Substance abuse

This study investigates whether a daily probiotic supplement containing Lactobacillus bacteria can help reduce alcohol cravings, withdrawal symptoms, and the severity of alcohol use disorder in adult men. Participants take either the probiotic or a placebo for 12 weeks, and resea…

This study tests whether adding a smartphone-based incentive program to standard counseling helps veterans with alcohol use disorder reduce heavy drinking. Participants use a mobile app to submit breath alcohol readings and earn rewards for abstinence. The trial compares this com…

This study tested whether brief or in-depth counseling could help people living with HIV in Zambia reduce unhealthy alcohol use and improve HIV treatment. 680 adults who were on HIV medication and had hazardous drinking plus mental health or substance use issues took part. Partic…

This study tests a 5-week community-based program that teaches protective behavioral strategies to reduce alcohol use in men aged 35–44 with hazardous drinking habits in rural Vietnam. Participants learn to set safe drinking limits, choose nonalcoholic drinks, and plan ahead, wit…

This study compares a fully automated digital screening and brief intervention (e-SBI) to the traditional in-person approach for reducing harmful alcohol consumption. Researchers will enroll over 500 adults from Brazilian public health clinics to see which method works better at …

This study tests whether virtual reality exposure therapy (VRET) can help men with alcohol use disorder reduce their psychological dependence on alcohol and prevent relapse. Eighty men who have completed detox will be randomly assigned to either VRET or standard treatment. VRET u…

This small pilot study tested whether giving spironolactone, a drug normally used for heart conditions, could help people with HIV reduce their alcohol use. Twenty-one participants received the drug along with support from a pharmacist and psychiatrist. The study focused on wheth…

This study tested whether a paced breathing app could help women with substance use disorder resist triggers in real time. 77 women used the app whenever they felt a craving or faced a trigger. Researchers tracked substance use and feedback to see if the app helped reduce drinkin…

This study tested whether a mobile health unit that offers HIV prevention, treatment, and medication for opioid use disorder all in one place helps people who inject drugs stay on treatment. About 447 adults with opioid use disorder took part. The goal was to see if this approach…

This study tested a device called the Bridge, which uses mild electrical pulses to ease opioid withdrawal symptoms. 36 adults with opioid addiction were randomly assigned to get the active device, withdrawal medication (lofexidine), or a placebo. The goal was to see if the device…

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested whether a once-monthly injection of buprenorphine works as well as daily pills to treat opioid use disorder in 140 pregnant women. The goal was to see if the monthly shot could reduce illicit opioid use during pregnancy and after birth. Results help doctors choo…

This study tested whether a personalized talk with a pharmacist could help people take opioid painkillers for a shorter time. 100 adults with non-cancer pain in a hospital rheumatology ward took part. The goal was to see if the pharmacist's advice could keep opioid use closer to …

This study tested a program that combines personalized feedback with text messages to help young adults (ages 18-25) who drink to cope with anxiety or depression. Participants were in a psychiatric partial hospitalization program and drank heavily. The program aimed to reduce dri…

This phase 2 trial tested whether the drug sunobinop (V117957) can reduce heavy drinking in adults with moderate to severe alcohol use disorder who want treatment. 209 participants took either sunobinop or a placebo daily for several weeks. The study measured changes in heavy dri…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tested a non-invasive brain stimulation technique called TMS to see if it could help people with alcohol use disorder drink less. 147 adults who wanted to cut back on drinking received TMS and were tracked for 4 months. The goal was to measure changes in drinking days,…

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This study tested a behavioral activation program given as part of a freshman orientation course at the University of Kansas. The program helps students set personal goals and engage in rewarding activities to indirectly reduce alcohol misuse, stress, binge eating, and depression…

This early-phase pilot study tested whether combining topiramate (a seizure medication) with N-acetyl cysteine (a supplement) is safe and tolerable for people with alcohol use disorder. Seventeen adults who were heavy drinkers and seeking treatment took either the combination or …

This early-phase study tested a single nasal spray dose of BPL-003, a psychedelic drug, combined with psychological support in 13 adults with moderate to severe alcohol use disorder. The main goals were to check safety and tolerability, and to explore effects on drinking behavior…

This completed trial tested whether a combination of nutraceutical supplements and psychological support could lower GGT, a liver enzyme, in 197 adults with alcohol use disorder. Participants received liver-supporting supplements and counseling to reduce drinking. The goal was to…

This study tested a web-based addiction treatment program that was culturally adapted for American Indians and Alaska Natives. 53 adults in outpatient treatment used the program for 12 weeks. The goal was to see if it helped them stay away from drugs and alcohol and to decide if …

This study looked at whether medical cannabis can help people with chronic pain reduce their use of opioid painkillers. 29 patients who wanted to lower their opioid dose but couldn't afford medical cannabis were given access to it. Over 5 months, doctors tracked their pain levels…

This early study tested a smartphone app that rewards people for staying sober. Participants submitted breath samples three times a day to prove they hadn't been drinking. The goal was to see if this approach is practical and helps people with alcohol use disorder. Only 12 people…

This study tested a program called the Transitions Clinic Network (TCN) for people leaving jail with opioid addiction. The program combines primary care, medication options, and a community health worker to address social needs. Researchers compared this to standard care and foll…

This early-phase study tested whether adding a medication called Auvelity (a combination of dextromethorphan and bupropion) to standard buprenorphine treatment is safe and might help reduce cravings, withdrawal, and negative feelings in people with opioid use disorder. 18 adults …

This study tested whether tolcapone, a drug used for Parkinson's disease, could change how people with both alcohol use disorder and ADHD respond to alcohol and make decisions. 23 adults completed the trial, which involved taking tolcapone or a placebo and then undergoing alcohol…

This study tested two versions of a remote therapy program for teens (ages 14-24) who came to the emergency room for a violent injury. One version was standard, the other used artificial intelligence to adapt the therapy in real time. The goal was to see if the AI version could b…

This study tested whether kudzu, an herbal supplement, can help people who binge drink reduce their alcohol use and related risky sexual behaviors. Researchers enrolled 120 sexually active adults who binge drink and are at high risk for HIV. Participants received either kudzu or …

This study tested whether a broccoli sprout extract supplement could improve gut health in older adults (50+) who drink at least 8 alcoholic drinks per week and have a low-quality diet. Over 28 days, 40 participants took either the supplement or a placebo. The goal was to see if …

This study tested a blended collaborative care model that uses telemedicine to integrate mental health treatment into primary care at smaller VA clinics serving rural veterans. Researchers enrolled 318 veterans who screened positive for depression, alcohol use disorder, or PTSD. …

This study tested a culturally adapted relapse prevention program (RPM-08) for people with substance use disorder in Pakistan. 70 male participants in residential rehab either received the program plus usual care or usual care alone. The program consisted of eight weekly group se…

This study tested whether people with opioid use disorder and severe injection-related infections can be safely treated at home with antibiotics and buprenorphine (a medication for opioid use disorder). 71 participants were enrolled. The goal was to see if this integrated approac…

This study tested a special digital pill and smartphone app to help HIV-negative men who have sex with men and who also have substance use disorder take their daily HIV prevention medication (PrEP) consistently. Forty participants took a PrEP pill with a sensor that recorded when…

