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Rewiring the brain: could neurofeedback break the loop of suicidal thoughts?

NCT ID NCT06481033

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 20, 2026 · Updated 3 times

Summary

This pilot study explores whether real-time fMRI neurofeedback can help veterans reduce suicide-specific rumination—the repetitive mental fixation on suicidal thoughts. Sixteen veterans will receive two brain-training sessions, learning to modulate activity in brain regions linked to rumination while receiving real-time feedback. The study primarily assesses feasibility and acceptability, with secondary measures tracking changes in rumination and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Real-time fMRI neurofeedback, a brain-training technique that shows veterans their own brain activity in real time to help them learn to control regions linked to rumination.
What this could lead to
If successful, this could lead to a new, non-invasive therapy that helps veterans break the cycle of repetitive suicidal thoughts, potentially reducing suicide risk.
What could go wrong
This is a small pilot study focused on feasibility, not proof of effectiveness. The technique may not work for everyone, and benefits might not last beyond the training sessions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Aug 2024

Finished

Apr 2026

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * U.S. military Veteran * negative pregnancy test on MRI scan days * score greater than or equal to 10 on the Suicide Rumination Scale * clinically stabilized on psychotropic medications * engaged in mental health care treatment * able to provide written, informed consent Exclusion Criteria: * no major medical or neurological disorders that could interfere with treatment * moderate or severe traumatic brain injury * current imminent suicide risk, as determined through psychiatric interview, responses to C-SSRS, and clinical judgment of the assessor * any current psychotic disorder * MRI contraindications * any substance use disorder for substances other than cannabis or alcohol (mild alcohol or cannabis use disorder does not exclude participants but moderate or severe alcohol or cannabis substance use disorder is disqualifying) * pregnant or trying to become pregnant

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder mood disorder Suicide

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression Mood disorders Suicide

Contacts and locations

Locations

  • James J. Peters VA Medical Center, Bronx, NY

    The Bronx, New York, 10468-3904, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.