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Vibration or electrical stimulation: which better fights ICU muscle loss?

NCT ID NCT07336810

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tested two non-drug treatments—whole-body vibration and neuromuscular electrical stimulation—in 60 ICU patients with muscle weakness. Patients received one of the therapies twice daily for two weeks, alongside standard care. Researchers measured muscle strength and thickness to see which approach worked better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
whole-body vibration device and neuromuscular electrical stimulation device
What this could lead to
If successful, this could point toward a simple, non-drug way to help ICU patients recover muscle strength faster.
What could go wrong
This is a small, completed trial with only 60 participants, so results may not apply to all ICU patients. The interventions are short-term and effects may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Jan 2026

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ICU patients who were aged ≥ 18 and \<65. * Sepsis-related Organ Failure assessments (SOFA) score ≥ 9 within the first 72 h after ICU admission. * Patients with no central and peripheral nervous system injury. * Expected to be treated in the ICU for more than 1 week. * Medical Research Council (MRC) sum score of less than 36/60. * Dominant-hand handgrip dynamometry scores of less than 11 kg (interquartile range (IQR) 10-40) in males and less than 7 kg (IQR 0-7.3) in females Exclusion Criteria: * Patients with comorbidities interfering with or compromising the training, like cardiac arrhythmia, pericardial effusion, congestive heart failure, or unstable acute coronary syndrome. * Patients are hemodynamically unstable. * Patients who had a major neurological deficit (upper motor neuron lesion). * Age \< 18 years and more than 65. * Implanted pacemaker or defibrillator. * Pregnancy. * Unhealed fractures or recently attached implants in the body region to be stimulated. * Acute venous thrombosis.

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Conditions

The condition(s) this trial relates to.

acute quadriplegic myopathy critical illness polyneuropathy muscle tissue disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intensive care (ICU) Intensive care (ICU) myopathy Muscle weakness | patient

Contacts and locations

Locations

  • critical care department (DR. Sherief Mokhtar unit) in kasr Al-Ainy medical school, Cairo, Egypt.

    Cairo, Cairo Governorate, 12345, Egypt

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