This study tested whether adding a support person—like a family member or friend—to standard buprenorphine treatment helps people with opioid addiction stay in treatment longer. 439 patients and their support persons took part. The support persons learned CRAFT, a counseling prog…

This study tested a short, motivational counseling session for injured patients who drink alcohol, delivered in the emergency department in Tanzania. Over 600 adults took part, and the goal was to see if the intervention could reduce binge drinking and related harms. The approach…

This study tested whether giving people with alcohol dependence a one-month course of diazepam (40 mg per day) after detoxification could reduce the chance of relapsing into drinking within the next three months. The standard detoxification treatment is usually about one week. Th…

This study looked at whether providing mental health care to people who inject drugs can improve their mental health and reduce their risk of getting HIV or hepatitis C. Over 500 participants in Haiphong, Vietnam, received free psychiatric consultations, medications, and support …

This study tested two tools to help older adults (65+) on long-term opioid therapy use painkillers more safely. The PainTracker tool helps doctors focus on improving daily function and mental health, while the Opioid Misuse Measure screens for risky opioid use. Researchers studie…

This study tested whether N-acetylcysteine (NAC), a widely available supplement, could help people with both alcohol use disorder and PTSD. 182 adults took either NAC or a placebo daily for 12 weeks, along with weekly therapy. Researchers measured changes in drinking habits, crav…

This study tested a therapy called Multisystemic Therapy-Emerging Adults (MST-EA) for young people aged 16-26 with substance use issues and recent arrests. The therapy works with the young adult and their social network at home and in the community to reduce criminal behavior and…

This study tested two ways to help primary care doctors prescribe opioids more safely for patients with chronic pain, depression, or anxiety. One approach used an electronic tool that reminded doctors about risk checks and guidelines. The other added a team of a pharmacist, a soc…

This study tested two long-acting injectable medications, aripiprazole and paliperidone, in 165 people who use stimulants and have psychosis. The goal was to see if these drugs could better manage psychosis and prevent progression to chronic schizophrenia compared to standard tre…

This study tested a program for 160 HIV-positive fisherfolk in Uganda who were heavy drinkers and struggling to stick with their HIV medication. The program combined individual and group counseling with help opening savings accounts and building social support. The goal was to re…

This study tested whether a single high dose of psilocybin (the active ingredient in magic mushrooms) combined with psychological support could help people with alcohol use disorder drink less. 60 adults in Denmark who were heavy drinkers took part. The main goal was to see if th…

This study tested whether adding the sleep medication lemborexant (Dayvigo) to the standard alcohol craving drug naltrexone helps people with alcohol use disorder and insomnia. Eight adults took either the combination or naltrexone plus a placebo. Researchers measured alcohol cra…

This pilot study tested a 4-week virtual intensive outpatient program for 63 people with moderate to severe alcohol use disorder. The program included group therapy, individual therapy, medication management, and multiple daily breathalyzer checks using facial recognition. The go…

This study tested whether a gentle brain stimulation technique called tDCS, combined with cognitive training, could improve thinking skills and reduce relapse in veterans with alcohol use disorder. 45 veterans received either real or sham tDCS during cognitive exercises. The goal…

This completed study tested a program called RISE (Resiliency in Stressful Experiences) for young men ages 18-35 leaving state prisons in Florida. The program combines trauma counseling with practical help like housing and job support. Researchers measured whether participants ha…

This study tested whether giving adults with chronic pain discounted vouchers for medical cannabis soft-gel capsules could help them reduce their opioid painkiller use. 270 participants were randomly assigned to receive vouchers for placebo or cannabis capsules with different THC…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce methamphetamine use in people already receiving methadone maintenance therapy. Fifty-five adults with both opioid and methamphetamine use dis…

This study tested two smartphone apps designed to reduce risky drinking and its effects during the COVID-19 pandemic. One app focused on the drinker, the other on their family partner. About 400 pairs (a drinker and a family member) joined the 12-month study. The goal was to see …

This study tested whether giving small rewards for attending treatment and providing negative alcohol tests helps people with alcohol use disorder stay sober. 74 adults in outpatient treatment were randomly assigned to standard care or standard care plus rewards. The goal was to …

This study tested a drug called GET73 in 79 people with moderate-to-severe alcohol use disorder who were not seeking treatment. Participants took GET73 or a placebo for 8 days and had MRI scans to see how their brains reacted to alcohol cues. The goal was to see if GET73 could re…

This completed trial tested a workplace program designed to teach young employees (ages 16-24) skills like goal-setting, stress management, and communication. Over 1,100 workers from participating stores took part. The goal was to see if the program could improve job satisfaction…

This study tested a mobile app designed to help gay and bisexual men reduce their methamphetamine use and risky sexual behaviors. The app includes games, lessons, and resources. 226 men who use meth took part. The goal was to see if the app could help them cut back on meth and lo…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could help veterans with alcohol use disorder stay sober for six months. Forty-nine veterans who were already in treatment received either real or sham …

This study tested whether a technique called Episodic Future Thinking (EFT) — where people vividly imagine positive events in their future — could help reduce drinking in 154 adults with alcohol use disorder. Participants either practiced EFT or recalled past events (control), th…

This study tested different combinations of counseling, rewards, and text reminders to help people on methadone therapy reduce methamphetamine use and improve HIV outcomes. 667 participants from methadone clinics in Vietnam took part. The goal was to find the best approach to sup…

This study tested different combinations of three programs—New Hope (coping skills), Elders Resilience (cultural strength), and Case Management—to see which best reduces suicidal thoughts and builds resilience in American Indian youth ages 10-29. The 304 participants were identif…

This early-stage trial tested a new drug called DCR-AUD in 16 healthy adults who are social drinkers. The drug is designed to reduce the effects of alcohol by targeting the liver. The main goal was to check safety and how the body processes the drug, not to treat alcohol use diso…

This Phase 2 trial tested whether a naltrexone implant, placed under the skin, can help people with alcohol use disorder drink less heavily. 210 adults received either a low-dose, high-dose, or placebo implant, plus counseling. Researchers tracked heavy drinking days over 24 week…

This study tested a structured emotional regulation program for adults in residential rehab for substance use. The program combined techniques from behavior therapy, dialectical behavior therapy, and acceptance and commitment therapy over 11 weekly sessions. Researchers compared …

This study tested whether combining virtual reality mindfulness sessions with cognitive bike exercises could reduce the risk of relapse in people hospitalized for alcohol addiction. 135 patients were split into two groups: one received standard care, the other added six VR mindfu…

This study tested whether a gentle brain stimulation technique called tDCS could help people with alcohol disorder stay sober. 90 participants who had already stopped drinking received either real or fake tDCS sessions. Researchers then checked if the real stimulation helped them…

This study tested a mindfulness program designed for women in residential treatment for substance use disorders. The program, called Mindfulness-Based Relapse Prevention for Women (MBRP-W), teaches stress management skills to help women stay in treatment and avoid relapse. Resear…

This completed study tested whether reducing loneliness through group therapy could lower opioid misuse in 102 adults on long-term opioids for chronic pain. Participants received either cognitive behavior therapy or social navigation in weekly sessions. Researchers measured chang…

