Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a Blood-Derived membrane boost gum healing?

NCT ID NCT07782736

Disease control Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time

Summary

This trial tests whether adding a special membrane made from a patient's own blood, called A-PRF+, to standard deep-cleaning of the gums can improve healing of periodontal pockets in adults with periodontitis. Each participant receives both treatments—standard cleaning plus A-PRF+ on one side of the mouth, and standard cleaning alone on the other—so results can be compared directly. The study measures changes in pocket depth and gum attachment over 8 weeks to see if the added membrane makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Advanced Platelet-Rich Fibrin Plus (A-PRF+), a membrane made from the patient's own blood, added to standard scaling and root planing
What this could lead to
If effective, adding A-PRF+ to routine gum cleaning could enhance healing of deep gum pockets, potentially reducing the need for surgery in periodontitis.
What could go wrong
This is a small early-stage trial with only 14 participants, so results may not apply broadly. The procedure is invasive and may not provide significant benefit over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

14 people

The number who actually took part.

Started

Oct 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Participant-level criteria: * Adults aged 18 years or older. * Diagnosis of periodontitis according to the 2017 World Workshop criteria. * At least one eligible periodontal tooth/site in each half-mouth. * Provision of written informed consent and agreement to attend the scheduled follow-up visits. Site-level criteria: * Probing pocket depth of 5 mm or greater at baseline. * Clinical attachment loss of 3 mm or greater at baseline. * Positive bleeding on probing at baseline. Exclusion Criteria: Participant-level criteria: * Current use of tobacco or related products. * Systemic conditions closely associated with periodontitis or treatment response, including diabetes mellitus, rheumatoid arthritis, or hematologic disease. * Pregnancy or lactation. * Periodontal surgery within the preceding 6 months. * Use of medications affecting blood coagulation. * Abnormal preintervention complete blood count, prothrombin time, or activated partial thromboplastin time. * Poor oral hygiene. * Failure to attend protocol-specified visits. Tooth/site-level criteria: * Untreated dental caries or pulpal disease. * Teeth undergoing active orthodontic treatment. * Teeth with defective restorations. * Third molars. * Teeth with mobility grade II or greater. * Sites with a plaque index of 2 or greater during follow-up were excluded from the site-level analysis.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Periodontitis are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

Contacts and locations

Locations

  • Specialty Dental Clinic, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City

    Ho Chi Minh City, Vietnam

More trials for these conditions

Other studies related to the condition(s) this trial covers.