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Weekly antibiotic rotation could slash UTIs in neurogenic bladder patients

NCT ID NCT01388413

Prevention Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking a different antibiotic once a week, rotating between two drugs, could prevent urinary tract infections in people with neurogenic bladder. The 45 participants had at least four infections per year and used a catheter. The goal was to see if this approach reduces infections and hospital stays compared to standard care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Weekly oral cyclic antibiotics (amoxicillin, amoxicillin/clavulanic acid, cefixime, fosfomycin trometamol, trimethoprim/sulfamethoxazole)
What this could lead to
If successful, this could offer a new way to prevent frequent urinary tract infections in people with neurogenic bladder, reducing hospital visits and antibiotic resistance risks.
What could go wrong
This is a small Phase 4 study with only 45 participants, so results may not apply to everyone. Long-term antibiotic use still carries risks of side effects and resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

45 people

The number who actually took part.

Start date

Aug 2011

Finished

Feb 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * subject over 18 years of age * having a neurogenic bladder with automatic catheter and pharmacologic disconnection of the detrusor muscle * having at least 4 symptomatic UTIs per year with bacterial sensitivity to the chosen antibiotics * having given full consent to participate in the study * being the recipient of social security benefits Exclusion Criteria: * known allergy or hypersensitivity to useful antibiotics (to which the bacterium or bacteria are sensitive) or to one of their components * other contraindication in the administering of useful antibiotics * urinary volume flow \>500 ml during automatic catheter * different urinary drainage method than automatic catheter * occurrence of stones in the urinary tract * infection due to endo urinary material (urinary prosthesis, ureteral stent) * creatinine clearance \<60 ml/min * patient under guardianship * women who are pregnant, nursing, or who may become pregnant

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Conditions

The condition(s) this trial relates to.

Urinary Bladder, Neurogenic urinary tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Neurogenic bladder Urinary tract infection

Contacts and locations

Locations

  • University Hospital, Bretonneau / TOURS

    Tours, 37000, France

  • University Hospital, Pontchaillou / RENNES

    Rennes, 35000, France

  • University Hospital, Raymond Poincaré / APHP

    Garches, 92380, France

  • University Hospital, St Jacques / NANTES

    Nantes, 44000, France

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