal was to gather information, not to test a …

This study followed 163 people who got dental implants between 1999 and 2005 to see how well the implants held up over time. Researchers checked patient satisfaction, implant survival, bone loss, and signs of inflammation. They also looked for risk factors that might lead to prob…

This completed study looked at 108 Turkish adults to see if understanding dental health information is linked to gum health. Participants took a reading test about dentistry and had a dental exam. The goal was to find out if people with lower health literacy have worse gum diseas…

This study looked at how smoking affects gum healing after non-surgical treatment for stage II gum disease. Researchers measured two proteins (PLAP-1 and Sclerostin) in the gum fluid of 36 patients—both smokers and non-smokers—before and after deep cleaning. The goal was to see i…

This study looked at 100 people with gum disease, some also with obesity, to see how non-surgical gum cleaning affects the body's immune system. Researchers measured changes in inflammation and immune cells before and after treatment, comparing men and women. The goal was to find…

This study examined how smoking influences immune cells (macrophages) in gum disease. Researchers compared gum tissue from 80 smokers and non-smokers with and without periodontitis. They measured specific markers to see how smoking shifts the balance of immune responses, which ma…

This study looked at levels of two immune-related substances, fractalkine and CX3CR1, in the gum fluid of people with gingivitis or periodontitis. Researchers measured these before and after standard non-surgical gum treatment, like deep cleaning and oral hygiene advice. The goal…

This study looked at how inflammatory bowel disease (IBD) affects oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to understand which factors, like medic…

This completed study looked at how smoking affects gum health in 484 adults. Researchers compared current smokers to non-smokers by measuring plaque, gum bleeding, pocket depth, and gum recession. The goal was to better understand the link between smoking and periodontal disease.

This study examined 80 postmenopausal women to see if there is a connection between gum (periodontal) disease and osteoporosis. Researchers measured two substances in blood and gum fluid called sclerostin and TNF-α, which may help explain how these conditions affect each other. T…

This study looked at whether smoking and severe gum disease (Stage III periodontitis) increase damage to DNA and RNA in cells. Researchers measured two markers of oxidative stress in saliva from 88 adults, including smokers and non-smokers with and without gum disease. They found…

This study looked at whether gum disease (periodontitis) and Parkinson's disease are connected through inflammation. Researchers collected saliva and blood samples from 60 people—some with both conditions, some with only gum disease, and some healthy. They found that certain subs…

This study tested whether a deep cleaning of the gums (nonsurgical periodontal therapy) could lower inflammation and improve quality of life in 20 people who have both rheumatoid arthritis and gum disease. Researchers measured changes in immune markers, bacteria in the mouth, and…

This study examined how gum disease (periodontitis) and type 2 diabetes affect each other. Researchers measured immune markers, bacteria, and other health signs in 226 adults aged 30-70. The goal was to better understand the connection between these two conditions, not to test a …

This study tested whether treating severe gum disease (periodontitis) with a deep cleaning procedure could also reduce teeth grinding (bruxism) during the day and night. Forty adults with advanced gum disease or healthy gums took part. Researchers measured grinding events before …

This study looked at three proteins in saliva—IL-6, IL-8, and LIGHT—to see if they can tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers measured these proteins in 60 non-smoking, healthy adults (20 …

This completed study looked at two ways to clean below the gumline in 80 adults with early-stage gum disease. One group received Guided Biofilm Therapy, a newer technique, while the other got conventional cleaning with hand tools and an ultrasonic device. Researchers measured gum…

This completed study analyzed blood test results from 100 people over age 50 to see if there is a connection between gum inflammation and Alzheimer's disease. Researchers measured gum health and looked at various blood cell counts. The goal was to find blood markers that might li…

This completed study looked at jawbone X-rays from 120 people—half with gum disease and half healthy. Researchers used special computer analysis to measure bone structure differences. The goal was to see if routine dental X-rays could help detect early bone changes caused by peri…

This study looked at certain proteins in the saliva and gum fluid of people with and without gum disease. The goal was to see if these proteins could help explain how gum disease develops. 44 healthy adults took part, and no treatments were given.

This completed study followed 471 young adults (under 36) with periodontitis for 10 years to see how their gum disease progressed. Researchers looked at factors like disease stage, treatment adherence, and biological markers to understand why some patients got worse or stopped tr…

This study looked at 120 adults with type 2 diabetes and gum disease to see how well their blood sugar was controlled and how it related to the severity of gum problems and cavities. Researchers measured gum health, tooth decay, and HbA1c levels (a measure of blood sugar control)…

This study looked at the free amino acids in saliva from 120 people with healthy gums, gingivitis, periodontitis, healthy implants, implant mucositis, or implantitis. Researchers wanted to see if different amino acid patterns could help tell these conditions apart. The goal is to…

This completed study looked at how low oxygen levels and a metabolic pathway called the kynurenine pathway are involved in gum inflammation (periodontitis). Researchers collected blood and saliva from 45 healthy adults with either periodontitis or healthy gums. They measured mark…

This completed study examined whether people with psoriasis have worse gum health and how it affects their daily lives. Researchers compared 226 adults with and without psoriasis through oral exams and questionnaires. The goal was to understand if the chronic skin condition also …

This completed study looked at whether people with advanced gum disease (periodontitis) also grind or clench their teeth more during sleep. Researchers used a small portable device to measure muscle activity in the jaw over 24 hours in 40 adults, half with severe gum disease and …