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Ultrasound reveals how hypermobile wrists change the median nerve

NCT ID NCT06918613

Knowledge-focused Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study used ultrasound to compare how the median nerve changes shape in different wrist positions (neutral, bent, extended, and tilted) between people with generalized joint hypermobility and healthy individuals. 36 women participated. The goal was to understand if hypermobility makes the nerve more deformable, which could help explain wrist symptoms. This was an observational study, not a treatment trial.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

36 people

The number who actually took part.

Started

Feb 2024

Finished

Jun 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects who met the criteria were selected from those who presented to Istanbul Physical Medicine Rehabilitation Training and Research Hospital.

Ages

15 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 15-45 years of age * Female gender * Diagnosed with GJH according to the hypermobility spectrum disorders definition * Patients who agree to participate in the study and provide written consent Exclusion Criteria: * Having wrist pain * Inability to complete full range of motion in the wrist joint * Patients diagnosed with carpal tunnel syndrome * Anatomical abnormalities (bifid median nerve, aberrant persistent median artery, Martin-Gruber or other anastomoses) * History of trauma, operation, fracture, or steroid injection of the hand/wrist * History of known rheumatological, hereditary, genetic disease, or connective tissue disease other than GJH * Having neurological disease affecting hand functions (cervical radiculopathy, peripheral nerve lesion, polyneuropathy, cerebrovascular event, etc.) * Patients with history of regular steroid or non-steroid use, receiving oral glucosamine/hyaluronate supplementation * Those with systemic diseases (inflammatory joint diseases, diabetes mellitus, acromegaly, hypothyroidism, kidney failure, etc.) * Having a body mass index (BMI) of 30 or above, or history of morbid obesity * Being pregnant or in lactation period * Presence of malignancy

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Conditions

The condition(s) this trial relates to.

hypermobility spectrum disorder hypermobility syndrome median nerve neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypermobility syndrome (disorder) Median nerve Ultrasonography

Contacts and locations

Locations

  • Istanbul Physical Medicine Rehabilitation Training and Research Hospital

    Istanbul, Bahçelievler, 34158, Turkey (Türkiye)

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