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Can probiotics boost gum disease treatment? a trial puts it to the test

NCT ID NCT07792902

Disease control Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This trial tests whether taking a probiotic supplement alongside standard deep cleaning of the tooth roots improves gum health in adults with advanced periodontitis. Researchers will compare two groups: one receiving deep cleaning alone and another receiving deep cleaning plus the probiotic. They will measure gum bleeding, pocket depth, and inflammatory markers before and after treatment. The goal is to see if probiotics can reduce inflammation and help balance the bacteria in the mouth and gut.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Probiotic supplement containing Bifidobacterium animalis subsp. lactis HN019
What this could lead to
If it works, adding probiotics to standard gum treatment could reduce inflammation and improve gum health in people with advanced periodontitis.
What could go wrong
This is an early-stage trial with only 40 participants, so results may not apply to everyone. Probiotics may not change gum disease outcomes, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

40 people

The number who actually took part.

Started

Jun 2026

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy individuals; * Age of 30 years or older; * Both genders; * At least 15 teeth, excluding third molars and teeth indicated for extraction * At least 30% of the teeth presenting probing depth (PD) and clinical attachment loss (CAL) greater than or equal to 5 mm; * Individuals diagnosed with generalized Stage III or IV, Grade B or C periodontitis; * Presence of at least 8 teeth with at least one non-contiguous interproximal site presenting probing depth (PD) and clinical attachment level (CAL) greater than or equal to 5 mm. Exclusion Criteria: * Current smokers or former smokers who quit within the past 5 years; * Pregnant or breastfeeding women; * History of periodontal treatment within the previous 6 months; * Continuous use of oral antiseptics, systemic antibiotics, corticosteroids, nonsteroidal anti-inflammatory drugs, immunosuppressive agents, estrogen, selective estrogen receptor modulators, or medications that may affect bone metabolism (such as alendronate, calcitonin, and others) within the previous 6 months; * Presence of systemic conditions that may alter the host response to periodontal treatment (such as diabetes, human papillomavirus infection, or Down syndrome) or that require antibiotic prophylaxis before dental treatment (such as mitral valve prolapse); * Use of probiotics within the previous 6 months.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis Periodontitis stage IV

Contacts and locations

Locations

  • Universidade de São Paulo

    Ribeirão Preto, São Paulo, 14040-904, Brazil

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