Peripheral neuropathy

This Phase 2 trial tests two experimental drug combinations in 63 women with a specific type of ovarian cancer (BRCA-mutant or HRD-positive) that has worsened after prior PARP inhibitor treatment. Participants receive either tuvusertib plus niraparib or tuvusertib plus larteserti…

This study tests a new drug, Tuvusertib, combined with an immunotherapy called Cemiplimab in people with a specific type of advanced lung cancer (non-squamous non-small cell) that has worsened after prior treatments. The trial aims to see if the combination can shrink tumors and …

This early-stage trial tested a combination of two oral drugs, tipifarnib and alpelisib, in 45 adults with recurrent or metastatic head and neck squamous cell carcinoma that has specific genetic changes (HRAS overexpression or PIK3CA mutations). The goal was to find a safe dose a…

This trial tests whether adding graded motor imagery training, a technique where children mentally rehearse movements, to standard physiotherapy can improve arm function, balance, and quality of life in children aged 7 to 18 with obstetric brachial plexus injury, a birth-related …

This phase II trial tests whether the combination of lenalidomide and dexamethasone can help people with POEMS syndrome, a rare blood disorder that damages nerves and causes other symptoms. Participants receive the drug combo either before local radiation or intensive treatment, …

This trial tests whether a single 10-minute dose of electrical stimulation, delivered during surgery for a nerve injury in the arm, can improve healing and recovery. About 13 adults who need nerve repair will be randomly assigned to receive the stimulation on top of standard care…

This study tested a gene transfer treatment for giant axonal neuropathy (GAN), a rare genetic disease that damages nerves and affects movement, breathing, and other functions. Fourteen people aged 3 and older received a single injection of the treatment into the fluid around the …

This trial tests whether adding structured telemonitoring—weekly text messages and video calls—to standard conservative care helps people with temporomandibular disorder (TMD)-related jaw pain. Participants receive behavioral counseling, habit reversal training, and home exercise…

This trial tests a surgical technique to restore elbow bending in people who have lost this ability due to a brachial plexus injury that occurred more than a year earlier. Surgeons take a muscle from the thigh and move it to the arm, connecting its nerve to either the spinal acce…

This study tests two approaches to help people with diabetic neuropathy improve their balance. One group uses textured insoles in their shoes, while the other group does a series of quick stretches and compressions called Rood's facilitatory technique. Both groups also receive co…

This study tests a drug called SHP611, given as a spinal injection, in 36 children with late infantile metachromatic leukodystrophy (MLD), a rare and severe brain disease. The main goal is to see if the treatment helps children keep their ability to walk and move for as long as p…

This study tests whether a special hand therapy program can prevent chemotherapy-induced nerve damage in the hands of people with pancreatic cancer. Participants are randomly assigned to either the hand therapy or traditional occupational therapy. The goal is to see if the hand t…

This study tests whether a combination of a gentle sedation strategy (called eCASH) and early, personalized exercise can prevent muscle weakness that often develops in ICU patients who need a breathing machine. The trial will include 70 adults on ventilators, with half receiving …

This completed Phase 3 study tested TAK-771, a combination of immune globulin and hyaluronidase, in 26 Japanese adults with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) or multifocal motor neuropathy (MMN). The main goals were to check for side effects and see…

This study looks at people who received a total lumbar disc prosthesis (Baguera®L) for lower back pain or sciatica caused by disc degeneration or herniation. The goal is to see how many return to their original job five years after surgery. Unlike spinal fusion, which often limit…

This early-stage trial tested a new combination therapy using a polymer called polyethylene glycol (PEG) to help fuse severed nerve endings right after injury. The goal was to see if this approach could restore nerve function faster than current methods. The study involved 45 peo…

This study tests an experimental drug called AT-007 (Govorestat) in 56 adults with SORD deficiency, a rare genetic condition that causes nerve damage and muscle weakness. The drug aims to lower high levels of sorbitol, a sugar that builds up and harms nerves. Researchers will mea…

This study tested whether a 20-minute arm cycling exercise, done twice daily for five days, could improve lung function and recovery in 60 elderly patients after colon cancer surgery. Participants also received standard physical therapy. The goal was to see if the arm exercise co…

This study tested a surgical technique to help people with a severe arm nerve injury (pan-brachial plexus injury) regain the ability to bend their fingers and grasp objects. Seventeen patients who already had some elbow movement from a prior nerve surgery received a tendon transf…

This study tested an oral drug called AZ-3102 in 13 people with GM2 gangliosidosis (Tay-Sachs or Sandhoff disease) or Niemann-Pick type C disease. The main goal was to check safety and how the drug moves through the body over 12 weeks. It was a randomized, double-blind, placebo-c…

This completed study tested whether lotus seed capsules could improve nerve health, blood sugar, and immune function in 60 people with type 2 diabetes and nerve damage. Participants took either lotus seed or placebo capsules for 9 months alongside their regular diabetes treatment…

This study looked at whether a short electrical stimulation treatment after surgery can help people with severe nerve injuries in the arm regain hand function. 136 adults with complete nerve damage were randomly assigned to receive either electrical stimulation or standard care. …

This phase 2 trial tests an experimental drug called ARGX-117 in 54 adults with multifocal motor neuropathy (MMN), a condition that causes muscle weakness. Participants receive either ARGX-117 or a placebo by IV, and researchers check if the drug can safely delay the need for sta…

This study tested whether custom silicone toe orthoses (inserts) could reduce foot pressure and prevent pre-ulcerative lesions in people with diabetic neuropathy. Sixty participants with diabetes and foot deformities wore the orthoses for six months. The goal was to see if these …

This small study tested whether injecting a person's own fat-derived cells (called stromal vascular fraction) into the foot could help heal diabetic nerve damage and foot ulcers. Eight adults with diabetic peripheral neuropathy received injections around the wound and along nerve…

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study looked at whether a 12-week intensive lifestyle program focused on weight loss and diabetes control could improve diabetic peripheral neuropathy, a common nerve complication. Fifty adults with diabetes and a BMI between 30 and 45 took part. The program included diet, e…

This study looked at whether a high-fat diet changes how children with mitochondrial disease burn energy. 36 children aged 5 to 21 were randomly assigned to eat either a normal or high-fat diet for a month, then switched. Researchers measured their resting energy use and body com…

This study followed 24 people with metachromatic leukodystrophy (MLD), a rare and serious brain disease, who were already receiving an experimental drug called HGT-1110. The main goal was to check for side effects and immune reactions over a long period. Researchers wanted to see…

This study tested whether neuromuscular electrical stimulation (NMES) can prevent muscle wasting in patients on mechanical ventilators in the ICU. 22 adults were split into a control group and an NMES group, receiving stimulation sessions for at least 7 days. Researchers used ult…

This phase 3 trial tested the drug patisiran in 360 people with ATTR amyloidosis with cardiomyopathy, a condition where abnormal protein builds up in the heart, making it stiff and weak. Participants received either patisiran or a placebo intravenously. The study measured how far…

This study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. About 61 participants were assigned to either the program or standard care. The goal was to see if the…

This study tested whether adults with CIDP, a nerve disorder causing weakness and numbness, could safely switch from regular intravenous immunoglobulin (IVIg) infusions to a new injectable drug called efgartigimod PH20 SC. Twenty-three participants who were stable on IVIg were gi…

This study tested a drug called alemtuzumab (Campath) as a first treatment for children with hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The goal was to see if it could help children survive until they could receive a stem cell transplan…

This study looked at a collagen wrap used during nerve surgery to help healing. 40 patients had the wrap placed around repaired nerves in their arms or legs. Early results suggest it may improve movement and feeling, but more research is needed.

This study tested an experimental drug called METAZYM (a lab-made enzyme) in one child with late infantile metachromatic leukodystrophy (MLD) who had already received a stem cell transplant. The goal was to see if the enzyme could improve nerve function and reduce harmful buildup…

This study tested a gene therapy called OTL-200 in 10 children with early-onset metachromatic leukodystrophy (MLD), a rare and severe brain disease. The treatment uses the child's own blood stem cells, modified to produce a missing enzyme, and aims to slow or stop disease progres…

This study tested whether a drug that blocks TNF-alpha, a protein involved in inflammation and scar formation, can reduce sciatica pain in people who developed spinal scar tissue after back surgery. 38 adults with persistent pain after discectomy received either the drug or a pla…

This study tested a gene therapy for children with early-onset metachromatic leukodystrophy (MLD), a rare and severe brain disease. Five children aged 6 months to 5 years received injections of a harmless virus carrying a working copy of the ARSA gene directly into their brains. …

This study tested whether using a computer model to adjust doses of two common drugs (sitagliptin for diabetes and duloxetine for nerve pain) works better in people with liver cirrhosis. 64 patients with cirrhosis, diabetes, and nerve pain were grouped by liver severity and given…

This early-stage study tested a new drug called ALN-TTRSC04 in 96 healthy people to see if it is safe and how the body processes it. The drug aims to lower a harmful protein that causes transthyretin amyloidosis, a serious disease affecting nerves and the heart. Participants rece…

This early-stage trial tests NTLA-2001, a CRISPR-based gene editing therapy, in 72 adults with hereditary ATTR amyloidosis—a condition where abnormal protein builds up in nerves or the heart. The treatment aims to turn off the faulty gene to reduce protein levels. The study focus…

This phase 3 trial tested a one-time gene therapy called Zolgensma in 22 infants under 6 months old with spinal muscular atrophy (SMA) type 1, a severe muscle-weakening disease. The treatment delivers a working copy of the missing SMN gene via an IV infusion. The main goals were …

This study tested a one-time gene replacement therapy in infants under 6 months old with spinal muscular atrophy (SMA) type 1, a severe muscle-weakening disease. The main goal was to see if treated babies could sit without support for at least 10 seconds by 18 months of age. The …

This study tested a one-time gene replacement therapy in 33 infants under 6 months old with spinal muscular atrophy (SMA) type 1, a severe muscle-weakening disease. The treatment aims to replace the missing SMN1 gene to improve muscle function. Key results showed that many babies…

This study tested a single dose of Zolgensma gene therapy in 30 infants diagnosed with spinal muscular atrophy (SMA) before symptoms appeared. The goal was to see if the treatment helps them reach motor milestones like sitting or standing alone. The therapy delivers a working cop…

This Phase 3 trial tested apitegromab, a drug that blocks a muscle-limiting protein, in 188 nonambulatory children and young adults with later-onset spinal muscular atrophy (SMA types 2 and 3). All participants were already taking standard SMA therapies (nusinersen or risdiplam).…

This study tested whether an ultrasound-guided nerve block, using a steroid and local anesthetic, could better control pain from shingles and prevent postherpetic neuralgia (long-term nerve pain). 100 adults with acute shingles and moderate to severe pain were randomly assigned t…

This early-stage trial tested a single dose of a new drug called KINE-101 in 9 adults with chronic inflammatory demyelinating polyneuropathy (CIDP) that hadn't improved with steroids. The main goal was to check if the drug is safe and tolerable. Researchers also looked at whether…

This study tested a one-time gene therapy called OAV101 in 126 children aged 2 to 18 with type 2 spinal muscular atrophy (SMA) who had never received other SMA treatments. The therapy was given as a spinal injection and compared to a sham procedure. The goal was to see if it coul…

