DEPRESSIVE DISORDER, MAJOR

This study tests whether adding a new drug called brenipatide to standard depression treatment can delay the return of major depressive symptoms. About 1000 adults with major depression who are already on stable medication will receive either brenipatide or a placebo as a shot, a…

This study tests a drug called seltorexant, taken with standard antidepressants, to see if it improves depression and sleep in people with major depression and insomnia. About 752 adults and elderly who haven't fully responded to their current antidepressant will receive either s…

This study tests whether a new drug called JNJ-89495120 can reduce depression symptoms better than a placebo. About 100 adults with major depressive disorder will take the drug or a placebo for a few days. The main goal is to see if symptoms improve within 5 days.

This study tests whether a new drug, seltorexant, can improve mood in people with major depression who also have trouble sleeping. About 600 adults will receive either the drug or a placebo for several weeks, then all can take the drug in an extended safety phase. The goal is to …

This study tests a new treatment called Prism for people with major depression who have lost interest or pleasure in activities (anhedonia). Prism is a software device that uses neurofeedback to train the brain's reward system. About 170 participants will receive either real Pris…

This study tests a new drug called mitizodone phosphate for people with major depression. About 600 adults will receive either the drug or a placebo for 8 weeks. The goal is to see if the drug reduces depression symptoms better than a placebo and to find the best dose.

This study tests a new method to dose repetitive transcranial magnetic stimulation (rTMS) for treating depression in people with spinal cord injury (SCI). Standard rTMS dosing requires thumb movement, which many with SCI cannot do. The study will enroll 24 adults with SCI and maj…

This study tests whether a nasal spray containing esketamine, given alongside standard care, can quickly reduce symptoms of major depression and suicidal thoughts in teenagers. About 258 adolescents with acute suicidal behavior will receive either the spray or a placebo. The main…

This study tests whether a new drug called (2R,6R)-HNK can quickly improve symptoms in adults with major depression that hasn't responded to other treatments. About 50 participants will receive four infusions of the drug and four of a placebo over several weeks, with their mood a…

This study tests two ways of using magnetic brain stimulation (called iTBS) to treat depression in teenagers who haven't gotten better with medication. One group gets three sessions a day for a few days, while the other gets one session daily for several weeks. The goal is to see…

This study tests whether adding roflumilast, an anti-inflammatory drug, to standard antidepressants can better reduce depression symptoms. About 60 adults with major depression who still have significant symptoms will take either roflumilast or a placebo for 8 weeks. The main goa…

This study tests whether using a bright light at home for 40 minutes each morning can help teenagers aged 13-17 with major depression. Participants are split into three groups: high-intensity light, medium-intensity light, or a dim red placebo light. The goal is to see if the the…

This study tests whether using a personalized brain scan to guide a non-invasive treatment called iTBS works better than the standard one-size-fits-all approach for people with major depression. 210 adults will receive 6 weeks of iTBS, with half getting the standard target and ha…

This study looks at how ketamine helps people with hard-to-treat depression and PTSD. Researchers will give participants ketamine with or without another drug called perampanel to see how it changes brain activity. The goal is to understand the brain processes behind ketamine's f…

This study explores how nitrous oxide (laughing gas) changes brain connections related to emotion and depression. About 50 people—half with treatment-resistant depression and half healthy—will inhale the gas or a placebo and get brain scans. The goal is to understand how the drug…

This study tests whether a virtual reality (VR) tool called bWell is practical and acceptable for people with major depression who have trouble with thinking and memory. Forty adults aged 19-55 will try the VR assessments and either cognitive training or VR scenes twice a week fo…

This study aims to find biological markers that can predict whether electroconvulsive therapy (ECT) will work for people with severe depression. Researchers will use brain scans, blood tests, and spinal fluid samples from 30 patients before and after ECT. The goal is to better un…

This study aims to find biological markers in the brain that can help diagnose major depression and predict how well a person will respond to treatment. Researchers will use MRI and EEG scans to monitor changes in the brain during transcranial magnetic stimulation (TMS) therapy. …

This study looks at how everyday physical activities (like walking to the bus) affect energy and mood in people with major depression. Researchers will use activity trackers and daily diaries to collect real-time data from 180 participants. The goal is to design personalized trea…

This study aims to understand sleep patterns in people with major depressive disorder, comparing those with moderate-to-severe insomnia to those with little or no insomnia. About 80 participants will wear a headband at home that records brain activity during sleep, and also fill …

This study is testing a new social skills training program designed to help veterans with serious mental illness (like schizophrenia, bipolar disorder, or PTSD) improve their work relationships and job success. About 20 veterans will take part in weekly group sessions and practic…

This study tests an experimental drug to see if it can change how the brain processes decisions involving reward or risk in people with major depression or anxiety disorders. Participants will undergo brain scans and complete behavioral tasks while taking the drug or a placebo. T…

This study looks at whether increasing dopamine can help with motivation and movement problems in people with major depression who have signs of inflammation. Researchers will give a dopamine-boosting drug or a placebo to 165 participants (depressed patients and healthy volunteer…