University Hospital, Tours

This study tests whether giving extra fluids and a diuretic (furosemide) during laser kidney stone surgery helps flush out more stone fragments. About 374 adults needing this surgery will be randomly assigned to receive either the extra fluids plus furosemide or standard care. Th…

This study tests whether a structured diet and exercise program can increase lean muscle mass in adults with cystic fibrosis who are already taking the medication Trikafta. About 100 participants will be followed for 12 months. The goal is to improve muscle strength and overall h…

This study tests whether using a diuretic (water pill) as the second blood pressure medication, after an ACE inhibitor or ARB, works better than usual care for people with moderate to severe chronic kidney disease and uncontrolled high blood pressure. About 720 adults will take p…

This study looks at two common ways to start labor in pregnant women whose cervix hasn't softened enough after 24 hours of preparation. One method uses the hormone oxytocin, and the other uses a different hormone called prostaglandins. The goal is to see which approach leads to f…

This study tests whether serving food in easy-to-grip, bite-sized pieces (finger food) helps elderly residents in care homes eat more, gain weight, and enjoy meals more. Researchers will track weight, food intake, and independence in 30 participants aged 75 and older who are unde…

This study looks at how mucus in the airways of people with bronchiectasis (a chronic lung condition) affects a new inhaled antibody treatment. Researchers will collect sputum samples from 30 adults to test how well the antibodies can reach and bind to bacteria. The goal is to un…

This study looks at 100 sickle cell patients in intensive care who are receiving morphine for severe pain crises. Researchers want to see if faster kidney function (common in sickle cell disease) causes morphine to be cleared too quickly, leading to underdosing and poor pain cont…

This study aims to improve how doctors detect early Alzheimer's disease by testing a new memory assessment that considers personal and emotional aspects of memory. Researchers will enroll 150 adults aged 50 and older with mild memory problems. Participants will take the new test …

This study compares immune cells from 50 lupus patients with active disease to those with inactive disease. Researchers measure specific receptors on natural killer T cells and monocytes to understand how lupus flares. No new treatment is tested; the goal is to learn more about t…

This study looks at whether patients in the ICU with severe breathing problems can safely keep eating and drinking before they need a breathing tube, instead of fasting. Current practice is to fast, but this may cause discomfort and lack of nutrition without clear benefit. The st…