University Hospital, Tours

This completed Phase 3 trial tested whether adding two infusions of rituximab to standard mycophenolate mofetil (MMF) therapy improves lung function in 122 adults with interstitial lung disease (ILD) who did not respond to initial treatment. The main goal was to measure changes i…

This study looked at whether 6 weeks of antibiotics works as well as the standard 12 weeks for treating infections in hip or knee replacements after surgery. Over 400 adults in France took part, receiving either the shorter or longer course. The goal was to see if the shorter tre…

This study tested two ways to prepare the cervix for labor in women who are 41 to 42 weeks pregnant. One method uses a drug called Propess (dinoprostone), and the other uses a soft balloon device placed in the cervix. The goal was to see which method leads to fewer C-sections due…

This study looked at whether patients with a serious heart valve infection (endocarditis) can safely switch from intravenous (IV) antibiotics to oral pills after an initial course of IV treatment. The trial involved 324 adults with left-sided endocarditis caused by certain bacter…

This study tested the drug sirolimus in 63 children aged 6 to 18 with large, complicated slow-flow vascular malformations (abnormal blood or lymph vessels). The goal was to see if sirolimus could shrink the malformations and ease symptoms like pain, bleeding, and swelling. MRI sc…

This study tested whether patients with a serious heart valve infection (endocarditis) caused by staph bacteria could safely switch from intravenous (IV) antibiotics to oral pills after at least 10 days of IV treatment. The trial involved 162 adults with left-sided endocarditis. …

This study looked at 48 very low birth weight newborns to see if using a continuous glucose monitor (a small sensor that checks sugar levels all the time) could better manage low blood sugar compared to standard finger-prick tests. The goal was to reduce how often and how long th…

This study tested whether people with HIV who have a low viral reservoir can safely switch from a three-drug regimen to a two-drug regimen (Truvada alone) while keeping the virus under control. The goal is to reduce long-term side effects and treatment costs. The trial involved 2…

This study tested whether adding the drug rituximab to standard care could stop acute rejection in kidney transplant patients. 40 adults who had a kidney transplant within the past year and showed signs of acute humoral rejection took part. The main goal was to see if rituximab c…

This study looked at two types of stents used in a procedure called TIPS, which creates a bypass in the liver to relieve complications of cirrhosis. One stent is covered with a special material to stay open longer but costs more; the other is a standard bare stent that is cheaper…

This study looked at whether the flu vaccine can reduce inflammation in people with stable coronary artery disease. Inflammation plays a key role in heart disease progression. The trial involved 47 adults aged 60 and older with stable heart disease, who received the flu vaccine e…

This study tested whether adding a low-dose steroid (hydrocortisone) to standard care could help people with severe community-acquired pneumonia survive. Over 900 critically ill adults in intensive care took part. The goal was to see if the steroid reduced deaths within 28 days.

This study tested a daily dab of sirolimus solution on the tongue for people with a rare condition causing fluid-filled cysts on the tongue. The goal was to see if it could reduce symptoms like oozing, bleeding, and trouble eating or speaking. Twelve children and adults used the …

This study looked at whether adding methotrexate to adalimumab (a biologic drug) reduces the chance that the body makes antibodies against adalimumab in people with ankylosing spondylitis. About 110 adults with active disease who did not respond well to NSAIDs took part. The goal…

This study tested a cream containing sirolimus on rare skin growths called microcystic lymphatic malformations, which can ooze, bleed, and cause pain. 55 children and adults applied the cream to one area and a placebo cream to another for 12 weeks. The goal was to see if the siro…

This study looked at whether tears and cells from the eye surface can help diagnose ALS or predict how the disease will progress. Researchers collected tear samples and performed eye exams on 55 people with ALS and healthy controls. They analyzed the chemical makeup of tears to s…

This study tests whether a device called Fibroscan can diagnose fatty liver disease (steatosis) without needing a biopsy. Researchers will measure liver stiffness and viscosity in 72 people, including healthy volunteers and patients with confirmed fatty liver. Results will be com…

This study tested whether a painless, non-radiation ultrasound of the chest can find early signs of lung scarring in people with scleroderma. Thirty patients without known lung disease on CT scans underwent thoracic ultrasound. The goal was to see how often ultrasound detects hid…

This study tested whether a dye called iohexol can accurately measure kidney function in 100 ICU patients with unstable blood pressure. The goal was to see if this method could help detect acute kidney injury earlier than current tests. Researchers tracked how quickly the dye cle…

