Mood disorder

This study tests different ways to bring mental health treatment into methadone clinics in Ukraine. 1,350 patients from 12 clinics are taking part. Some clinics get extra training and financial rewards to help screen and treat depression. The goal is to see if these strategies im…

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

This study tested a special program to help people with both bipolar disorder and substance use problems stick to their treatment after leaving the hospital. 178 adults were split into two groups: one received extra counseling and support, while the other got enhanced safety moni…

This study follows adults in the United States who were prescribed zuranolone for postpartum depression (PPD) after giving birth. Researchers will track symptom changes using a standard questionnaire called the Edinburgh Postnatal Depression Scale (EPDS) at several time points, i…

This trial tests whether combining an online form of Acceptance and Commitment Therapy with a noninvasive brain stimulation technique can improve sleep quality in adolescents with depression and sleep problems. About 160 teens aged 11 to 19 are randomly assigned to receive the co…

This trial tests whether adding minocycline or celecoxib to a standard antidepressant helps people with treatment-resistant depression. Treatment-resistant depression means symptoms have not improved enough with previous antidepressant treatment. About 78 adults aged 18 to 65 wil…

This phase 2 trial tests whether a single dose of insulin given through the nose can change how the brain produces energy and improve thinking in people with psychotic disorders like schizophrenia, schizoaffective disorder, or bipolar disorder with psychosis. Researchers will com…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This trial tests whether continuous smartphone monitoring can detect early warning signs of depression or mania in people with bipolar disorder. Participants use an app that tracks activity and location, and some receive personalized alerts from their doctor when the app detects …

This trial tests whether psilocybin, the active ingredient in magic mushrooms, given alongside psychological therapy, can help adults with treatment-resistant depression. Participants receive either psilocybin or a placebo in a single dosing session, combined with therapy. The st…

This trial tests whether a peer-led support program, where trained patients guide group sessions, can reduce depressive symptoms in adults with major depression. Researchers in Mallorca will compare this approach to an online mental health app. About 70 participants from primary …

This trial tests whether a specialized two-year early intervention service, called OPUS YOUNG, can improve daily and social functioning in adolescents aged 12-17 who have experienced a first episode of psychosis. Participants are randomly assigned to either OPUS YOUNG or standard…

This trial explores whether it is possible to run a larger study of mirtazapine, an antidepressant, in people who have both major depression and inflammatory bowel disease (IBD). About 76 adults with IBD and depression will be randomly assigned to take either mirtazapine or a pla…

This trial tests an experimental medicine called BI 1569912 in adults aged 18 to 65 with major depressive disorder whose current antidepressants aren't working well enough. Participants take a single dose of the drug or a placebo, in addition to their usual antidepressant, and ar…

This study tested whether levodopa, a drug used for Parkinson's disease, can improve thinking speed, walking, and mood in older adults with depression. Researchers gave 79 participants either levodopa or a placebo for three weeks. The goal was to see if boosting dopamine could he…

This study tests whether adding Gottman couple therapy to usual depression treatment helps women with major depressive disorder who are in distressed relationships. The therapy focuses on improving communication and emotional connection between partners. Researchers will compare …

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This study tests whether using MRI to guide transcranial magnetic stimulation (TMS) works better than the usual scalp-based method for treating depression. It involves 54 participants, including those with treatment-resistant depression and others with COVID-related distress. The…

This study tests a new group program called Forging New Paths for adults with serious mental illness who have also been involved with the criminal justice system. The program combines cognitive behavioral therapy with social learning techniques to reduce aggression and help peopl…

This study tests a program called Compassionate Mind Training for Teachers (CMT-T) to see if it can reduce depression, anxiety, and self-criticism in elementary school teachers. Forty teachers from public schools in Aracaju, Brazil, will take part in group sessions that include m…

This study compares two treatments for depression in children aged 7 to 13: a family-focused therapy that works with both the child and parents, versus individual therapy for the child alone. The family approach aims to improve parent-child interactions, communication, and coping…

This study tests a new virtual reality (VR) software that delivers behavioral activation therapy for people with depression. Behavioral activation helps people re-engage in positive activities to improve mood. Participants use hand-tracking to interact with the VR environment, co…

This trial studies three approaches for adults with major depression that hasn't responded to standard antidepressants. Participants either add aripiprazole (Abilify) to their current medication, add repetitive transcranial magnetic stimulation (rTMS), or switch to venlafaxine XR…

This pilot study is testing whether adults with serious mental health issues like psychosis, anxiety, or depression can receive hospital-level care in their own homes. Researchers will see how many people are eligible and willing to try this approach. The goal is to offer a safe,…

This study tested a behavioral program called CAE-AYA to help teens and young adults with bipolar disorder take their medication more consistently. The program included up to five in-person sessions and a follow-up phone call over eight weeks. Researchers measured adherence using…

This study tests whether a personalized mobile health app (iTAB-CV) plus self-monitoring helps people with bipolar disorder or major depression take their blood pressure medication more regularly and lower their blood pressure. About 176 adults aged 21-80 with both conditions and…

This trial investigates whether adding low-intensity transcranial magnetic stimulation (Li-TMS) to standard antidepressant medication can improve depressive symptoms and sleep disorders in people with major depression. The study involves 40 participants who receive either real Li…

This study tested a weight-loss program called CoachToFit for 257 veterans with serious mental illness (like schizophrenia or bipolar disorder) who were obese. Participants used a smartphone app, an activity tracker, and a Bluetooth scale, and worked with a peer coach. The goal w…

This study tested a stepped care model for depression in 14 HIV clinics in Malawi. 487 adults with moderate to severe depression received group counseling and, if needed, antidepressant medication. The goal was to see if this approach could reduce depression symptoms and improve …

About half of people with bipolar disorder struggle to take their medication as prescribed, which can lead to severe consequences. This study tested a customized program called Customized Adherence Enhancement (CAE) that includes education, motivational interviewing, and help wit…

This study tested a special team-based program called R-FACT for people with serious mental illness who are also involved with the criminal justice system. The program provides intensive, community-based support with close coordination between mental health and justice staff. Res…

This study tested magnetic seizure therapy (MST) in 239 adults with treatment-resistant depression to see if it works as well as electroconvulsive therapy (ECT) but with fewer memory side effects. MST uses magnetic pulses to trigger a controlled seizure, aiming to relieve depress…

This study looked at whether adding lithium to personalized maintenance ECT can help prevent depression relapse in people who already got better with ECT. 96 adults with major depression took part. The goal was to see if the combination keeps depression away longer than ECT alone…

This study tested a culturally adapted psychoeducation program (CaPE) for 303 adults with bipolar disorder in Pakistan who were currently stable. Participants were randomly assigned to receive CaPE plus their usual care or just usual care alone. The goal was to see if CaPE could …

This study looked at 6 people with schizophrenia who were already taking a combination of two long-acting injectable medications: Abilify Maintena and Rexulti. Researchers tracked their symptoms and side effects over 6 months to see how well the combo worked in everyday life. The…

This study tested a blended collaborative care model that uses telemedicine to integrate mental health treatment into primary care at smaller VA clinics serving rural veterans. Researchers enrolled 318 veterans who screened positive for depression, alcohol use disorder, or PTSD. …

This study tested whether deep brain stimulation (DBS) can help people with severe depression that hasn't responded to other treatments. 46 patients received either active DBS or a sham (inactive) device. The goal was to see if DBS reduces depression symptoms safely.

This study tested whether a 3-year physical activity program could help prevent colon cancer from coming back in 889 patients who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. Participants were randomly assigned to either the exercise program plus…

This study tested a program called Positive Minds-Strong Bodies Enhanced (PMSB-E) in 427 older adults from racial, ethnic, and linguistic minority groups who had depression, anxiety, and some mobility issues. The program combined mental health support with physical exercises to h…

This study looked at whether providing mental health care to people who inject drugs can improve their mental health and reduce their risk of getting HIV or hepatitis C. Over 500 participants in Haiphong, Vietnam, received free psychiatric consultations, medications, and support …

This study looked at the long-term safety of a new daily medication called BHV-7000 for people with major depressive disorder. A total of 233 adults who had already completed an earlier study took the pill once a day. Researchers tracked side effects, lab results, and heart chang…

This study tested a 12-month telephone-based nurse care program for 805 adults with depression and signs of opioid use disorder. Participants were randomly assigned to receive nurse support or usual care. The goal was to see if the program could improve treatment for opioid use a…

This study looked at whether repeated ketamine infusions can help people with hard-to-treat bipolar depression stay well. 41 adults who had already responded to an initial course of ketamine received up to 6 more infusions over 12 weeks. The goal was to see if maintenance doses c…

This study tested whether a smartphone app designed for people with serious mental illness can help them quit smoking better than standard methods. Researchers enrolled 343 adults with conditions like bipolar disorder or schizophrenia who wanted to quit. Participants used either …

This completed study tested whether painting metal roofs with a special heat-reflecting coating can lower indoor temperatures and improve health in Niue, a Pacific island nation facing record heat. Researchers enrolled 288 adults living in single-story homes with metal roofs. The…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This study tested whether a program called Circadian Reinforcement Therapy (CRT) — which helps people strengthen their sleep-wake cycle and daily routines — could reduce the chance of depression coming back after leaving a psychiatric hospital. 103 adults with major depression us…

This trial tested a 9-month group program called Illness Management and Recovery (IMR) for 198 adults with schizophrenia or bipolar disorder. The program focused on helping participants set personal goals and manage their symptoms. Researchers measured changes in daily functionin…

This study tested whether adding mental health care (like therapy and education) to standard job support helps people on sick leave due to anxiety or depression return to work sooner. Over 600 participants in Denmark were randomly assigned to one of two programs or usual care. Th…

This early-stage trial tested whether a one-time infusion of donor stem cells is safe for people with both alcohol use disorder and major depression. Thirty-one participants received either the stem cells or a placebo. The main goal was to check for serious side effects, like sui…

This study tested whether delivering coordinated specialty care (CSC) via telehealth works as well as standard in-person care for young people (ages 16–35) with early psychosis. Over 12 months, researchers tracked hospitalizations and engagement in 74 participants. The goal was t…