This early-stage trial tested whether a one-time infusion of donor stem cells is safe for people with both alcohol use disorder and major depression. Thirty-one participants received either the stem cells or a placebo. The main goal was to check for serious side effects, like sui…

This study tested whether a non-invasive brain stimulation technique called deep TMS can help veterans with alcohol use disorder drink less or stay sober. Eight veterans in treatment received the therapy, and researchers checked their drinking habits 6 months later. The goal was …

This study tested whether semaglutide (Rybelsus), a drug used for diabetes, can help people with alcohol use disorder drink less. Fifty adults who wanted to cut down took either the drug or a placebo for 8 weeks. Researchers measured changes in alcohol cravings and daily drinking…

This study tested whether trained community health workers visiting pregnant women at home could improve health for both mothers and children in a rural area of South Africa. The program focused on supporting women with HIV, depression, or alcohol use, and on improving child grow…

This study tested a program that combines community-based fetal ultrasound with care navigation to help pregnant women with substance use disorder engage in prenatal care and substance use treatment. The program used motivational interviewing and strength-based education to suppo…

This study tested whether semaglutide, a drug used for diabetes and weight loss, can safely reduce alcohol drinking in people with alcohol use disorder. 80 adults took either semaglutide or a placebo, and researchers tracked how much they drank over several weeks. The goal was to…

This study tested whether peer recovery coaches in emergency departments can help people with substance use disorders connect to treatment and support. 144 adults were randomly assigned to get in-person coaching, coaching via video call, or just a list of resources. Researchers f…

This study tested whether giving caregivers prize draws for attending court hearings, treatment sessions, and probation meetings could reduce substance use and delinquency in teens already in juvenile drug court. Fifty-three teens aged 13-17 and their caregivers took part. The go…

This completed trial tested a digital health app (QG-A) that combines cognitive-behavioral therapy with the medication naltrexone to help adults with moderate to severe alcohol use disorder reduce their drinking. 242 participants were randomly assigned to either the app-based pro…

This study tested a new way to stimulate the brain in people addicted to amphetamines. Nine adults received closed-loop transcranial alternating current stimulation (tACS), which adjusts the stimulation based on their real-time brain activity. The goal was to improve executive co…

This study tested a stepped care system to help Congolese refugees and local community members in Zambia reduce unhealthy alcohol and drug use. The program started with a quick screening and brief advice, then offered more support if needed. 400 adults took part, and the main goa…

This early-phase study tested whether suvorexant (Belsomra), a sleep medication, can reduce stress sensitivity and heavy drinking in 81 adults with moderate to severe alcohol use disorder. Participants took either suvorexant or a placebo for 4 weeks, and researchers measured thei…

This study tested whether topiramate, a seizure medication, can help people who are dependent on both alcohol and nicotine. 236 adults received either a low or high dose of topiramate or a placebo, plus behavioral therapy. The goal was to see if the drug could reduce heavy drinki…

This study tested a 4-session program called PARTNER for young men who have sex with men (ages 18-29) and are in a relationship. The program uses motivational interviewing and video exercises to improve communication about drug use, PrEP (HIV prevention pills), and safer sex. 196…

This study tested whether a trained peer recovery specialist could help low-income, minority individuals stick with their methadone treatment for opioid use disorder. 200 participants in Baltimore were assigned to either the peer-led support program or standard care. The goal was…

This study looked at whether juvenile probation officers can deliver a behavioral program called Contingency Management to teens on their caseload who have drug problems. The program uses rewards and counseling to encourage teens to stop using drugs. Researchers measured drug use…

This study tested a smartphone-based program that uses rewards, coaching, and breathalyzer tests to help 236 adults with alcohol use disorder reduce drinking. Participants earned money for staying sober, tracked via breath tests and self-reports. The goal was to see if this digit…

This study tested a mindfulness program for 392 women in prison who have alcohol use disorder. The goal was to see if mindfulness training could reduce alcohol cravings, drinking, and criminal behavior after release. The program targets mental habits that often lead to relapse an…

This study tested a digital pill and smartphone app to help people with substance use disorders take their HIV prevention medication (PrEP) consistently. Thirty HIV-negative men who have sex with men and have moderate to severe substance use disorder participated. They used a dig…

This study tested a brief counseling program delivered by pharmacists to help people who take prescription opioids and also drink alcohol. The program combined medication review with motivational interviewing to encourage safer use. Researchers enrolled 112 adults and measured ch…

This completed study tested whether a Mediterranean diet could improve metabolic syndrome markers in 30 hospitalized adults with psychiatric conditions. Participants followed either a Mediterranean diet or a standard hospital diet for 8 weeks, then switched. Researchers measured …

This completed study tested a mindfulness-based program (MBS) against standard care in 130 adults recovering from polydrug addiction. The goal was to see if MBS could reduce cravings and relapse risk. Researchers also looked at improvements in emotional control, mood, and motivat…

This study tested a 12-session telehealth counseling program for young people aged 18-29 living with HIV. The program used text messaging and video calls to help them stay engaged in care, manage mental health, and reduce substance use. Fifty participants were enrolled to see if …

This study tested whether the drug baclofen, typically used for muscle spasms, can help people with alcoholism reduce their drinking. Over 300 adults who wanted to cut back or quit took either baclofen or a placebo for a year. The main goal was to see if more people on baclofen a…

This study tested a digital program designed to prevent teens from starting to misuse opioids. About 533 high school students who had never misused opioids but were at higher risk took part. The program aimed to increase their understanding of the serious risks of misusing prescr…

This study tested a program called PRE-FAIR to prevent opioid and methamphetamine addiction in young parents (ages 16-30) already involved with Oregon's child welfare system. 240 parents who were at risk but not yet addicted were randomly assigned to either the PRE-FAIR program o…

This study tested whether a new personalized feedback program helps young adults ages 18-25 reduce risky alcohol and drug use. Researchers enrolled 660 participants across the U.S. and measured changes in drinking, drug problems, and readiness to change. The goal is to prevent su…

This study tested a smartphone app designed to help people recovering from alcohol dependence avoid relapse. The app uses a training game to change unconscious habits that make people reach for alcohol. 600 participants used either the active training or a placebo version. The go…

This study tested whether text message reminders can encourage people to keep their opioid pain medication in a safe place and throw away any leftover pills after treatment. About 479 adults who received an opioid prescription took part. The goal was to reduce the chance of these…

This study tested a program for high school students to prevent misuse of prescription drugs like painkillers and sedatives. Over 1,800 teens participated in either the program or standard classes. The program used online lessons and group activities to change attitudes and build…

This completed trial tested two school-based programs—Connect and CMCA—to prevent drug and alcohol misuse among 10th graders in rural Cherokee Nation high schools. Over 900 students from 20 schools participated, with some schools receiving the programs and others serving as contr…

This small pilot study tested an 8-week mindfulness and meditation program in 3 adults with substance use disorders. Participants reported lower stress and improved mindfulness after the program. One person stayed sober long-term, while two relapsed within a year. The study shows…

This study tested an online parenting program called Family Check-Up Online for rural families where a parent may misuse opioids. 356 parents of young children (18 months to 5 years) took part. The program aimed to improve parenting skills, reduce stress and depression, and preve…

