Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New pill aims to lift depression in days, not weeks

NCT ID NCT06785012

Symptom relief Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 4 times

Summary

This study tests an experimental drug called JNJ-89495120 in 107 adults with major depression. The goal is to see if it can reduce depression symptoms faster than a placebo, with checks as early as day 2 and day 5. Participants take the drug alone (no other antidepressants) and are monitored for safety and mood changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

107 people

The number who actually took part.

Started

Dec 2024

Finished

Aug 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 64 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Primary psychiatric diagnosis of recurrent major depressive disorder, without psychotic features, based on clinical assessment using diagnostic and statistical manual of mental disorders (DSM)-5 criteria and confirmed with the mini international neuropsychiatric interview (MINI) * Participant had to have at least one previous major depressive disorder (MDD) episode prior to their current episode * Were first diagnosed with depression before the age of 55 * Are in a current episode of depression: Episode length must be at least 2 months but not longer than 24 months * Have taken 0, 1, or 2 treatments for depression in your current episode * Body mass index (BMI) within the range 18 to 35 kilograms per square meter (kg/m\^2) at screening Exclusion Criteria: * Treatment with vagus nerve stimulation (VNS), electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), or ketamine/esketamine within the current or past major depressive episodes * Current or past DSM-5 diagnosis of bipolar disorder, psychotic disorders, borderline personality disorder, antisocial personality disorder, or current obsessive-compulsive disorder * Post-traumatic stress disorder within the past three years of screening * Dementia, any dementing disease, intellectual disability, or neurocognitive disorder * History of Alcohol and Substance use disorders within 6 months of screening, with the exclusion of nicotine, caffeine, and mild cannabis use disorder, according to the MINI and Clinical Assessment * Known allergies, hypersensitivity, or intolerance to JNJ-89495120 or its excipients

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Depressive disorder, major are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depressive disorder, major

Contacts and locations

Locations

  • ATP Clinical Research

    Orange, California, 92866, United States

  • Accelerated Clinical Research Group LLC

    Snellville, Georgia, 30078, United States

  • Advanced Research Institute of Miami

    Homestead, Florida, 33030, United States

  • Alpine Research Organization

    Clinton, Utah, 84015, United States

  • Anderson Clinical Research

    Redlands, California, 92374, United States

  • Artemis Institute for Clinical Research

    San Diego, California, 92103, United States

  • Best Choice Medical and Research Service

    Pembroke Pines, Florida, 33024, United States

  • CBH Health

    Gaithersburg, Maryland, 20877, United States

  • CI Trials

    Bellflower, California, 90706, United States

  • Chandler Clinical Trials

    Chandler, Arizona, 85224, United States

  • Coastal Carolina Research Center

    North Charleston, South Carolina, 29405, United States

  • Core Clinical Research

    Everett, Washington, 98201, United States

  • DelRicht Research

    New Orleans, Louisiana, 70115, United States

  • Gulfcoast Medical Research Center

    Fort Myers, Florida, 33912, United States

  • Health Synergy Clinical Research

    West Palm Beach, Florida, 33407, United States

  • IMA Clinical Research PC Phoenix

    Phoenix, Arizona, 85012, United States

  • Indiana University IU Health

    Indianapolis, Indiana, 46202, United States

  • Inland Psychiatric Medical Group Inc

    Temecula, California, 92591, United States

  • Integrative Clinical Trials LLC

    Brooklyn, New York, 11229, United States

  • Interventional Psychiatry of Tampa Bay

    Tampa, Florida, 33629, United States

  • K2 Medical Research

    Maitland, Florida, 32751, United States

  • Lumos Clinical Research Center LLC

    San Jose, California, 95124, United States

  • Mountain View Clinical Research

    Denver, Colorado, 80209, United States

  • National Institute Of Clinical Research

    Garden Grove, California, 92844, United States

  • Noble Clinical Research

    Tucson, Arizona, 85704, United States

  • OSU Department of Psychiatry and Behavioral Health

    Columbus, Ohio, 43210, United States

  • Paradigm Research Professionals, LLC

    Oklahoma City, Oklahoma, 73116, United States

  • Patient Priority Clinical Sites LLC

    Cincinnati, Ohio, 45215, United States

  • Pharmax Research Clinic Inc

    Miami, Florida, 33126, United States

  • Revival Research Institute LLC

    McKinney, Texas, 75071, United States

  • Sunwise Clinical Research

    Walnut Creek, California, 94596, United States

  • Synexus Clinical Research US Inc

    Atlanta, Georgia, 30328, United States

  • Syrentis Clinical Research

    Santa Ana, California, 92705, United States

  • The Medici Medical Research

    Hollywood, Florida, 33021, United States

  • UAB Huntsville Regional Medical Campus

    Huntsville, Alabama, 35801, United States

  • University of Arizona

    Tucson, Arizona, 85724, United States

  • University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

  • University of Cincinnati

    Cincinnati, Ohio, 45219, United States

  • University of Massachusetts Medical School

    Worcester, Massachusetts, 01655, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • WR-Newport Beach

    Newport Beach, California, 92660, United States

  • Wake Research PRI Encino

    Encino, California, 91316, United States

  • Wellness Research Center

    Miami, Florida, 33135, United States

  • iResearch Atlanta LLC

    Decatur, Georgia, 30030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.