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Sound waves target deep brain areas to fight depression

NCT ID NCT05147142

Symptom relief Sponsor: Ocean State Research Institute, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study explores whether low intensity focused ultrasound (LIFU) can safely change brain activity linked to depression and anxiety in 25 veterans. Participants receive LIFU during MRI scans, and researchers monitor for side effects and brain changes. The goal is to see if this technique could lead to new treatments for psychiatric disorders.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

25 people

The number who actually took part.

Started

Sep 2021

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

US military Veterans Inclusion Criteria: * Patients must meet DSM-5 criteria for major depressive disorder with and without anxiety symptoms * Patients must also be symptomatic (i.e. symptom severity above clinical thresholds using standard rating scales) and, if relevant, stable treatment(s) for \>6 weeks. Exclusion Criteria: * history of seizure disorder or serious neurologic illness including dementia * structural or neurologic abnormalities present or in close proximity to sonication site for patients (e.g., clinically significant calcification as might be observed in Fahr disease) * history of brain surgery, iv) pacemaker or implanted central nervous system device * greater than mild traumatic brain injury, or any head injury within sixty days of participation * greater than moderate alcohol or substance use disorders (last six months; excluding nicotine/caffeine) * active use or withdrawal from alcohol or substances (assessed via breathalyzer/urine testing as indicated) * metal in the head * impediment to vision, hearing and/or hand use likely to interfere with assessments * pregnant or lactating (assessed via pregnancy test) * unable to follow protocols * acute suicidality, defined as "Yes" on item 4 of the Columbia Suicide Severity Rating Scale (C-SSRS), (i.e., active suicidal ideation with some intent to act on thoughts), or any endorsement of item 5 (active ideation with specific plan and intent) or any actual, interrupted, aborted attempt or preparatory behavior within the past month. * symptom threshold considered in the "very severe" range using standard rating scales will be excluded.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression

Contacts and locations

Locations

  • VA Providence Healthcare System

    Providence, Rhode Island, 02908, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.