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Scientists use brain scans to unravel thought problems in bipolar disorder

NCT ID NCT02794129

Knowledge-focused Sponsor: CHU de Reims Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study used functional MRI to look at brain activity in people with bipolar disorder while they performed tasks involving language and meaning. The goal was to better understand why some patients experience disorganized thinking or speech. 79 participants took part, including both patients and healthy volunteers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help explain how thought disorders arise in bipolar disorder, potentially guiding future therapies.
What could go wrong
This is an observational imaging study with no treatment. Results may not directly translate to clinical practice or benefit patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

79 people

The number who actually took part.

Started

Aug 2013

Finished

Sep 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria BD patients : * Men or women, right-handed * diagnosis of type 1 bipolar disorder, according to the DSM-IV criteria * aged from 18 to 65 years-old * Native French speaker * Affiliated to the social security Healthy Controls (HC): * Men or women, right-handed * aged from 18 to 65 years-old * Native French speaker * Affiliated to the social security Exclusion criteria BD patients : * recent alcohol and/or drug abuse or dependence * significant general medical illness, including neurological disorders or head trauma * sensorial impairment (visual and/or hearing) * Contraindication to the use of MRI HC: * first-degree-relative history of bipolar disorder, schizophrenia or schizoaffective disorder according to DSM-IV * recent alcohol and/or drug abuse or dependence * significant general medical illness, including neurological disorders or head trauma * sensorial impairment (visual and/or hearing) * Contraindication to the use of MRI

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Conditions

The condition(s) this trial relates to.

bipolar disorder bipolar I disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bipolar disorder

Contacts and locations

Locations

  • Chu Reims

    Reims, 51092, France

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