Light or nerve zap: which eases diabetic nerve pain better?
NCT ID NCT07078058
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested two non-invasive treatments—low-level laser and transcutaneous vagus nerve stimulation—in 30 adults with diabetic neuropathy. The goal was to see which better improves blood flow and reduces nerve pain. Participants had diabetes for over 5 years and stable blood sugar control.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Started
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Aug 2025
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: The patient selection will be according to the following criteria: 1. 30 patients diagnosed with diabetic neuropathy from both genders their ages will be ranged from 45-60 years old. 2. All patients are ambulant independently. 3. All patients are under full medical control 4. Glycated hemoglobin is ranged from 6.5: 7 %. 5. Patients have had diabetes for more than 5 or 10 years. 6. patients experiencing painful peripheral neuropathic symptoms for more than 6 months involving both lower extremities and complained of burning pain with paresthesia in both legs. 7 Neurological examination revealed abnormal sensation appeared at the ends of the extremities. Exclusion Criteria: 1. Patients had unstable glycemic control and/or medical conditions that would confound assessment of neuropathy such as malignancy, active/untreated thyroid disease, peripheral vascular diseases, vascular insufficiency (claudication, skin discoloration, ulceration). 2. Following the implantation of cardiac pacemakers or other electrical stimulation devices. 3. Patient had sinus bradycardia, long QT syndrome, or other arrhythmias or mental disorders. 4. Patients whose heart rate dropped below 50 beats/min after vagus nerve stimulation. 5. Nerve damage as a result of prior reconstructive or replacement knee surgery, back surgery, spinal stenosis, spinal compression or radiculopathy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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out-patient clinic, faculty of physical therapy, Horus university
Damietta, Egypt
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Other studies related to the condition(s) this trial covers.
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