This study tested two common treatments for depression and PTSD—talk therapy (IPT) and an antidepressant (fluoxetine)—in a large public hospital in Kenya. Over 2,100 adults participated to see if these treatments could be effectively delivered by non-specialists in primary care. …

This study looked at the long-term safety of cariprazine, a medication, in 310 children and teens with schizophrenia, bipolar I disorder, or autism spectrum disorder. Over 52 weeks, researchers monitored side effects, vital signs, lab results, and movement disorders. The goal was…

This study tested whether peer specialists—people who have serious mental illness themselves and are trained to help others—can effectively deliver two types of therapy: Cognitive Behavioral Social Skills Training (CBSST) and Social Skills Training (SST). The goal is to help vete…

This study tested whether a new tablet called VHX-896 works the same as the standard drug iloperidone in 26 adults with schizophrenia or bipolar I disorder. Participants took both versions at different times to compare drug levels in the blood and check for side effects. The goal…

This study looked at the long-term safety of esketamine nasal spray (a fast-acting antidepressant) when used together with standard antidepressants in 183 people with treatment-resistant depression. Participants had already completed 32 weeks of esketamine treatment and continued…

This study tested a 12-session telehealth counseling program for young people aged 18-29 living with HIV. The program used text messaging and video calls to help them stay engaged in care, manage mental health, and reduce substance use. Fifty participants were enrolled to see if …

This study is testing whether a mobile app can help detect postpartum depression early in pregnant women. Researchers will follow 120 women for 6 months, using daily mood questions and monthly surveys through the app. The goal is to understand how symptoms change over time and to…

Researchers are checking whether a short 3-question depression survey can identify moderate-to-severe depressive symptoms in older adults having surgery as accurately as the standard 9-question version. The study analyzes existing records from more than 10,000 patients aged 65 an…

This study tests a voice-analysis device designed to help clinicians screen for moderate to severe depression. Adults aged 22 and older will record their voice, and the device's assessment will be compared to a standard clinical interview. The goal is to see if the device can acc…

This study tests a voice-analysis device designed to help clinicians screen for moderate to severe depression in adults. About 1,600 English-speaking adults aged 22 and older will record their voices, and the device's screening results will be compared with a standard clinical in…

This study tested whether a French version of the HSCL25 questionnaire can help general practitioners diagnose depression more accurately. Over 1,100 adults visiting their primary care doctor took the questionnaire, and their scores were compared to a standard diagnostic intervie…

Researchers at Yale University are testing whether adding cognitive behavioral therapy (CBT) after esketamine treatment helps prevent relapse in people with major depression and suicidal thoughts. All participants receive esketamine, then half are randomly assigned to also get co…

This trial tests whether a group prenatal care model that includes social services can improve maternal mental health and reduce preterm birth compared to standard individual care with added services. Pregnant women eligible for Medi-Cal in central California are randomly assigne…

Researchers are testing a school-based program that screens adolescents for anxiety, depression, and other mental health concerns, then offers stepped support. Students at eight schools in Spain complete regular mental health questionnaires. Based on their results, they receive d…

This study tested whether giving a low-dose ketamine drip after surgery could prevent depressive symptoms in 32 neurosurgical patients who had a history of depression. Researchers measured depression scores before surgery and for two weeks after. The main goal was to see if a lar…

This trial is testing whether a smartphone app called M.Bapp, which delivers cognitive behavioral therapy, is a feasible and acceptable way to prevent postpartum depression in mothers at high risk. The study will enroll pregnant women who are at least 32 weeks along and have no r…

This trial tests whether a one-day online workshop based on cognitive behavioural therapy (CBT) can reduce the risk of postpartum depression and anxiety. Pregnant women in their third trimester who have a history of depression but are not currently depressed will be randomly assi…

This study tests whether computer-based training that targets emotional memory or attention can prevent major depression in young people who have depressive symptoms or have recovered from a depressive episode. Participants are randomly assigned to one of three active training pr…

This study tests whether virtual prenatal yoga classes can prevent postpartum depression in pregnant women who have a history of depression. About 62 women will be randomly assigned to either take yoga classes or receive standard care. Researchers will track depression symptoms a…

This study tests a simple writing exercise for new mothers who had a stressful childbirth. In the days after giving birth, participants write about their experience for 15 minutes a day for three days. The goal is to see if this can prevent post-traumatic stress disorder (PTSD) a…

This study tested whether personalized, intensive nursing follow-up (by phone, home visits, or hospital consultations) after a suicide attempt could prevent another attempt or crisis in people with mood disorders. 380 participants were followed for one year. The goal was to see i…

This study follows up on 217 children who took part in a cognitive behavioral therapy program for anxiety and depression 5 years earlier. Researchers want to see if the program helped prevent these conditions from developing or worsening over time. The children, now teenagers, wi…

This study tested an online program called PROCARE-I+ designed to prevent anxiety and depression in teenagers who are at high risk. Thirty adolescents with early symptoms took part in the program, which included extra modules tailored to their needs. Results showed improvements i…

This study tested an online psychological program designed to prevent depression in people with atrial fibrillation (AF), a common heart rhythm problem. The program combined phone or video sessions with online modules and exercises over 4-12 weeks. The trial included 28 adults wi…

This study tested a program called iDOVE2 for teens at risk of peer violence and mild-to-moderate depression. The program started with a brief session in the emergency department, followed by automated text messages designed to prevent violence and depressive symptoms. Researcher…

This study looked at how to keep a program called ROSE, which prevents postpartum depression, running in clinics that serve low-income pregnant women. Researchers tested different levels of support—like coaching—to see what clinics need to keep offering the program long-term. The…

This study tested whether a 12-week healthy lifestyle program could prevent depression in older adults who recently lost a spouse. Participants used digital tools to track sleep, meals, and activity, plus received weekly health coaching. The goal was to see if this approach reduc…

This study tested whether a single 3-hour group therapy session based on Acceptance and Commitment Therapy (ACT) could prevent mental health disorders in 120 women recently displaced by war in Ukraine. The women had mild to moderate symptoms of anxiety or depression. The goal was…

This study tested a trauma-informed program to prevent postpartum depression in women living in earthquake-affected regions of Türkiye. The program included education, emotional support, and coping skills, delivered by healthcare workers. 106 women took part, and the study measur…

This study tested whether taking daily vitamin D or fish oil supplements could prevent depression in over 18,000 adults without significant mood issues at the start. Participants were followed for about 5 years. The results showed that neither supplement reduced the risk of devel…

This study tested a behavioral program called PREPP, which provides coaching sessions to pregnant women at risk for postpartum depression. The program focuses on improving infant sleep and reducing fussiness, aiming to lower depression risk. 216 women participated, receiving eith…

Researchers at the University of Tulsa are testing a five-session psychological treatment called Exposure, Relaxation, and Rescripting Therapy for adults who have bipolar disorder and chronic trauma nightmares. The therapy asks participants to revisit and rewrite their nightmares…

This trial tests whether drinking lavender herbal tea twice daily for nine days around each menstrual cycle can reduce the emotional and physical symptoms of premenstrual syndrome (PMS), such as anxiety, depression, stress, and pain. Sixty women with PMS will be randomly assigned…

Researchers are testing a stepped mental health program for adolescents in Pakistani public schools. The program starts with teacher-led support for emotional distress. Students who do not improve move to a CBT-based guided self-help app. The study checks whether this approach is…

This study tests an experimental drug called GM-2505 in people with major depressive disorder. Participants receive two doses of the drug two weeks apart. The study has three parts: one for people not on antidepressants, one for those partially responding to current treatment, an…

Researchers are testing whether a 10-week mindful yoga program eases depression, anxiety, and stress in women who have recently given birth. The trial enrolls 198 postpartum women with depressive symptoms and assigns them to either weekly mindful yoga sessions or a psychoeducatio…

Researchers are testing an accelerated form of brain stimulation called iTBS for depression. A single participant with major depressive disorder receives 50 iTBS sessions over 5 days while researchers monitor blood flow in the brain using fNIRS. The study measures changes in oxyg…

Researchers are testing a home-based program called action observation and motor imagery (AOMI) training for adults with spinal cord injury. Participants watch exercise videos and imagine themselves doing the movements without actually moving. The trial aims to see if this traini…

Many people who move to a new country face depression, anxiety, stress, and trouble adjusting. This pilot study tests whether EMDR, a psychotherapy that uses guided eye movements to process distressing memories, can help when adapted for migration-related experiences. First-gener…

Researchers are testing whether a home-based program led by community health workers can reduce depression in older adults living in a low-resource district of Lima, Peru. The program, called VIDACTIVA, combines problem-solving exercises and physical activation over eight home se…

Researchers are studying whether adding a Chinese herbal capsule called Shuganjieyu to the antidepressant fluoxetine helps ease depression symptoms more than fluoxetine alone. The trial enrolls 160 adults with depression, ages 18 to 65, who score at least 18 on a standard depress…

Researchers in Chile are testing whether pediatricians trained to detect and respond to social withdrawal can help late and moderately late preterm infants engage more with their parents. The study enrolls 110 preterm infants born between 32 and 36 weeks and their Spanish-speakin…

Researchers in Pakistan are comparing two psychological treatments, Eye Movement Desensitization and Reprocessing (EMDR) and Cognitive Behavioral Therapy (CBT), for people with post-traumatic stress disorder (PTSD) and major depression. The trial enrolls 100 adults aged 18 to 60 …

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study tests whether pairing meditation with a brain stimulation technique called rTMS can better treat depression. rTMS is already FDA-approved but only works for about 15-30% of patients. The researchers hope that adding a focus on internal attention (like breathing) during…

People with type 2 diabetes often face higher rates of anxiety and depression than the general public. Researchers at Dasman Diabetes Institute are testing whether six weeks of guided breath awareness, practiced inside a pyramid-shaped structure, can reduce those symptoms. The pi…

This study tested whether a special type of heated yoga (hyperthermic yoga) could help adults with mild to moderate depression. 80 people were randomly assigned to either take yoga classes twice a week or join a waitlist. The main goals were to see if people would stick with the …

Researchers at the University of Utah are testing a new non-invasive brain stimulation method for people with moderate-to-severe depression. The study uses a device called the Diadem prototype to deliver personalized low-intensity focused ultrasound to specific brain areas. Parti…

