The First Affiliated Hospital Of Soochow University

This study tests a new treatment for adults with a type of blood cancer called B-cell acute lymphoblastic leukemia (B-ALL). It combines a targeted immunotherapy drug (blinatumomab) with reduced-dose chemotherapy to improve remission and survival. About 101 people aged 15-65 will …

This study tests a new treatment for adults with a rare form of acute myeloid leukemia (AML) that has a specific genetic change. Instead of standard strong chemotherapy, patients receive a combination of drugs including venetoclax. The goal is to see if this approach can achieve …

This study tests whether a new chemotherapy combination (TmBU) works better than the standard one (mBUCY) before a stem cell transplant in people with high-risk or hard-to-treat leukemia. About 48 adults aged 65 or younger will be randomly assigned to one of the two regimens. The…

This study tests a personalized cell therapy for people with B-cell acute lymphoblastic leukemia that has not responded to standard treatments. The therapy uses the patient's own immune cells, modified to target and destroy cancer cells. The goal is to achieve remission and monit…

This study tests whether combining two drugs, venetoclax and azacitidine, can help people newly diagnosed with T-cell acute lymphoblastic leukemia (T-ALL). About 28 participants aged 15 and older will receive the treatment to see how many achieve remission. The goal is to control…

This study tests whether a newer drug, gilteritinib, works better than the current standard, sorafenib, to prevent leukemia from coming back after a stem cell transplant. About 594 adults and teens with a specific genetic mutation (FLT3-ITD) will be randomly assigned to take one …

This study tests whether menin inhibitors can help prevent leukemia from returning after a stem cell transplant. About 20 adults with certain genetic types of acute leukemia will take these drugs as part of their regular care. Researchers will track how many patients stay cancer-…

This study tests whether a once-weekly injection (romiplostim) can help platelets recover faster and more safely after a donor stem cell transplant in people with myelodysplastic syndrome (MDS) or severe aplastic anemia. About 66 adults will be randomly assigned to receive either…

This study tests whether combining zanubrutinib and rituximab can control secondary hemophagocytic lymphohistiocytosis (HLH), a dangerous immune overreaction, in people with B-cell lymphoma. About 40 participants aged 14–80 will receive the drugs for 4 weeks along with other supp…

This study tests whether combining two drugs—romiplostim and rituximab—can safely raise platelet counts in adults with primary immune thrombocytopenia (ITP) who did not respond to standard oral treatments. About 30 participants will receive weekly injections of romiplostim and fo…

This early-phase study tests a new treatment called CT0596 CAR-T cells for people with multiple myeloma or plasma cell leukemia that has come back or not responded to standard therapies. About 24 adults will receive the therapy to see if it is safe and how well it works. The goal…

This study compares four different drug combinations for adults newly diagnosed with acute myeloid leukemia (AML) who are not healthy enough for strong chemotherapy or choose not to have it. About 172 participants will be randomly assigned to one of four groups to see which combi…

This study tests a new treatment plan for adults with B-cell acute lymphoblastic leukemia (B-ALL) who cannot or choose not to have a donor stem cell transplant. The approach uses the drug blinatumomab before and after an autologous (self-donated) stem cell transplant to try to cl…

This study tests a new treatment called U96 for people with B-cell leukemia or lymphoma that has come back or not responded to standard therapy. U96 is a type of CAR-T therapy that works inside the body to help the immune system attack cancer cells. The main goals are to check if…

This study is for people newly diagnosed with a rare and aggressive form of T-cell leukemia called ETP-ALL. The trial will test a combination of five drugs (venetoclax, azacitidine, chidamide, vindesine, and dexamethasone) to see if it can help more patients achieve remission. Ab…

This study is for people with a slow-growing blood cancer called marginal zone lymphoma who haven't had treatment yet. It tests a new approach: a short course of standard chemo followed by a targeted drug (Orelabrutinib) to keep the cancer under control. The goal is to see if thi…

This study tests a combination of three drugs (anti-PD-1 antibody, lenalidomide, and azacitidine) in people with peripheral T-cell lymphoma that has come back or not responded to prior treatment. The goal is to see if this combination can shrink tumors and improve survival. About…

This study is for people with aplastic anemia, a condition where the bone marrow stops making enough blood cells. Researchers are testing if adding umbilical cord blood to a half-matched stem cell transplant from a family member can help the body accept the new cells faster and w…

This study tests a new combination of drugs (cladribine, lisaftolax, and busulfan) given before a stem cell transplant in people aged 50 and older with relapsed or hard-to-treat acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The goal is to make the transplant saf…

This study is for people aged 16 to 70 with acute myeloid leukemia (AML) that has returned or not improved after standard treatment. Researchers are testing a combination of three drugs (venetoclax, cladribine, and low-dose cytarabine) to see if it can shrink or eliminate the can…

This study tests a combination of three drugs (pirtobrutinib, lisaftoclax, and rituximab) in adults with diffuse large B-cell lymphoma that has come back or not responded to at least one prior treatment. The goal is to see if this combo can shrink tumors or make them disappear. A…

This study tests a combination of three treatments—a PD-1 inhibitor, azacitidine, and low-dose donor lymphocyte infusion—in people whose acute myeloid leukemia has returned after a stem cell transplant. The goal is to see if this approach can help control the leukemia and improve…

This early-phase trial tests a new oral drug called BY002 in 18 adults with acute leukemia that has come back or not responded to standard treatments. The drug targets specific genetic changes (KMT2A rearrangements or NPM1 mutations) that drive the cancer. The main goals are to c…

