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Zapping muscles in the ICU: a simple way to stop weakness?

NCT ID NCT06409611

Disease control Sponsor: Universidade Federal do Rio de Janeiro Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether neuromuscular electrical stimulation (NMES) can prevent muscle wasting in patients on mechanical ventilators in the ICU. 22 adults were split into a control group and an NMES group, receiving stimulation sessions for at least 7 days. Researchers used ultrasound to measure muscle changes like thickness and quality.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
neuromuscular electrical stimulation (NMES) device
What this could lead to
If it works, this could point toward a simple way to prevent muscle weakness in ICU patients on breathing machines.
What could go wrong
This is a very small, early study (22 people) that only measured muscle changes with ultrasound, not long-term outcomes. Results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

22 people

The number who actually took part.

Started

May 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years; 2. On mechanical ventilation in the first 24 hours; 3. Provision of written, informed and/or agreed consent for a family member. Exclusion Criteria: 1. Trauma to the lower limb; 2. History of neurological, neuromuscular or debilitating diseases; 3. Spinal cord injury; 4. Rhabdomyolysis; 5. Vascular insufficiency or amputation of the lower limb; 6. Previous immobility; 7. Epilepsy; 8. Musculoskeletal and skin conditions or situations that may interfere in conduct.

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Conditions

The condition(s) this trial relates to.

critical illness polyneuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intensive care unit-acquired weakness

Contacts and locations

Locations

  • Pedro Ernesto University Hospital

    Rio de Janeiro, Rio de Janeiro, 20551-030, Brazil

  • State University of Rio de Janeiro

    Rio de Janeiro, Rio de Janeiro, 20551-030, Brazil

  • Universidade do Estado do Rio de Janeiro

    Rio de Janeiro, Rio de Janeiro, 20950-000, Brazil

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