This study tested new ways to prevent opioid misuse and addiction in teens and young adults (ages 16-30) who visited the emergency department. Participants received support starting in the ER and continuing through telehealth after they went home. The goal was to find the most ef…

This study tested whether a program designed specifically for women who use drugs could help them reduce their risk of HIV and other sexually transmitted diseases. 501 women were randomly assigned to receive either standard counseling, standard counseling plus a well-woman exam, …

This study tested a program called Trust-based Relational Intervention (TBRI) to prevent opioid and other drug use in 250 teens aged 15-18 who were leaving juvenile justice facilities. Each teen worked with a trusted adult to build supportive relationships. The goal was to see if…

This study tested whether teaching financial skills and providing economic support could reduce alcohol and drug use among teens and young adults living with HIV in poor areas of Uganda. Researchers enrolled 95 participants aged 15-24 who were already in HIV care and had used alc…

This study tested two strategies to prevent HIV among young couples (ages 18-30) in Cape Town who use alcohol or drugs. One strategy was a community workshop to reduce stigma around HIV and drug use. The other was a couples program that provided HIV testing and counseling to help…

This pilot study tested whether involving young people in designing and running substance misuse prevention programs makes those programs more effective. Four community organizations in North Carolina took part; some used the youth engagement approach while others did not. Resear…

This study tested a mobile program called Comunică to help Romanian gay and bisexual men reduce HIV risk and heavy drinking. 300 participants used their phones or laptops to complete surveys and eight one-hour sessions with a counselor or by reading health information. The progra…

This study tested whether giving homeless young people (ages 18-24) a place to live plus support services could help them avoid developing opioid use disorder. 240 participants who were homeless but did not yet have opioid addiction were randomly assigned to receive either housin…

This study tested a program called TACUNA plus Wellness Circle, designed to prevent opioid misuse among American Indian and Alaska Native young adults aged 18-25 in California. The program uses motivational interviewing and traditional practices in virtual workshops. Researchers …

This study tests a group program that combines mindfulness and art therapy for adolescents with a history of abuse. The program aims to improve how teens see their bodies and reduce feelings of shame. Participants attend sessions that include meditation, creative art activities, …

This study looked at whether adding medical cannabis to a behavioral program helps adults with long-term non-cancer pain lower their opioid dose and manage pain better. 87 participants on stable, high-dose opioids were randomly assigned to either start medical cannabis or not, wh…

This study tested whether a digital mindfulness app is practical and acceptable for people in early recovery from substance use disorders. 36 participants were randomly assigned to standard group therapy alone or standard therapy plus the app for 8 weeks. The main goal was to see…

This study tests whether adding the blood pressure medication propranolol to cognitive processing therapy (a type of talk therapy) helps people with both post-traumatic stress disorder (PTSD) and alcohol use disorder. About 48 adults aged 18 to 70 with both conditions will receiv…

This pilot study tested whether a mindfulness program could help veterans with chronic pain and thoughts of suicide. 76 veterans took part to see if the program was acceptable and could reduce pain, depression, and suicide risk. The goal was to improve quality of life and daily f…

This study tested a type of talk therapy called Behavioral Activation (BA) in 10 U.S. veterans who have both alcohol use disorder and PTSD. BA helps people change their daily activities and thinking to reduce drinking and PTSD symptoms. The study compared BA to another therapy ca…

This completed Phase 2 trial tested whether a drug called sunobinop can reduce alcohol cravings in people with moderate to severe alcohol use disorder who want treatment. Forty participants took either sunobinop or a placebo pill daily. Researchers measured cravings using questio…

This study looked at whether a special sports program, designed with an understanding of trauma, could help teens aged 14-18 with substance use disorder. 120 teens took part, with half joining an 8-week program of sports and group talks, while the other half received no extra act…

This study tested a small, disposable device that gently stimulates nerves in the ear to see if it could reduce the amount of strong painkillers (opioids) needed after open abdominal or pelvic surgery. 286 adults who had surgery for cancer or a liver transplant took part. The goa…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This pilot study tests whether a nerve block called the serratus anterior plane (SAP) block can reduce pain and opioid use after heart surgery. Fifty adults having valve or bypass surgery through a chest incision will receive either the numbing drug ropivacaine or a placebo throu…

This study tested two brief, video-based therapies for women who experienced sexual assault and now struggle with PTSD and heavy drinking. One therapy focused on facing trauma memories, the other on building healthier drinking habits. The goal was to see if these short treatments…

This study tested whether low-intensity focused ultrasound (LIFU) can safely reduce cravings in people with cocaine use disorder. 25 adults received either real or fake (sham) ultrasound while their brain activity was measured with MRI. The goal was to see if LIFU lowers craving …

This study tested whether a CBD oral solution (Epidiolex) can help manage pain and reduce the need for opioids in 37 adults undergoing double knee replacement. Participants received either a placebo or one of two CBD doses. The goal was to see if CBD could lower opioid use while …

This small pilot study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve cognitive flexibility in people recently detoxified from alcohol. Fourteen adults with alcohol use disorder received either re…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested whether a curcumin supplement (NatureU Cheers Friends Curcumin) could reduce hangover symptoms in 12 healthy adult men. Participants took either the curcumin or a standard hangover product before drinking alcohol, then reported their hangover severity the next m…

This study tested a brain stimulation technique called closed-loop tACS in 21 people with methamphetamine addiction. The device uses brain wave patterns to deliver targeted electrical stimulation aimed at reducing cravings. Researchers measured craving levels and impulse control …

This pilot study tested whether people experiencing alcohol withdrawal can be safely treated at home using telemedicine. Thirty adults who wanted to quit drinking received remote monitoring and symptom-triggered medication over three days. The goal was to see if this approach kep…

This study tested a 6-session therapy called Acceptance and Commitment Therapy (ACT) for cancer patients at risk of opioid misuse. 40 adults with cancer and a high score on an opioid risk tool participated. The goal was to see if the therapy was feasible and acceptable, not yet t…

This study tested two types of therapy for insomnia in 134 people also being treated for alcohol use disorder. The goal was to see if improving sleep could help them stay sober and feel better during the day. Participants received either a standard insomnia treatment or a tailore…

This study tested whether adding a personalized therapy scale to standard treatment helps reduce cravings in people with substance use disorders or behavioral addictions like gambling. 151 adults seeking outpatient care participated. The approach aimed to tailor treatment to each…

This study tested whether a type of brainwave training called neurofeedback could help people with alcohol use disorder feel more confident about staying sober and improve mindfulness. Seventeen adults took part: some received 24 sessions of neurofeedback over 8 weeks, while othe…

This study tested a combination of a smartphone breathalyzer, a blood alcohol estimator app, and a brief counseling session to help young adults ages 18-25 drink more moderately. Twenty-four participants used the tools for two weeks while drinking. The goal was to see if the tech…

This study tested a 5-week behavioral therapy for women who experienced sexual assault and use alcohol. The therapy combines writing about the trauma with skills to manage alcohol cravings. Researchers measured changes in drinking habits and PTSD symptoms. The goal is to see if e…

This study tested a one-day educational workshop for people with chronic non-cancer pain who take high doses of opioids. The workshop, led by a team of doctors, psychologists, and pharmacists, provided information on opioid risks and taught coping strategies. Researchers wanted t…