This study tested a drug called alpelisib combined with hormone therapy (fulvestrant or letrozole) in 383 people with advanced breast cancer that has a specific genetic change (PIK3CA mutation). The goal was to see how many patients were alive without their cancer getting worse a…

This study tested a new drug called vutrisiran in 164 people with a rare inherited disease that damages nerves and organs. Participants received either vutrisiran as a shot every 3 months or the standard treatment patisiran as an IV infusion every 3 weeks. The goal was to see if …

This phase 2 trial tested a combination of two oral drugs, RMC-4630 and sotorasib, in 47 adults with advanced KRASG12C-mutant non-small cell lung cancer that had progressed after standard treatments. The goal was to see if the combination could shrink tumors. The study is now com…

This study tested whether giving muscle relaxants along with sedation helps improve oxygen levels in patients with severe COVID-19 lung failure (ARDS) who need a breathing machine. Forty adults were enrolled. The goal was to see if this approach could reduce complications and imp…

This completed early trial tested a single intravenous dose of EN001 stem cells in 3 adults with Charcot-Marie-Tooth disease type 1E, a severe hereditary nerve disorder with no approved treatment. The main goal was to check safety, including infusion reactions, while also looking…

This early study tested whether adding a patient's own Schwann cells (nerve-supporting cells) to a nerve graft could safely improve recovery after severe peripheral nerve injury. Five adults with large nerve gaps received the cell-enhanced graft. The main goal was safety, checkin…

This early-phase trial tested the safety of a gene therapy called Engensis (VM202) in 12 adults with Charcot-Marie-Tooth disease type 1A (CMT1A), a genetic nerve disorder that causes muscle weakness. Participants received multiple injections into their leg muscles and were monito…

Researchers want to know how many people with neuropathy of unknown cause carry a mutation in the TTR gene, which leads to a rare and potentially fatal inherited disease called familial amyloid neuropathy. The study enrolls up to 400 adults under 90 who have neuropathy confirmed …

This study explores whether artificial intelligence can analyze ultrasound images of muscles to detect intensive care unit-acquired weakness (ICUAW), a common complication in critically ill patients. Researchers will compare AI-based assessments with standard clinical evaluations…

This study tests whether tissue taken during routine carpal tunnel release surgery can help diagnose amyloidosis, a condition where abnormal proteins build up in organs. People with bilateral carpal tunnel syndrome and certain risk factors—like age, heart issues, or family histor…

This trial tests a wearable device called CAVA that records eye and head movements for 30 days in people with dizziness conditions like Meniere's disease and BPPV. The goal is to see if the device can accurately detect episodes of nystagmus, an eye movement linked to dizziness, a…

This study aims to translate and test a diagnostic tool called CTS-6 for Turkish-speaking patients with carpal tunnel syndrome. Researchers will enroll 126 adults, including healthy volunteers, people with symptoms, and those already diagnosed. The goal is to ensure the tool is a…

This study tested a new genetic screening approach to find cases of a rare inherited nerve disease called TTR-FAP in 130 patients with chronic neuropathy of unknown cause. The goal was to see how many of these patients actually have TTR-FAP, which is often missed due to varied sy…

This study tested whether using specialized eye-movement tests (HINTS and v-HIT) in the emergency room can help doctors correctly diagnose the cause of sudden vertigo. Researchers tracked 90 adults with acute vertigo to see if these tests reduced misdiagnosis and sped up treatmen…

This study tested a new, rapid MRI method in 102 infants with brachial plexus birth palsy (nerve damage from birth). The goal was to see if the MRI could help doctors decide earlier and more accurately whether the baby needs nerve surgery. The MRI was done without anesthesia, and…

This study tested two simple bedside tools—the Neuropathy Disability Score and Neuropathy Symptom Score—to screen for diabetic nerve damage. Researchers compared them to standard nerve tests in 228 adults with diabetes. The goal was to see if these easy-to-use tools could help de…

This study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…

This study tested whether a special PET/MR scan using a radioactive tracer called F-18 florbetapir can detect amyloid protein buildup in the nerves of people with amyloidosis. Eight adults with confirmed nerve amyloidosis or other nerve diseases took part. The goal was to see if …

This study compared different ways to detect early nerve damage in people with hereditary TTR amyloidosis, a condition that can cause progressive nerve problems. Researchers used blood tests, skin imaging, and standard nerve exams in 47 participants. The goal was to see which too…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study tested whether ultrasound can accurately diagnose mild to moderate carpal tunnel syndrome (CTS) by measuring the median nerve. Researchers compared ultrasound results with standard nerve tests and checked how they related to pain, symptoms, and quality of life in 75 pe…

This study tested a new blood test (liquid biopsy) that looks for cancer DNA in the blood of 30 women with advanced ER+/HER2- breast cancer. The goal was to see if the test can accurately find cancer mutations without needing a traditional tissue biopsy. The results will help doc…

This study tested whether a special eye-tracking device (video-oculography) helps emergency room doctors more accurately diagnose the cause of vertigo or dizziness. About 130 adults with dizziness were randomly assigned to get either the eye-tracking test plus standard care, or s…

This study tested whether ultrasound of the nerves can help diagnose CANVAS, a rare genetic disorder that causes balance problems, nerve damage, and dizziness. Researchers measured nerve size in 35 people with confirmed CANVAS and compared them to healthy individuals. The goal wa…

This pilot study tested whether a radioactive tracer called F-18 florbetapir (Amyvid) can detect amyloid protein buildup in the heart using a PET scan. Researchers enrolled 23 people with known cardiac amyloidosis and a control group without the condition. The goal was to see if …

This study tested a new, non-invasive tool that measures skin conductance to detect small nerve fiber damage in children undergoing chemotherapy. Nerve damage is a common and serious side effect of cancer treatment, but current tests are often painful or not suitable for children…

This study looked at 46 people with carpal tunnel syndrome to see how ultrasound measurements of the median nerve relate to their symptoms and nerve test results. Researchers measured nerve size and appearance at different points in the wrist and compared them to pain scores and …

This trial tests whether memantine, a drug used for Alzheimer's disease, can prevent the chronic nerve pain that sometimes develops after breast cancer surgery. Half of the participants receive memantine for four weeks, starting two weeks before their operation, while the other h…

This study tested whether tadalafil, a drug often used for erectile dysfunction, can prevent nerve damage caused by docetaxel chemotherapy in men with metastatic prostate cancer. 90 participants were randomly assigned to receive either tadalafil plus standard care or standard car…

This study tested whether omeprazole, a common heartburn medication, could prevent nerve damage caused by oxaliplatin chemotherapy in 46 adults with colorectal or pancreatic cancer. Participants took omeprazole before and during chemotherapy cycles. The goal was to see if it redu…

Diabetic polyneuropathy damages nerves in the feet, dulling the sense of touch and raising the risk of unnoticed injuries. This trial tests whether transcutaneous electrical nerve stimulation (TENS) can restore that sensation. Researchers compare high-frequency TENS, low-frequenc…

Electromyography (EMG) and nerve conduction studies (NCS) check how nerves and muscles work, and many patients find them painful or stressful. Researchers are testing whether letting adults choose and listen to their own music during these tests lowers anxiety and pain compared w…

This study tested whether a web-based exercise program could reduce nerve pain and improve quality of life in breast cancer patients receiving chemotherapy. 90 patients with stage II-III breast cancer and neuropathy symptoms took part. The program was guided by a physiotherapist …

Researchers are testing whether a two-week course of functional magnetic stimulation applied to the sole of the foot can improve feeling, foot strength, balance, and walking in adults with type 2 diabetes and diabetic peripheral neuropathy. Participants are randomly assigned to r…

Researchers are testing three non-drug approaches for nerve pain caused by paclitaxel, a common chemotherapy for breast cancer. The trial enrolls 140 women receiving weekly paclitaxel who develop mild nerve symptoms. Participants are assigned to TENS, compression, cryotherapy, or…

Pudendal neuralgia is a painful condition caused by a trapped nerve in the pelvis. Researchers at Nantes University Hospital are comparing three injection mixtures placed near the pudendal nerve: lidocaine alone, lidocaine plus a steroid, and lidocaine plus steroid plus a large v…

This completed trial tested whether electroacupuncture (acupuncture with a mild electric current) can reduce pain in people with postherpetic neuralgia, a lingering nerve pain after shingles. 448 adults aged 45-75 with moderate-to-severe pain were randomly assigned to real or sha…

This study tests two different exercise programs in 40 people with diabetic peripheral neuropathy, a condition that causes numbness and balance problems. One program uses Feldenkrais exercises, which focus on movement awareness, and the other uses task-oriented gait training, whi…

This study tests whether adding a specific leg-rotation technique to standard physical therapy can better relieve sciatica caused by disc problems in the lower back. Researchers will measure pain, flexibility, and daily function in 70 adults aged 18 to 50. The goal is to see if t…

This study tests whether a new medicine called CagriSema can reduce nerve pain in people with type 2 diabetes. About 142 adults with painful diabetic neuropathy will receive either CagriSema or a placebo for around 10 months. The main goal is to see if the drug lowers weekly pain…

Researchers are testing a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) in adults with chronic neuropathic pain. The trial compares three approaches: stimulating two brain targets alternately, stimulating one target, or a sham (pla…

This study tested whether electrostimulation and compression can reduce nerve pain and improve quality of life in people with gastrointestinal cancer who developed peripheral neuropathy from oxaliplatin chemotherapy. 140 patients were split into four groups: control, electrostimu…

This study compares a 6-month physiotherapy program focused on pelvic floor relaxation to no structured exercise in women with pudendal neuralgia, a chronic pelvic pain condition. Researchers will measure muscle stiffness using ultrasound and track symptoms like pain and sexual d…

This trial tests whether real acupuncture can reduce the numbness, tingling, and pain that chemotherapy often leaves behind. Cancer survivors with persistent nerve symptoms will receive either genuine acupuncture or a sham version with superficial needling at non-acupoints. The g…

This early-stage study tested a new drug called 4ET1103 in 40 healthy volunteers to see if it is safe and how the body processes it. Each person received a single dose of either the drug or a placebo. The goal was to check for side effects and measure drug levels, not to treat pa…

This study tests whether wearing cooling gloves and socks can reduce nerve pain and numbness in children aged 7 to 18 who are receiving vincristine chemotherapy for cancers like leukemia and Wilms tumor. The therapy uses adjustable gel packs that wrap around the hands and feet wi…

This trial tests whether a sensory rehabilitation program, guided by physiotherapists, can reduce nerve pain and improve balance in people with chemotherapy-induced peripheral neuropathy (CIPN). Participants are adults who finished chemotherapy more than three months ago and repo…

Cubital tunnel syndrome happens when the ulnar nerve gets compressed near the elbow, causing pain, numbness, and hand weakness. This trial tests whether adding ulnar nerve-specific strengthening and nerve-gliding exercises to soft tissue mobilization relieves pain and improves ar…

This trial tests whether injecting lidocaine under the skin at the shingles rash site can reduce pain and help prevent post-herpetic neuralgia, a long-lasting nerve pain that can follow shingles. Adults with acute shingles pain or established post-herpetic neuralgia will receive …

This study tests a special fabric shoulder brace designed to mimic muscle support for people with neuromuscular disorders like muscular dystrophy, SMA, and ALS. About 30 participants will wear the brace and perform arm tasks to see if it improves movement, strength, and daily fun…