This study tests whether a maintenance drug called HMA can help people with a favorable type of acute myeloid leukemia (AML) stay in remission longer and live longer. About 77 adults who have already achieved remission after initial treatment will receive HMA therapy. The goal is…

This study tests a combination of three drugs (venetoclax, cladribine, and low-dose cytarabine) in 36 people aged 15-70 with relapsed or treatment-resistant Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia. The goal is to see how many patients achieve complete…

This study tests a new approach for people newly diagnosed with a fast-growing blood cancer called diffuse large B-cell lymphoma that has a specific genetic change (TP53 mutation). The treatment is matched to each person's genetic subtype to improve effectiveness. About 35 adults…

This study tests a three-drug combination (chidamide, venetoclax, and azacitidine) in adults with acute myeloid leukemia whose cancer did not respond to the first round of venetoclax and azacitidine. The goal is to see if adding chidamide can improve remission rates. About 32 par…

This study tests a two-step immunotherapy approach for people with B-cell acute lymphoblastic leukemia (B-ALL) who are older, too frail for standard chemo, or whose cancer has returned. Participants will receive two targeted drugs in sequence: blinatumomab and inotuzumab ozogamic…

This study tests a combination of three drugs (venetoclax, azacytidine, and chidamide) for people newly diagnosed with a specific type of leukemia called acute monocytic leukemia who are not healthy enough for standard intensive chemotherapy. The goal is to see if this drug combo…

This study tests a new drug combination called VABu given before a stem cell transplant in people aged 60 and older with acute myeloid leukemia (AML). The goal is to see if this approach can help control the disease and improve survival. About 20 participants will receive the VAB…

This study tests a new mix of three drugs—zeprumetostat, azacitidine, and mitoxantrone hydrochloride liposome—in adults whose peripheral T-cell lymphoma has come back or not responded to earlier treatments. About 26 people will receive up to 6 cycles of the combination, then up t…

This study tests a combination of three drugs (venetoclax, a hypomethylating agent, and low-dose cytarabine) in adults newly diagnosed with a specific genetic subtype of acute myeloid leukemia (CEBPA-mutated) who cannot tolerate strong chemotherapy. The goal is to see if this tre…

This early-stage trial tests a new treatment called U69, which uses specially engineered immune cells (CAR-T cells) to find and attack cancer cells in patients with T-cell leukemia or lymphoma that has come back or not responded to standard treatments. The study aims to check the…

This study is testing whether new types of MRI scans can more accurately find and grade prostate cancer without using contrast dye. About 300 men with suspected prostate cancer will get both standard and new MRI scans. The results will be checked against biopsy or surgery results…

This study is testing whether a highly sensitive blood test can accurately diagnose systemic mastocytosis, a rare disease where too many mast cells build up in the body. Currently, diagnosis requires an invasive bone marrow biopsy. Researchers will compare the blood test results …

This study is testing a new artificial intelligence (AI) tool that helps doctors find early-stage stomach cancer during an endoscopy. The AI looks at different types of images from the scope, plus patient information, to give a clearer and more explainable diagnosis. About 100 ad…

This study tests whether giving patients their own healthy gut bacteria (via a fecal transplant) can prevent acute graft-versus-host disease (GVHD) after a half-matched stem cell transplant. About 100 bone marrow transplant patients will be randomly assigned to receive the fecal …

This study tests a single infusion of amimestrocel, made from human umbilical cord cells, to prevent severe mouth and gut sores in 22 adults receiving a stem cell transplant. Patients get the infusion 1-2 days before transplant, and researchers will monitor for sores, pain, and s…

This study tests whether taking letermovir for a longer time (up to 28 weeks) can prevent cytomegalovirus (CMV) infection in 330 high-risk Chinese adults who have received a stem cell transplant. CMV is a common and serious complication in these patients because their immune syst…

This study tests whether low-frequency magnetic pulses aimed at a specific brain area can reduce chronic belly pain in people with irritable bowel syndrome with diarrhea (IBS-D). 42 adults will receive either real or sham treatment for two weeks, and researchers will measure chan…

This early-stage study is testing a new drug called IBI3002 in adults with asthma to see if it is safe and how the body handles it. About 12 to 27 participants will receive either the drug or a placebo by injection. The study lasts about 24 weeks and focuses on side effects, not …

This study tests whether virtual reality-based mindfulness therapy can reduce pain and improve daily function in adults with chronic low back pain. About 214 people aged 20-70 will either receive 8 weeks of VR mindfulness sessions plus usual care, or just usual care. The goal is …

This study looks at whether warming the numbing medicine used in epidurals can lower the chance of fever during childbirth. About 424 women giving birth vaginally will receive either room-temperature or body-temperature medicine. Researchers will track fevers, pain levels, and he…

This study looks at how certain carbohydrates (FODMAPs) in the diet are broken down by gut bacteria and whether that relates to graft-versus-host disease (GVHD) after a bone marrow transplant. Researchers will follow 100 patients who have had a successful transplant to track when…

This study looks at the nutritional health of 200 people who have had a stem cell transplant. Researchers will measure body fat, muscle, food intake, and blood protein levels to see how these factors relate to recovery and survival. The goal is to learn how diet might improve lon…

Objectives: This study aims to evaluate the clinical efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in patients with diarrhea-predominant irritable bowel syndrome (IBS-D), and to explore the potential underlying mechanisms by which rTMS alleviates clin…