This study tested an enhanced version of internet-delivered cognitive behaviour therapy (ICBT) for people who misuse alcohol. Researchers added real patient stories and optional resources for common issues like anxiety and depression. 205 adults from Saskatchewan took part, eithe…

This pilot study tested whether taking naltrexone only when needed can help people who want to reduce or stop drinking during Dry January. Nineteen adults who did not have severe alcohol problems took a 50mg pill before drinking or daily as a precaution. The study checked if this…

This study looked at whether a 4-week circuit training program could improve heart and lung fitness in men recovering from drug addiction. Sixty men were split into two groups: one did circuit training (like push-ups, stair climbing, and high knees) three times a week, and the ot…

This study tested whether slowly reducing prescribed opioids (tapering) can help people with long-term chronic pain use fewer painkillers without worsening their pain or quality of life. 140 adults on daily opioids for chronic non-cancer pain were randomly assigned to start taper…

This study tested whether giving testosterone to older women with chronic back pain and low testosterone could improve pain, physical function, and quality of life. 36 women received weekly injections of either testosterone or a placebo for several weeks. The goal was to see if t…

This study looked at 46 adults having spinal surgery to find out if giving a pain-relieving nerve block (ESP block) before or after surgery works better. The goal was to see which timing reduces opioid use and improves recovery. Results will help anesthesiologists choose the best…

This study tested two methods to control pain after laparoscopic gallbladder removal: a nerve block (external oblique intercostal block) and injecting pain medicine into the surgical cuts (port-site infiltration). Sixty adults were followed for 24 hours after surgery to see which…

This study tested two remotely delivered programs—mindfulness-based cognitive therapy and internet-based cognitive behavioral therapy—against standard remote monitoring alone for reducing depression and substance use related to COVID-19 stress. 113 adults from a health system par…

This study tested a breathing and meditation program called SKY Recovery in 100 people recovering from substance use disorder at a residential center. Participants either took the program right away or after a delay. Researchers measured changes in emotion regulation, cravings, a…

This study tested whether dronabinol, a drug similar to cannabis, can help reduce the need for opioid painkillers after total knee replacement. 114 adults scheduled for knee surgery were randomly given either dronabinol or a placebo before and after their operation. Researchers m…

This study looked at whether an online cognitive behavioral therapy program, called Breaking Free Online, helps people with substance use disorder cut back on their drug or alcohol use. About 200 adults from an outpatient addiction program took part. Some got standard care with g…

This study looked at whether listening to music can help heart surgery patients need less strong pain medicine. 54 adults who had heart surgery through a cut in the chest took part. The goal was to see if music therapy could lower the amount of opioid painkillers they used.

This study tested whether the drug acetazolamide can improve sleep-disordered breathing in 39 adults with chronic pain who use opioids. Participants took either the drug or a placebo for one week each. The goal was to see if the pill could reduce sleep apnea events as an alternat…

This study tested whether a nerve block (suprazygomatic maxillary nerve block) can reduce pain and the need for strong painkillers in children after tonsil and adenoid removal. 114 children aged 6 months to 18 years took part. The block was given during surgery, and some children…

This study looked at whether people with chronic pain and opioid use disorder would do art on their own at home, and if it helped their pain and mood. 31 adults tried self-directed artmaking up to four times. Researchers measured how many people stuck with it and whether anxiety,…

This study looked at whether adding a low-dose ketamine infusion to standard pain medication can help people who just had knee replacement surgery. One hundred adults were randomly assigned to get either standard pain relief alone or standard relief plus ketamine through a patien…

This study tested whether cytisine, a plant-based medication, is safe and helpful for quitting smoking in people who also have alcohol use disorder. Twenty adults who smoked daily and wanted to quit took part. The main goal was to see if the drug was well-tolerated and if partici…

This study tested whether an ultrasound-guided nerve block (Serratus Anterior Plane Block) can improve pain, breathing, and coughing in emergency room patients with rib fractures. Forty adults with confirmed rib fractures received either the nerve block or usual care. Researchers…

This study tested a special type of talk therapy (cognitive-behavioral therapy, or CBT) delivered over telehealth to help veterans who feel lonely and struggle with substance use. The goal was to see if the program was practical and well-liked by participants. Thirty-six veterans…

This pilot study tested a web-based mind-body program (Web-TIRELESS) in 5 adults with painful upper-limb conditions and risky substance use. Participants completed 4 video sessions at their own pace. The goal was to see if the program was feasible, acceptable, and helpful for bui…

This study tested a behavioral program called IMPROVE to help college students who drink heavily and feel anxious. The program teaches skills to handle anxiety and uncertainty without turning to alcohol. Forty students took part, and researchers checked if the program was easy to…

This study tested whether real-time brain scans (fMRI) could help 21 adults with alcohol use disorder learn to control their cravings. Participants practiced shifting their brain activity toward future goals instead of alcohol. The goal was to see if this mental training could re…

This study tested two methods to control pain after major abdominal surgery: a spinal injection of morphine and a newer nerve block technique. The goal was to see which provides better pain relief with fewer side effects. 56 adults participated, and the study measured how much ex…

This study tested whether an online program for insomnia (called SHUTi) could help heavy drinkers reduce their alcohol use. 113 adults who drank heavily and had trouble sleeping took part. The goal was to see if improving sleep would also lead to less drinking and fewer binge epi…

This study tested a mobile health app designed to help young adults aged 18-25 reduce heavy drinking. 40 participants were randomly assigned to use the app or just complete surveys. Over 4 weeks, they received text message surveys to track drinking and engagement. The goal was to…

This study tested a mindfulness-based treatment (MBRP) combined with cognitive behavioral therapy to help people reduce alcohol use and quit smoking. 67 adults who smoked and drank heavily participated. The goal was to see if the program was practical and satisfying for patients,…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This pilot study tested an oral cannabinoid oil (CBD with a small amount of THC) in 51 adults with chronic pain. The goal was to see if it's practical to run a larger trial and to gather early data on pain relief and safety. Participants took the oil daily for up to 12 weeks, and…

This study tested whether giving lidocaine through a vein during and after liver surgery can reduce pain and the need for strong painkillers like opioids. 124 adults having minor liver surgery were randomly assigned to receive either lidocaine or a placebo (salt water). Researche…

This study tested whether a virtual reality experience where people see an avatar of their future self could help those in early recovery from opioid use disorder reduce drug use and stay abstinent. 104 participants were split into a VR group and a control group. Researchers meas…

This study tested whether a specific nerve block, called a rectointercostal fascial plane block, could reduce pain and the need for strong painkillers after laparoscopic sleeve gastrectomy. Fifty-six adults undergoing weight-loss surgery were randomly assigned to receive either t…

This study looked at a voluntary program to help people with chronic pain slowly lower their opioid medications. 51 adults who wanted to reduce their opioid dose worked with their doctor over 4 months using a personalized tapering plan and a self-help book. The main goal was to s…

This study looked at whether a gentle brain stimulation technique called tACS can improve cognitive problems like memory and attention in people recovering from methamphetamine addiction. Researchers tested 68 participants using thinking tests, brain wave recordings, and blood sa…