This pilot study tests whether a mindfulness program delivered through a web app can help hospitalized neurological patients and their caregivers cope with stress and anxiety. Participants learn mindfulness techniques in an initial face-to-face session, then practice via weekly o…

This study investigates whether foot massage using a roller can reduce nerve pain caused by chemotherapy in cancer patients. About 80 adults receiving certain chemotherapy drugs will either receive foot massage twice daily for three weeks or continue with routine care. The goal i…

This study tested a non-invasive treatment called radial pressure wave therapy for people with mild to moderate carpal tunnel syndrome. 60 adults received three weekly sessions of either a constant or modulated dose of the therapy. Researchers measured pain, hand function, and ne…

This trial tests whether thread-embedding acupuncture, given twice over two weeks, can reduce tingling and numbness in people with mild-to-moderate carpal tunnel syndrome as effectively as electroacupuncture, which requires ten sessions. Eighty adults with confirmed carpal tunnel…

This trial tests whether mirogabalin, a newer pain medication, can reduce nerve pain caused by chemotherapy better than the standard drug duloxetine. Cancer survivors with peripheral neuropathy in their feet will take one of the two drugs daily for four weeks. The study measures …

This trial tests whether adding neural mobilization—gentle exercises that help the median nerve move freely—to a standard physical therapy program can improve symptoms and hand function in women with carpal tunnel syndrome. Participants receive either the combined treatment or st…

This trial tests whether the Otago Exercise Program, a supervised routine of strengthening, balance, and walking exercises, can reduce muscle weakness in people with chemotherapy-induced peripheral neuropathy (CIPN). About 48 adults aged 35-55 who have received taxane chemotherap…

This study tests whether a mobile app can teach family caregivers safe massage techniques to help cancer survivors with long-term nerve pain and numbness caused by chemotherapy. About 300 participants (survivors and their caregivers) will use the app at home. The goal is to reduc…

This trial tests whether electrical stimulation—using TENS and NMES—can improve nerve function and physical activity in people with diabetic peripheral neuropathy. Sixty adults aged 55–65 with type 2 diabetes and neuropathy will receive either real or placebo stimulation sessions…

This small early-phase trial tests whether a single oral dose of a hemp-derived CBD/CBD-A extract can reduce neuropathic pain and change brain activity in people with spinal cord injury. Six participants with moderate to severe nerve pain for at least three months will receive ei…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This trial tests whether two different kinesio taping techniques, combined with exercise, can reduce pain and improve hand function in people with mild to moderate carpal tunnel syndrome. Participants will receive one of the taping methods or serve as a control, with measurements…

This trial tests whether injecting a mix of ketamine and lidocaine into the skin, a technique called mesotherapy, can reduce neuropathic pain in people with complex regional pain syndrome type 1 (CRPS1). Participants receive four sessions of either the drug mixture or lidocaine a…

This trial tests whether adding neural mobilization—a gentle, controlled leg movement technique—to standard manual therapy can improve pain, function, and quality of life in people with lumbar disc herniation and sciatica. About 72 adults aged 18–65 with unilateral leg symptoms w…

This study tests whether pain neuroscience education (PNE) can improve symptoms in people with mild to moderate carpal tunnel syndrome. Participants will receive PNE along with standard home exercises and a wrist splint. The goal is to see if understanding pain better leads to le…

This study tests whether pressing specific points on the ear (auricular point acupressure) can reduce pain, numbness, and tingling caused by chemotherapy. About 225 cancer patients will try this non-needle technique. Researchers will also measure changes in nerve function and bod…

This trial tests whether ultrasound therapy, nerve gliding exercises, or a combination of both can reduce pain and improve hand function in people with mild-to-moderate carpal tunnel syndrome. Participants will be randomly assigned to one of three groups: ultrasound alone, nerve …

This trial tests whether adding kinesio taping to a standard exercise program helps people with carpal tunnel syndrome more than exercise alone. Carpal tunnel syndrome happens when the median nerve is compressed at the wrist, causing pain, numbness, and weakness. Participants wil…

This study looks at how well corticosteroid injections relieve carpal tunnel syndrome symptoms in people whose nerve tests (EMG) are normal or only mildly abnormal. Researchers will review past data from 300 patients who received the injection and filled out a questionnaire about…

This study tests whether using a robotic arm to guide injections for carpal tunnel syndrome is better than the standard manual method. Twenty adults with moderate to severe carpal tunnel syndrome will receive a corticosteroid injection either by robot or by hand. The goal is to s…

This study compares mirror therapy, brain stimulation (rTMS), and robotic hand training added to standard rehab for stroke patients. 120 adults who had a stroke at least 3 months ago will receive 20 sessions over 4 weeks. The goal is to see which approach best improves arm functi…

This pilot study is testing whether injecting Botox directly into the painful area inside the mouth can reduce continuous nerve pain in the teeth or jaw. Eight adults with long-lasting dentoalveolar pain that hasn't responded to standard treatments will receive two rounds of inje…

This phase 2 trial tests whether mazisotine, an oral drug, can reduce the persistent nerve pain that often complicates diabetes. About 400 adults with diabetic peripheral neuropathic pain will receive either mazisotine or a placebo for roughly 24 weeks. Researchers will measure c…

This trial tests whether a non-invasive device that delivers pulsed radiofrequency energy behind the knee can reduce pain and improve function in people with diabetic neuropathy whose pain persists despite medication. About 92 participants will receive either the active device or…

This study tested two non-drug treatments—whole-body vibration and neuromuscular electrical stimulation—in 60 ICU patients with muscle weakness. Patients received one of the therapies twice daily for two weeks, alongside standard care. Researchers measured muscle strength and thi…

This trial tests whether moving specific wrist bones (scaphoid, lunate, triquetrum) one by one relieves carpal tunnel symptoms better than moving the whole wrist. Adults aged 30–60 with at least two months of mild-to-moderate carpal tunnel syndrome are randomly assigned to one of…

This study tests whether applying pregabalin gel through ultrasound (phonophoresis) combined with nerve flossing exercises can reduce pain and improve sensation in people with diabetic peripheral neuropathy. The trial includes 24 adults aged 40–75 who have chronic nerve pain in t…

This trial compares a spinal cord stimulation device (HF10 therapy) plus standard medical care against standard care alone for people with long-term, hard-to-treat leg pain caused by diabetic neuropathy. About 430 adults with stable pain levels and no major neurological changes a…

This study tested two ultrasound-guided injections for carpal tunnel syndrome: one using a sugar-water solution (hydrodissection) and the other using a steroid. 53 adults with moderate carpal tunnel took part. The goal was to see which treatment better reduces symptoms and improv…

This study tests whether a wearable device that vibrates the legs can help relieve persistent nerve pain and numbness caused by chemotherapy. The device, called Myovolt, is worn on the legs for about 30 minutes twice a day. Researchers are looking at how practical and acceptable …

This study compares two common treatments—shockwave therapy and therapeutic ultrasound—each given alongside standard physiotherapy, for people with chronic sciatica. The goal is to see which approach better reduces pain, improves hamstring flexibility, enhances sleep quality, and…

This study tests whether graded motor imagery—a brain-based therapy involving left/right judgment, imagined movements, and mirror exercises—can relieve nerve pain and improve leg function in cancer patients with chemotherapy-induced peripheral neuropathy. Half the participants wi…

This study looks at three non-surgical treatments for carpal tunnel syndrome, a condition that causes pain, numbness, and weakness in the hand. Researchers compared standard physical therapy (ultrasound, exercises, and a wrist splint) with the same therapy plus either high-intens…

This study tests an experimental drug called ONO-1110 to see if it can safely reduce pain in people with postherpetic neuralgia, a type of nerve pain that persists after a shingles infection. About 140 Japanese adults with pain lasting at least 3 months will receive either the dr…

This study tested a 90-minute pain management class for 110 youth aged 10-18 with chronic pain. The class teaches pain science and self-regulation skills like relaxation and cognitive techniques. Researchers checked if the class was acceptable and helpful by surveying participant…

This study tests whether acupuncture can reduce the nerve pain, numbness, and tingling that often lingers after chemotherapy. Cancer survivors who completed chemo at least three months ago will receive either real acupuncture, a sham (fake) version, or no extra treatment. The goa…

This study tests a new drug called LY3848575 for people with long-term nerve pain starting in the feet and moving up the legs. About 558 participants will receive either the drug or a placebo to see if it safely reduces pain. The trial lasts up to 30 weeks and measures pain inten…

This study tests a 12-week online program for mothers of infants (12-36 months old) with SMA Type 1. The program aims to teach mothers how to support their baby's development and improve their own knowledge. Thirteen mothers will take part, with 10 receiving the program and 3 rec…

This study tests if low-level laser therapy can reduce pain and improve quality of life in people with meralgia paresthetica, a condition causing numbness or burning on the outer thigh. About 44 adults will receive either real laser or a sham laser, both combined with TENS (a mil…

This study tests whether special balance exercises or sensory retraining better improve walking and stability in people with diabetic nerve damage. 80 adults aged 40-75 with diabetes and nerve problems will be randomly assigned to one of two training programs. Both groups also re…

This completed pilot study tested whether shining a low-level laser into the blood (intravenous laser therapy) can improve sleep and reduce pain in people with chronic sciatica. Sixty-six adults with sciatica and poor sleep received either electroacupuncture alone or electroacupu…

This study tests whether inhaling medical cannabis three times a day can safely reduce pain in people with diabetic peripheral neuropathy. 122 adults will receive either a low, medium, or high dose of THC or a placebo using a special inhaler. The main goal is to see if pain score…

This completed pilot study tested a behavioral program called PIVOT in 33 adults with chemotherapy-induced peripheral neuropathy. Participants worked with coaches to set personal health goals using a structured goal-setting method. The study aimed to see if this approach is safe …

This study tested two non-invasive treatments—high-intensity laser therapy and shock wave therapy—for people with cubital tunnel syndrome after an arm burn. 75 adults with healed burns and confirmed ulnar nerve problems received either laser or shock wave therapy plus nerve glidi…

This study tests a device that cools and compresses the arms and legs to see if it can prevent nerve damage caused by chemotherapy. The device is first tested in healthy volunteers to find the best temperature and pressure, then in cancer patients receiving weekly paclitaxel. The…

This study tested whether a TENS device, which sends mild electrical pulses through the skin, can reduce leg pain in people with Charcot-Marie-Tooth disease. Ten adults with chronic pain participated. The goal was to see if pain scores dropped by at least 30%.

This study tested whether teaching good sleep habits could help people with painful diabetic nerve damage sleep better and feel better overall. Twenty-four patients were split into two groups: one received a booklet and face-to-face sleep training from a nurse, while the other co…

This completed study compared two minimally invasive surgeries for herniated discs: full endoscopic lumbar discectomy (FELD) and microdiscectomy (MD). Researchers enrolled 200 adults aged 18-85 with single-level disc herniation and sciatica. The goal was to see which technique pr…

This pilot study tested whether a TENS device, placed on the forehead, is safe and practical for treating chronic eye pain in 39 veterans. Participants used the device at home for 6 months. The goal was to see if it reduces pain and to prepare for a larger trial.

This study looked at how common nerve pain is in cancer patients getting chemotherapy and tested if a simple exercise program could help. 282 patients took part, and those who did supervised exercises for 21 days reported less nerve pain than those who got usual care. The results…

This study tested whether taking gabapentin along with oxcarbazepine works better than oxcarbazepine alone for trigeminal neuralgia, a condition causing severe facial pain. 44 adults were split into two groups and had their pain measured over 2 months. The goal was to see which a…

This study tested whether a new type of brain stimulation, called controlled transcranial magnetic stimulation (cTMS), can reduce pain and improve daily function in people with painful diabetic neuropathy. Twenty adults with the condition received either real or sham cTMS over fi…

This completed study tested a laser device (BTL-043) on 31 adults with temporomandibular joint (TMJ) pain. Participants received four 20-minute laser sessions over a few weeks. Researchers measured pain levels, jaw movement, and daily function at 1 and 3 months after treatment to…

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This study tested two numbing methods for carpal tunnel surgery in 100 adults. One method uses lidocaine with epinephrine and no tourniquet (WALANT), while the other uses lidocaine alone with a tourniquet. The main goal was to see which method causes less pain during the operatio…

This study tested an experimental drug called NMD670 in 52 adults with type 3 spinal muscular atrophy who can still walk. The goal was to see if the drug helps them walk farther in 6 minutes and improves muscle strength compared to a placebo. The trial is now complete, and result…

This study tested whether hypnosis sessions led by a nurse over video call are practical for people with long-term nerve pain. Thirty adults with peripheral neuropathic pain for over a year took part. The goal was to see if patients would complete five sessions and if it helped w…

This study tested whether roasted nux vomica capsules can help with nerve pain caused by the chemotherapy drug bortezomib in multiple myeloma patients. Twenty-two participants took the capsules for six weeks while continuing their regular chemo. Researchers measured changes in ne…

This study looked at whether hypnosis or a placebo pill (given honestly, without deception) can reduce chronic nerve pain and improve how the brain handles pain. Seventy-two adults with long-term nerve pain were randomly assigned to hypnosis, open-label placebo, or usual care. Th…

This small pilot study tested whether a 4-week course of repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain and improve quality of life in 18 adults with diabetic neuropathy. Participants received rTMS and were monitored using questionnaires, nerve tests, a…

This study tested whether a spinal cord stimulation device can reduce chronic leg pain caused by diabetic neuropathy. Twenty-eight people with diabetes received the implant and reported their pain relief and overall improvement over 12 months. The goal was to see if this device c…

This study tested whether adding shockwave therapy to standard treatment (kinesio taping and physical therapy) helps relieve pain and numbness in women with mild-to-moderate carpal tunnel syndrome. One hundred female physical therapists participated. The goal was to see if the co…

This study tested a portable knee training device in 13 children aged 6-12 with spinal muscular atrophy (SMA). The goal was to see if regular exercise with the device could improve leg muscle strength and function. Researchers measured muscle size, strength, and nerve activity ov…

This study looked at whether a type of electrical stimulation called Russian current can help people regain hand grip strength and function after carpal tunnel release surgery. Fifty-two adults aged 30 to 50 with hand weakness after surgery took part. Researchers measured grip st…

This study looked at two types of nerve blocks—fascia iliaca block and femoral nerve block—to see which one works better for pain control in people having hip fracture surgery. 80 adults were randomly assigned to receive one of the two blocks before spinal anesthesia. The main go…

This study tested new non-drug treatments to reduce nerve pain in the feet and legs of people with HIV. 161 adults with HIV-related nerve pain tried these approaches to see if they could ease pain and improve quality of life. The goal was to find better ways to manage this common…

This study tested two non-invasive treatments—low-level laser and transcutaneous vagus nerve stimulation—in 30 adults with diabetic neuropathy. The goal was to see which better improves blood flow and reduces nerve pain. Participants had diabetes for over 5 years and stable blood…

This study tested whether an ultrasound-guided injection of sugar water around the sciatic nerve could safely reduce sciatica pain in the emergency department. Researchers enrolled 69 adults with acute sciatica and followed up 72 hours later. The goal was to see if the procedure …

This study tested whether combining balance exercises with mental tasks (like naming animals) can improve balance and mild memory problems in people with diabetic nerve damage. Fifty adults aged 50 and older with type 2 diabetes and mild cognitive issues took part in 24 sessions …

This study tested whether adding a four-cell galvanic bath therapy to standard rehabilitation could reduce pain and improve balance in people with diabetic nerve damage. 66 adults with type 2 diabetes and diabetic neuropathy participated. Over 4 weeks, some received the bath ther…

This study tested whether applying antibiotics directly into the tooth socket after wisdom tooth removal works as well as taking antibiotic pills. 90 adults having their lower wisdom teeth taken out were split into two groups: one got antibiotic gel at the surgery site, the other…

This study tested whether remote monitoring through the Neurosphere app could improve pain relief and lower healthcare costs for people with chronic pain using spinal cord stimulators. Thirty-two adults were split into two groups: one had in-person clinic visits, the other used r…

This completed trial tested whether combining neurodynamic exercises with proprioceptive neuromuscular facilitation (PNF) techniques can reduce pain and improve range of motion in people with carpal tunnel syndrome. Forty-eight diagnosed patients performed the exercises for two w…

This study tested two non-drug treatments for piriformis syndrome, a condition where a muscle in the buttock presses on a nerve, causing pain. Seventy adults received either low-level laser therapy or radial shockwave therapy, both combined with exercise, over four weeks. Researc…

This study looked at whether adding dexmedetomidine to standard spinal anesthesia could lower the chance of acute neuropathic pain after a leg amputation. Thirty adults having elective lower limb amputation were split into two groups: one got the standard anesthetic plus a placeb…

This study compared two physical therapy methods—pulsed ultrasound and pulsed shortwave diathermy—in 40 adults with mild-to-moderate carpal tunnel syndrome. All participants wore a wrist splint and did exercises for three weeks, plus one of the two treatments. Researchers measure…

This study tested whether NT 201 injections can reduce pain in adults with long-term nerve pain caused by shingles or a nerve injury. 123 people received either NT 201 or a placebo shot, and researchers tracked their pain levels over 20 weeks. The goal was to see if the treatment…

This pilot study tested whether electro-acupuncture—a treatment that combines traditional acupuncture with mild electrical current—is practical and helpful for people with nerve pain and numbness from chemotherapy. Twenty cancer survivors who had completed chemotherapy at least t…

This study tested whether a special set of exercises, called modified Otago exercises, could help people with type 2 diabetes who have nerve damage in their feet. 38 participants did these exercises for 8 weeks, and researchers measured their balance, joint position sense, blood …

This study tested a new drug called SR750 in 138 people with trigeminal neuralgia, a condition that causes sudden, severe facial pain. Participants took either SR750 or a placebo for 6 weeks and recorded their daily pain levels. The goal was to see if SR750 reduces pain better th…

This study looked at different rehabilitation programs for 90 adults who had back surgery for degenerative lumbar disease. The goal was to see which rehab approach best reduces nerve pain, helps patients regain function, and improves quality of life. Participants were randomly as…

This study tested whether injecting platelet-rich plasma (PRP) near nerves can reduce pain and nerve damage caused by chemotherapy. 62 cancer patients with persistent nerve pain received PRP injections guided by ultrasound. Researchers measured pain levels and nerve function to s…

This study looked at whether two common drugs, memantine and dextromethorphan, can help maintain or improve pain relief after a ketamine treatment in people with long-term nerve pain. Seven adults with chronic neuropathic pain who had already responded to ketamine took part. The …

This study tested whether ethosuximide, a drug already used for epilepsy, can reduce pain in people with nerve damage. 114 adults with peripheral neuropathic pain took either the drug or a placebo for 42 days. Researchers measured pain levels and quality of life to see if the dru…

This study compared two hands-on treatments—post-facilitation stretch and active release technique—for piriformis syndrome in 40 women aged 25 to 45. Researchers measured pain, disability, quality of life, and hip movement over six weeks. The goal was to see which approach offers…

This completed study compared two treatments for piriformis syndrome, a condition causing buttock and leg pain. Forty adults whose pain lasted at least three months were randomly assigned to receive either five sessions of focused sound wave therapy or a single steroid injection.…

This study tested whether a rehabilitation program using a smartphone app (MORA) could help bedridden hospital patients improve their physical function. Twenty-five adults who could not walk used the app to do personalized exercises twice daily for two weeks. The goal was to see …

This study compared a capsaicin patch (Qutenza) to a standard nerve pain medication (amitriptyline) in 13 head and neck cancer survivors with long-term nerve pain. The goal was to see if the patch could reduce pain and improve quality of life. Participants received either the pat…

This study tested two exercise techniques—dynamic stretching and nerve gliding—in 72 adults with lumbar radiculopathy (nerve-related back pain). Both groups also received standard physiotherapy. The goal was to see which approach better reduced pain and improved daily function ov…

This study tested whether a mild electrical stimulation (40 kHz) applied through the skin can safely reduce nerve pain in people with spinal cord injury. Thirty adults with paraplegia and chronic nerve pain received either real or placebo stimulation alongside their usual treatme…

This study tested if a simpler numbing method called WALANT works as well as a standard arm block for carpal tunnel release surgery. WALANT involves injecting numbing medicine directly into the wrist area, avoiding the need for a tourniquet or sedation. The trial included 130 adu…

This study tested two physical therapy techniques—nerve gliding exercises and manual muscle release—to see which better relieves sciatica pain. 48 adults with long-term sciatica took part. Researchers measured pain, leg movement, and daily function to find the most effective appr…

This study tested two types of nerve mobilization exercises—slider and tensioner—in 36 adults with chronic neck pain from cervical radiculopathy. Participants received standard care plus one of the two techniques. The goal was to see which better reduces pain, improves neck movem…

This study tested whether using the WALANT technique (numbing the hand with local anesthetic and epinephrine) along with nerve blocks at the wrist could make carpal tunnel release surgery more comfortable than using a standard tourniquet. 60 adults having endoscopic carpal tunnel…

This study looked at whether adding foot exercises to aerobic exercise helps people with type 2 diabetes and nerve damage in their legs. 74 participants were split into three groups: usual medical care, aerobic exercise only, or aerobic exercise plus foot exercises. The goal was …

This pilot study tested whether adding cognitive behavioral therapy and mindfulness meditation to ketamine infusions could make pain relief last longer for people with chronic nerve pain. Thirty adults with moderate-to-severe neuropathic pain were randomly assigned to receive ket…

This pilot study tested whether acupuncture could reduce tingling, numbness, and pain in the hands and feet caused by chemotherapy in breast cancer survivors. Fifty-seven women who had completed taxane-based chemotherapy were randomly assigned to receive acupuncture immediately o…

This study tested whether a low-immunogenic oat variety called Saul is well-tolerated by adults with celiac disease who are in remission. Forty participants ate 50 grams of gluten-free Saul oat flakes daily for 14 days. Researchers tracked symptoms and blood markers to see if the…

This study looked at whether progressive relaxation exercises can help people with type 2 diabetes who have nerve pain, fatigue, and poor sleep. 88 adults took part. The goal was to see if these simple exercises could improve their symptoms and quality of life.

