Substance abuse

This phase 2 trial tested whether cannabidiol (CBD), a non-psychoactive compound from cannabis, could help people with alcohol use disorder reduce their drinking. The study also looked at whether CBD could protect the brain and liver from alcohol's harmful effects. Only 10 people…

This study tested whether a type of brain stimulation called intermittent theta burst stimulation (iTBS) could help people with alcohol use disorder reduce cravings and risky behavior during inpatient treatment. Only 2 people were enrolled before the trial was stopped early. The …

This phase 2 study tested a drug called TMP-301 in 110 adults with alcohol use disorder to see if it is safe and helps reduce drinking. Participants took TMP-301 or a placebo daily for 14 weeks. The trial was terminated early, so we don't have clear results on whether the drug wo…

This study tested a drug called acamprosate in adults with alcohol dependence who were part of a DUI court program. The goal was to see if the medication could help them stay sober and reduce cravings. Only 4 people enrolled before the study was stopped, so results are very limit…

This study tested educational videos for Hispanic/Latinx families with teens aged 15-17 to prevent opioid misuse and overdose. The program focused on safe storage, opioid knowledge, and changing attitudes. Only 6 families took part before the study ended early.

This study tested a program to help HIV-negative transgender women and men who have sex with men who also have a substance use disorder stick with PrEP, a daily pill or shot that prevents HIV. Participants received counseling and text support, with extra help for those who strugg…

This study tested whether adding vaccine discussions to routine behavioral health visits could reduce hesitancy and increase COVID-19 and flu shots among Latinx adults with mental illness. Clinicians used motivational interviewing and could offer a warm handoff to a nurse for vac…

This study tested whether a combination of non-opioid medicines (ketamine, ketorolac, and acetaminophen) can control pain after robotic prostatectomy as well as standard opioid painkillers. Men aged 40-75 with prostate cancer were randomly assigned to receive either opioids or th…

This study tested whether a specially designed video game could reduce alcohol-related problems like hangovers, blackouts, and risky sex in LGBTQ+ teens aged 14-18. The game was meant to teach safer drinking habits. The study was stopped early and only 28 people took part, so res…

This study tested a mindfulness-based mobile app designed specifically for young Black men (ages 18-29) to help them handle stress from racism and reduce alcohol or marijuana use. Participants used a self-guided app, some with real-time feedback, and reported their daily stress a…

This study tested a school-based program called Proud & Empowered, designed to help LGBTQ students cope with minority stress and improve mental health. About 228 high school students took part. The program was led by school counselors and social workers. The study was terminated …

This study aimed to see if a short test called BEARNI could detect alcohol-related cognitive impairments (like memory and thinking problems) in people with alcoholic cirrhosis. The researchers planned to enroll patients with cirrhosis, but the study was stopped early after only o…

This study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …

This study examined whether ride-sharing services like Uber and Lyft are linked to fewer alcohol- and drug-related car accidents and sexual assaults. Researchers collected data from trauma registries, transportation departments, and crisis centers in the Dallas area. The study wa…

This study tracked 239 adults in France taking baclofen for alcohol use disorder. Researchers called participants monthly for a year to see how many stopped the drug due to side effects. The goal was to better understand which side effects are caused by baclofen versus other fact…