Depressive disorder, major
Clinical trials for Depressive disorder, major explained in plain language.
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Matching depression treatment to your symptoms: a smarter approach?
Disease control By invitation onlyThis study tests whether choosing depression treatments based on a person's specific symptoms (like anhedonia or anxious distress) works better than the usual trial-and-error method. 150 adults with major depressive disorder will receive either standard care or a treatment matche…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase 4 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jun 26, 2026 13:50 UTC
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Magic mushroom compound psilocybin tested in major depression trial
Symptom relief OngoingThis Phase 3 study tests whether a single 25 mg dose of synthetic psilocybin can reduce depression symptoms in 238 adults with major depressive disorder. Participants receive either psilocybin or a placebo, and their depression severity is measured over 43 days. The trial also lo…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase 3 • Sponsor: Usona Institute • Aim: Symptom relief
Last updated Jul 25, 2026 00:00 UTC
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Zapped away blues? study of brain stimulation for tough depression pulled
Symptom relief CancelledThis study aimed to see if a mild electrical current applied to the scalp (transcranial direct current stimulation) could help people with severe depression that didn't improve after at least five treatments or electroconvulsive therapy. Participants would have received 30 sessio…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Depression dose study pulled before starting
Knowledge-focused CancelledThis study aimed to see if measuring sertraline (Zoloft) levels in the blood and checking a specific gene (CYP2C19) could help doctors give the right dose to people with major depression. The goal was to reduce side effects and improve treatment. However, the study was withdrawn …
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Sponsor: University of Belgrade • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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Shock therapy vs. pills: which depression treatment wins on cost?
Knowledge-focused OngoingThis study looks at two treatments for severe depression: electroconvulsive therapy (ECT) and antidepressant medication. Researchers want to see which one works better and is more cost-effective in the long run. The study involves 220 adults in the Netherlands who have not gotten…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Sponsor: Radboud University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Ultrasound brain probe study pulled before it began
Knowledge-focused CancelledThis study was designed to see if low-intensity focused ultrasound could safely change brain activity related to emotion and thinking. It planned to test the device on healthy volunteers using brain scans. However, the study was withdrawn before enrolling any participants, so no …
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Sponsor: The University of Texas Health Science Center, Houston • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Massive study aims to unlock secrets of depression, bipolar, and psychosis
Knowledge-focused By invitation onlyThis study is collecting DNA, brain scans, and other biological samples from 2,000 people with major depression, bipolar disorder, or psychotic disorders, as well as healthy volunteers. The goal is to better understand the physical and genetic factors behind these conditions, whi…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Sponsor: Vanderbilt University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Brain zaps for suicide prevention? study pulled before starting
Knowledge-focused CancelledThis study aimed to see if a fast-acting form of brain stimulation (called accelerated TMS) could change brain activity linked to suicidal thinking in adults hospitalized for major depression. The researchers planned to measure changes in suicidal thoughts using a standard questi…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC