DEPRESSIVE DISORDER, MAJOR

This study aimed to test if a mild, non-invasive electrical brain stimulation could help people with severe depression that hasn't improved with at least five different antidepressant medications or other intensive treatments. Participants would have received either real or fake …

This study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' can help reduce symptoms of major depression. About 240 adults with depression will receive either a high dose, a low dose, or a placebo pill, all accompanied by therapy sessions …

This study is testing whether matching depression treatments to a person's specific symptoms works better than standard care. Researchers will first sort 150 adults with major depression into one of five subtypes, like trouble feeling pleasure or high anxiety. Then, half will get…

This study aimed to test whether an accelerated form of magnetic brain stimulation could quickly reduce suicidal thoughts in hospitalized patients with severe depression. Researchers wanted to see if delivering multiple short stimulation sessions per day over a few days could pro…

This Stanford University study is testing whether a faster form of non-invasive brain stimulation can help reduce depressive symptoms in people who have both borderline personality disorder (BPD) and depression. The study compares real magnetic stimulation targeted at two differe…

This study observes 545 adults with major depression who still feel significant sadness and lack of pleasure (anhedonia) despite taking common antidepressants. Researchers will track what treatments doctors try next in real-world settings and monitor how patients' symptoms and da…

This study aimed to understand how a gentle, non-invasive ultrasound technique affects brain activity related to emotions and thinking in healthy volunteers. Researchers planned to use brain scans to see if the ultrasound could safely change activity in areas linked to mood. The …

This research project aims to understand the genetic and biological roots of serious mental health conditions like major depression, bipolar disorder, and psychotic disorders. It involves collecting DNA, brain scans, and detailed health information from 2,000 participants, includ…