Researchers at MIT are testing whether a smartwatch that vibrates in time with your heartbeat can improve interoceptive awareness, the ability to sense what is happening inside your body. The study enrolls 29 people with high alexithymia scores, a trait linked to difficulty ident…

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults (ages 18-24) who have faced early life hardships find the program helpful and easy to use. The study also checks if the program reduces sympto…

This study tests a nasal spray containing (R)-Ketamine, a fast-acting drug, in 98 adults with major depression who are currently having suicidal thoughts. Participants receive either the spray or a placebo twice a week for 4 weeks. The goal is to see if the spray can quickly redu…

This trial tests a telephone-based coaching program called MOTIVATE for older veterans who live with chronic musculoskeletal pain and depression. Participants receive eight individual phone sessions with a health coach over up to five months, focusing on managing pain and mood. R…

This study looks at whether mindfulness meditation can help first-generation college students feel less anxious or depressed and stay in school. About 53 students will be randomly assigned to either mindfulness meditation or a general mental health education group. Researchers wi…

Researchers are testing whether psilocybin, the active compound in magic mushrooms, can safely help people with Parkinson's disease who also struggle with depression or anxiety. In this pilot study, 12 participants receive two oral doses of psilocybin with psychological support. …

This study is testing whether two devices used together can help new mothers with both depression and urinary incontinence. One device uses magnetic pulses to stimulate brain areas linked to mood, while the other strengthens pelvic floor muscles with electromagnetic energy. Sixty…

This study tests whether a text-message based chatbot support program can reduce symptoms of postpartum depression in people of color who recently gave birth. About 156 participants will either get the chatbot or usual care. The goal is to see if the chatbot lowers depression sco…

This study tested a new cognitive behavioral skills program (CBI) delivered in the metaverse for people with depression and anxiety. 306 participants were split into three groups: one using virtual reality, one using a flat-screen device, and a waitlist group. The program taught …

This study tests whether adding a group therapy called Kiesler Circle Training (KCT) to standard cognitive behavioral therapy (CBT) helps people with depression or anxiety improve their interpersonal skills. About 156 participants will receive either CBT alone or CBT plus KCT. Th…

Researchers are testing whether a series of multisensory stimulation sessions can reduce depressive symptoms in adults with moderate-to-severe depression. Fifteen participants receive nine 20-minute sessions combining auditory, thermal, and pressure stimuli, calibrated to about 6…

This study tested a wearable morning light device (Re-Timer) for women with postpartum depression. 95 women wore either bright or dim light glasses for 60 minutes each morning for 5 weeks. Researchers measured changes in depression symptoms, sleep, and body clock timing. The goal…

Researchers at Brigham and Women's Hospital are testing whether automated motivational messages or coach support can improve engagement with SilverCloud, a digital mental health intervention for depression and anxiety. The trial enrolls adults with clinically significant symptoms…

This small study tests whether empagliflozin (Jardiance), a diabetes medication, can reduce symptoms of major depression. The drug helps the body produce ketones, which may provide an alternative energy source for the brain. Sixteen adults with moderate to severe depression will …

This trial tests whether aromatherapy with rose oil or a massage using that oil can reduce pain, anxiety, and discomfort in women after a cesarean delivery. About 90 first-time mothers will be randomly assigned to receive one of these treatments or a placebo. The goal is to see i…

This study tested whether a type of compassion meditation could help Veterans with chronic pain who also have depression or PTSD. 142 Veterans were randomly assigned to either compassion meditation training or a health education group. The goal was to see if meditation could redu…

This study tested a new drug called ropanicant in 41 adults with moderate to severe major depressive disorder. The main goal was to check safety and side effects, while also measuring how well it improved depression symptoms using a standard rating scale. The trial was open-label…

Researchers at UCLA are testing whether a savoring intervention, which teaches people to focus on and amplify positive experiences, can improve mood and reduce inflammation in young adults with low positive affect. The study involves 20 participants aged 18 to 25 who will complet…

This study tests an experimental drug called JNJ-89495120 in 107 adults with major depression. The goal is to see if it can reduce depression symptoms faster than a placebo, with checks as early as day 2 and day 5. Participants take the drug alone (no other antidepressants) and a…

This study tests whether a mushroom supplement called Ganoderma lucidum spore powder can reduce depression in women who have had thyroid cancer surgery. Three hundred participants will take either the supplement or a placebo daily for three months. Researchers will measure change…

This study is testing whether an 8-week mindfulness program can help hospital staff and older adults sleep better and feel less depressed. Researchers will measure changes in sleep quality, depressive symptoms, and well-being using questionnaires and overnight sleep tests. The go…

This trial tests whether adding virtual reality to standard pulmonary rehabilitation can reduce depression in people with COPD. Adults aged 45 to 85 with COPD and mild or worse depression will be randomly assigned to receive either pulmonary rehab with virtual reality or rehab al…

Researchers are testing whether daily sessions with a bright light lamp can ease depressive episodes in people with bipolar II disorder. The trial compares a bright 10,000 lux lamp against a dim placebo lamp, with each session lasting 30 minutes. Participants are adults whose dep…

This study tested whether an 8-week mindfulness-based stress reduction program could lower depression, anxiety, stress, and hopelessness in parents of children with autism. 96 parents took part in weekly 60-minute group sessions. The goal is to see if this simple, non-drug approa…

This trial tests whether an online therapy platform, BetterHelp, can reduce symptoms of moderate to severe depression and anxiety. Adults in the US with elevated scores on standard anxiety or depression scales will either get access to the platform for 16 weeks or be in a control…

This study tested a new approach: having people with major depressive disorder do 30 minutes of moderate exercise right before a therapy session. 40 adults were split into two groups: one exercised on a stationary bike, the other watched nature videos. The goal was to see if exer…

This study tests whether using brain scans to guide transcranial magnetic stimulation (TMS) works better than standard head measurements for treating depression. Participants with major depressive disorder receive accelerated TMS, but they won't know if their treatment spot was c…

This phase 2 trial tests an experimental drug called TJ0113 for people with depression. About 150 adults aged 18 to 65 will take either 200 mg or 400 mg of TJ0113 or a placebo daily for 8 weeks. Researchers will measure changes in depression symptoms using a standard rating scale…

This study tested a program called ENCODE designed to help family caregivers of people with dementia manage stress and communicate better about pain. 452 caregivers were randomly assigned to either the ENCODE program or friendly video calls. The goal was to see if the program imp…

This trial tests whether a structured, adapted physical activity program can improve emotion regulation in adults with depressive disorders who have recently been discharged from psychiatric hospitalization. Participants are randomly assigned to either a standard exercise program…

This study tested whether a painless brain stimulation technique called tDCS could help veterans suffering from chronic pain, PTSD, and depression. 38 veterans received tDCS sessions during an intensive outpatient program. Researchers measured changes in pain levels and mental he…

This pilot study tests whether a four-week telehealth program can reduce depressive symptoms in caregivers of children with cerebral palsy. Participants receive a behavioral intervention via telephone every four weeks, and their depression and anxiety levels are measured before a…

This study tests a digital program called Rauha that combines online cognitive behavioral therapy with coaching from trained mental health coaches. It is designed for adults with hearing or mobility disabilities who also experience anxiety or depression. The trial will see if peo…

This trial tests whether a 20-minute foot massage, given daily for three days after open heart surgery, can reduce pain, improve sleep quality, and boost mood. Adults undergoing coronary artery bypass grafting who report significant pain after surgery are randomly assigned to rec…

This study tests an 8-week hybrid physiotherapy program for adults aged 45-75 who live with both chronic pain and depression. The program combines weekly face-to-face sessions on pain science with guided exercises and online videos. Researchers will measure changes in pain intens…

This pilot study explores whether real-time fMRI neurofeedback can help veterans reduce suicide-specific rumination—the repetitive mental fixation on suicidal thoughts. Sixteen veterans will receive two brain-training sessions, learning to modulate activity in brain regions linke…

This trial tests whether a group-based psychological treatment for insomnia, adapted for people with depression, anxiety, or PTSD, can improve sleep and reduce psychiatric symptoms. Participants receive either the adjusted CBT-i program or usual care. The study measures changes i…

This study tests a new device that uses mild electrical currents to stimulate the brain in people with major depression. The device adjusts the stimulation in real time based on brain activity. The goal is to see if the device works correctly and if it can help reduce depression …

This trial tests three different approaches to help people with bipolar disorder become more physically active. Participants are randomly assigned to receive brief advice alone, or brief advice plus supervised and home-based exercise with either health education or cognitive-beha…

This six-week study tests whether two liquid supplements, BrainJuice Peach Mango and BrainJuice ACTIVE Pomegranate Acai, can improve cognitive function, performance, and mood in healthy adults aged 18-57 who have concerns in these areas. Participants drink one supplement daily fo…

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This study tested a fast-dissolving film (BXCL501) placed under the tongue to quickly reduce agitation in people with bipolar disorder. About 380 adults with bipolar I or II who were very agitated took part. The goal was to see if the film safely calms agitation better than a pla…

This trial tests whether an 8-week mindfulness-based stress reduction program can help first-time pregnant women feel less depressed, improve their psychological well-being, and strengthen their attachment to their unborn baby. About 108 women in their first pregnancy, between 13…

This study tested a program that combines mindfulness training, music listening, and video counseling to help new mothers manage depression and persistent pain after childbirth. The program was designed for use in outpatient care and includes digital tools. 1,720 healthy women wh…

This trial tests whether two natural soy compounds, genistein and equol, can improve memory, thinking speed, and mood shortly after a single dose. Around 53 generally healthy adults will take either one of the supplements or a placebo, then complete a series of computer and paper…

This study tests whether nicotine patches can improve cognitive control (like focus and memory) and mood in adults aged 60 and older with depression. Sixty participants will wear either a nicotine or placebo patch daily for 12-15 weeks. Researchers will measure changes in depress…

This study looks at whether nicotine patches can safely improve mood and thinking in adults aged 60 and older with depression. Participants who completed a previous blinded trial will wear a patch daily for up to 12 weeks, then taper off. The goal is to see if nicotine helps the …

This 12-week trial tests whether two natural soy compounds, genistein and equol, can improve memory, thinking speed, and mood in healthy adults. Participants take one of the supplements or a placebo daily and complete four one-hour sessions of cognitive and mood tests. The goal i…

