Can ultrasound spot early joint wear in diabetic nerve damage?
NCT ID NCT07801131
First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time
Summary
Researchers are using ultrasound to measure the thickness of ankle cartilage in people with type 2 diabetes who have nerve damage, and comparing it with healthy adults. Diabetic polyneuropathy may change how the lower limbs move, which could affect the ankle joint. The study includes 30 participants aged 40 to 70, half with confirmed diabetic nerve damage and half without. The goal is to see whether ultrasound can detect early joint changes that might otherwise go unnoticed.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ultrasonography (non-invasive imaging to measure talar cartilage thickness)
- What this could lead to
- If cartilage thinning is detected early, it could help identify joint damage sooner in people with diabetic nerve disease.
- What could go wrong
- This is a small observational study, so findings may not apply broadly. Ultrasound measurements can vary, and the study does not test a treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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30 people
The number who actually took part.
- Started
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Jun 2026
- Finished
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Jul 2026
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population will consist of individuals aged 40-70 years diagnosed with type 2 diabetes mellitus for at least one year. Participants will include patients with electromyography (EMG)-confirmed diabetic polyneuropathy and no history of trauma or surgical intervention affecting the foot or ankle. Individuals with degenerative, rheumatologic, or infectious conditions of the lower extremity, as well as those with other systemic causes of neuropathy or skin conditions preventing ultrasonographic assessment, will be excluded.
- Ages
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40 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Individuals aged between 40 and 70 years * Individuals diagnosed with type 2 diabetes mellitus for at least 1 year * Diagnosis of diabetic polyneuropathy confirmed by electromyography (EMG) * No history of trauma or surgery affecting the ankle or foot Exclusion Criteria: * Presence of degenerative joint disease, rheumatologic disease, or infection affecting the foot or ankle * History of trauma or surgical intervention involving the foot or ankle * Presence of other systemic diseases that may cause neuropathy * Presence of any local skin lesion or deformity that would prevent ultrasonographic assessment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Istabul Physical Medicine and Rehabilitation Hospital
Istanbul, bahçelievler, 34180, Turkey (Türkiye)
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