DEPRESSIVE DISORDER, MAJOR

This study followed 183 adults with treatment-resistant major depression who had already been using esketamine nasal spray for 32 weeks. The goal was to check the long-term safety and side effects of continuing the spray along with standard antidepressants. Participants were moni…

This small study tested whether cannabis oil can improve sleep in people with major depression and insomnia. 14 adults took part. The goal was to see if a larger study is possible and to compare different types of cannabis oil. The study is now complete.

This study tested whether a single 25 mg dose of psilocybin (the active ingredient in magic mushrooms) could reduce depression symptoms in 347 adults with major depressive disorder. Participants received either psilocybin or an active placebo (niacin) and were followed for 43 day…

This study tested an experimental medicine called BI 1569912 in 243 adults aged 18–65 with major depressive disorder that didn't improve with prior treatments. Participants took either a placebo or one of three doses of the medicine daily for 6 weeks, while continuing their usual…

This study tested a drug called seltorexant in 588 adults with major depression and insomnia who were not fully helped by their current antidepressant. Participants took either seltorexant or a placebo pill alongside their regular antidepressant for about 6 weeks, with a longer s…

This study tested whether a new oral drug called zelquistinel can quickly improve mood in adults with major depression. 251 participants received either the drug or a placebo, and researchers measured depression symptoms using a standard rating scale. The main goal was to see if …

This study tested whether adding aticaprant to standard antidepressants helps adults with major depression who still feel little pleasure or interest (anhedonia). 444 participants received either aticaprant or a placebo pill for about 6 weeks. The main goal was to see if depressi…

This study tested a drug called aticaprant in 513 adults with major depression who still had symptoms—especially loss of interest or pleasure (anhedonia)—even after taking standard antidepressants. Participants took either aticaprant or a placebo pill alongside their usual antide…

This study tested a new, non-invasive light therapy called transcranial photobiomodulation (tPBM) for people with major depression. 50 adults received either active light or a sham treatment on their forehead three times a week for six weeks. The goal was to see if this light the…

This study explored whether daily training with different odors can improve both smell function and emotional well-being in people with mild depressive symptoms or major depression. Researchers enrolled 150 participants, including healthy volunteers and depressed patients, who pr…

This study tested if computer-based cognitive fitness activities could improve thinking and depression in 38 older adults who were already taking antidepressants. Participants did brain training exercises, and researchers measured changes in their mental flexibility, memory, and …

This study used brain scans (fMRI) to see how people with major depression think during different mental states. 89 adults had their brain activity recorded while they engaged in various thoughts, including negative thinking. The goal was to identify brain circuits involved in ge…

This study looked at information from nearly 10,000 people to understand which depression medications work best for different individuals. Researchers combined data from clinical trials and electronic health records to find patterns. The goal was to develop methods that help doct…

This study observed 545 adults with major depression and anhedonia (loss of interest or pleasure) who were not helped enough by their current antidepressants. Researchers tracked their personal and medical backgrounds, treatment patterns, and outcomes like sexual function and rel…