This study tested a digital program called 'Empowered Relief: On-Demand' to see if it could help people with chronic pain who misuse prescription opioids. 234 adults with chronic pain and opioid misuse were randomly assigned to either the digital pain relief program or a health e…

This study tested a short video and a 3-week text messaging program for adults who recently experienced sexual assault. The goal was to see if these tools could help prevent or reduce posttraumatic stress disorder (PTSD) and opioid misuse. Fifty participants received the video du…

This study tested whether giving acupuncture during hip replacement surgery helps patients use fewer opioids and recover faster. 484 adults having hip replacement were split into two groups: one received ear acupuncture with mild electrical stimulation while sedated, and the othe…

This study tested an 8-week cognitive training program delivered via telehealth for veterans recovering from alcohol use disorder. The goal was to see if the program was feasible and acceptable to participants. Nineteen veterans took part, and the study focused on recruitment, re…

This study tested different ways to help people on medication for opioid use disorder do more yoga to manage their chronic pain. 192 adults who had been in treatment for at least 3 months took part. The goal was to see which combination of support methods helped them practice yog…

This study compared methadone to standard opioids like fentanyl for pain relief during and after outpatient surgery. Over 900 adults aged 18-65 having moderately painful procedures took part. The goal was to see if methadone could reduce the total amount of opioids patients used …

This completed trial tested whether a combination of four non-opioid drugs (magnesium, dexmedetomidine, ketamine, and lidocaine) given during major surgery could improve patient recovery compared to standard opioid-only anesthesia. 240 adults undergoing planned major surgery were…

This study tested a program called "Choizitaconso" that teaches people with alcohol use disorder how to control their drinking and reduce harm. About 110 adults took part, learning skills to manage their alcohol use and avoid negative consequences. The goal was to see if the prog…

This study tested whether giving a single dose of pregabalin (Lyrica) before ureteroscopy—a surgery for kidney stones that often leaves a temporary stent in the ureter—can reduce pain and the need for opioid painkillers afterward. 118 adults were randomly assigned to receive eith…

This study tested a new web-based tool called LDART that provides daily social support to people who drink heavily and want to cut down. Each night, users set a goal for the next day and check in the following night to see if they met it, receiving encouraging messages from the r…

This study tested a mobile app called STAMP+CBT for advanced cancer patients with chronic pain. The app helps patients track their pain, mood, and opioid use while providing tailored education and cognitive behavioral therapy (CBT) exercises. Fifty-two patients used the app for 4…

This study looked at whether adding a specific nerve block (genicular and anterior femoral cutaneous nerve block) to standard care can lower pain and the need for strong painkillers after total knee replacement. 244 adults having knee replacement surgery took part. Half received …

This study looked at 23 adults going through alcohol detox to see how the bacteria in their mouth and gut change over time. Researchers collected stool and mouth samples along with diet and mood questionnaires. The goal was to better understand the link between gut bacteria, anxi…

This study aims to create and improve cognitive tasks used during functional MRI scans to better understand how drugs affect the brain. It involves 525 healthy volunteers, including both drug users and non-users, aged 18 to 65. Participants perform tasks like memory tests or reac…

This study tested whether portable devices like PDAs and GPS units can give a more accurate picture of stress and drug use as it happens. About 373 adults in treatment for heroin addiction carried these devices for 16 weeks, recording drug use and stress levels. The goal was to s…

This study tested a harm reduction program designed specifically for Black adults who misuse opioids or stimulants. 63 participants completed surveys before and after the program to see if their knowledge, confidence, and willingness to use overdose prevention techniques improved…

This study tested whether doctors can use simple decision guides to better manage opioid misuse behaviors in patients on long-term opioid therapy for chronic pain. Researchers worked with 49 clinicians at community clinics to see if the guides were easy to use and helpful. The go…

This study used brain scans to see if heavy drinking causes inflammation in the brain and how that affects memory and thinking. 74 adults aged 30-75, including heavy drinkers and healthy volunteers, had PET and MRI scans along with thinking tests. The goal was to measure brain in…

This study looked at how sleep quality and beliefs about sleep affect the risk of relapse in people recovering from alcohol dependence. Researchers followed 198 adults as they left inpatient rehab and returned home, measuring sleep with questionnaires and activity monitors. The g…

This study tested a computer-assisted method for people to self-administer alcohol intravenously, aiming to achieve precise blood alcohol levels for research. 229 healthy volunteers aged 21-45 took part in sessions where they could give themselves alcohol infusions using a comput…

Sleep problems affect up to 90% of people with alcohol dependence and often lead to relapse. This study tests whether a short questionnaire called the Short Sleep Index (SSI) can reliably measure sleep quality compared to a longer, standard sleep questionnaire. Researchers will a…

This completed study in Norway looked at how opioids like morphine, oxycodone, and fentanyl affect patients' mood and pain right before surgery. Over 1,000 healthy adults scheduled for day surgery answered questions about anxiety, relaxation, and pain after receiving a small dose…

This study tests whether recalling a positive memory can improve mood and decision-making in 80 adults recovering from methamphetamine use disorder. Participants will do computer tasks and brain scans before and after remembering a happy event or a neutral memory. The goal is to …

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study looked at how much intravenous (IV) medication is wasted in intensive care units (ICUs) across France. Researchers measured the amount of prepared but unused drugs thrown away, which can harm the environment. Over 1,000 patients took part, and the goal was to find ways…

This study looked at how much injectable drug is prepared but not used in operating rooms across France. Over 3,700 patients were included. The goal was to measure waste and find ways to reduce it, helping the environment and improving healthcare practices.

This study tested a brief digital alcohol intervention for smokers who drink heavily. Participants enrolling in a smoking cessation program through an online portal were offered the intervention if they scored high on a drinking questionnaire. The main goal was to see how many pe…

This study looked back at the records of 652 patients who were seen in the emergency department of a French hospital and then referred to a special addiction liaison team. The goal was to understand the social and medical backgrounds of these patients. The findings could help hos…

This study looked at whether combining two existing drugs—duloxetine (an antidepressant) and methylphenidate (an ADHD medication)—could reduce the desire to drink alcohol in people with alcohol use disorder. Nineteen adults who were not seeking treatment participated in a lab set…

This study looked at how nalmefene, a drug that blocks opioid receptors, changes brain activity and drinking behavior in heavy drinkers. Thirteen healthy heavy drinkers took nalmefene or a placebo and had brain scans while seeing alcohol-related cues. They also could self-adminis…

This study tested two methods to encourage COVID-19 testing among people who use opioids: having friends refer others (chain referral) and using trusted community members (credible messengers). About 500 people took part. The goal was to see which method got more people tested an…

This study looked at how Alcoholics Anonymous (AA) helps people with alcohol use disorder reduce their drinking. Researchers tracked 192 adults daily for six months to see which AA activities—like building social support or spiritual practices—led to fewer drinking days. The goal…

This study looked at brain activity in pregnant women with opioid use disorder who were taking medication therapy. Researchers compared their brain scans to those of healthy pregnant women to see if there were differences. The goal was to learn more about how the body processes t…

This study looked at whether changes in a person's voice can help detect opioid use in people being treated for opioid use disorder. Researchers collected voice samples from 41 patients and used machine learning to find patterns linked to opioid intoxication or withdrawal. The go…

This study tested whether a mobile app could help people on probation or parole who are receiving treatment for substance use disorder. 31 adults used the app alongside their usual care. Researchers measured how easy the app was to use and how satisfied participants were with it.