This study tested an experimental oral drug called NORA520 in 93 women with severe postpartum depression. Participants took the drug or a placebo for just 3 days. Researchers measured how well it reduced depressive symptoms, checked for side effects, and looked at how much of the…

This study explores whether virtual reality goggles and noise-cancelling headphones can make ketamine/esketamine treatment for depression more tolerable and effective. Participants receive a single treatment while immersed in a relaxing virtual environment. The goal is to see if …

This trial tests whether an eight-session cognitive-behavioral psychoeducation program can reduce internalized stigma in adults with bipolar disorder who are in remission. Participants are randomly assigned to the program or usual care, and their stigma levels are measured before…

This trial tests whether choline alphoscerate, a dietary supplement, can improve depression, anxiety, and memory complaints in adults aged 60 and older with major depression. Participants take either the supplement or a placebo alongside their usual antidepressant medication. The…

This study explores whether low intensity focused ultrasound (LIFU) can safely change brain activity linked to depression and anxiety in 25 veterans. Participants receive LIFU during MRI scans, and researchers monitor for side effects and brain changes. The goal is to see if this…

This study tested whether a 12-session parenting group therapy, called the Connecting and Reflecting Experience (CARE) program, is helpful and doable for new parents struggling with postpartum depression or anxiety. Seventeen parents of babies aged 3 to 12 months took part. The g…

This study tested a counseling program called the Friendship Bench for 106 teens aged 13-18 who have HIV and feel depressed or anxious. The program aims to improve their mood and help them stay engaged in their HIV care. Researchers measured how well the program worked by looking…

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This study tests whether a new type of group therapy, called Group Cognitive Evolutionary Therapy, can help reduce symptoms of depression and anxiety. Sixty-four adults with mild to severe depression will either receive two full days of therapy or be placed on a waiting list. Res…

This study tests a specially adapted form of cognitive behavioral therapy for insomnia (CBT-i) in people with bipolar disorder who have sleep problems. The therapy includes sleep scheduling, light exposure, and relaxation techniques. Researchers want to see if it improves sleep q…

This study tests whether a very low dose of LSD (26 micrograms) can improve mood in people with depression compared to a placebo. Researchers measure mood changes, sleep quality, and brain activity using EEG. The trial involves 41 adults with depression and aims to see if this ap…

This pilot study tests whether a brief psychological program called Problem Management Plus (PM+) can help reduce anxiety and depression symptoms in people held in Dutch remand prisons. The program, developed by the World Health Organization, teaches problem-solving, stress manag…

This study tests whether a 10-week storytelling (narrative therapy) program can reduce anxiety and depression in middle school students living in refugee camps in northern Palestine. About 120 students aged 12-15 with moderate-to-severe symptoms took part. The program uses cultur…

This early study tests a new, personalized brain stimulation method (tACS) for depression during pregnancy. Ten women (5 with depression and 5 healthy) will receive the treatment to see if it is safe, tolerable, and practical. The goal is to gather initial data to guide larger fu…

This study tested whether listening to Baroque music for 30 minutes could reduce anxiety in 18 adults with major depressive disorder. Participants listened to a specially chosen set of Baroque pieces, and their anxiety levels were measured before and after. The idea is that the m…

This study tests whether a one-day Acceptance and Commitment Therapy (ACT) workshop can improve psychological flexibility and well-being in university students who have moderate to severe anxiety or depression. Participants are randomly assigned to either attend the workshop or j…

This study tested a behavioral sleep program for 16 depressed teenagers who slept less than 7 hours on school nights or had irregular sleep schedules. The program included one session with a provider and used smartphone tools to help teens create a plan for longer and more regula…

This study tests whether adding passive sensing technology (like smartphone data) to a standard counseling program helps community health workers better treat postpartum depression in low-resource settings. The trial compares the digital-enhanced approach to standard counseling a…

This trial tests whether a brief online group therapy called EMDR Flash can help adults who survived the 2023 Kahramanmaraş earthquakes in Türkiye. Participants receive two 60-90 minute group sessions via Zoom and are compared to a waitlist group. The study measures changes in PT…

This pilot study tested a six-session culturally adapted cognitive behavioral therapy (Ca-CBT) for depression and anxiety in 50 people living with HIV in Pakistan. The therapy was delivered by trained HIV health workers and included culturally relevant stories and materials. The …

This study tested whether adding dog-assisted therapy to usual care helps teens aged 12-18 with mental health issues like anxiety, depression, and emotional dysregulation. 70 teens in a day hospital were randomly assigned to either get dog therapy plus usual care or usual care al…

This study tested an experimental drug called CLE-100 (oral esketamine) in 99 adults with major depression that didn't get better after trying at least two standard antidepressants. Participants took CLE-100 or a placebo pill alongside their usual antidepressant for several weeks…

This pilot study tested whether a non-invasive device that uses magnetic pulses to stimulate the brain (rTMS) could safely help cancer survivors with depression and anxiety. Twenty-four adults who had been treated for any type of cancer and still had major depression received eit…

This study tested whether daily gummies containing L-theanine and lion's mane mushroom extract could reduce stress, anxiety, and improve sleep in university students. 67 students aged 18-25 took either the gummies or no supplement for 8 weeks. The goal was to see if this natural …

This study looked at whether adding supervised Pilates exercises and structured prenatal education to standard care could reduce depressive symptoms, low back pain, and labor pain in first-time mothers. 85 pregnant women participated, with some attending the program and others re…

This study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…

This study tested a program to reduce anticholinergic medications (like benztropine) in 53 adults with schizophrenia, bipolar disorder, or other serious mental illnesses who had been taking these drugs for at least 6 months. The goal was to safely taper or stop these medications …

This study tested an online guided self-help program called EMPOWER for medical professionals with mild depression or anxiety. The program teaches problem-solving and acceptance skills through videos and stories. 161 participants were randomly assigned to the program or a control…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested a 6-week mindful self-compassion program for homeless women with PTSD and substance use. The program includes meditation, group discussions, and home practices. Researchers compared the program to usual care in 202 women living in a residential drug treatment fa…

This study tested whether internet-delivered cognitive behavior therapy (ICBT) can help teens aged 13-17 with mild to moderate depression. 219 participants were randomly assigned to guided ICBT (with therapist support), self-guided ICBT (without support), or usual care. The goal …

This study tested an 8-week program called STAIRS for people recovering from depression. The program combines group meetings with homework exercises to help improve personal recovery and daily functioning. 36 adults in the final phase of depression treatment took part. The goal w…

This study tested a brief, community-based psychological program called Problem Management Plus to see if it can reduce depression, anxiety, and distress. Over 1,200 adults with mild to moderate symptoms took part. The program focuses on practical problem-solving skills in just f…

This small study tested whether adding whole-body hyperthermia (like a sauna session) to cognitive behavioral therapy (CBT) is feasible for adults with major depression. Sixteen participants received up to 8 weekly or 4 bi-weekly sauna sessions along with 8 weekly CBT sessions. T…

This study tested whether adding whole-body hyperthermia (mild heat sessions) to standard cognitive behavioral therapy (CBT) could help adults with major depression. Thirty participants received either real or sham heat sessions alongside weekly therapy. The main goal was to see …

This study tested a program called MOSAIC Plus for pregnant women and mothers of children under 5 who have experienced intimate partner violence and have symptoms of depression or PTSD. The program pairs women with community advocates who provide support and teach skills to impro…

This study tested whether taking buprenorphine (a low-dose opioid) after a ketamine infusion can reduce suicidal thoughts more quickly and effectively than ketamine alone in people with major depression. Fifty adults participated, and researchers measured changes in suicidal idea…

This study tested whether giving clonidine, a blood pressure medication, before electroconvulsive therapy (ECT) could reduce the confusion and agitation that often follows the procedure. ECT is effective for severe depression and bipolar disorder, but up to 65% of patients experi…

This study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…

This study tested a new drug, centanafadine, in 337 adults with major depression who hadn't responded well to at least one prior treatment. Some participants took the drug alone, others added it to their current antidepressant. The main goal was to see if it reduced depression sy…

This study tested a 3-week program that helps cancer patients identify their personal strengths (like hobbies, social support, or personal qualities) and use them to cope better. 32 adults with different cancers took part in card-sorting sessions, phone calls, and home exercises.…

This study tested whether a 6-session educational program could help people receiving electroconvulsive therapy (ECT) feel less stigma and anxiety about their mental health treatment. Sixty adult inpatients with conditions like depression or bipolar disorder took part. Those who …

This study tested a group therapy program called HUGS for mothers with postpartum depression. The goal was to see if it improves the mother-baby relationship compared to a playtime group. 104 mothers participated, and researchers measured bonding through video analysis. The thera…

This study tested whether adding virtual reality (VR) nature experiences to standard treatment helps adults with mild to moderate depression feel better. 45 participants were split into three groups: one used a high-end VR lab setup, another used a simple self-managed VR, and a c…

This study tested whether a short behavioral program called Acceptance and Commitment Therapy (ACT) could reduce pain and improve function in veterans at risk for persistent pain after knee replacement. 402 veterans were randomly assigned to ACT or an attention control group. Res…

This study tested whether virtual peer support groups, co-led by a mental health clinician and a trained peer specialist, could help veterans with serious mental illness (like schizophrenia or bipolar with psychosis) feel more socially connected and less distressed. Twenty-eight …

This small study tested whether combining digital cognitive behavioral therapy for insomnia (CBT-I) with sessions in a sauna blanket is feasible for adults with insomnia. Ten participants used an online CBT-I program and a sauna blanket at home for 9 weeks. The goal was to see if…

This study tested an online program called ORCHID that helps people with HIV feel more positive emotions. The goal was to see if it could reduce depression and improve HIV care. 29 adults from Chicago clinics took part. The program was designed to be used on a phone or computer.