This study tested a minimally invasive procedure for carpal tunnel syndrome using ultrasound guidance. 40 patients who did not get better with standard treatments received the procedure. Researchers measured pain, hand function, quality of life, and how quickly patients could ret…

This study tested two types of magnetic brain stimulation (TMS) to see if they can reduce nerve pain in people with spinal cord injury. 26 adults with long-term nerve pain that didn't respond to medication took part. The goal was to measure changes in pain severity, daily functio…

This study looked at whether a diabetes education program plus cinnamon supplements could help adults with type 2 diabetes who have painful nerve damage in their feet. Sixty-two participants were split into two groups and followed for six months. Researchers measured changes in b…

This study tested a device that delivers pain medicine directly to the spinal cord for cancer patients with severe pain not controlled by oral opioids. Researchers compared the pump to standard medical management in 30 adults. The goal was to see if the pump reduces pain intensit…

This study looked at whether doing hip abductor strengthening exercises could help people with piriformis syndrome feel less pain and move better. 48 adults with the condition took part. The exercises focused on strengthening muscles that move the leg away from the body. The goal…

This completed Phase 3 trial tested whether brivaracetam, a drug used for seizures, can reduce chronic nerve pain in people with spinal cord injury. 44 adults with persistent pain took part. The study compared brivaracetam to a placebo and measured changes in pain intensity and d…

This early-stage study tested whether an experimental pill called PIPE-791 is safe and can lower pain in adults with long-term osteoarthritis knee pain or chronic low back pain. 43 participants stopped their usual pain meds, then took either the study drug or a placebo daily for …

This study tested several experimental treatments for painful diabetic peripheral neuropathy, a common complication of diabetes that causes burning or shooting pain in the feet and hands. 127 adults with this condition rated their daily pain on a 0-10 scale to see if the treatmen…

This study tested whether a daily capsule called NRD135S.E1 can safely reduce nerve pain caused by diabetes. 127 adults with painful diabetic neuropathy took either the drug or a placebo for 13 weeks. Researchers measured pain changes using a 0-10 scale and tracked any side effec…

This study tested a minimally invasive procedure called pulsed radiofrequency on a nerve bundle in the face (the sphenopalatine ganglion) to see if it could reduce pain in 55 people with chronic headaches or facial pain who hadn't gotten relief from medication. The procedure uses…

This small pilot study tested whether a temporary spinal cord stimulator (like a pacemaker for the spine) could help people with spinal muscular atrophy types 3 and 4 move their legs better. Three adults who could stand independently received the implant for up to 29 days. The go…

This study tested two different doses of lidocaine given through an IV to women who had nerve pain after mastectomy for breast cancer. Thirty women took part, and researchers measured how the pain felt (like burning or stinging) using a special scale. The goal was to see if lidoc…

This study tested whether a non-invasive magnetic brain stimulation technique called rTMS can reduce chronic low back pain. Thirty adults with long-lasting pain received multiple sessions of rTMS over the brain's motor cortex. Researchers measured pain changes using a standard pa…

This study tested whether a set of foot and ankle exercises could reduce pain and improve quality of life in 100 people with painful diabetic neuropathy. Participants performed exercises like ankle circles, toe spreads, and rolling a warm bottle under the foot. Researchers measur…

This study compared two physical therapy techniques—neurodynamic mobilization and Mulligan SNAGs—for people with chronic sciatica caused by a disc problem. 66 participants completed the trial at Cairo University. Researchers measured pain intensity, pressure pain threshold, and l…

This study tested whether Pilates or Gyrotonic exercises can ease nerve pain and reduce fall risk in 100 cancer survivors who have nerve damage from chemotherapy. Participants did one of the two exercise programs. The goal was to see if these exercises improve symptoms like numbn…

This study tested whether the diabetes drug acarbose, adjusted using continuous glucose monitoring (CGM), can reduce pain in adults with painful diabetic neuropathy. 170 participants with type 2 diabetes and high blood sugar swings were enrolled. The goal was to see if controllin…

This completed study tested whether an injection of 5% dextrose (a sugar solution) works as well as a steroid (betamethasone) to relieve pain and symptoms in people with mild-to-moderate carpal tunnel syndrome. Thirty participants received one of the two ultrasound-guided injecti…

This study tested whether acupuncture can help prevent or reduce nerve pain, numbness, and tingling caused by chemotherapy in people with early-stage breast cancer. 89 participants were split into two groups: one received acupuncture, the other watched nature videos and did relax…

This small pilot study looked at whether osteopathic manipulative therapy (OMT) can reduce stiffness in the median nerve and improve symptoms in people with mild to moderate carpal tunnel syndrome. Ten participants received OMT along with standard care. Researchers measured nerve…

This study looked at whether adding mud therapy (peloidotherapy) to standard care (wrist splint and exercises) can further reduce pain and improve hand function in people with mild to moderate carpal tunnel syndrome. 70 adults took part, with half receiving mud therapy plus stand…

This study tested whether adding pulsed electromagnetic field (PEMF) therapy to standard physical therapy could reduce nerve pain and disability in people with a slipped disc in the lower back. Forty-six patients completed the trial, receiving either real or fake PEMF alongside u…

This study tested whether low-level laser therapy (using Nd:YAG or diode lasers) can help repair nerve damage in the lower jaw after dental procedures like wisdom tooth removal or implant placement. Thirty adults with numbness or tingling in their lower lip and chin received lase…

This study tested an experimental drug called LX9211 in 79 adults with postherpetic neuralgia, a type of nerve pain that can last for months after a shingles rash heals. The goal was to see if the drug reduces pain and helps with sleep compared to a placebo over 11 weeks. Partici…

This study tested a device called SinuSonic that combines sound vibrations with gentle pressure to help people with Eustachian tube dysfunction (ETD) and facial pain. Thirty adults used the device twice a day for six weeks. Researchers measured changes in symptoms like ear pressu…

This study looked at whether adding a muscle relaxation technique (integrated neuromuscular inhibition) to a standard set of strengthening exercises (McGill program) helps people with piriformis syndrome more than the exercises alone. Fifty-six adults with chronic buttock pain fr…

This study tested two types of laser therapy (red and infrared) to help repair damaged nerves in the face. Thirty adults with nerve injuries that had not improved for at least six months received treatment. The goal was to reduce pain and improve sensation, offering a possible al…

This study looked at whether adding low-level laser therapy or nerve mobilization (gentle stretching of the median nerve) after carpal tunnel release surgery improves nerve function more than surgery alone. Forty-five adults who had carpal tunnel surgery were split into three gro…

This study tested a drug that blocks a pain-signaling protein (CGRP) in 26 adults with trigeminal or glossopharyngeal nerve pain caused by small fiber neuropathy or fibromyalgia. The goal was to see if it reduces pain and the need for other pain medications, while checking for si…

This study tested a single injection of 5% dextrose (sugar water) guided by ultrasound to separate the median nerve from surrounding tissues in 37 people with mild-to-moderate carpal tunnel syndrome. Participants were followed for 3 months to see if pain and hand function improve…

This study tested whether wearing prism goggles during pointing exercises can reduce pain in people with Complex Regional Pain Syndrome (CRPS) type I. Fifty-four patients with CRPS after a wrist fracture or surgery were split into two groups: one used real prism goggles, the othe…

This study tested whether low-level laser therapy, combined with a self-care program, could help people with jaw joint pain (TMJ disorders). 66 adults with recent jaw muscle pain received the treatment. Researchers measured pain levels, jaw movement, and tender spots to see if th…

This study looked at 113 adults with carpal tunnel syndrome to see if there is a difference in pain and hand function shortly after surgery. One group had endoscopic surgery (small incisions) and the other had open surgery (larger incision). Researchers measured pain and function…

This study tested whether adding shockwave therapy to simple hand exercises helps people with carpal tunnel syndrome feel less pain and use their hands better. Twenty-six adults with mild to moderate symptoms received either shockwave plus exercises or physical therapy plus exerc…

This study tested whether adding sensory integration exercises (like brushing and textured balls on the feet) to standard exercises could improve body awareness and balance in people with diabetic nerve damage. Thirty participants with moderate nerve damage were split into two gr…

This study tested a topical cannabidiol (CBD) cream against a placebo cream to see if it could reduce nerve pain, numbness, and tingling in the hands and feet caused by chemotherapy. Forty adults with moderate to severe chemotherapy-induced peripheral neuropathy (CIPN) applied th…

This small study tested whether combining mirror therapy (watching the healthy hand move in a mirror) with electrical stimulation could help people with recent nerve injuries in the forearm regain hand movement and feeling. Seven participants did hand exercises with or without th…

This study tested two different modes of transcutaneous electrical nerve stimulation (TENS) to relieve chronic pelvic pain in 60 men who had prostate surgery. Participants received TENS sessions three times a week for three months. The goal was to see which mode works better for …

This study tested whether adding nerve mobilization exercises to standard ultrasound therapy helps people with mild-to-moderate carpal tunnel syndrome. 86 adults aged 20-55 took part. Researchers measured pain, hand strength, and nerve size before and after three weeks of treatme…

This study tested whether nursing interventions based on the Levine Conservation Model could help colorectal cancer patients cope with fatigue, nerve damage, and anxiety caused by chemotherapy. 68 patients receiving the FOLFOX regimen were taught to use sensory balls, progressive…

This study tested whether adding a painless magnetic stimulation treatment to standard manual therapy (like massage and stretching) helps people with sciatica caused by a herniated disc. Forty adults were split into two groups: one got manual therapy alone, the other got manual t…

This study tested a combined laser and ultrasound treatment for people with type 2 diabetes who have early nerve damage in their feet. Sixty participants received either the real treatment or a placebo over 24 sessions. The results showed that the treatment helped reduce pain, bu…

This completed study tested whether botulinum toxin type-A injections relieve pain from myofascial pain syndrome better than a standard local anesthetic (prilocaine). Thirty-eight adults with long-term muscle pain were randomly assigned to receive either botulinum toxin or priloc…

This study tested a new way to treat carpal tunnel syndrome using ultrasound guidance to perform the release procedure right in the doctor's office. 149 adults with carpal tunnel syndrome who had not improved with other treatments took part. The goal was to see if this office-bas…

This study tested whether adding thymoquinone, a compound from black seed oil, to the standard pain drug pregabalin could better relieve nerve pain in people with diabetes. Fifty adults with diabetic peripheral neuropathy took both treatments daily for two months. Researchers mea…

This study looked at whether supervised exercise training is better than unsupervised exercise for improving balance and quality of life in people with diabetic nerve damage in their feet and legs. 32 adults aged 55-70 with type 2 diabetes for at least 10 years took part. The goa…

This study tested a steroid injection into a trapped nerve in the lower back to see if it reduces pain and improves daily activities. 41 adults with low back pain from superior cluneal nerve entrapment received the injection. The goal was to measure pain levels and disability bef…

This study tested whether doing nerve-gliding exercises on both hands (bilateral) is better than only the affected hand (unilateral) for people with carpal tunnel syndrome. 28 adults completed the trial. The goal was to see which approach reduces symptoms like pain and numbness m…

This study tested a dietary supplement containing ingredients like palmitoylethanolamide, alpha lipoic acid, and several B vitamins to see if it could reduce nerve pain in cancer patients receiving chemotherapy. 71 newly diagnosed patients who had not yet started treatment took e…

This study tested whether a combination of nucleotides and B vitamins (Nucleo CMP and Neurorubine) could provide better and longer-lasting pain relief than the standard drug carbamazepine for people with trigeminal neuralgia, a severe facial pain condition. 38 adults with classic…