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This observational study looked at how legal cannabis use changes alcohol drinking habits, gut bacteria, and brain function in people who regularly use both alcohol and cannabis. 77 heavy drinkers who also smoke cannabis took part, providing blood and stool samples and completing…

This study tested whether hands-on training could help people convicted of driving under the influence (DUI) better understand the risks of drinking alcohol. A total of 112 participants took part. The goal was to see if this training could reduce binge drinking and cravings.

This study tested a smartphone app called CampusGANDR that uses a game about college life to give students personalized feedback on their drinking habits. Over 1,100 first-year college students in California and Texas played the game for 12 weeks. Researchers measured changes in …

This study looks at how alcohol use disorder (AUD) might reorganize the way the brain links words and ideas. Researchers will compare 30 AUD patients and 30 healthy controls using word-association tasks and brain tests. The goal is to see if these mental patterns can help predict…

This study looked at how the brains of people with alcohol use disorder respond to pictures of social situations and alcohol. Researchers used MRI scans to measure brain activity and tested whether a technique called neurofeedback could help people control their cravings. The stu…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This study tested whether a coaching program for primary care doctors at one VA clinic could improve care for veterans with unhealthy alcohol use. The program aimed to help doctors offer more counseling, medications, and referrals to specialty treatment. Researchers tracked chang…

This study looked at whether a simple slow-breathing exercise can help binge drinkers control their reactions to alcohol-related images and improve their ability to say no. One hundred binge drinkers completed tasks measuring brain activity and attention after either slow breathi…

This study tested a mobile app called WisePath designed to help adults who are thinking about suicide and may also misuse alcohol. Over 12 weeks, 127 participants either used the WisePath app or received standard self-help resources. Researchers measured changes in suicidal thoug…

This completed Phase 1 study looked at how marijuana and an opioid drug influence each other's use in healthy adults aged 18-50 who had experience with both substances. Eight participants lived at a research unit for about 6.5 weeks and could earn doses of each drug under control…

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study explores the link between gut bacteria and alcohol use disorder (AUD). Researchers compared gut microbiota in three groups: current heavy drinkers with AUD, people with AUD who have been abstinent for at least 4 weeks, and healthy moderate drinkers. Participants provid…

This study looked at the best ways to bring FDA-approved digital treatments (reSET and reSET-O) for opioid and other substance use disorders into primary care clinics. Over 18,000 adults who screened positive for substance use took part. Researchers tested whether health coaching…

This study tested a digital toolkit designed to help leaders in child welfare and substance use treatment agencies choose partners and build effective collaborations. Nine implementation support professionals in Ohio used the guide and rated how acceptable, appropriate, and feasi…

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This completed Phase 1 study at UCLA looked at how smoking cannabis with different amounts of THC and CBD affects drug levels in oral fluid and blood, as well as thinking and feeling. Nineteen adults who use cannabis occasionally took part. The goal was to better understand how t…

This study looked at 385 adults diagnosed with their first lung or head & neck cancer to see how many continued using tobacco or alcohol over the next year. Researchers tracked smoking and drinking habits, as well as how long patients lived without the cancer getting worse. The g…

This study looked at pregnant women being treated for opioid use disorder with two different forms of buprenorphine: a monthly shot and a daily tablet. Researchers measured drug levels in the mother's blood and checked the baby's heart rate to see how each treatment affected both…

This study looked at 71 babies born to mothers who took either a monthly injection or a daily tablet of buprenorphine for opioid use disorder during pregnancy. Researchers measured the babies' thinking, language, and motor skills using a standard child development test. The goal …

This study looked at how negative emotions and stress influence alcohol use in 81 women veterans, including those with PTSD. Researchers measured cravings, heart rate, and drinking patterns, and also examined how these effects change across the menstrual cycle. The goal was to be…

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This completed study surveyed 3,100 adults in Slovakia to find out how many people have mental disorders like depression, anxiety, PTSD, or addiction. Researchers used a standard interview tool to measure current and lifetime rates, and looked at who gets help and who doesn't. Th…

This completed study in Slovakia examined how psychological factors like resilience, stress, and positive thinking relate to the body's immune system. Researchers measured immune markers in blood and compared them to mental health questionnaires in 700 adults, including people in…

This study looked at whether gradually lowering opioid doses over time affects pain, quality of life, and mood in people with chronic non-cancer pain. 18 adults on stable opioid therapy were followed to compare slow tapering versus staying on their current dose. The goal was to s…

This study looked at whether people with alcohol dependence or a history of early life stress have more trouble learning to feel calm after a scary event. Researchers used brain scans, mild electric shocks, and genetic tests to understand these differences. The goal was to learn …

This study tested whether sending e-mails to doctors could encourage them to use a state-run prescription monitoring program and reduce unsafe opioid prescribing. About 7,800 Minnesota physicians and physician assistants who were not using the program as required took part. The r…

This study looked at whether a questionnaire called the Behavioral Activation for Depression Scale (BADS) is a good tool for measuring depression-related behaviors in people with substance use disorders. Researchers analyzed answers from 289 adults receiving treatment for substan…

This study looked at whether a single dose of methylphenidate (Ritalin) changes how people with both ADHD and alcohol use disorder respond to alcohol-related cues. Thirty-one adults aged 18-25 completed brain scans, EEG, and behavioral tests after taking either the drug or a plac…

This study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…

This study tested a Spanish-language electronic screening tool called TAPS-ESP to identify tobacco, alcohol, prescription drug, and illicit substance use in primary care. About 1,000 Spanish-speaking adults from a clinic participated. The goal was to see if the tool accurately de…

This study looked at 125 young adults aged 18-25 to understand what makes someone more likely to binge drink. Researchers used brain scans, genetic tests, and thinking skill assessments to find patterns. The goal is to identify risk factors and improve prevention efforts.

This study explored whether adding mindfulness training to physical therapy is practical for people with long-term muscle and joint pain who also take opioid painkillers. Researchers developed a training manual for physical therapists and tested different ways to teach them mindf…

This completed study looked at how thinking skills (like flexibility and self-control) and social understanding (like reading emotions) are connected to alcohol use disorder. Researchers tested 216 people using puzzles, eye-tracking, and brain scans. The goal was to find early wa…

This study looked at whether a strong sense of 'presence' during virtual reality therapy could help people with alcohol dependence manage cravings and avoid relapse. Sixty abstinent patients who had recently completed withdrawal treatment took part. Researchers measured craving l…

This study tested a new way to help addiction treatment clinics use an AI platform that coaches counselors in evidence-based techniques. Researchers worked with 479 leaders and staff from state agencies and clinics in Oregon and Indiana. The goal was to see if this strategy impro…

This study looked at whether giving patients educational materials about opioids and a way to dispose of unused pills could reduce the number of leftover opioid pills after shoulder replacement surgery. 140 adults scheduled for shoulder replacement took part. Half received the ed…

This study looked at how a person's genes might change the way they think and act after drinking alcohol. Nine healthy adults completed tasks measuring aggression after consuming alcohol or a placebo. The goal was to better understand why some people react differently to alcohol,…