This study tested whether pramipexole, a drug used for Parkinson's disease, can help people with depression who still have trouble feeling pleasure or motivation despite taking standard antidepressants. 85 adults with depression and significant anhedonia took either pramipexole o…

This study tested a version of cognitive behavioral therapy (CBT) that was adapted to fit the cultural background of Canadians of South Asian origin. Researchers worked with 146 adults who had depression or anxiety to see if this tailored therapy could help reduce their symptoms.…

This pilot study tested whether a single dose of a ketone drink could improve information processing and cognition in 28 people with schizophrenia or bipolar disorder. Participants drank either the ketone drink or a carbohydrate drink, then had brain wave tests, cognitive tasks, …

This study tested whether a single dose of the experimental drug zelquistinel (AGN-241751) can quickly improve depression symptoms compared to a placebo. 251 adults with major depressive disorder took either the drug or a dummy pill, and researchers measured mood changes using a …

This pilot study tested a remotely delivered self-management program called TEAM-Red for depressed young African American women who also have risk factors for high blood pressure. 83 women participated in group video sessions over 12 weeks, with researchers tracking changes in de…

This study looked at whether adding pramipexole (a drug used for Parkinson's) for 6 months can safely reduce anhedonia — the loss of pleasure or interest — in people with depression. 55 adults who had already been in a shorter trial took pramipexole alongside their usual treatmen…

This study tested whether a blend of online and in-person therapy (called blended CBT) works as well as standard face-to-face therapy for adults with major depression. 105 participants were randomly assigned to either blended CBT or usual care. Researchers measured depression sym…

This study tested a program that helps mothers with depression and their young children (ages 2-4) with behavior problems at the same time. The program combines parenting support with short videos to help moms cope with stress. Researchers wanted to see if treating both together …

This study tested a structured psychiatric nursing program for family caregivers of people with bipolar disorder. The program included education, stress management, and emotional support. Researchers measured changes in caregiver burden, resilience, and emotional well-being over …

This study tested a type of talk therapy called interpersonal psychotherapy (IPT) for women who became severely depressed after losing a baby during pregnancy or shortly after birth. About 199 women in Michigan took part. The goal was to see if IPT helps them recover from depress…

This study tested whether a program called PRISM (Promoting Resilience in Stress Management) could help young adults aged 18-39 who have cancer or desmoid tumors manage anxiety and depression. The program teaches skills like stress management, goal setting, and positive thinking.…

This study tested whether emotion-focused therapy (EFT) can improve mood awareness and reduce emotional reactivity in people with bipolar disorder. Fifty patients in remission took part, with half receiving six sessions of EFT plus standard care. The goal was to see if this thera…

This study tested a 5-week digital counseling program for 54 women who had a pregnancy loss within the past two months. The program focused on emotional support and coping skills. Researchers measured grief and stress levels before, right after, and up to 6 months later to see if…

This study tested whether an 8-week group therapy program called behavioral activation could help adults with depression in rural Vietnam. The program was delivered at local health stations by trained staff. Researchers measured changes in depression symptoms, distress, and quali…

This small study tested a new virtual reality (VR) therapy called VR-Moodboost in 12 teenagers and young adults with depression. The therapy focuses on increasing positive feelings, like joy and interest, rather than just reducing sadness. Over 12 weekly sessions, participants us…

This study tested a new, non-invasive treatment for major depression called transcranial photobiomodulation (tPBM), which uses near-infrared light on the scalp. Fifty adults with depression received either real light therapy or a sham treatment three times a week for six weeks. T…

This study tested a mindfulness-based program (including breathing exercises and meditation) in 39 Generation Z nursing students during their clinical internship. The goal was to see if it could improve mental health and reduce anxiety, depression, and stress compared to usual ca…

This study tested a program that combines counseling (behavioral activation) with medication adjustments to reduce depression and anxiety in adults aged 60 and older who were scheduled for hip or knee replacement surgery. 116 participants were randomly assigned to receive the pro…

This study looked at whether taking magnesium supplements alongside the antidepressant fluoxetine can improve cognitive function in adults with major depression. Forty participants took either fluoxetine plus magnesium or fluoxetine alone for six weeks. Researchers measured chang…

This study tested an experimental drug called AGN-241751 in 226 adults with major depressive disorder. Participants received either the drug or a placebo to see if it could quickly improve depression symptoms. The trial was completed and aimed to measure changes in mood using a s…

This study tested whether a low dose of interleukin-2 (IL-2), a protein that helps regulate the immune system, could improve depressive symptoms in people with bipolar disorder. Fourteen participants already on mood stabilizers received the treatment. The goal was to see if it in…

This study tested a computer program called BrainWorks that uses fun games to train thinking skills like memory, attention, and problem-solving. 72 adults with bipolar disorder and psychosis played these games over several sessions. Researchers measured changes in cognitive abili…

This study tested a therapy called Cognitive Behavioral Therapy for Work Success (CBTw) in 294 veterans with serious mental illness (like depression, bipolar disorder, or PTSD) who were unemployed. The goal was to help them find and keep competitive jobs, which can improve their …

This study tested whether giving primary care doctors access to an online cognitive behavior therapy program helps treat major depression in rural West Virginia and Kentucky. Over 1,200 adults participated. The goal was to see if remote therapy can improve depression remission ra…

This study tested a 9-week online mindfulness program for teens aged 12-17 with anxiety or depression. Half of the teens also had a parent or caregiver join the program. Researchers wanted to see if adding a caregiver improved the teen's symptoms. The study was very small (32 par…

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This study tested a new parenting program called ADAPT for depressed parents of children aged 6 to 10 with emotional and behavioral difficulties. The program combines emotion regulation skills with parenting techniques. The goal was to see if the program is feasible and acceptabl…

This study tested a new way of giving electroconvulsive therapy (ECT) for severe depression. The goal was to see if a different electrode placement on the head could reduce memory loss while still effectively treating depression. 156 adults with severe depression took part, recei…

This study tested whether a program called MindUP could help lower depression, anxiety, and stress in orphan teenagers in Pakistan. 61 boys aged 11-16 living in orphanages took part. Some did the MindUP program, which teaches mindfulness and emotional skills, while others did the…

This study tested whether progressive muscle relaxation (PMR) — a technique where you tense and then relax different muscle groups — could help nursing students feel less depressed, anxious, and stressed. Over 100 students were split into two groups; one group practiced PMR three…

This study tested whether a gentle electrical current applied to the scalp (tDCS) can reduce symptoms of major depression, schizophrenia, OCD, generalized anxiety, and insomnia. 320 adults aged 16–65 received multiple sessions over weeks. Researchers measured symptom changes usin…

This phase 2 trial tested four intravenous ketamine infusions over two weeks in 71 adults with treatment-resistant bipolar depression. Participants received either ketamine or a sedative (midazolam) to see if ketamine could quickly reduce depression symptoms. The study measured c…

This study tested whether installing special LED lights that mimic sunlight in hospital rooms could help treat depression and improve sleep. Fifteen adults with major depression participated. The goal was to see if the lights were comfortable and if they could reduce depression s…

This study followed 120 adults with bipolar I disorder who were having a major depressive episode and starting cariprazine (Vraylar). Researchers measured changes in depression symptoms, daily functioning, and quality of life over 24 weeks in a real-world clinic setting. The goal…

This pilot study tested whether time-restricted eating and blue-blocking glasses can help people with bipolar disorder during manic episodes. The goal was to see if these simple, drug-free approaches are feasible and safe for inpatients. Twenty-one participants were enrolled to t…

This study tested whether a single 60-minute session of a videogame called 'ACTing Minds' could improve mental health in 302 adults with mild to moderate depression, anxiety, or stress. The game is based on Acceptance and Commitment Therapy (ACT) and aims to increase psychologica…

This study tested whether adding aticaprant to a standard antidepressant helps adults with major depression who still feel little pleasure or interest (anhedonia). About 444 people took either aticaprant or a placebo pill for 6 weeks. The main goal was to see if depressive sympto…

This study tested whether personalizing transcranial magnetic stimulation (TMS) based on an individual's brain structure and activity could improve outcomes for people with treatment-resistant depression. 75 adults received 20 sessions over 4 weeks, comparing fully personalized T…

This study tested a collaborative care model for people with depression in general practice. 389 Danish-speaking adults with depression were randomly assigned to either collaborative care (involving a care manager and stepped treatments like therapy and medication) or standard co…

This pilot study tested a brief virtual mindfulness program called RECLAIM in 36 veterans who had difficulty adjusting to civilian life after service. The program aimed to reduce depressive symptoms and improve community reintegration. Participants completed questionnaires about …

This study tested a program called MOSAIC Plus for 15 pregnant women and mothers of young children who had experienced intimate partner violence and had symptoms of depression or PTSD. The program lasted 6 months and aimed to reduce those symptoms and prevent further violence. Th…

This study tested a text messaging program designed to reduce the risk of major depression in pregnant and postpartum women. The program sent tailored texts with links to videos and a chat feature where participants could talk with each other. The study included 40 women who were…

This study tested two types of online therapy for anxiety and depression in 2477 adults. Participants received either a cognitive behavioral treatment or a psychodynamic treatment, delivered over 8 or 16 weeks, with or without a support forum. The goal was to see which combinatio…

This study tested a 10-week, at-home cognitive training program for 9 veterans with major depression and a recent suicide attempt. The program aimed to improve decision-making and reduce depression through problem-solving exercises delivered via video calls. Early results suggest…

This study tested a short talking therapy called CALM for advanced cancer patients with depression. It involved 90 people in Korea and aimed to see if the therapy was practical and helpful. The therapy focuses on managing symptoms, relationships, and finding meaning.

