Uremic neuropathy

This study tests a special dialysis machine, the MultiFiltratePRO, in children with acute kidney failure. The goal is to see if it can deliver at least 80% of the prescribed treatment within 72 hours while being safe. About 43 children weighing between 8 and 40 kilograms will be …

This trial tests a device called JuxtaFlow that applies mild suction to the kidneys during heart surgery. The goal is to see if it can protect kidney function in people with pre-existing kidney problems. 124 adults undergoing heart surgery with a heart-lung machine will be random…

This study tests a device called Walkasins, worn on the lower legs, that vibrates to give sensory feedback about foot pressure. The goal is to see if using it daily for six months improves balance and walking in 200 adults aged 55+ with peripheral neuropathy. Participants will do…

This study tests a single dose of hydroxynidone capsules in 56 people with different levels of kidney function and healthy volunteers. The goal is to see how the drug moves through the body and if it is safe in people with kidney problems. Participants will have blood and urine t…

This study looks at how a new cholesterol-lowering tablet, HRS-1301, behaves in people with mild, moderate, or severe kidney problems compared to healthy volunteers. The goal is to understand if kidney function changes how the drug works, so doctors can give the right dose. About…

This study is collecting information from 4,000 adults with peripheral neuropathy (nerve damage) to better understand the condition. Researchers will combine standard tests with nerve ultrasound to see if it helps diagnose and track the disease. No new treatments are being tested…

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms …