Small study probes dangerous duo: opioids and sedatives
NCT ID NCT04315181
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 1 study looked at how opioids and sedatives affect the body and mind when taken together. Eleven healthy adults who use these drugs non-medically rated their drug liking and other effects. The goal was to understand the interaction between these common prescription medications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Opioid agonist and sedative
What this could lead to
If successful, this could help understand the risks of combining opioids and sedatives, potentially guiding safer prescribing practices.
What could go wrong
This is a very small, early-phase study (11 participants) focused on measuring effects, not testing a treatment. Results may not apply to broader populations.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Center on Drug and Alcohol Research
Lexington, Kentucky, 40508, United States