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help adults with persistent post-concussion symptoms like headaches, fatigue, and memory problems. Twenty participants with mild traumatic brain injury received either real tr…

This study tested whether the drug fisetin, found naturally in fruits, can safely reduce symptoms of mild to moderate carpal tunnel syndrome. Forty adults took fisetin capsules for two days, then again a month later. Researchers measured changes in symptom severity and hand funct…

This study looked at whether adding extra sensory feedback to physical therapy could improve balance and reduce fall risk in women with nerve damage from cancer treatment. Forty women who had recovered from breast cancer took part. The group that received the extra sensory feedba…

This study looked at whether specific hand and wrist exercises could help people with mild to moderate carpal tunnel syndrome. 91 participants did either nerve gliding exercises or strengthening exercises daily for three weeks. The results suggest these exercises may reduce stiff…

This study tested an experimental drug called MT-8554 in 61 adults with painful diabetic peripheral neuropathy, a common complication of diabetes causing nerve pain. The goal was to see if the drug could safely reduce pain compared to a placebo. Participants took the drug or plac…

This study tested a drug called MT-8554 (Elismetrep) in 156 adults with painful diabetic peripheral neuropathy. The goal was to see if it reduces pain better than a placebo over 12 weeks. Participants took either the drug or a placebo capsule, and pain was measured using a 0-10 s…

This study tested a non-invasive brain stimulation method called tDCS to see if it can reduce chronic nerve pain. Researchers compared real stimulation to a placebo in 24 healthy volunteers and patients with long-term nerve pain. The goal was to measure changes in pain levels and…

This study looked at whether adding a special self-stretching technique to standard physical therapy can better reduce pain and improve hand function in people with mild to moderate carpal tunnel syndrome. 36 adults with stage I or II carpal tunnel took part. One group did the se…

This study tested surgery to treat Complex Regional Pain Syndrome (CRPS) in the upper limb. 74 adults with CRPS who had not improved with other treatments received either nerve decompression or correction of a specific structural problem. Pain levels were measured before surgery,…

This study looked at whether a targeted ultrasound-guided nerve block (SPSIPB) can reduce pain in people with postherpetic neuralgia, a chronic pain condition that can linger after shingles. Researchers reviewed records of 34 adults who received this injection and measured pain l…

This study tested if people with painful diabetic neuropathy can safely use a new electrical stimulation device at home. 40 adults who had not gotten enough relief from standard pain medicines used the device for 10 days. The goal was to see if the device is easy to use and has s…

This study tested two local anesthesia methods for hand, wrist, or elbow surgery. One used lidocaine alone, the other added ropivacaine for longer pain relief. 91 adults participated. Researchers measured pain and recovery quality 48 hours after surgery to see if the combination …

This study tested whether gabapentin pills or a simple physiotherapy hand stretch (nerve mobilization) can reduce pain and improve hand function in people with carpal tunnel syndrome. 126 adults with confirmed carpal tunnel took part. The goal was to see if either treatment works…

This completed study tested whether combining a hand therapy technique (nerve mobilization) with two pain medications (gabapentin and ibuprofen arginine) reduces pain better than ibuprofen alone in people with carpal tunnel syndrome. 129 adults with confirmed carpal tunnel took p…

This pilot study tested whether a structured foot-ankle exercise program could help adults with type 2 diabetes manage nerve pain, stress, and quality of life, compared to walking or standard care. Over 12 weeks, 108 participants either did foot-ankle exercises, walked regularly,…

This study looked at whether very low-level electrical stimulation of nerves near the spine can reduce chronic pain more than a sham (inactive) device. Twenty adults who already have a nerve stimulator implant took part. Each person received both the real low-level stimulation an…

This study tested whether a numbing injection near the hip (femoral nerve block) works better than IV fentanyl for pain from a broken hip in the emergency room. 104 adults with hip fractures took part. The goal was to see which method provides faster and more effective pain relie…

This study tested whether manually mobilizing the sacroiliac joint (a joint in the lower back) can reduce tension and pain in the piriformis muscle, a deep hip muscle that often cramps. Researchers used physical therapy techniques on 40 adults with lower back or hip pain and musc…

This study tested whether foot-ankle exercises and walking exercises can reduce foot nerve pain, stress, and improve quality of life in people with type 2 diabetes. 375 adults with diabetes were split into three groups: foot-ankle exercises, walking exercises, or standard care. T…

This study tested two stretching techniques—Post-Isometric Relaxation and Post-Facilitation Stretching—in 36 adults with piriformis syndrome, a condition that causes buttock pain and limits hip movement. Participants did the exercises three times a week for four weeks. Researcher…

This study tested two ways of performing nerve-mobilization exercises in 56 people with carpal tunnel syndrome. One group did the exercises from the wrist toward the neck, the other from the neck toward the wrist. The goal was to see which sequence better reduced pain, improved w…

This small study tested whether combining virtual walking (watching a first-person walk video) with mild brain stimulation (tDCS) could help ease chronic nerve pain in people with spinal cord injury. Four participants tried the 2-week program, keeping pain diaries and reporting h…

This study tested a virtual reality device to see if it could reduce pain in adults with chronic low back pain that didn't respond to medication. 122 participants used the VR system, which creates a 3D environment with changing colors. The main goal was to measure pain levels aft…

This study tested a type of hands-on therapy called fascial mobilization in 30 new mothers with carpal tunnel syndrome. The goal was to see if it could reduce pain and improve grip strength and hand function. Results may offer a drug-free option for managing postpartum wrist disc…

This study compared two surgical treatments for carpal tunnel syndrome: a newer ultrasound-guided procedure with a small incision and traditional open surgery. Researchers wanted to see if the less invasive method leads to faster symptom relief and better hand function. Two hundr…

This study tested two treatments for meralgia paresthetica, a condition causing pain, numbness, and tingling in the outer thigh. Researchers compared pulsed radiofrequency ablation (using heat to calm the nerve) with steroid injections in 22 adults who did not get relief from sim…

This study looked at whether medical cannabis can reduce nerve pain and inflammation in people with HIV. Thirty-five adults with HIV and neuropathic pain used different ratios of THC and CBD over 14 weeks. Researchers measured changes in pain severity and blood markers of inflamm…

This study tested a new device called Incremental Velocity Error (IVE) that uses a headband to help retrain the brain's balance system. It compared the device to standard eye and head exercises in 24 adults with dizziness from mild traumatic brain injury or inner-ear nerve damage…

This study tested a new medicine called NMD670 in 81 adults with Charcot-Marie-Tooth disease types 1 and 2. Participants took either the drug or a placebo twice daily for 21 days. The main goal was to see if the drug could improve walking distance in 6 minutes. The study also che…

This study tested a device called the Sana Pain Reliever for people with long-term nerve pain. 75 adults used the device at home for 8 to 14 weeks. Researchers measured changes in pain symptoms using a standard pain scale. The goal was to see if the device could help reduce pain …

This study tested whether a high-intensity exercise program, run by physical therapy students, can help people with neurologic disabilities move better in everyday life. Fifteen participants with conditions like cerebral palsy, stroke, or spinal cord injury completed the program.…

This study followed 101 people who had previously received either the experimental drug Engensis or a placebo for painful diabetic neuropathy. No new treatment was given; researchers simply monitored participants for 6 months to see if any safety issues or lasting pain relief app…

This Phase 3 study tested whether injections of engensis, a gene therapy, can reduce pain in the feet and legs caused by diabetic nerve damage. 162 adults with type 1 or 2 diabetes received either engensis or a placebo. The main goal was to see if pain scores improved over 180 da…

This study tested a drug called LX9211 in 496 adults with diabetic peripheral neuropathic pain (nerve pain from diabetes). The goal was to see if it reduces average daily pain and improves sleep compared to a placebo over 8 weeks. The trial is complete, and results will show if L…

This study tested whether a gene therapy called VM202 could safely reduce pain in people with diabetic peripheral neuropathy. Over 500 adults with type 1 or type 2 diabetes received either VM202 injections or a placebo in their legs. The main goal was to see if the treatment lowe…

This study tested whether a gene therapy called engensis can safely reduce pain from diabetic nerve damage over 6 to 12 months. About 100 people who completed an earlier trial received either engensis or placebo injections into their leg muscles. Researchers measured changes in d…

This early-phase trial tested a gene therapy called Engensis (VM202) in 12 people with painful diabetic peripheral neuropathy. Participants received injections into their calf muscles to see if it was safe and could reduce pain. The study focused on safety and pain scores over 12…

This study tested a gene therapy called Engensis (VM202) to see if it safely reduces pain in people with diabetic peripheral neuropathy. 104 adults with type 1 or 2 diabetes and leg pain for at least 6 months received either low-dose, high-dose, or placebo injections into their c…

This study tested three different injection techniques using a sugar-water solution (5% dextrose) to treat mild to moderate carpal tunnel syndrome. 74 adults received one of the methods, and researchers measured pain, tingling, and hand function over three months. The goal was to…

This study tested a cream containing cannabidiol (CBD) and urea on 23 adults with diabetic foot neuropathy and dry skin. The goal was to see if it could reduce nerve pain and improve skin quality. While the treatment aims to ease symptoms, it does not cure the underlying diabetes…

This study looked at two ways to help people with diabetic nerve pain in their legs: high-intensity laser therapy and moderate aerobic exercise. Sixty adults with symptoms like numbness, tingling, or burning took part. The goal was to see which approach improves leg function and …

This study tested prefabricated carbon fiber ankle-foot orthoses (AFOs) in 65 children and teenagers with conditions like cerebral palsy, spina bifida, or spinal cord injuries that affect walking. Researchers measured stride length, walking speed, and user satisfaction by compari…

This study tested a non-invasive device that stimulates the vagus nerve through the ear to see if it can reduce fatigue in people with lupus. 75 participants received either active or sham stimulation over two phases. The main goal was to measure changes in fatigue using a standa…

This study compared two types of carpal tunnel release surgery: one using ultrasound guidance with a tiny incision (less than 1 cm) and the traditional mini-open method with a slightly larger cut. Forty-one adults with carpal tunnel syndrome were randomly assigned to one of the t…

This pilot study tested whether sound acupuncture — using tuning forks on energy points instead of needles — can reduce nerve pain caused by chemotherapy. Forty adults with chemotherapy-induced neuropathy took part. Half received standard medical therapy alone, and half received …

This study tested whether applying ultrasound with a hyaluronic acid gel to the wrist could help women who developed carpal tunnel syndrome from hormone therapy after mastectomy. Sixty women were split into two groups: one received the ultrasound gel treatment plus standard physi…

This study tested whether high-power laser therapy can reduce pain and disability in people with sciatica caused by a herniated disc. Thirty-six adults with at least 12 weeks of symptoms received either real or sham laser treatments. The goal was to see if the laser improves pain…

This study tested whether group dance classes can improve balance and motivation in breast cancer survivors who have nerve damage from chemotherapy. Fifty-two survivors participated in either dance-based exercise or standard exercise for several weeks. The goal was to see if danc…

This study tested whether an injection of ES135, a lab-made version of a natural growth factor, could help people with carpal tunnel syndrome. Twenty-four adults with confirmed CTS received either ES135 or a placebo injection guided by ultrasound. Researchers tracked changes in s…

