DEPRESSIVE DISORDER, MAJOR

This study followed 183 people with treatment-resistant depression for up to two years to check the long-term safety of esketamine nasal spray. Participants had already completed 32 weeks of treatment in a previous study and continued taking their regular antidepressant alongside…

This study tested whether adding a new daily pill called aticaprant to a person's current antidepressant could better treat major depression, specifically for people who experience a severe lack of pleasure (anhedonia). Over 500 adults who weren't getting enough benefit from thei…

This study tested whether computer-based brain training exercises could improve thinking skills and reduce depression in older adults who were already taking antidepressants. Researchers enrolled 38 older adults with mild to major depression, some with mild memory concerns, and r…

This study tested whether a non-invasive light therapy, delivered through a headset to the forehead, could help reduce symptoms of major depression. Fifty adults with depression were randomly assigned to receive either real light treatment at different settings or a fake (sham) t…

This study tested whether adding a new drug called aticaprant to a person's current antidepressant could help improve symptoms in adults with major depression who also experience a severe loss of pleasure (anhedonia) and haven't gotten enough relief from their current medication.…

This study investigated whether daily smell training could improve mood and emotional perception in people with depressive symptoms. Researchers enrolled 150 participants, including both healthy individuals and those diagnosed with depression, to test if practicing with different…

This small, completed pilot study explored whether a cannabis-infused oil could help improve sleep for people with major depression who also have chronic insomnia. Fourteen participants were randomly assigned to receive either a placebo or one of two oil formulas with different C…