New drug cocktail aims to boost stem cell transplant success in elderly leukemia patients

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 60 years. 2. Confirmed diagnosis of acute myeloid leukemia (AML) according to WHO classification, with intermediate or high-risk prognosis. 3. Previous response to Venetoclax-based therapy. 4. Planned to undergo allogeneic hematopoietic stem cell transplantation (HSCT). 5. Donor availability: Related donor matched at least 5/10 at HLA-A, -B, -C, -DQB1, and -DRB1; OR unrelated donor matched at least 8/10 at the same loci. 6. Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) score ≤ 4. 7. ECOG performance status 0-2. 8. Adequate organ function as defined by: Creatinine ≤ 1.5 × ULN or creatinine clearance ≥ 45 mL/min (Cockcroft-Gault formula or 24-hour urine collection)； AST ≤ 3.0 × ULN and ALT ≤ 3.0 × ULN； Total bilirubin ≤ 1.5 × ULN； Left ventricular ejection fraction (LVEF) \> 50%； Baseline oxygen saturation \> 92%； DLCO ≥ 40% and FEV1 ≥ 50%； 9. Ability to understand and provide written informed consent. Exclusion Criteria: 1. Age \< 60 years. 2. Poor response to prior Venetoclax-based therapy. 3. Unstable systemic disease (unstable angina, myocardial infarction, cerebrovascular accident within 3 months; NYHA Class III-IV heart failure; severe arrhythmia; pulmonary hypertension). 4. Active uncontrolled infection or active bleeding in vital organs. 5. CNS symptoms grade ≥ 2 requiring treatment. 6. Major organ surgery within 6 weeks. 7. History of malignant disease other than AML within 5 years. 8. History of thrombosis, embolism, or cerebral hemorrhage within 1 year. 9. ECOG performance status \> 2. 10. HCT-CI score \> 4. 11. Organ failure meeting specified criteria. 12. Known HIV, active HBV, or active HCV infection. 13. History of autoimmune disease requiring systemic immunosuppressive therapy. 14. Pregnancy, breastfeeding, or unwillingness to use effective contraception in patients of childbearing potential. 15. Drug abuse or chronic alcoholism. 16. Psychiatric disorder or other condition compromising informed consent or compliance. 17. Any other condition making the patient unsuitable for study participation in the investigator's judgment.