This study tested two treatments for people with ongoing back pain after spinal surgery: pulsed radiofrequency (a procedure using mild electrical pulses) and a standard steroid injection. About 130 patients were followed for several months to see which approach reduced pain and i…

This study tested the long-term safety and effectiveness of HSK16149, a drug for nerve pain, in 301 Chinese patients over 52 weeks. All participants had previously completed a shorter trial and tolerated the drug. Researchers tracked side effects and pain scores to see if the dru…

This study tested whether adding dry needling to standard exercises helps people with mild to moderate carpal tunnel syndrome. 78 adults received either exercises alone or exercises plus dry needling for 3 weeks. Researchers measured pain, wrist movement, and hand function to see…

This observational study follows 75 people with shoulder impingement syndrome who are already receiving standard physical therapy. Researchers want to see if nerve-related pain and negative thinking about pain (called pain catastrophizing) affect how well patients stick to their …

This study looked at whether high-intensity interval training (HIIT) or weight-loss surgery can reduce the risk of nerve damage (peripheral neuropathy) in people with obesity. About 140 adults who were candidates for bariatric surgery took part. Researchers measured nerve health …

This study looks at how the severity of carpal tunnel syndrome relates to ultrasound images of the nerve, nerve conduction tests, hand grip strength, and pain sensitivity. Researchers will assess 90 adults with the condition using these measures during a single visit. The goal is…

Researchers at Nantes University Hospital are studying whether nerves feel stiffer in people with three rare peripheral neuropathies: CIDP, CMT1a, and anti-MAG neuropathy. They use ultrasound shear wave elastography to measure nerve stiffness in 36 participants aged 18 to 65 and …

This study looks at how common nerve pain is in people aged 80 and older. Researchers will check pain levels and overall health in 450 volunteers. The goal is to better understand the link between nerve pain and aging, not to test a new treatment.

This study looks at how the constant vibration from tattoo machines may damage nerves in the hands of tattoo artists. Researchers will test touch, strength, and sensation in 20 tattoo artists and compare them to 20 people who don't use vibrating tools. The goal is to understand i…

This study examines people with trigeminal neuralgia and persistent idiopathic facial pain, two conditions that cause chronic facial pain. Researchers will use sensory tests and MRI scans to look for signs of nerve damage and see how they relate to each other. The goal is to bett…

Researchers are using ultrasound to measure the thickness of ankle cartilage in people with type 2 diabetes who have nerve damage, and comparing it with healthy adults. Diabetic polyneuropathy may change how the lower limbs move, which could affect the ankle joint. The study incl…

Researchers are testing an oral drug called Ketamir-2, a chemical cousin of ketamine, in healthy adults aged 18 to 65. The trial gives single or repeated doses to small groups and compares them against a placebo to see how the body handles the drug and what side effects occur. Th…

This study looked at whether certain blood markers of inflammation and vitamin B12 levels are linked to carpal tunnel syndrome. Researchers compared 70 people with and without the condition. The goal was to see if these markers could help explain why some cases are more severe.

This study looked at how the brain adapts when people have a nerve injury in their dominant arm. Researchers used brain scans to see which parts of the brain help people move skillfully with their left, non-dominant hand. The study included 120 adults, some with a chronic nerve i…

This study looks at whether a substance in the blood called neurofilament light chain (NfL) is linked to how severe nerve damage is, how well people balance, and their risk of falling. Researchers will measure NfL levels in 80 adults with type 2 diabetes, some with and some witho…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This Phase 1 trial evaluates the safety, tolerability, and how the body processes an experimental oral drug called AJH-2947. It involves healthy Korean or Caucasian men aged 19 to 55, who receive either the drug or a placebo. The study aims to determine safe dosing and preliminar…

This study looked at how often thiamine (vitamin B1) deficiency occurs in hospitalized veterans who do not abuse alcohol. Thiamine deficiency can cause symptoms like fatigue, confusion, and weakness, and may be more common in veterans due to food insecurity and chronic illness. R…

This study looks at whether chronic neuropathic pain and the medications used to treat it—like antidepressants, antiepileptics, or opioids—are linked to changes in hormone levels. Researchers will compare hormone levels in 120 adults with chronic pain to healthy volunteers matche…

This study looks at how lung function, respiratory muscle strength, balance, and quality of life relate in Paralympic athletes. Researchers will measure breathing capacity, muscle strength, and balance in 24 athletes from sports like athletics, swimming, archery, and wheelchair b…

This study looks at whether placing patients face-down (prone) to help them breathe can damage nerves in the shoulder area. Researchers will use electrical tests to check for nerve injury in adults with severe lung failure who are sedated and on a ventilator. The goal is to find …

This completed study looked at how often hospitalized patients with cirrhosis experience pain. Researchers asked 30 patients about their pain, its location, intensity, and whether it was chronic. The goal was to highlight an often-overlooked issue and encourage better pain care f…

This study looks at whether cardiac autonomic neuropathy (nerve damage that affects heart rate control) changes the heart's electrical recovery time (QT interval) in people having coronary artery bypass surgery. Researchers will test nerve function before surgery and measure hear…

This study used a special ultrasound technique to measure stiffness in pelvic floor muscles of 94 women — some healthy and some with pudendal neuralgia, a chronic nerve pain condition. Researchers compared the muscle stiffness between the two groups to see if differences exist. T…

This study looks at tiny nerve fibers in the skin of people with Long COVID, POTS, diabetic neuropathy, and those who had COVID-19 without lasting symptoms. By comparing skin samples, researchers hope to find unique patterns that help explain ongoing symptoms like pain and dizzin…

This completed study examined muscle cells from 8 children with obstetrical brachial plexus palsy, a birth injury that affects arm nerves. Researchers took small muscle samples during planned shoulder surgery to see if the cells can repair themselves. The goal was to understand w…

This study looks at whether a French version of the SMAFRS questionnaire gives reliable results when used twice in adults with spinal muscular atrophy (SMA). About 60 participants will fill out the questionnaire during a routine visit and again 15 days later. No treatment is give…

This study looked for substances in the blood that could signal chronic pain after a spinal cord injury. Researchers compared blood samples from 120 people with and without pain, including those with recent and long-term injuries. The goal was to find early warning signs that cou…

This study from the University of Oxford aims to understand how specific physiotherapy exercises (neurodynamic exercises) work for carpal tunnel syndrome. Researchers will compare these exercises to standard steroid injections and simple advice in 78 patients with mild to moderat…

This study looked at 144 adults who had carpal tunnel surgery to see if the thickness of a wrist ligament (the flexor retinaculum) is linked to developing heel pain afterward. Researchers measured the ligament during surgery and compared patients who got heel pain with those who …

This completed study in Russia checked how many people with carpal tunnel syndrome also have a rare inherited nerve condition called hereditary transthyretin amyloidosis. Researchers reviewed medical records of 721 patients and will test some for the genetic mutation. The goal is…

This study tested a new way to monitor vision during brain surgery near the optic nerve. Researchers used special goggles and anesthesia to track brain signals (visual evoked potentials) in 40 patients. The goal was to see if this method could help surgeons avoid damaging eyesigh…

This small study tested whether adding exercise (stationary biking) to standard sensory training could improve sensation and reduce pain after nerve injuries in the arm or hand. Seven adults who had a nerve injury between 2010 and 2025 took part. The goal was to see if this appro…

This study tested whether a new device called KForce Sens can reliably measure how well people with mild to moderate carpal tunnel syndrome sense their wrist position. Researchers compared it to a standard tool (Baseline electrogoniometer) in 70 adults. The goal was to see if the…

This study looked at how the way words sound (phonotactic probability) and how they are spelled (orthography) affect vocabulary learning in 23 children with low oral language skills (DLD). All children took part in the same 12-week program, which used real words to improve vocabu…

This completed study looked at 393 adults aged 65 and older with chronic pain to see how frailty relates to the type and location of pain, as well as nutritional risk. Researchers measured frailty using standard criteria and assessed pain intensity and type. The goal is to help d…

This study looked at whether advanced MRI scans and a nerve test called MUNIX can detect the earliest signs of nerve damage in people who carry a gene mutation for familial amyloid neuropathy. Researchers studied 60 adults with the TTR mutation, comparing those with and without s…

This study involved 156 people with Charcot-Marie-Tooth disease type 1A (CMT1A), a rare nerve condition that slowly gets worse. Researchers took blood and skin samples over two years to find biological markers that could show how the disease progresses. The goal was to develop mo…

This study looked at how 8 children aged 4 to 17 with moderate foot drop walk when using different supports: barefoot, a Lycra sock, a rigid ankle-foot orthosis (AFO), and a new OrthoPed splint. The goal was to see if the OrthoPed splint allows more natural ankle movement while s…

This study looked at how to improve care for dizzy patients in the emergency department. Over 90,000 adults participated. The goal was to help doctors use proven tests and treatments for common causes of dizziness like BPPV. The study tested new training and tools to make sure pa…

This completed study from Denmark looked at 101 people to see if nerve damage from type 2 diabetes is linked to memory and thinking problems. Researchers compared people with and without diabetes using tests of thinking skills, nerve function, and brain scans. The goal was to und…

This completed study looked at how muscle oxygen levels change during exercise in people with various neuromuscular diseases compared to healthy volunteers. Seventeen participants did a knee-extension exercise while a device measured muscle oxygen. The goal was to understand diff…

This study examined whether pseudoexfoliation syndrome (an eye condition) is related to carpal tunnel syndrome (a wrist nerve problem). Researchers measured blood markers in 159 adults aged 50-80. The goal was to see if these conditions share a common cause, not to test a treatme…

This study looked at how a nerve condition called cardiovascular autonomic neuropathy (CAN) affects the risk of kidney injury in people having heart bypass surgery. Researchers tracked 912 adults before, during, and after surgery to see if those with CAN had worse kidney function…

This study used ultrasound to measure the thickness of certain hip muscles in 60 adults with hip pain on one side (Greater Trochanteric Pain Syndrome) and compared them to healthy people. The goal was to see if muscle thickness differs between the groups and to check for related …

This study looked at how neck pain changes the way people walk and control their movements. Researchers tested 60 adults—some with chronic neck pain and some without—while they performed walking tasks. The goal was to understand how neck problems affect balance and coordination d…

This study looked at 110 people who needed surgery for a broken wrist. Some had an extra procedure to release the carpal tunnel at the same time, while others waited to see if carpal tunnel symptoms developed later. The goal was to see which approach led to fewer repeat surgeries…

This study looked at 65 people with fibromyalgia to figure out what kind of pain they have—nerve pain, tissue pain, or a mixed type. Researchers used a special checklist and simple tests like brushing the skin or pressing with a tool. The goal is to help doctors choose better tre…

This completed observational study looked at 84 people to understand how diabetic polyneuropathy (nerve damage from diabetes) changes the median nerve in patients with carpal tunnel syndrome. Researchers used advanced ultrasound techniques, including shear wave elastography and m…

This study looked at how spinal cord stimulation (SCS) affects pain processing in 34 people with chronic pain. Participants already had an SCS device as part of their care. Researchers tested different stimulation patterns (burst, kHz, tonic, and sham) to see how they changed the…

This completed study looked at how different levels of carpal tunnel syndrome affect people's ability to do daily activities and participate in life. Researchers measured quality of life, hand function, and symptoms in 156 adults with carpal tunnel in their dominant hand. The goa…