This study tested a new high-frequency ultrasound probe to see if it can measure gum pocket depth as accurately as the standard manual probing method for diagnosing periodontal disease. Thirty-nine adults participated, and researchers compared measurements from both methods. The …

This study tested whether a special ultrasound with contrast dye (CEUS) can accurately identify liver lesions found on regular ultrasound. Researchers compared CEUS to CT, MRI, and biopsy in 878 adults. The goal was to see if CEUS could provide a cheaper, safer, and equally relia…

This study tested whether a special ultrasound using contrast dye can better diagnose placenta accreta, a condition where the placenta grows too deeply into the womb and can cause severe bleeding after birth. Researchers studied 80 pregnant women at high risk for this condition. …

This study tested whether giving inhaled amikacin for three days could prevent pneumonia in 850 adults on breathing machines. Patients received either the drug or a placebo starting day 4 of ventilation. The goal was to see if the treatment reduced pneumonia cases up to day 28.

This study tested a two-step vaccine approach to prevent pneumococcal infections in 26 adults with diffuse large B-cell lymphoma who were receiving chemotherapy with rituximab. The vaccines, Prevenar and Pneumovax, were given in a prime-boost sequence to boost immune protection. …

This study looked at whether taking a low-dose aspirin (160 mg) at bedtime, starting early in pregnancy (before 16 weeks), could prevent pre-eclampsia and small babies in first-time mothers identified as high-risk through an ultrasound. Over 1,100 women participated. The goal was…

This study tested whether taking a single dose of antibiotics once a week, alternating between two different drugs, can prevent urinary tract infections (UTIs) in adults with neurogenic bladder (a bladder that doesn't work normally due to nerve damage). The study included 45 peop…

This study tested whether having conscious COVID-19 patients with breathing problems lie face down (prone position) while on high-flow oxygen could reduce the need for a breathing tube. Over 400 adults with COVID-19 pneumonia and mild to severe acute respiratory distress syndrome…

This study tested whether a mild electrical brain stimulation technique called tDCS could improve the results of trauma-focused therapy for people with PTSD. 63 adults with chronic PTSD received either real tDCS or a fake version during therapy sessions. The goal was to see if th…

This study tested two ways of positioning patients with severe lung injury (ARDS) who are on ventilators and placed face-down (prone) to help breathing. The goal was to see if a 'swimmer' position—where the head is turned and one arm is bent—causes fewer severe pressure sores tha…

This study tested whether using magnetic pulses (rTMS) on the brain while people recall their traumatic memories can reduce PTSD symptoms. 39 adults with PTSD for at least 3 months received either 10Hz or 1Hz rTMS over 2 weeks. Researchers measured changes in PTSD severity using …

This study looked at whether a specific breathing exercise (forced expiration while lying on the side of the surgery) can shorten the time children need a chest tube after lung surgery. The tube drains fluid that builds up after the operation. The study involved 140 children aged…

This study tested whether daily smell training for 12 weeks could improve mood and smell perception in 150 people with mild to moderate depression. Participants practiced smelling different odors each day. The goal was to see if this simple, drug-free activity could help ease dep…

This study tested the drug levetiracetam as a first treatment for seizures in 18 full-term newborns who had brain injury from lack of oxygen at birth. The goal was to find the right dose and check if the drug is safe and works well. The study measured how much seizures decreased …

This study tested whether a phone-based cognitive behavioral therapy program could help people with severe or morbid obesity reduce their food addiction. 154 participants received either 12 therapy sessions over 18 weeks or their usual care. The goal was to see if the therapy cou…

This study looked at whether a one-hour dose of nitrous oxide (laughing gas) can quickly reduce depression symptoms in older adults (ages 60-90) whose depression hasn't improved with standard treatments. Sixty participants received either the gas or a placebo (medical air) and we…

This study looked at two different surgical methods for fixing hip fractures in people over 65. The goal was to see if a newer, less invasive method (MISS) causes less blood loss than the standard method (PHS). The study involved 108 participants and measured blood loss from the …

This study looked at whether giving the drug salbutamol (often used in asthma inhalers) through a nebulizer helps people with severe COPD who are having a flare-up and need a breathing machine. The trial included 43 adults and compared the drug to a placebo. The main goal was to …

This study tested if a high-flow nasal system (AIRVO 2) can deliver the bronchodilator salbutamol as effectively as a standard mask for people with COPD. 25 adults with COPD and reversible airway blockage took part. The goal was to see if the new method works just as well at impr…

This completed study looked at how metabolism differs in people with ALS. Researchers took blood and skin samples from 9 patients to analyze molecules and genes. The goal was to better understand the disease, not to test a treatment.

This completed study looked at blood and bone marrow samples from 102 healthy volunteers aged 18 to 85. Researchers measured levels of reactive oxygen species (a type of cell stress) and the activity of antioxidant genes. The goal was to see how age affects these factors, which c…

This completed study looked at whether using ultrasound to measure the cervix can better predict the time from labor induction to delivery compared to the standard Bishop exam. Researchers followed 342 women with full-term, single pregnancies who had an unfavorable Bishop score. …

This study looked at 40 adults—some with phenylketonuria (PKU) and some healthy—to see if PKU causes low-level inflammation in the body. Researchers measured inflammatory markers in blood samples. The goal was to better understand how PKU affects overall health, not to test a new…

This study used special PET and MRI scans to look at brain activity in 27 men with autism, Fragile X syndrome, or no condition. The goal was to measure a brain chemical called glutamate, which helps nerve cells communicate. Researchers hope this will reveal how brain signaling di…

This study looked at whether a device that delivers rapid puffs of air (intrapulmonary percussion ventilation) can help inhaled medication reach scarred lung areas in people with idiopathic pulmonary fibrosis (IPF). Nine participants inhaled a radioactive tracer with and without …

This study followed 150 children aged 2 to 12 who have a port wine stain on a leg. Researchers tracked how the stain changes as the child grows, and whether it leads to problems like blood vessel issues or bone growth differences. The goal was to learn more about the condition an…

This study looked at how adults with autism spectrum disorder (ASD) and bipolar disorder (BD) experience and show emotions. Researchers measured things like heart rate, pupil size, and facial expressions in a lab, and also tracked emotions in daily life for a week. The goal was t…

This study looked at 92 adults aged 55 and older with major depression to see if their brains had amyloid plaques, which are linked to Alzheimer's disease. Researchers used a special PET scan to measure plaque levels after 8 weeks of antidepressant treatment. The goal was to unde…

This study looked at two methods to help women who have not been screened for cervical cancer get tested. One group received a vaginal self-sampling kit in the mail, while the other was invited to visit their general practitioner. The goal was to see which approach leads more wom…

This study looked at the specific symptoms of complex post-traumatic stress disorder (PTSD) compared to regular PTSD. Researchers used questionnaires to measure dissociation, emotional control, and trauma in 300 adults. The goal was to better understand and identify complex PTSD,…

This study looked at how the brain reacts to nitrous oxide (laughing gas) in people with treatment-resistant depression. Researchers used ultrasound and MRI scans to measure brain activity before, during, and after a one-hour session of breathing the gas. The goal was to understa…

This study analyzed blood samples from 33 men with advanced prostate cancer that no longer responds to hormone therapy. Researchers looked for tiny molecules called microRNAs that might predict whether a patient will resist chemotherapy or newer hormone drugs. The goal is to help…

This study looked at whether the color of the artificial lens used in cataract surgery affects sleep and mood. 400 adults aged 60-90 received either a white or yellow implant in each eye. Researchers measured changes in sleep time, sleep quality, and mood two months after surgery…

This study aimed to find biological markers (biomarkers) in muscle, blood, and cells to help diagnose amyotrophic lateral sclerosis (ALS) earlier and understand the disease better. Researchers analyzed samples from 37 adults with ALS using advanced techniques to look at molecules…

This study looked at 600 premature babies born between 25 and 32 weeks of pregnancy. Researchers used MRI scans around the time the babies were due to be born and then tested their thinking and problem-solving skills at age 5. The goal was to see if early brain differences could …

This study aimed to find biological markers in blood, urine, and saliva that could help explain why up to 40% of people with depression do not respond to standard antidepressants. Researchers analyzed samples from 50 adults with major depression who had not taken antidepressants …

This study looked at whether mindfulness meditation can change brain metabolism and improve memory in students. Thirty female speech therapy students were split into two groups: one did mindfulness training, the other did muscle relaxation. Both groups had brain scans and memory …

This study looked at whether giving a written sheet to melanoma patients, to pass on to their close relatives, helps those relatives get a skin exam from a doctor. 420 patients and their family members took part. The goal was to see if the written reminder works better than just …

This pilot study tested whether a portable ultrasound device can help paramedics quickly tell which type of stroke a person is having. The goal is to get patients to the right hospital faster—some need a clot-busting drug, others need a procedure to remove a large clot. The study…

This study explored whether analyzing the fluid used to preserve donor kidneys on a special machine can help predict how well the kidney will work after transplant. Researchers measured substances in the fluid and compared them to how the kidney functioned in the first week after…

This study looked at whether a phone call from a medical student to older adults with heart disease or mental health conditions during the COVID-19 lockdown in France could reduce hospitalizations within a month. About 22,000 people took part. The goal was to see if this simple c…

This study looked at 69 adults with rheumatoid arthritis who were taking the drug adalimumab (Humira). Researchers measured drug levels in the blood over 6 months to see if they could predict who would respond well to treatment. The goal was to find a way to adjust doses early, i…

This study looked at how muscle cells produce energy in women with ovarian or endometrial cancer who have lost weight. Researchers compared women with different body mass indexes (BMI) to see if metabolism differs. The goal was to understand the biology behind cancer-related weig…

This study tested whether advanced MRI and ultrasound techniques can better measure muscle changes in people with rotator cuff tears. Three adults with a tear on one side and a healthy shoulder on the other took part. The goal was to see if these imaging tools could provide clear…

This study looked at 220 adults with phenylketonuria (PKU), a rare genetic condition that requires a special diet from birth. Researchers wanted to see if adults with PKU experience mental decline or other brain problems, and how the disease affects their daily life and social in…

This study involved 2,200 adults who had a double J stent removed. Researchers wanted to find out if a standard urine test before removal actually helps prevent urinary infections afterward. Participants were followed for one month to track any infections. The goal was to see if …

This study followed 73 adults with bone or joint infections who needed antibiotics for at least 6 weeks. Researchers tracked the number and severity of side effects over one year to see how they affect patients' daily lives and treatment success. The goal was to better understand…

This study followed 137 people who had severe COVID-19 pneumonia and needed high-flow oxygen in the ICU. Researchers checked their quality of life and survival more than 2 years after they were randomly placed on their stomachs while awake or not. The goal is to see if this simpl…

This study aims to validate a special MRI technique called tractography, which maps the brain's white matter connections. Researchers will compare MRI scans from 134 older adults (aged 82+) with actual brain tissue samples after donation. The goal is to ensure this non-invasive i…

This study looked at whether waiting to place an arterial catheter (a thin tube in an artery to monitor blood pressure) in critically ill patients with shock is as safe as placing it right away. Over 1,000 adults in intensive care were randomly assigned to either early or delayed…

This study tested a new ultrasound device to measure skin stiffness (fibrosis) in people with lymphedema or venous insufficiency. Researchers compared results from 130 participants, including healthy volunteers, to see if the device could detect differences in skin hardness. The …

This study looked at how muscle energy works in 51 people with gastrointestinal cancer who were losing weight. The goal was to understand why cancer-related weight loss happens and find new ways to help. Researchers measured muscle cell energy use and fat storage, but this was an…

This study looked at whether a specific gene (BDNF) influences how well people with major depression respond to antidepressants. Researchers compared the gene variations in 188 patients who either improved or did not improve after 3 to 6 weeks of treatment. The goal is to better …

This study tested whether holding regular, structured team meetings about ethics in the intensive care unit (ICU) helps nurses feel more included in decisions to limit or stop life support. Researchers measured changes in nurses' perception of the decision-making climate, their w…

This study looked at how people with current depression, those who have recovered from depression, and healthy people react physically to emotions. Researchers measured heart rate, breathing, skin sweat, and brain blood flow during emotional tasks. The goal was to understand diff…

This study looked for early warning signs in eye fluids that could predict if someone will develop dry eye or other surface problems after cataract surgery. Researchers collected tiny samples from the eye's surface and inner fluid from 100 adults having cataract surgery. They use…

This study tested a new ultrasound method called Fast Cerebral Pulsatility Imaging (FCPI) to measure tiny brain movements in healthy adults aged 18 and older. Researchers aimed to see how these movements change from young adulthood to old age. The study involved 53 participants a…

This study looked at how prostate tissue heals after a Greenlight laser treatment for benign prostatic hyperplasia (BPH), or enlarged prostate. Researchers used MRI and special ultrasound scans to measure the area of dead tissue created by the laser in 12 men over a year. The goa…