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Can natural gels boost gum healing?

NCT ID NCT07415148

Disease control Sponsor: Inonu University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study looks at whether adding hyaluronic acid gel or a special blood product (Alb-PRF) to standard deep-cleaning treatment helps people with advanced gum disease (periodontitis). 51 adults aged 30-60 with Stage III periodontitis will be randomly assigned to one of three groups: standard cleaning alone, cleaning plus hyaluronic acid, or cleaning plus Alb-PRF. Researchers will measure gum health and inflammation markers at 1 and 3 months to see if these add-ons improve healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

51 people

The number who actually took part.

Started

Apr 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy individuals aged between 30 and 60 years * No history of periodontal treatment or antibiotic use within the last 6 months * Non-smokers * Accepting to regularly attend the follow-up sessions planned during the study period * Diagnosis of Stage III periodontitis * Presence of at least 15 teeth in the oral cavity, with more than 30% of the existing teeth affected by periodontal disease * Presence of probing pocket depth ≥6 mm and clinical attachment loss ≥5 mm in affected teeth * Presence of vertical bone loss ≥3 mm * Radiographic evidence of alveolar bone loss extending to the middle third or beyond (≥33%) of the root length in affected teeth Exclusion Criteria: * Presence of any systemic disease * History of periodontal treatment or antibiotic use within the last 6 months * Pregnancy or lactation * Presence of acute oral lesions or necrotizing ulcerative periodontitis * Use of medications known to affect periodontal tissues * Current smoking * Presence of immune system disorders or use of immunosuppressive medications * Presence of prosthetic restorations on teeth selected for gingival crevicular fluid sampling

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal inflammation Periodontitis

Contacts and locations

Locations

  • Inonu University Faculty of Dentistry

    Malatya, Battalgazi, 44280, Turkey (Türkiye)

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