Could a Brain-Targeting drug curb alcohol cravings?

NCT ID NCT04831684

Completed Disease control Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a drug called GET73 in 79 people with moderate-to-severe alcohol use disorder who were not seeking treatment. Participants took GET73 or a placebo for 8 days and had MRI scans to see how their brains reacted to alcohol cues. The goal was to see if GET73 could reduce drinking and change brain chemistry related to alcohol cravings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GET73
What this could lead to: If it works, this could point toward a new medication to help people with alcohol use disorder drink less or stop.
What could go wrong: This is an early-phase trial with only 79 participants, so results may not apply widely. The drug may not reduce drinking more than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER

Contacts and locations

Locations

Charleston Alcohol Research Center, Institute of Psychiatry, Medical University of South Carolina

Charleston, South Carolina, 29425, United States

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