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Brain training device aims to restore pleasure in depressed patients

NCT ID NCT06982820

First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 29 times

Summary

This study tests a new treatment called Prism for people with major depression who have lost interest or pleasure in activities (anhedonia). Prism is a software device that uses neurofeedback to train the brain's reward system. About 170 participants will receive either real Prism therapy or a sham version to see if it improves mood and pleasure. The study uses MRI and EEG to measure brain activity.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Butler Hospital

    RECRUITING

    Providence, Rhode Island, 02906, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Houston Center For Advanced Psychiatric Treatment

    RECRUITING

    Houston, Texas, 77401, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sheba Medical Center

    RECRUITING

    Ramat Gan, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.