This completed study looked at how women who inject drugs view a long-acting injectable HIV prevention medication called CAB-LA. Researchers interviewed 144 women to understand what influences their decisions to use this option versus daily pills. The goal is to learn how to bett…

This completed study worked with 65 African American/Black adults who use cocaine or other illicit substances to develop a manual called I-DREM. The goal was to gather their feedback on how to improve recruitment and retention in substance use disorder clinical trials. Participan…

This study tested a program where trained peer providers help young people with early psychosis reduce or stop using alcohol and drugs. 113 participants from coordinated specialty care teams took part. The goal was to see if the program could be delivered as planned and whether i…

This study tested a new painkiller called cebranopadol, given as a nasal spray, to see how much recreational opioid users liked it compared to oxycodone and a placebo. 48 healthy volunteers who had used opioids for fun in the past took part. The goal was to measure the drug's abu…

This study looked at whether thinking about financial scarcity changes how people with alcohol use disorder value alcohol and make decisions. 124 adults who wanted to cut down on drinking listened to either a story about scarcity or a neutral story. Researchers then measured thei…

This study looked at whether adults with ADHD are more likely to relapse into drinking after completing a detox program. Researchers followed 113 people for 12 weeks, using interviews and questionnaires to assess ADHD and other mental health conditions. The goal was to see if ADH…

This study looked at how young adults with bipolar disorder respond to alcohol compared to healthy people. Sixty participants aged 21-26 completed brain scans and surveys after drinking alcohol or a placebo. The goal was to understand differences in brain activity and feelings of…

This study compared two simple questionnaires—the MoCA and the BEARNI—to see which one better detects cognitive problems in people with alcohol use disorder. Researchers tested 90 patients and compared the results against a full set of standard neuropsychological tests. The goal …

This study looked at over 36,000 adults in the UK to see if people with vitiligo are more likely to have mental health problems like depression, anxiety, or self-harm compared to those without vitiligo. Researchers used medical records to compare risks and also checked if these r…

This study tested whether showing people in early recovery from alcohol use disorder personalized, high-intensity images of future events could help them think more about long-term rewards and increase their interest in treatment. Fifty-eight participants were split into two grou…

This study looked at how two brain networks—one that controls impulses and one that reacts to alcohol cues—interact in people with alcohol use disorder. Using a powerful 7 Tesla MRI scanner, researchers compared 59 participants (patients and healthy controls) to see if a stronger…

This study tested two programs—one focused on sexual communication and consent, the other on reducing alcohol misuse—among over 2,000 U.S. Air Force Academy cadets. Cadets received one or both programs, and researchers tracked self-reported sexual assault experiences and alcohol …

This study looked at whether a blood test called carbohydrate deficient transferrin (CDT) can better detect long-term alcohol abuse in people aged 60 and older compared to standard methods. Researchers enrolled 194 older adults in France and compared CDT results with a common que…

This study looked at how alcohol and opioids (like prescription painkillers) affect people when taken together. Eleven healthy adults who use both substances but are not dependent on them took part. Researchers measured how much participants liked the drug combination and how dru…

This study looked at how drinking alcohol and using high-THC cannabis concentrates together affects people. 146 heavy drinkers who also use cannabis regularly took part. Researchers measured things like blood alcohol level, heart rate, and how impaired they felt, depending on whe…

This study looked at how accurately patients with alcohol intoxication in the emergency department estimate their own blood alcohol concentration (BAC) compared to a real blood test. Researchers enrolled 34 adults aged 15-64 with a BAC of 60 mg/dL or higher. The goal was to see i…

This study tested whether using electronic health records and support staff could help more people with alcohol use disorder get the care they need. Researchers looked at how often patients started and stayed in treatment when their doctors had extra reminders and help. The goal …

This early-phase trial tested the safety of a new drug called CS-1103 in 32 healthy adults. Researchers gave single doses by IV to see if it causes side effects and how the body processes it. The goal is to gather basic safety information before testing it in people with methamph…

This study tested a computer tool that helps doctors and patients with chronic pain make treatment decisions together. The tool was used in primary care clinics for patients with long-term muscle or bone pain who had recently taken opioids. The goal was to see if clinics would ad…

This study tested whether a bacterial toxin called endotoxin can increase alcohol consumption in people with alcohol use disorder. 27 participants received either endotoxin or a placebo, and their alcohol intake was measured during a 2-hour session. The goal was to gather early d…

This study looked at 488 adults with alcohol use disorder who had suicidal thoughts or attempts. Researchers wanted to understand why some people call the National Suicide Prevention Lifeline during a crisis and others don't. They also tested if a therapy session about the hotlin…

This study developed a computer program that can scan hospital records to find patients who may be misusing drugs or alcohol. Researchers tested it on nearly 65,000 adults admitted to the hospital. The goal was to see if the tool could help doctors offer counseling and support to…

This study tested a brief, computer-based personalized feedback program for adults with chronic pain who drink heavily and take prescription opioids. The program was designed to educate participants about the risks of mixing alcohol and opioids and to motivate them to reduce drin…

This completed Phase 1 study looked at how opioids and sedatives affect the body and mind when taken together. Eleven healthy adults who use these drugs non-medically rated their drug liking and other effects. The goal was to understand the interaction between these common prescr…

This completed study looked at 224 adults who already had at least one psychiatric condition to see how many also had undiagnosed ADHD. Researchers measured how often ADHD was missed and tracked quality of life in those diagnosed. The goal is to highlight the need for better dete…

This study tested whether combining a policy change with professional training can reduce stigma toward substance use in mental health clinics. Twelve providers from two sites participated. The goal was to see if the combined approach improves how often substance use is addressed…

This study tested whether sending letters to doctors about their patients' opioid overdoses would reduce how often they prescribe strong painkillers. Researchers looked at 61 clinicians who had prescribed opioids to patients who later had a non-fatal or fatal overdose. The goal w…

This study tested a program called Asdzáán Be'eená (Female Pathways) for Navajo girls ages 10-14 and their female caregivers. The goal was to see if the program improves communication, monitoring, and teens' plans to delay sex and avoid substance use. About 408 pairs took part, a…

This study tested an educational program designed to improve teenagers' knowledge and behavior around substance abuse. The program used a model called the Behavior Change Wheel to guide learning. Researchers worked with 226 adolescents aged 10 to 18 who had not received similar e…

This study looked at whether using a Fitbit activity tracker can help people receiving inpatient treatment for alcohol use disorder increase their physical activity and improve their emotional state. Ninety adults in treatment wore the tracker and completed questionnaires about t…

This completed study looked at how living in rural areas and drinking alcohol might make people more likely to use tobacco products or less likely to quit. Researchers asked 737 adults about their hypothetical choices in a simulated tobacco marketplace. The goal was to understand…

This study tested whether pop-up alerts in electronic medical records help doctors check a state database before prescribing opioids or sedatives. Over 3,600 providers were randomly assigned to different alert designs. The goal was to see if the alerts increase use of the Prescri…

This study used brain imaging (fMRI) to see how heavy drinkers' brains respond to pictures of alcohol versus non-alcoholic drinks. 72 non-treatment-seeking heavy drinkers made hypothetical decisions about buying alcohol at different prices while in the scanner. The goal was to un…