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Brain scans reveal link between depression and Alzheimer's plaques in seniors

NCT ID NCT01962753

Knowledge-focused Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 92 adults aged 55 and older with major depression to see if their brains had amyloid plaques, which are linked to Alzheimer's disease. Researchers used a special PET scan to measure plaque levels after 8 weeks of antidepressant treatment. The goal was to understand how depression and these brain changes are connected, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

92 people

The number who actually took part.

Started

May 2012

Finished

Jan 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Adult 55 years or older * Native language : french * Study period \> 7 years * Major depression defined on the DSM-IV criteria assessed by MINI and HDRS score of 10 or over * Affiliation to the national health insurance system * Signed informed consent Exclusion Criteria * History of alcoholism or drug addiction * MMSE less than or equal to 17 * Major depression with psychotic features * Depressive episode resistant, patient who received two different antidepressants well conducted without significant therapeutic response * Any current or past episode of mania, schizophrenia or any other psychotic disorder * Any past history of stroke or Parkinson's disease * Any current significant unstable illness * Any past diagnosis of Alzheimer's disease * Any current treatment by AcethylCholinesterae inhibitor, memantine or antidepressant therapy. * Contraindications to MRI in patients with: 1. Metallic foreign body eye. 2. Any implanted electronic medical irremovably (pacemaker, neurostimulator, cochlear implants ...) 3. Metal heart valve, 4. Vascular clips formerly located on cranial aneurysm. * Contraindications to antidepressants * History of progressive disease that can affect the central nervous system such as uncontrolled diabetes, blood pressure greater than or equal to 180/100; chronic lung disease with hypoxia, head trauma with loss of consciousness greater than or equal to 15 minutes; brain surgery, encephalitis, recently treated cancer (\<1 year), altered cerebral metabolism including subjects with stroke sequelae extended. Patients with lacunar stroke without thalamic or striatal may be included.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Elderly Major depression

Contacts and locations

Locations

  • Le Rouvray Hospital

    Sotteville-lès-Rouen, 76300, France

  • Sainte-Anne Hospital

    Paris, 75014, France

  • University Hospital of Besançon- Jean Minjoz

    Besançon, 25030, France

  • University Hospital of Caen

    Caen, 14000, France

  • University Hospital of Lille

    Lille, 59000, France

  • University Hospital of Nice

    Nice, 06000, France

  • University Hospital of Strasbourg - HUS

    Strasbourg, 67098, France

  • University Hospital of Toulouse - Purpan

    Toulouse, 31059, France

  • University Hospital of Tours

    Tours, 37000, France

  • University hospital of Rennes-Guillaume Régnier

    Rennes, 35000, France

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