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Could a softer sedation and early exercise keep ICU patients stronger?

NCT ID NCT07677488

Disease control Sponsor: The First Affiliated Hospital of Soochow University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests whether a combination of a gentle sedation strategy (called eCASH) and early, personalized exercise can prevent muscle weakness that often develops in ICU patients who need a breathing machine. The trial will include 70 adults on ventilators, with half receiving the new approach and half receiving standard care. Researchers will measure muscle strength and other outcomes like breathing function and medication use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
eCASH-based analgesia and sedation strategy combined with early goal-directed mobilization
What this could lead to
If effective, this approach could become a standard care method to help ICU patients on ventilators recover strength faster and reduce long-term disability.
What could go wrong
This is a small, single-center trial with 70 participants, so results may not apply broadly. The intervention is complex and may be difficult to implement consistently across different ICUs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

70 people

The number who actually took part.

Started

Oct 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients admitted to the ICU who require invasive mechanical ventilation and have a mechanical ventilation duration of at least 48 hours. * Age 18 years or older. * Patients who are not undergoing secondary intubation. * Patients with relatively stable organ function. * Written informed consent provided by the patient's family member or legally authorized representative. Exclusion Criteria: * Patients in the acute stress phase with hemodynamic instability, including severe patient-ventilator asynchrony, severe traumatic brain injury with intracranial hypertension, status epilepticus, or after cardiopulmonary resuscitation. * Patients with severe acute respiratory distress syndrome. * Patients with neurological diseases, organic neurological lesions, or neurological injury. * Patients with a history of psychiatric disease. * Patients with complications causing altered mental status and inability to cooperate, such as hepatic encephalopathy or pulmonary encephalopathy. * Patients diagnosed with myasthenia gravis. * Patients with a history of psychoactive drug abuse, illicit drug use, or alcohol abuse.

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Conditions

The condition(s) this trial relates to.

agnosia Critical Illness critical illness polyneuropathy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Icu acquired weakness Mechanical ventilation

Contacts and locations

Locations

  • The First Affiliated Hospital of Soochow University

    Suzhou, Jiangsu, 215006, China

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