University Hospital, Tours

This study tested whether adding low-dose hydrocortisone (a steroid) to standard care could help people with severe community-acquired pneumonia survive. About 952 adults in intensive care took part. The goal was to see if the steroid reduced deaths within 28 days.

This study looked at whether adding methotrexate to adalimumab (a biologic) lowers the chance of the body making antibodies against adalimumab in people with ankylosing spondylitis, a type of arthritis affecting the spine. About 110 adults with active disease who did not respond …

This study looked at whether people with HIV who have a very low amount of virus in their body can safely switch from a three-drug regimen to a two-drug regimen. The goal is to keep the virus under control while reducing side effects and treatment costs. The study included 224 ad…

This study tested two ways to soften the cervix before inducing labor in women whose pregnancies lasted 41 weeks or longer. One method uses a medicine (Propess), the other uses a small balloon placed in the cervix. The goal was to see if the balloon method leads to fewer emergenc…

This study tested whether a systematic phone call from a medical student to patients with chronic heart or mental health conditions during the COVID-19 lockdown in France could reduce hospitalizations within one month. Over 22,000 patients aged 70 and older took part. The goal wa…

This study looked at whether people with a serious heart infection (endocarditis) caused by staph bacteria can safely switch from intravenous (IV) antibiotics to oral pills after an initial treatment period. 162 adults with left-sided heart infection were enrolled. The goal was t…

This study looked at whether using a continuous glucose monitor in real time could help manage low blood sugar in very low birth weight newborns. 48 babies were randomly assigned to either real-time monitoring or standard finger-prick testing during their first three days of life…

This study looked at 410 adults with infected hip or knee replacements. All had surgery to clean or replace the joint. Half got 6 weeks of antibiotics, the other half got 12 weeks. The goal was to see if the shorter treatment works just as well to cure the infection without it co…

This study tested whether the drug rituximab can help treat a type of kidney rejection called humoral acute rejection in people who had a kidney transplant within the past year. The trial included 40 adults and measured if the treatment prevented graft loss or improved kidney fun…

This study looked at 138 people with cirrhosis who needed a TIPS procedure to relieve complications of high blood pressure in the liver. Researchers compared two types of stents: a newer, more expensive covered stent and a traditional bare stent. The goal was to see if the covere…

This study looked at whether a chest ultrasound can find early signs of lung disease in people with systemic scleroderma, a condition that often leads to deadly lung scarring. Current methods like CT scans have drawbacks, so researchers tested ultrasound in 30 patients without kn…

This study tested whether a special ultrasound with contrast dye (CEUS) can accurately identify liver lesions found on regular ultrasound. Researchers compared CEUS to CT, MRI, and biopsy in 878 people. The goal was to see if CEUS could provide a reliable, non-invasive, and cheap…

This study looked at whether chemicals in tears and eye cells can help diagnose ALS, a disease that affects nerve cells. Researchers compared samples from 55 people with and without ALS. The goal was to find biomarkers that could lead to a simple, non-invasive test for earlier di…

This study looked at whether giving a written sheet to melanoma patients, to pass on to their close relatives, helps those relatives see a doctor for a skin check. About 420 patients and their relatives took part. The goal was to see if the written advice works better than just t…

This study tested whether taking a single dose of antibiotics once a week, rotating between two different drugs, could prevent urinary tract infections (UTIs) in adults with neurogenic bladder (a bladder that doesn't work normally due to nerve damage). Participants had at least 4…

This study tested whether taking low-dose aspirin (160 mg) at bedtime, starting early in pregnancy (before 16 weeks), could prevent pre-eclampsia and low birth weight in first-time mothers at high risk. Over 1,100 women with abnormal blood flow in the uterine artery participated.…

This study tested whether giving an inhaled antibiotic (amikacin) for three days could prevent ventilator-associated pneumonia (VAP) in ICU patients. 850 adults on breathing machines for at least 3 days received either the drug or a placebo. The goal was to see if the treatment r…

This study tested if giving a common breathing medicine (salbutamol) through a high-flow nasal system works as well as the usual mask method for people with COPD. 25 adults with COPD took part. The goal was to see if the new method could improve lung function similarly to the sta…

This study tested whether a phone-based cognitive behavioral therapy (Tele-CBT) program could help people with severe or morbid obesity reduce food addiction. 154 adults with a BMI of 35 or higher and diagnosed food addiction took part. The intervention group received 12 phone th…

This study looked at 69 people with rheumatoid arthritis taking the drug adalimumab (Humira). Researchers measured drug levels in the blood over 6 months to see if they could predict how well the treatment would work. The goal was to find a way to adjust doses early, improving re…

This study looked at how prostate tissue changes after a Greenlight laser treatment for benign prostatic hyperplasia (BPH), or enlarged prostate. Researchers used MRI and special ultrasound to measure the area of dead tissue (necrosis) created by the laser. The goal was simply to…

This study looked for tiny molecules called microRNAs in the blood of 33 men with advanced prostate cancer that no longer responds to hormone therapy. The goal was to see if certain microRNA patterns could predict whether a patient's cancer would resist chemotherapy or newer horm…

This study tested a new ultrasound method called Fast Cerebral Pulsatility Imaging (FCPI) to measure tiny brain movements caused by blood flow. Researchers studied 53 healthy adults to see how these pulsations change from young adulthood to old age. The goal was to better underst…

This study aimed to find early warning signs in eye fluid and cells that could predict if someone will develop dry eye or other surface problems after cataract surgery. Researchers collected samples from 100 adults before and during surgery and analyzed them for specific molecule…

This study looked at whether a specific gene (BDNF) influences how well people with major depression respond to antidepressants. Researchers compared the gene variations in 188 patients who either improved or did not improve after 3 to 6 weeks of treatment. The goal is to better …

This study looked at how muscle cells produce energy in undernourished patients with gastrointestinal cancer. Researchers measured muscle energy function and fat content in 51 patients to better understand cancer-related wasting. The goal was to gather knowledge, not to test a tr…

This study looked at blood and bone marrow samples from 102 healthy volunteers aged 18 to 85 to understand how age changes the balance of natural cell chemicals called reactive oxygen species. The goal was to create a reference for future research on blood diseases. No treatment …

This study aims to see if a special MRI technique can correctly map the brain's wiring. Researchers will compare MRI scans of 134 older adults (82+) with actual brain tissue after they pass away. The goal is to make MRI a reliable tool for studying brain diseases.

This study looked at whether a urine test before removing a double J stent (a tube that helps drain urine from the kidney) can prevent urinary infections afterward. Over 2,200 adults who were scheduled for stent removal took part. Researchers tracked how many people developed a u…

This study looked at how muscle cells produce energy in women with ovarian or endometrial cancer who have lost weight. Researchers compared women of different body sizes (BMI) to see if muscle metabolism differs. No treatments were tested; the goal was simply to understand the ch…

This study looked at whether ultrasound measurements of the cervix can better predict the time between starting labor induction and giving birth, compared to the standard Bishop score. It included 342 women with a full-term, single pregnancy who had an unfavorable Bishop score. T…

This study looked at how mindfulness meditation affects brain chemistry and memory in 30 female speech therapy students. Participants were split into two groups: one practiced mindfulness meditation, the other did muscle relaxation exercises. Over 6 weeks, researchers measured br…

This study used a special brain scan (PET imaging) to measure how a chemical called glutamate works in the brains of 27 men with autism, Fragile-X syndrome, or no condition. The goal was to understand brain differences, not to test a treatment. Participants had one imaging sessio…

This study looked at whether adults with phenylketonuria (PKU) have low-level body-wide inflammation. Researchers measured inflammatory markers in the blood of 40 participants (20 with PKU and 20 healthy volunteers matched by age, sex, and weight). The goal was to better understa…

This study looked at whether waiting to place an arterial catheter (a tube in an artery to monitor blood pressure) is as safe as placing it early in ICU patients with severe low blood pressure. Over 1,000 adults were randomly assigned to either early or delayed catheter insertion…