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Brain plaques linked to depression in seniors?

NCT ID NCT01962753

First seen May 23, 2026 · Last updated May 23, 2026

Summary

This study looked at 92 adults aged 55 and older with major depression to see if their brains had amyloid plaques—sticky proteins linked to Alzheimer's. Researchers used a special PET scan to compare plaque levels in people whose depression got better, partly better, or didn't improve after 8 weeks of antidepressants. The goal was to understand connections between depression, thinking problems, and Alzheimer's risk, not to test a new treatment.

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Contacts and locations

Locations

  • Le Rouvray Hospital

    Sotteville-lès-Rouen, 76300, France

  • Sainte-Anne Hospital

    Paris, 75014, France

  • University Hospital of Besançon- Jean Minjoz

    Besançon, 25030, France

  • University Hospital of Caen

    Caen, 14000, France

  • University Hospital of Lille

    Lille, 59000, France

  • University Hospital of Nice

    Nice, 06000, France

  • University Hospital of Strasbourg - HUS

    Strasbourg, 67098, France

  • University Hospital of Toulouse - Purpan

    Toulouse, 31059, France

  • University Hospital of Tours

    Tours, 37000, France

  • University hospital of Rennes-Guillaume Régnier

    Rennes, 35000, France

Conditions

Explore the condition pages connected to this study.