DEPRESSIVE DISORDER, MAJOR
Clinical trials for DEPRESSIVE DISORDER, MAJOR explained in plain language.
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Depression relapse prevention drug study ends early
Disease control TerminatedThis study tested whether adding the drug aticaprant to standard antidepressant therapy could prevent depression from returning in people with major depressive disorder who also experience a loss of interest and pleasure (anhedonia). The study was terminated early and involved 47…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: PHASE3 • Sponsor: Janssen Research & Development, LLC • Aim: Disease control
Last updated May 22, 2026 13:54 UTC
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New combo therapy for stubborn depression shows promise
Symptom relief TerminatedThis study tested whether adding a type of talk therapy (behavioral activation) to esketamine treatment helps people with depression that hasn't improved with other treatments. The goal was to help patients build positive habits while the medication improved their mood. The study…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: NA • Sponsor: The Royal's Institute of Mental Health Research • Aim: Symptom relief
Last updated May 26, 2026 06:29 UTC
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New hope for Depression's 'Empty Feeling'? trial ends early
Symptom relief TerminatedThis study tested a drug called aticaprant added to standard antidepressants for people with major depression who still feel no pleasure or interest (anhedonia). The trial was stopped early, but researchers wanted to see if aticaprant could improve mood and pleasure more than a p…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: PHASE3 • Sponsor: Janssen Research & Development, LLC • Aim: Symptom relief
Last updated May 26, 2026 06:25 UTC
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Depression drug study halted: aticaprant safety trial ends early
Symptom relief TerminatedThis study looked at the long-term safety of adding aticaprant to standard antidepressants for adults with major depressive disorder. About 871 people were planned to take part, but the trial was stopped early. The main goal was to track side effects and other safety measures ove…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: PHASE3 • Sponsor: Janssen Research & Development, LLC • Aim: Symptom relief
Last updated May 26, 2026 06:18 UTC