DEPRESSIVE DISORDER, MAJOR

This study tests whether a fast form of brain stimulation, called accelerated intermittent theta-burst stimulation (aiTBS), can help ease depression in people with borderline personality disorder (BPD). About 45 adults will receive either real or fake (sham) stimulation to see if…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can safely reduce depression symptoms in adults with major depressive disorder. About 238 participants will receive either 25 mg, 5 mg, or a placebo. The main goal is to measure change…

This study aimed to see if a mild electrical brain stimulation (tDCS) could help people with severe depression that didn't improve after at least five treatments. Participants would have received 30 sessions over six weeks, either real or fake stimulation, alongside their usual c…

This study tests whether adding the anti-inflammatory drug celecoxib to standard depression treatment helps people with a specific type of depression linked to inflammation and energy-related symptoms like fatigue and weight gain. About 140 adults with this depression subtype wil…

This study aims to collect DNA, brain images, and other biological samples from 2,000 people with major depression, bipolar disorder, or psychotic disorders, as well as healthy volunteers. By analyzing these samples, researchers hope to find physical and genetic factors that can …

This study aimed to see if low-intensity focused ultrasound could safely change brain activity related to emotions in healthy people. Researchers planned to use brain scans to measure effects. However, the study was withdrawn before any participants were enrolled, so no results a…

This study aimed to test a fast-acting brain stimulation method (accelerated theta-burst stimulation) on suicidal thinking in people hospitalized with major depression. It was withdrawn before any participants enrolled, so no results or conclusions are available. The goal was to …

This study planned to check if measuring sertraline levels in the blood and looking at a specific gene (CYP2C19) could help doctors give the right dose to people with major depression. It aimed to find out how many patients get too much or too little medicine with standard dosing…

This study tests whether choosing depression treatments based on a person's specific symptoms (like loss of pleasure or anxiety) works better than usual care. Researchers will enroll 150 adults with major depressive disorder. The goal is to see if this personalized approach leads…

This study looks at whether electroconvulsive therapy (ECT) or antidepressant medication is more cost-effective for treating severe major depression. Researchers will follow 220 adults in the Netherlands who have not gotten better with at least one antidepressant. The goal is to …