DEPRESSIVE DISORDER, MAJOR
Clinical trials for DEPRESSIVE DISORDER, MAJOR explained in plain language.
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New hope for tough depression: boosting a Fast-Acting drug with talk therapy
Disease control TerminatedThis study tested whether combining a fast-acting antidepressant nasal spray (esketamine) with a specific type of talk therapy (Behavioral Activation) works better than the spray alone for people with hard-to-treat depression. The goal was to see if the therapy, done while the dr…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: NA • Sponsor: The Royal's Institute of Mental Health Research • Aim: Disease control
Last updated Apr 03, 2026 14:41 UTC
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Halted trial tests new drug to keep depression at bay
Disease control TerminatedThis study tested whether adding a new drug called aticaprant to standard antidepressants could help prevent depression from coming back in people who had recently gotten better. It focused on people whose depression includes a severe loss of interest and pleasure in life. The tr…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: PHASE3 • Sponsor: Janssen Research & Development, LLC • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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New drug aims to restore joy for those whose depression resists treatment
Symptom relief TerminatedThis study tested whether adding an experimental drug called aticaprant to a person's current antidepressant could better treat major depression, specifically for people who struggle with severe anhedonia—the inability to feel pleasure. It involved 101 adults whose depression had…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: PHASE3 • Sponsor: Janssen Research & Development, LLC • Aim: Symptom relief
Last updated Mar 24, 2026 12:02 UTC