This small pilot study tested whether cannabis oil (with different ratios of CBD to THC) could help with insomnia in people who also have major depression. Fourteen adults took either a high-CBD oil, a low-CBD oil, or a placebo for a short time. The main goal was to see if a larg…

This study tested whether an AI voice coach called Lumen can help adults with mild-to-moderate depression or anxiety. 200 participants were randomly assigned to receive problem-solving training from Lumen, a human coach, or a waitlist. The goal was to see if the AI coach could im…

This study tested a simple web-based platform called Adhere.ly to help therapists and their clients with therapy homework. 79 adults with anxiety or depression took part. The goal was to see if using the tool improved symptoms and quality of life compared to standard therapy alon…

This study tested an experimental drug called ABBV-932 in 161 adults with bipolar I or II disorder who were experiencing a depressive episode. Participants took either the drug or a placebo daily for 6 weeks. Researchers measured changes in depression symptoms using standard rati…

This study looked at whether doing Zumba for 10 weeks could help reduce anxiety and depression in healthy adults aged 40 to 65. Forty people were split into two groups: one did Zumba three times a week, and the other continued their normal routine. Researchers measured mood befor…

This study tested a therapist-guided online program called AMOR for pregnant women and new mothers with ADHD. 31 participants listened to podcasts and attended online group sessions. The goal was to see if the program was easy to use and helpful for managing ADHD, stress, anxiety…

This Phase 3 trial tested whether solriamfetol, a drug used for sleepiness, can safely ease depression symptoms in adults with major depressive disorder. 346 participants received either solriamfetol or a placebo daily. Researchers measured changes in depression scores and tracke…

This early-stage trial tested the safety and tolerability of a new drug called NH102 in 40 healthy adults. Participants received either the drug or a placebo to check for side effects and how the drug moves through the body. The study is complete, but it does not yet test if NH10…

This study tested a type of brain stimulation called theta burst stimulation (TBS) to see if it could reduce depression symptoms. 21 adults with current depression received the treatment, and some also got positive affect training. The main goal was to measure changes in depressi…

This study tested whether daily smell training over 12 weeks can improve mood and smell perception in 150 people with mild depressive symptoms or major depression. Participants practiced smelling different odors each day. Researchers measured changes in smell ability and emotiona…

This study tested a 10-session therapy program delivered by phone or video to help adults with moderate-to-severe depression become more physically active. The goal was to see if the program was practical and liked by participants, and if it could reduce depressive symptoms. 65 a…

This study tested a problem-solving program delivered by phone and online for Spanish-speaking caregivers of veterans who had a stroke. The program taught caregivers the COPE model (Creativity, Optimism, Planning, Expert Advice) to help them manage caregiving challenges. Research…

This study tested whether qigong relaxation exercises can lower anxiety and depression in adults hospitalized for depression. 70 patients participated in a randomized controlled trial. The goal was to see if adding qigong to standard care improves mood and reduces anxiety symptom…

This study tested whether a single dose of ketamine plus daily milnacipran can reduce depression in people with severe, progressive diseases. 42 participants in palliative care were split into two groups: one received the drug combo, the other a placebo plus milnacipran. The goal…

This pilot study tested whether pramipexole, a drug used for Parkinson's disease, could help people with depression who struggle with anhedonia—the inability to feel pleasure or motivation. Thirteen adults with depression and significant anhedonia took pramipexole alongside their…

This study tested a short talk therapy called behavioral activation for veterans with traumatic brain injury (TBI) and depression. About 46 veterans took part, with some receiving the therapy plus usual care and others only usual care. The goal was to see if the therapy was pract…

This small pilot study tested whether a ketone ester drink combined with a low-glycemic diet could help people with bipolar disorder. Fifteen adults with bipolar I or II took the supplement twice daily and made simple diet changes for several weeks. Researchers measured blood ket…

This study tested a 4-week movement program called Dance-Walk in 117 adults seeking mental health support. Participants either started the program right away or waited. The goal was to see if combining dance and walking could improve body awareness, energy, and reduce stress, anx…

This study looked at whether two types of talk therapy—cognitive behavioral therapy (CBT) and relaxation training—could improve mood and thinking in people with relapsing-remitting multiple sclerosis. 140 participants with mild to moderate disability were randomly assigned to one…

This study tested a program called Mood Lifters for college students. 125 undergraduates attended 14 weekly virtual meetings to learn mental health strategies. The goal was to see if this low-cost, peer-led approach could reduce symptoms of depression, anxiety, and stress. Resear…

This study tested whether repeated doses of ketamine, given through an IV, can safely and effectively reduce depression in people with Parkinson's disease. 51 adults aged 40-80 with both conditions took part. Researchers compared ketamine to a placebo and used brain scans to expl…

This study tested a program called PRISM that teaches stress management, goal-setting, and coping skills to adolescents and young adults (ages 12-24) with advanced cancer. Researchers wanted to see if it could improve quality of life and reduce anxiety and depression. The program…

This study tested a new medicine, NH102, to see if it helps with major depression. 243 adults with depression took part. The goal was to check if NH102 reduces symptoms like sad mood and sleep problems better than a placebo or an existing drug. The results will help design larger…

This study tested whether online group singing classes could help new mothers with postnatal depression feel better. 37 mothers with babies up to 9 months old joined 6 weekly online singing sessions. The goal was to see if singing together could reduce depression symptoms, especi…

This study tested whether virtual reality (VR) sessions can help reduce anxiety and depression in people aged 12 to 25 who do not want to take medication. Forty participants completed five weekly VR sessions focused on relaxation, coping skills, and healthy habits. Researchers me…

This study tested whether ketamine, a fast-acting drug, can reduce suicidal thoughts in teenagers more quickly than standard treatments. Fifty teens aged 13-18 who had recent suicidal events received either ketamine or midazolam twice weekly for two weeks, then were monitored for…

This study tested whether a one-hour dose of nitrous oxide (laughing gas) can quickly reduce depression symptoms in adults aged 60-90 whose depression hasn't improved with standard treatments. Sixty participants received either the gas or medical air, and their mood was tracked o…

This study tested a new way of using a non-invasive brain stimulation technique called tDCS (transcranial direct current stimulation) for people with treatment-resistant depression. The new approach uses a higher dose and more frequent sessions than usual. The study was very smal…

This study tested a new web app that uses cognitive behavioral therapy (CBT) to help people with depression and anxiety. Researchers wanted to see if the app was easy to use and helpful. 50 adults from low- and middle-income countries took part. The goal was to see if this digita…

This completed study tested whether regular, friendly phone calls from trained volunteers could improve mental health in older adults at risk of loneliness and suicide. Over 670 participants aged 55+ received weekly calls for 8 weeks. Researchers measured changes in loneliness, d…

This study tested a drug called aticaprant in 513 adults with major depression who still had symptoms—especially loss of interest or pleasure (anhedonia)—even after taking standard antidepressants. Participants took either aticaprant or a placebo pill alongside their usual antide…

This study tested whether a brief, personalized activity or care routine (called IPPI) is feasible for nursing home residents with dementia who also show signs of distress or depression. Care partners delivered two short sessions per week for six months. The goal was to see if th…

This study tested a new type of talk therapy that helps people aged 50 to 90 learn to change how they think about upsetting memories and feelings. The goal was to reduce the risk of suicide after a hospital stay for suicidal thoughts or a suicide attempt. 107 participants took pa…

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble reintegrating into civilian life. The workshop taught skills like emotional control, problem solving, and attention to improve daily function and reduce anger. It was designed as a non-stigma…

This study tested whether adding a smartphone app (CBT MobileWork-V) to standard cognitive behavioral therapy helps veterans with depression learn and use therapy skills better. Fifteen OEF/OIF/OND veterans with depression took part. The app was designed to make it easier to prac…

This study tested a program called SHARP-CG for older Black caregivers of people with dementia. Caregivers, their loved ones with dementia, and a support person walked together while using a tablet to look at old neighborhood photos and talk about memories. The goal was to see if…

This study looked at whether music therapy sessions could help people with depression feel better and become more resilient. 84 participants aged 8 to 70 with depression took part in weekly music therapy or wellness concerts for three months. Researchers measured changes in depre…

This study tested whether support from a peer mentor through video chats and texts could help reduce depression in older adults, especially those with low income or from ethnic minority groups. 34 participants aged 50 and older with mild depression took part in 8 weekly video cha…

This study tested whether training traditional birth attendants (village midwives) to provide basic mental health support could reduce depression in pregnant women in rural Kenya. 220 pregnant women with depression were enrolled. The approach used simple, proven counseling techni…

This study tested whether using virtual reality (VR) exposure therapy could prevent anxiety, depression, and PTSD in people recovering from a lung transplant in the ICU. 62 adults on the lung transplant waiting list participated. They used a VR headset to gradually get used to st…

This study tested whether coloring mandalas (circular patterns) could improve mood and quality of life for 51 adults hospitalized with depression and anxiety. Participants completed 8 guided coloring sessions over 3 weeks. Researchers measured changes in depression, anxiety, stre…

This study tested whether taking part in art activities (like painting, music, or dance) can improve mental well-being. 382 people with mental health issues such as anxiety, depression, or emotional disorders were randomly assigned to either an art program or a waitlist. The stud…

This study tested whether a gentle magnetic brain stimulation technique, called rTMS with theta-burst stimulation, can help treat depression in people over 60. Over 100 participants received either real or sham stimulation daily for about 4 weeks. The goal was to see if this non-…

This study tested a three-week program where healthy adults and people with depression or bipolar disorder did cognitive training inside a room with low oxygen (like being at 4,400 meters altitude). The goal was to see if the combination improves memory, attention, and executive …

This study tested whether an internet-based therapy program could help older adults with depression. 84 people with mild to moderate depression took part, using a computer or smartphone to complete therapy sessions. Researchers measured changes in mood and anxiety over two years …

This study looked at whether cognitive behavioral therapy (CBT) can help veterans with serious mental illnesses like schizophrenia or bipolar disorder manage chronic pain. 47 veterans took part in a 12-session CBT program designed for chronic pain. The goal was to see if the ther…

This pilot study tested whether a therapy that combines behavioral activation for depression with physical rehabilitation is feasible for survivors of acute respiratory failure. Fifty-two adults who had been on life support in the ICU received home visits and phone calls from the…

This study tested a new 8-session psychotherapy called ChronoS in 67 adults with mood disorders (bipolar or depression) and chronic insomnia. The therapy focuses on sleep-wake awareness and habits. Researchers measured changes in insomnia severity using a standard questionnaire. …

This study tested whether using a hand fan for 10 minutes daily over six weeks could reduce shortness of breath, anxiety, and depression in people with COPD. Fifty-nine patients from a hospital in Turkey took part, with half using the fan and half receiving standard care. The goa…

This study tested whether a type of brain stimulation called theta burst stimulation (TBS) can help people with major depression who haven't gotten enough relief from standard treatments. 238 adults with moderate to severe depression received either real TBS or a sham (fake) vers…

This study tested a free smartphone app called the Healthy Minds Program (HMP) in over 1,100 US adults with mild to moderate depression. Participants used the app for 4 weeks and were compared to those who received only educational content or were placed on a waitlist. The goal w…