This study tested whether ultrasound can measure how tendons and nerves move inside the wrist in people with and without carpal tunnel syndrome. Researchers used sound waves to create images of the wrist in 257 participants. The goal was to better understand the condition, not to…

This study tested whether ChatGPT-4o could correctly diagnose polyneuropathies (nerve diseases) in 100 real patients. Researchers compared the AI's answers to those of nerve specialists and general neurologists. The goal was to see if AI can help non-specialist doctors make bette…

This study tested an online tool designed to help doctors decide which patients with chronic pain are good candidates for spinal cord stimulation. About 80 adults with conditions like failed back surgery syndrome or complex regional pain syndrome took part. The tool's recommendat…

This study looked at 77 adults with long-term nerve pain after shingles (postherpetic neuralgia) to see if a spinal nerve stimulation device works better for certain types of pain. Researchers grouped patients by their pain features and measured pain levels, quality of life, and …

This study followed 37 people with a genetic risk for hereditary ATTR amyloidosis over five years. Researchers measured levels of misfolded proteins in the blood to see if they could detect the earliest signs of the disease. The goal is to develop a way to catch the condition bef…

This study involved 50 people with gastrointestinal cancer who had nerve pain from the chemotherapy drug oxaliplatin. Researchers interviewed patients to understand their symptoms and how the pain affected their daily life. The goal was to use this information to design a medical…

This study looked at 30 adults in rehabilitation who needed a walking aid for the first time. Researchers checked their hand and wrist health before and after using the aid, using questionnaires and nerve tests. The goal was to see if using canes or walkers might lead to carpal t…

This study looked at 40 adults who had to wear a splint or cast on their dominant hand for 6 weeks after an injury. The goal was to see if being forced to use the non-dominant hand actually improves its function. Researchers measured hand skills and disability levels to understan…

This study used ultrasound to measure the thickness of the piriformis muscle and sciatic nerve in 19 people with piriformis syndrome, comparing the painful side to the pain-free side. The goal was to see if ultrasound can help tell whether the pain comes more from muscle or nerve…

This study followed 10 people with late onset Tay-Sachs disease to see how their symptoms and body chemistry changed over six months. Researchers measured balance, coordination, and brain chemicals. The goal was to gather information that will help design better clinical trials f…

This completed study looked at 125 patients of different ages to find out how much ciprofol (an anesthetic drug) they needed to lose consciousness. Researchers measured the dose and brain activity (bispectral index) during anesthesia induction. The goal is to help doctors tailor …

This study looked at 67 adults with spinal muscular atrophy (SMA) types 2 and 3 to see if special electrical tests (MUNE and CMAP) can track nerve loss over time. The goal was to find better ways to measure how the disease changes, not to test a treatment. Participants had geneti…

This completed study created a French national registry for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected medical and genetic information from 28 patients to better understand these conditions and estimate how many people are affecte…

This study looked at 20 adults with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) or multifocal motor neuropathy (MMN) who were starting intravenous immunoglobulin (IVIg) treatment. Researchers measured changes in IgG levels in the blood after the first dose to…

This study investigates how obesity affects the way the body processes intravenous immune globulin (IVIG), a treatment for immune deficiencies. Researchers measured body composition and blood levels of IVIG in 40 obese and normal-weight patients to find the best dosing strategy. …

This study looked at 150 patients who had surgery for trigeminal neuralgia, a condition causing severe facial pain. Surgeons used a Teflon implant to cushion a blood vessel pressing on a nerve. The study compared two ways of placing the Teflon—either directly against the nerve or…

This study looked at health records of nearly 69,000 adults aged 40 and older to see if those who develop lasting nerve pain after shingles (postherpetic neuralgia) have a higher chance of getting dementia later. Researchers compared people with and without this nerve pain, match…

This completed study used ultrasound to examine the structure of nerves in the neck (the brachial plexus) in 200 adults scheduled for elective surgery. Researchers recorded how many nerve bundles were visible at different nerve roots. The goal was to better understand normal anat…

This study looked at 39 people having lower back surgery for a herniated disc or spinal stenosis. Researchers checked for nerve pain before surgery and again 1, 3, 6, and 12 months after using a simple questionnaire. The goal was to see how common nerve pain is after surgery and …

This study tested whether brief smartphone surveys can help detect early signs of fall risk in people receiving chemotherapy that can cause nerve damage. Twelve cancer patients used a mobile app to report symptoms like numbness or tingling in their legs. The goal was to see if pa…

This study reviewed medical records of 60 adults who had radiofrequency treatment for intercostal neuralgia, a type of nerve pain in the chest wall. The goal was to find out which patient or clinical factors are linked to better pain relief after the procedure. Researchers measur…

This study looked at how different shoe fit guidelines affect pressure inside the shoe for people with diabetes and nerve damage. Researchers measured foot pressure while 26 participants walked in standardized shoes with different toe gap sizes. The goal was to see which fit guid…

This study tested whether prosthetists—specialists who fit artificial limbs—can screen for common but often unnoticed health problems like depression, nerve damage, and poor blood flow in people who have had a leg amputation. Seventy participants were split into two groups: one r…

This study looked at 120 women with early-stage breast cancer to see if having low muscle mass (sarcopenia) before treatment raises the risk of nerve damage from the chemotherapy drug paclitaxel. Researchers measured muscle mass on CT scans and checked for nerve symptoms using qu…

This study looked at how common nerve damage is in adults who had vincristine chemotherapy for childhood leukemia. 467 survivors were assessed using a questionnaire about nerve symptoms. The goal was to understand how often and how severe this side effect is long after treatment …

This completed study compared 72 adults with cervicogenic headache (headache from the neck) to healthy volunteers. Researchers used questionnaires to measure central sensitization (overactive pain signaling) and neuropathic pain (nerve pain). The goal was to see if these pain mec…

This study looked back at 80 children with spinal muscular atrophy (SMA) types II and III to see how using braces (orthoses) helped them sit, stand, and walk. Researchers recorded when and how often children achieved these milestones and what types of braces they used. The goal w…

This completed survey study asked 131 people with or at risk for Huntington disease about their feelings, attitudes, and beliefs toward clinical research. The goal is to help researchers design better studies that are more aware of participants' needs. No treatment or drug was te…

This study tested how different lower-limb prostheses and orthoses affect movement during daily life. Twenty participants with lower-limb amputation or drop foot wore each device for a period while sensors tracked their walking. The goal was to compare devices and improve how we …

This study followed 2,365 adults from urban areas of Chile for 12 months to learn more about chronic pain and its effects. Researchers looked at how chronic pain relates to mental health issues like depression and anxiety, as well as work stress and daily functioning. The goal wa…

This study looked at 151 adults with shingles to find clues that might predict who will develop lasting nerve pain (postherpetic neuralgia). Researchers collected blood samples and health information at the start and checked for pain three months later. The goal was to create a r…

This study looked at two types of plasmapheresis (blood filtering) in 8 people with CIDP, a rare nerve disorder causing weakness. The goal was to see how each method affects immune cells in the blood. It is a very early, small study focused on understanding how these treatments w…

This study looked at how two types of nerve diseases—inherited and acquired—affect walking and balance. Researchers used motion analysis and simple tests like the Timed Up and Go test in 67 participants. The goal was to find clear differences that could help doctors tell the two …

This study tested how well two different coenzyme Q10 supplements are absorbed into the blood after a single dose. Twenty-five healthy adults aged 50-65 took each product in a crossover design. The goal was to see if a new experimental formula (BMT® coenzyme Q10) leads to higher …

This study looked at 10 people with rare genetic conditions that cause very low cholesterol and trouble absorbing vitamins. Researchers measured a protective pigment in the eye called macular pigment, which may be low in these patients and could explain why some still develop vis…

This study looked at whether special rocker sole shoes cause balance problems in people with type 2 diabetes and nerve damage in their feet. 25 adults completed the trial. Researchers measured how much people swayed while standing still in the special shoes.

This study aimed to find the normal ultrasound size of the ulnar nerve at the elbow in 50 healthy adults. Participants had no history of ulnar nerve problems. Researchers measured the nerve's surface area to establish a reference range, which could help diagnose nerve issues in t…

This study checked if the Upper Extremity Functional Index is a reliable and accurate way to measure hand function in people with carpal tunnel syndrome. Researchers gave questionnaires to 101 patients and compared results over time. The goal was to confirm that this tool works w…

This study used ultrasound to compare how the median nerve changes shape in different wrist positions (neutral, bent, extended, and tilted) between people with generalized joint hypermobility and healthy individuals. 36 women participated. The goal was to understand if hypermobil…

This study used powerful MRI scans to track how a rare genetic disease called metachromatic leukodystrophy (MLD) damages the brain's white matter in young children. Researchers studied 29 children aged 1 to 6 years with MLD, along with a control group, to better understand how th…

This study looked at how a non-invasive magnetic brain stimulation technique called rTMS changes brain activity in healthy volunteers and people with long-term nerve pain. Researchers measured brain responses before and after stimulation to see if these changes relate to pain rel…

This study looked at whether whole genome sequencing (a complete read of a person's DNA) can help diagnose leukodystrophies, a group of rare brain diseases that are hard to identify. Researchers enrolled 236 children with white matter abnormalities on brain scans but no known gen…

This study looked at hospital records from 2015 to 2022 to find out how many people in France have a group of rare genetic conditions called PROS. Researchers counted new cases each year, described patient ages and other health problems, and estimated costs. No treatments were te…

This study looked at whether showing Black and Hispanic adults with long-term nerve pain a short, culturally sensitive video about nerve stimulation techniques could improve their understanding and expectations. Twenty-eight participants watched a video and reviewed educational m…

This early-stage study tested the safety and tolerability of a new drug called AFA-281 in 64 healthy volunteers. Participants received either a single dose or multiple doses over 14-21 days. The goal was to check for side effects and measure how the drug behaves in the body, not …

This study created and tested a new scale called the CMT Pediatric Scale to measure symptoms and physical function in children with Charcot-Marie-Tooth disease. Researchers enrolled 500 children under 21 with CMT types 1, 2, or 4 at multiple centers. The scale assesses foot and h…

This study followed 31 children with GM1 or GM2 gangliosidosis (including Tay-Sachs and Sandhoff disease) to carefully measure how their neurological symptoms, like walking and speech, change over time. The goal was to create a clear picture of disease progression to help design …

This study looked at 60 people with carpal tunnel syndrome to see if pain sensitivity is linked to nerve ultrasound and electrical nerve tests. Researchers measured pain thresholds and used questionnaires to assess central sensitization. The goal was to find better ways to unders…

This study looked at the quality of supportive and palliative care for infants under one year old with spinal muscular atrophy (SMA) type 1, a severe genetic muscle disease. Researchers followed 39 infants and asked families to keep a diary about care. One year after the child's …

This study looked at whether using telemedicine (video or phone consultations) can help people in rural communities with leg wounds get specialist care more quickly. Researchers compared the time from when a wound was found to when a specialist saw the patient, either through tel…

This study looked at whether the Duruöz Hand Index, a simple questionnaire, can reliably measure hand function in children aged 6-18 with obstetric brachial plexus palsy, a nerve injury at birth. Researchers tested 21 children using various hand strength and function tests. The g…