Could a Parkinson's drug help with alcohol and ADHD?
NCT ID NCT03904498
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether tolcapone, a drug used for Parkinson's disease, could change how people with both alcohol use disorder and ADHD respond to alcohol and make decisions. 23 adults completed the trial, which involved taking tolcapone or a placebo and then undergoing alcohol challenges, brain scans, and decision-making tests. The goal was to see if the drug affects alcohol cravings, intoxication, and brain activity related to attention and impulse control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tolcapone (Tasmar)
What this could lead to
If it works, this could point toward a new treatment option for people with both alcohol use disorder and ADHD.
What could go wrong
This was a small, early-phase study with only 23 participants. Results may not apply to everyone, and tolcapone has known liver risks.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045, United States