This study tested whether personalized home visits by midwives during the first three months after birth can improve how new mothers function, their breastfeeding success, and their emotional resilience. 94 first-time mothers with healthy babies took part. The visits included edu…

This study tested whether daily omega-3 supplements (fish oil) can help reduce stress, anxiety, depression, and improve memory and sleep in 64 Saudi adults who reported high stress. Participants took either omega-3 or a placebo for three months. Those taking omega-3 reported lowe…

This study looked at how hormone changes during perimenopause (the time around menopause) might affect mood and behavior. Over 1,100 women participated, including those with depression symptoms and healthy volunteers. No treatments were given; instead, researchers used surveys an…

This study investigates how the brain's emotion network works by recording brain activity directly from the surface of the brain in people with epilepsy who are already undergoing surgery for seizure monitoring. Participants watch short video clips designed to trigger emotions li…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

Researchers at the University of California, San Francisco are studying how the brain processes rewards in people with early-onset schizophrenia, major depressive disorder, post-traumatic stress disorder, or gambling disorder, compared with healthy volunteers. Participants comple…

Researchers are studying whether immune and inflammatory markers in the blood relate to mood, fatigue, and thinking symptoms in people with major depression. The trial follows 30 adults starting SSRI antidepressants and compares them with 20 healthy volunteers. Participants give …

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers are collecting DNA and health information from 4,185 adults to understand the genetic causes of the condition. The goal is to improve diagnosis and treatment in the future, but th…

Researchers want to know whether people with depression spend more time looking at their own reflection after recalling a personal failure. The study uses an eye tracker to measure where participants look on a reflective black screen before and after a directed autobiographical r…

This trial tests whether a single session of transcranial magnetic stimulation (TMS) can alter brain activity related to reward processing in people with major depressive disorder. Researchers will compare active TMS to a sham (inactive) version, measuring brain signals during a …

This observational study examines how the brain processes rewards in people with major depressive disorder compared to those without. Using MRI and EEG, researchers measure brain responses during reward anticipation and feedback. The goal is to identify distinct neural patterns, …

This study used brain scans to look at two things in people with depression or bipolar disorder: a glutamate receptor called mGluR5 and the density of connections between brain cells (synapses). Researchers compared 120 participants, including healthy volunteers, using PET and MR…

This pilot study is testing a program called Tiwahe Tewichaglapi, which adapts the Family Acceptance Project for Lakota 2SLGBTQ+ youth and their caregivers. The goal is to see if the program is acceptable, safe, and feasible, and to check if it helps reduce depression, anxiety, a…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This study tests whether brain scans and decision-making tasks can predict how well people with anxiety and depression respond to different types of talk therapy. Participants will be randomly assigned to one of three therapies: behavioral activation, exposure-based therapy, or s…

This observational study looks at whether voice characteristics can be linked to symptoms of depression and anxiety. Researchers will analyze voice recordings and mental health questionnaires from people who used the Kintsugi Voice Journaling app. The goal is to see if voice biom…

This study looks at women who have had bariatric (weight-loss) surgery and later given birth. It aims to understand if these women face higher rates of depression or anxiety after childbirth, and how their weight and nutrition change during this time. By tracking these factors, r…

This study aims to understand how common depression and anxiety are among parents involved with Swedish child welfare services due to child maltreatment or other family risks. Parents will fill out questionnaires about their symptoms and background. The results will be compared w…

This study tests a new approach called the Collaboration-Screening-Referral (SSH) model, which aims to identify parents involved with child welfare services who may have depression or anxiety. Social workers will be trained to use screening questionnaires and refer parents to men…

This study tested a new digital tool called CBTpro that uses artificial intelligence to help therapists improve their skills in cognitive behavioral therapy for psychosis (CBTp). Over 600 participants, including therapists and their clients with conditions like schizophrenia or b…

This study tested whether an AI-powered smartwatch could help teenagers and young adults with mental health conditions stick to their medication schedule. Researchers compared medication adherence in 78 people who wore the watch to those who did not. The goal was to see if the wa…

This study looks at whether teaching people in the hospital about their psychiatric medications helps them stick to their treatment and handle side effects. Researchers will work with 64 adults who have serious mental illnesses like schizophrenia or bipolar disorder. The goal is …

This study looked at how a gentle nerve stimulation device (tVNS) affects stress-related brain activity and body functions in people with major depression. Researchers compared active stimulation to a sham (fake) version in 62 adults, focusing on differences between men and women…

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study tests whether a mild electrical brain stimulation technique called transcranial direct current stimulation (tDCS) can alter brain activity in adults with major depression. Using MRI to guide the stimulation, researchers will measure changes in brain connectivity and al…

This study investigates whether women who experience heavy bleeding (postpartum hemorrhage) after childbirth are more likely to develop depression, anxiety, or stress in the following year. Researchers will follow over 1,200 women who had a hemorrhage and compare them to those wh…

This completed study looked at how the brain processes reward signals to improve mood in people with depression. Researchers used brain scans, a mild magnetic stimulation technique (TMS), and a single injection of buprenorphine (a painkiller) to see how these affect brain activit…

This study tests an 8-week school program called INSPIRE, designed to help Indonesian teenagers aged 13-15 learn about mental health, build resilience, and reduce symptoms of depression and anxiety. Trained school counselors deliver the program using lesson plans and activities, …

This study aims to adapt and validate a French version of the PAPA questionnaire, a tool designed to screen for psychological distress in fathers during the perinatal period. Researchers will test the questionnaire with 343 couples to see if it accurately captures symptoms like a…

This pilot trial tests whether adding social contact — personal stories and interactions with people who have mental illness — to standard mental health training can reduce stigma among primary care workers in Nepal. About 88 healthcare providers and their patients will take part…

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study looked at 15 people with depression who experienced temporary dissociative states (feeling disconnected from reality) while taking Esketamine. Researchers used interviews to understand these experiences better. The goal is to learn more about this side effect to improv…

This study will measure how many women at a high-risk pregnancy clinic experience postpartum depression. Researchers will use a standard questionnaire called the Edinburgh Postnatal Depression Scale (EPDS) to screen 100 women who gave birth 4 weeks to 6 months ago. The goal is to…

This study aims to reduce the number of people with depression who do not receive treatment. It compares two approaches: one where people only get a brief psychological therapy at a health center, and another where they also receive community support to encourage them to seek and…

This completed study looked at how well a collaborative care model works for common mental health issues like anxiety and depression in four French health clinics. The model involves a care manager who coordinates between family doctors and mental health specialists. Researchers …

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This study looked at 30 adults aged 40-70 with treatment-resistant depression to see if changes in thinking skills (like memory and attention) could predict when depression improves. Researchers measured mood, daily function, and cognitive abilities before and after starting a ne…

This study looked at how adults with autism spectrum disorder (ASD) and bipolar disorder (BD) experience and show emotions. Researchers measured things like heart rate, pupil size, and facial expressions in a lab, and also tracked emotions in daily life for a week. The goal was t…

This study used brain scans (fMRI) to look at how people process emotions and make decisions, comparing those who have attempted suicide, those with past suicidal thoughts, depressed patients without suicidal history, and healthy controls. The goal was to find brain activity patt…

This study watched 60 adults getting electroconvulsive therapy (ECT) for severe depression to see if their need for anesthesia changed over multiple sessions. Researchers measured the dose of anesthetic used each time and how it related to seizure quality and recovery. No new tre…

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This pilot study tested a new type of brain training called neurofeedback for people with depression. Participants learned to control their own brain activity using real-time feedback from both EEG and fMRI scans. The goal was to see if combining these two methods could help impr…

This study follows couples who gave birth in either a midwifery-led birth unit or a standard obstetric unit in France. Researchers want to see if the type of care affects parents' mental health, especially post-traumatic stress, and the child's development up to two years later. …

This study looked at whether listening to upbeat music can change how people with depression perceive emotions in faces and voices. Researchers compared the effects of positive and neutral music in 39 adults with and without depression. The goal was to see if positive music could…

This study tested whether daily mood check-ins via a mobile app could help predict and prevent depression in people who recently had a stroke. Over 400 participants used the app for three months while researchers tracked their emotional symptoms. The goal was to see if this kind …

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study used MRI brain scans and computer tasks to understand how people who attempted suicide make decisions. Researchers compared three groups: those who used violent means, those who used non-violent means, and healthy volunteers. The goal was to find brain activity pattern…

This study looked at 62 children with cerebral palsy (ages 2-18) and their primary caregivers to understand how the children's sleep problems relate to caregiver burden and mental health. Researchers used questionnaires to measure sleep quality in both children and caregivers, al…

This study tested an 8-week parenting program called Circle of Security-Parenting for mothers with depression and infants showing signs of social withdrawal. Researchers compared it to standard care to see if it improves how mothers interact with their babies and helps the child'…

This study looked at 92 adults aged 55 and older with major depression to see if their brains had amyloid plaques, which are linked to Alzheimer's disease. Researchers used a special PET scan to measure plaque levels after 8 weeks of antidepressant treatment. The goal was to unde…

This study aimed to create a better way to measure apathy—a lack of motivation and goal-directed behavior—in people with brain diseases like frontotemporal dementia and depression. Researchers used video recordings and body sensors to track behaviors in a real-life setting. 66 he…

This study looked at 56 adults with fully remitted depression who wanted to stop their antidepressant. Researchers wanted to see how much of the withdrawal symptoms are caused by the drug itself versus the person's expectations. Participants were randomly assigned to either stop …

This study tested whether a smartphone app that tracks how you type (speed, backspace use, autocorrect) can help monitor mood and thinking problems in people with mood disorders like depression or bipolar disorder. 132 adults aged 25-50 took part. The goal was to see if this simp…

This study interviewed 12 mothers who had participated in HUGS mother-baby therapy groups for postpartum depression. The goal was to understand how the program affected their bond with their baby and their daily lives, 6 to 12 months later. Researchers used in-depth interviews to…

This study tested whether smartphone notifications could improve mood, physical activity, and sleep in over 1,000 medical interns. Participants received daily mood, activity, or sleep notifications through a mobile app. The study measured mood scores, step counts, sleep duration,…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This completed study used fMRI brain scans to understand how people with major depression can disengage from negative thinking. Researchers analyzed brain activity patterns during different thinking states in 89 participants. The goal was to identify the neural circuits involved …

This study looked at 545 people with major depressive disorder who also have anhedonia (loss of interest or pleasure) and whose current antidepressants weren't working well enough. Researchers tracked their symptoms, treatments, and outcomes to better understand the disease and h…

This study looked at how children ages 8 to 17 use smartphones and tablets, including social media and games, and how that relates to their mental health, sleep, and physical activity. Over 900 children and their parents used the Aura app and completed surveys for three months. T…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This Norwegian study followed 169 elderly patients with depression for three years to see how they fared after specialist treatment. Researchers tracked whether depression returned or became chronic, and also checked for signs of dementia. The goal was to better understand the lo…

This completed study tested whether noninvasive brain stimulation can be personalized by measuring heart rate responses. Researchers mapped the scalp to find the best spot for stimulation in 34 healthy participants and people with depression, anxiety, and gut issues. They compare…

This study tested a simple program to help new mothers who are at higher risk for health problems after giving birth. 220 Black mothers who delivered at the Hospital of the University of Pennsylvania took part. Some received a helpful pamphlet and a patient navigator they could c…

This completed study followed 509 children aged 3 to 18 who were taking risperidone or aripiprazole for conditions like schizophrenia or bipolar disorder. Researchers measured weight changes over up to 50 months to understand long-term risks. The goal was to provide better safety…

This study tested how low (1 Hz) and high (20 Hz) frequency repetitive transcranial magnetic stimulation (rTMS) changes brain activity in 30 healthy adults. Participants received both types of stimulation in separate sessions, and their brain waves were measured before and after.…

This study looked at how keeping a diary helps parents and healthcare workers deal with the stress of having a baby in the neonatal unit. Fifteen parents of premature or low-weight babies and hospital staff took part. Researchers analyzed the diaries to understand emotions, stres…

This study looked at whether genetic testing can help doctors choose better medicines for depression, acute pain, and chronic pain. Over 4,000 people were screened to join one of three trials. The goal was to see if matching drugs to a person's genes improves outcomes compared to…

This study tested a program called NAVIGATE, which provides coordinated care for youth and young adults (ages 14-35) who have had a first episode of psychosis. The goal was to see if NAVIGATE helps improve recovery, reduce hospital stays, and lower healthcare costs compared to st…

This study looked at anhedonia, a symptom of depression where people lose interest or pleasure in activities. Researchers used brain scans, blood tests, and questionnaires to understand this symptom in 123 young people. Some participants also tried treatments like brain stimulati…

This study tested a modified behavioral parent training program for children with ADHD who also have peer problems. The program aimed to increase parent engagement, especially for parents with their own ADHD or depression symptoms. Thirty-three parents participated, and researche…

This study tested whether a generic selegiline skin patch works the same as the brand-name EMSAM patch. Twelve healthy adults wore both patches to measure how much drug got into their blood and to check for skin irritation. The goal was to see if the generic version is a safe and…

This pilot study looked at whether giving donor human milk instead of formula to full-term babies whose mothers received antibiotics during labor could improve their gut bacteria and health. The study included 105 infants born vaginally at full term. Researchers compared the babi…

This completed study surveyed 3,100 adults in Slovakia to find out how many people have mental disorders like depression, anxiety, PTSD, or addiction. Researchers used a standard interview tool to measure current and lifetime rates, and looked at who gets help and who doesn't. Th…

This pilot study tested an automated phone system called 'My Coach Connect' for people with chronic mental illness. Participants called in twice a week to answer questions about how they were doing. The goal was to see if the system was easy to use and helpful for both patients a…

This study tested whether combining mental health treatment with job coaching helps people on sick leave due to anxiety, depression, stress, personality disorders, or functional disorders return to work. 900 participants in Denmark received either the combined service or usual ca…

This study looked at 206 medical residents in France to see if their physical activity levels are linked to anxiety, depression, and burnout. Participants filled out online surveys about their exercise habits and mental health. The goal is to understand whether staying active mig…

This study looked at how social factors like income, housing, and stress, along with depression, affect blood vessel health in low-income racial and ethnic minority adults. Researchers measured depression, anxiety, stress, and social needs using questionnaires. The goal was to un…

This study used functional MRI to look at brain activity in people with bipolar disorder while they performed tasks involving language and meaning. The goal was to better understand why some patients experience disorganized thinking or speech. 79 participants took part, including…

This study looked at how people with current depression, those who have recovered from depression, and healthy people react physically to emotions. Researchers measured heart rate, breathing, skin sweat, and brain blood flow during emotional tasks. The goal was to understand diff…

This study tested whether keeping a hospital diary during a child's stay in the pediatric intensive care unit (PICU) could improve mental health outcomes for families. Over 400 families participated across four PICUs in Rio de Janeiro. Researchers measured anxiety, depression, PT…

This study tested a program called Collaborative Decision Skills Training (CDST) to help veterans with serious mental illness (like schizophrenia or major depression with psychosis) work more closely with their doctors in making treatment decisions. The program involved eight wee…

This completed study looked at 175 people with both coronary heart disease and depression. Researchers measured depression severity and heart risk markers to understand which symptoms, like fatigue and loss of interest, might be linked to worse heart outcomes. The goal is to find…

This study aimed to find biological markers in blood, urine, and saliva that could help explain why up to 40% of people with depression do not respond to standard antidepressants. Researchers analyzed samples from 50 adults with major depression who had not taken antidepressants …

This study looks at 125 patients who were in the ICU, on a breathing machine and sedated for at least 48 hours. Researchers want to see how many have trouble with thinking or memory four months after leaving the hospital. Patients will talk to a psychologist before leaving the IC…

This study looked at how people aged 15-45 with early psychosis process information about their surroundings, called state representation. Researchers tested two types of cognitive training and measured changes in thinking and brain activity using computer tasks and scans. The go…

This study looked at how young adults with bipolar disorder respond to alcohol compared to healthy people. Sixty participants aged 21-26 completed brain scans and surveys after drinking alcohol or a placebo. The goal was to understand differences in brain activity and feelings of…

This study looked at how inflammation affects feelings of pleasure and motivation in older adults (ages 60-80) with anxiety. Researchers used brain scans and computer tasks to measure reward responses. The goal was to better understand the link between anxiety, inflammation, and …

This study looked at whether giving doctors extra information from a blood test and genetics could help them choose better medications for people with depression. 79 adults with moderate to severe depression took part. Half of the doctors received this extra information, while th…

This completed study followed 1,290 adults with type 1 or type 2 diabetes for two years. Researchers tracked mental health issues like depression, anxiety, and eating problems alongside daily blood sugar levels using smartphone surveys and continuous glucose monitors. The goal wa…

This study looked at how the COVID-19 pandemic impacted the mental health of 501 nursing home workers in Occitanie, France. Researchers measured rates of post-traumatic stress disorder (PTSD), depression, and burnout using standard questionnaires. The goal was to understand how c…

This study looked at whether aerobic exercise can improve thinking skills and brain structure in older adults who have recovered from late-life depression. Forty-six participants aged 60 and older completed supervised exercise sessions over 6 months. Researchers measured changes …

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This study tested a community-based mental health screening and referral program for women aged 18-49 affected by floods in rural Pakistan. Trained health workers screened nearly 4,800 women for anxiety and depression, referred those with symptoms for counselling, and tracked how…

This study looked at how well people with bipolar I and bipolar II disorder recognize facial emotions compared to healthy individuals. Ten participants completed a facial emotion recognition test and questionnaires. The goal was to see if there are differences between the two bip…

This study looked at how stressful childhood experiences affect the ability of teens aged 12-15 with depression symptoms to learn a coping skill called cognitive restructuring. The skill helps teens notice and challenge negative thoughts. Researchers measured skill learning and r…

This completed study tested a tablet-based screening system for substance use, depression, and anxiety in over 10,000 HIV-positive adults during routine clinic visits. Patients who screened positive were offered behavioral treatments like motivational interviewing and cognitive b…

This study looked at how people aged 18-30 with early psychosis process information about their surroundings, compared to those without a psychiatric diagnosis. Participants completed computer-based tasks and cognitive training. The goal was to better understand thinking patterns…

This study looked at 48 adults with mood disorders and insomnia to see if a strong relationship with their therapist helped them get better results from a new type of therapy called ChronoS. The therapy combines sleep scheduling, mindfulness, and stress management. Researchers me…

This study tested whether group-based education classes for relatives of people with bipolar disorder could improve their mood stability and reduce stress. About 200 relatives participated, with half attending classes and half placed on a waiting list. The goal was to see if lear…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This completed study looked at how people aged 15-45 with early psychosis process information from their surroundings, compared to healthy young adults. Participants completed computer tasks and had their brain activity measured using EEG and MRI scans. The goal was to better und…

This completed study from the University of California, San Francisco enrolled 228 adults with major depression and healthy volunteers. Researchers measured blood levels of natural steroids, genetic markers, and gut bacteria before and after 8 weeks of standard SSRI treatment. Th…

This study followed 14 people who called a crisis hotline after terror attacks in Paris, London, Barcelona, and Strasbourg. Researchers asked them to rate how their symptoms changed over time. The goal was to understand what kind of help they needed.

This completed study interviewed 28 women with a history of bulimia or binge-eating disorder about their pregnancy and postpartum experiences. Researchers aimed to understand how these women cope with body changes and interact with healthcare services. The goal is to improve care…

This completed study looked at how depression affects the ability to recognize emotions in people with multiple sclerosis (MS). Researchers used EEG, heart rate monitoring, and questionnaires to compare emotion recognition in MS patients with and without depression, as well as he…

This study looked at whether certain proteins called beta-arrestins can predict how well people with major depression respond to the antidepressant venlafaxine (Effexor). Researchers followed 67 patients for three months, measuring their depression symptoms and checking blood sam…

This study looked at how healthy young adults (ages 18-35) suppress negative emotional memories. Researchers used EEG to track brain activity while participants performed memory-suppression tasks. The goal was to better understand the brain's natural ability to forget unpleasant …

This completed study compared smell abilities and brain scans between 240 people with bipolar disorder and healthy volunteers. Researchers tested odor threshold, discrimination, and identification to see if smell performance differs and relates to brain structure. The goal is to …