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Matching depression treatment to your symptoms: a smarter approach?

NCT ID NCT06580041

Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether choosing depression treatments based on a person's specific symptoms (like anhedonia or anxious distress) works better than the usual trial-and-error method. 150 adults with major depressive disorder will receive either standard care or a treatment matched to their symptom profile, including medications like pramipexole or behavioral therapies. The goal is to see if personalized treatment leads to greater improvement in depressive symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pramipexole, methylphenidate, phenelzine, mindfulness-based stress sensitivity therapy, complicated grief treatment
What this could lead to
If successful, this could show that choosing treatments based on a person's specific depression symptoms leads to better outcomes than standard trial-and-error approaches.
What could go wrong
This is a relatively small, early-phase study (150 people) at a single site, so results may not apply to everyone. The approach may not prove superior to usual care, and some medications have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant is able to provide informed consent * English speaker * 18 years of age or older at time of consent * Meets DSM-5 criteria for Major Depressive Disorder * The subject meets eligibility criteria for at least one study phenotype as determined by assessments, imaging and/or clinical judgment. * PHQ-8 score at baseline of \>= 10 * Scheduled for or completed intake in UCSF outpatient psychiatry Exclusion Criteria: * Unstable or untreated medical or psychiatric condition based on clinical assessment by investigator(s) * Significant risk of suicidal or violent behavior as determined by clinical judgement * In the Investigators' opinion, the subject is not capable of adhering to the protocol requirements, or the subject has a history of poor or suspected poor compliance in clinical research studies, or the subject has a history of poor or suspected poor compliance to antidepressant medication or that study participation is not in their best interest (e.g., different treatment is indicated given their clinical presentation) * Pregnant or breastfeeding or planning to become pregnant during the study

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression Depressive disorder, major Major depressive disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Nancy Friend Pritzker Psychiatry Building, University of California, San Francisco

    San Francisco, California, 94107, United States

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