Weekly antibiotic rotation could slash UTIs in neurogenic bladder patients

NCT ID NCT01388413

Completed Prevention Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking a different antibiotic once a week, rotating between two drugs, could prevent urinary tract infections in people with neurogenic bladder. The 45 participants had at least four infections per year and used a catheter. The goal was to see if this approach reduces infections and hospital stays compared to standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Weekly oral cyclic antibiotics (amoxicillin, amoxicillin/clavulanic acid, cefixime, fosfomycin trometamol, trimethoprim/sulfamethoxazole)
What this could lead to: If successful, this could offer a new way to prevent frequent urinary tract infections in people with neurogenic bladder, reducing hospital visits and antibiotic resistance risks.
What could go wrong: This is a small Phase 4 study with only 45 participants, so results may not apply to everyone. Long-term antibiotic use still carries risks of side effects and resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Urinary Bladder, Neurogenic urinary tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROGENIC BLADDER URINARY TRACT INFECTION

Contacts and locations

Locations

University Hospital, Bretonneau / TOURS

Tours, 37000, France
University Hospital, Pontchaillou / RENNES

Rennes, 35000, France
University Hospital, Raymond Poincaré / APHP

Garches, 92380, France
University Hospital, St Jacques / NANTES

Nantes, 44000, France

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